Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

Siglecs and their roles in the immune system

Crocker, P. R., Paulson, J. C., & Varki, A. P. (2007) · Nature reviews. Immunology · doi:10.1038/nri2056 · Cited by 2,032

Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation

Kaneko, Y., Nimmerjahn, F., & Ravetch, J. V. (2006) · Science · doi:10.1126/science.1129594 · Cited by 1,754

The Impact of Glycosylation on the Biological Function and Structure of Human Immunoglobulins

Arnold, J. N., Wormald, M. R., Sim, R. B., Rudd, P. M., & Dwek, R. A. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141702 · Cited by 1,354

Divergent Immunoglobulin G Subclass Activity Through Selective Fc Receptor Binding

Nimmerjahn, F., & Ravetch, J. V. (2005) · Science · doi:10.1126/science.1118948 · Cited by 1,057

Anti-inflammatory Activity of IVIG Mediated Through the Inhibitory Fc Receptor

Samuelsson, A., Towers, T. L., & Ravetch, J. V. (2001) · Science · doi:10.1126/science.291.5503.484 · Cited by 1,051

Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins

Varki, A. P. (2007) · Nature · doi:10.1038/nature05816 · Cited by 855

From Systemic T Cell Self-Reactivity to Organ-Specific Autoimmune Disease via Immunoglobulins

Korganow, A., Ji, H., Mangialaio, S., Duchatelle, V., Pelanda, R., Martin, T., Degott, C., Kikutani, H., Rajewsky, K., Pasquali, J., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80045-x · Cited by 691

A Two-Amino Acid Change in the Hemagglutinin of the 1918 Influenza Virus Abolishes Transmission

Tumpey, T. M., Maines, T. R., Hoeven, N. V., Glaser, L. J., Solórzano, A., Pappas, C., Cox, N. J., Swayne, D. E., Palese, P., Katz, J. M., et al. (2007) · Science · doi:10.1126/science.1136212 · Cited by 580

Higher levels of sialylated Fc glycans in immunoglobulin G molecules can adversely impact functionality

Scallon, B. J., Tam, S. H., McCarthy, S. G., Cai, A. N., & Raju, T. S. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.09.005 · Cited by 413

Influenza Virus Receptor Specificity and Cell Tropism in Mouse and Human Airway Epithelial Cells

Ibricevic, A., Pekosz, A. S., Walter, M. J., Newby, C. M., Battaile, J. T., Brown, E. G., Holtzman, M. J., & Brody, S. L. (2006) · Journal of Virology · doi:10.1128/jvi.02677-05 · Cited by 399

IgG glycans and glyco-engineering

(2012) · Elsevier eBooks · doi:10.1533/9781908818096.251

Faculty Opinions recommendation of Fc-glycosylation of IgG1 is modulated by B-cell stimuli.

Williams, M. A., & Collin, M. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.9047958.10601054

Mangel an Immunglobulinpräparaten 2008

(2008) · Bulletin des Médecins Suisses · doi:10.4414/saez.2008.13982

Editors' Picks

(2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.186

Faculty Opinions recommendation of Engineered sialylation of pathogenic antibodies in vivo attenuates autoimmune disease.

Michael, B. D., & Ellul, M. A. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732364665.793546495

Journal Club

(2008) · Kidney International · doi:10.1038/ki.2008.347

Genetically Engineered Antibody Molecules

Morrison, S. L., & Yoo, E. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.00129-x

Glycosylation and Antibody Function

Wang, L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00181-4

Multisystemic Inflammatory Syndrome in Children: A Retrospective Study

Bahous, E., Ayad, A., Abilkassem, R., Ourrai, A., Hassani, A., & Agadr, A. (2022) · Asian Journal of Pediatric Research · doi:10.9734/ajpr/2022/v10i4203

Advances in Immunomodulatory Treatment for Fulminant Myocarditis in Children

陈, 静. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.131040

The DAMP-Driven Host Immune Defense Program Against Pathogens

Land, W. G. (2023) · Springer eBooks · doi:10.1007/978-3-031-21776-0_4

Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV InfectionPreprint

Giron, L. B., Liu, Q., Adeniji, O. S., Yin, X., Kannan, T., Ding, J., Lu, D. Y., Langan, S. J., Zhang, J., Azevedo, J. L. L. C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.09.551369

N-glycans bring therapeutic antibody

Yonezawa, A. (2023) · Drug Delivery System · doi:10.2745/dds.38.297

Homoeostatic Versus Pathogenic Autoantibodies: Origin, Structure and Effector Functions

Atisha‐Fregoso, Y., Pozovskiy, R., Haque, S., Watanabe, M., Zou, Y.-R., & Diamond, B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95895-0.00006-4

Altered spike IgG Fc N-linked glycans are associated with hyperinflammatory state in adult COVID and Multisystem Inflammatory Syndrome in ChildrenPreprint

Sherman, J. D., Karmali, V., Kumar, B., Simon, T. W., Bechnak, S., Panjwani, A., Ciric, C. R., Wang, D., Huerta, C., Johnson, B. E., et al. (2024) · medRxiv · doi:10.1101/2024.07.14.24310381

Recombinant IgG1 Fc-μTP-L309C Ameliorates Endogenous Rheumatoid Arthritis in the K/BxN Mouse Model by Decreasing Th1 and Th17 Cells in the Spleen, Lymph Nodes and Joint and Increasing T Regulatory Cells and IL-10 in the Joint

Branch, D. R., Lewis, B. J. B., Cen, S. Y., Almizraq, R. J., Binnington, B., Spirig, R., & Käsermann, F. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14134509

More Than Just Antinuclear Antibodies: IgG Sialylation May Tip the Balance in Autoimmunity

Centeio, R., & Wang, T. T. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43379

Different strategies to make biobetters: physicochemical, pharmacodynamics, and pharmacokinetic aspects came into focus

Pishgahzadeh, E., Bozorgchami, N., Talebi, M., Masoudifar, R., Ahmadi, M., & Ghorbani-Bidkorpeh, F. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126319

Inhibiting glycan degradation prevents HIV-induced inflammaging and cognitive impairment

Giron, L. B., Borjabad, A., Hadas, E., Granche, J., de Menezes, E. G. M., Premeaux, T. A., He, H., Yeung, S. T., Singh, S. T., Friday, C., et al. (2026) · Med · doi:10.1016/j.medj.2026.101175

FcγRIIa in autoimmunity: Unraveling pathogenic mechanisms and therapeutic opportunities

Zhu, B., Cao, X., Wang, X., Yu, L., Zhou, W., Zhu, L. J., Yang, Q., & Rui, K. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103974

Asymmetrical Glyco-Engineering of Monoclonal Antibodies Provides Insights into α-Gal ImmunogenicityPreprint

Bosman, G. P., Ehlers, A. M., Buckley, T., Dobruchowska, J. M., Toraño, J. S., Bentlage, A. E. H., Knulst, A. C., Vidarsson, G., & Boons, G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.15.694461

The Contribution of Immunoglobulin G to Inflammation is Regulated by The Site of Production via Glycosylation

Ercan, A. (2025) · Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi · doi:10.65520/erciyesfen.1789878

Mapping the glycosylation code through synthetic chemistry

Li, X., & Tan, Z. (2026) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2026.103134

Antigen-specific IgG glycosylation profiles in hamsters and macaques following COVID-19 vaccination

Claushuis, B., Nouta, J., Wang, W., Koeleman, C. A. M., de Ru, A. H., van Veelen, P. A., Zahn, R. C., Roozendaal, R., Vidarsson, G., & Wuhrer, M. (2026) · iScience · doi:10.1016/j.isci.2026.115400

Evaluation of Children Who Develop Myocarditis Due to Coronavirus Disease 2019

Balık, H., Türe, M., AKIN, A., Uç, D., Yılmaz, K., Şehmusoğlu, K., Aktar, F., & Kan, A. (2026) · Harran Üniversitesi Tıp Fakültesi Dergisi · doi:10.35440/hutfd.1818455

Deciphering the immune response to respiratory pathogens - Role of programmed death-ligand 1

Victor, E. S. (2016) · theses.fr (ABES) · doi:10.70675/42f25aeez159bz4bf3z8f30z05634e3e8152

Mise en oeuvre de dosages pour le diagnostic précoce de l'hypothyroïdie

Iss, C. (2015) · theses.fr (ABES) · doi:10.70675/f9f2aeebza5a8z4cf3zb9afzd52e7504b286

Generic mass spectrometric workflows for mAb-related therapeutic protein quantification in pre-clinical species

Lanshoeft, C. (2017) · theses.fr (ABES) · doi:10.70675/70955a37z9a6cz40f5zbe72z9049aa84a7f0

The regulatory effects of circulating normal immunoglobulins on autophagy and Th17 response

Das, M. (2017) · theses.fr (ABES) · doi:10.70675/ea6bb914zc789z45bez864fz4c3386135691 · Cited by 2

Les IgA anti VIH-1 protecteurs comme lien entre immunité innée et adaptative : recrutement et activation des cellules effectrices par des IgA anti-gp41 pour éliminer les cellules infectées par le VIH-1 et potentielle coopération avec les IgG

Duchemin, M. (2020) · theses.fr (ABES) · doi:10.70675/f23b1521z398ez4fe3za54aze6b18e252fe2

Mise en oeuvre de microréseaux de lectines naturelles et recombinantes dédiés au suivi de production des glycoprotéines d'intérêt thérapeutique

Machon, O. (2019) · theses.fr (ABES) · doi:10.70675/603bc1c9z03f9z4582zbbb3z053819e4e2c7

Effets des immunoglobulines intraveineuses sur les cellules de l'immunité innée

Galeotti, C. (2018) · doi:10.70675/74e33db2z8ddbz4416zbad2zca91d0a11575

Ingénierie métabolique de la voie de N-Glycosylation chez la diatomée Phaeodactylum tricornutum

Dumontier, R. (2020) · theses.fr (ABES) · doi:10.70675/28ff391ez6f2fz496fz93dbzfbd714683c09

Regulation of immune cell metabolism by therapeutic normal IgG or intravenous immunoglobulin (IVIG)

Rambabu, N. (2020) · theses.fr (ABES) · doi:10.70675/bd594585z3904z4468z87f9zde346d039070

Role of Wnt/β-catenin pathway in the anti-inflammatory mechanism of therapeutic normal immunoglobulins

Karnam, A. (2019) · theses.fr (ABES) · doi:10.70675/ae464b4az3b90z42fazb943ze3b07d12e80f

Immunoglobulines G de patients sclérodermiques : optimisation des méthodes de purification, étude de la glycosylation et analyse de l'impact sur le profil protéomique de fibroblastes

Bourel, L. (2024) · theses.fr (ABES) · doi:10.70675/1b6dc764z6c88z4c8aza0c5z6caf80ea1bfd

IgG Glycosylation Analysis in Patients with Ring14 Syndrome Unveils Novel Pathomechanisms and New Therapy Perspectives

Messina, A., Palmigiano, A., Romeo, D. A., Sturiale, L., Parano, E., Crimi, M., Cirillo, A. C., Parano, E., Barone, R. M. E., & Garozzo, D. (2026) · Biomolecules · doi:10.3390/biom16060760

System-wide immunoregulation by polyvalent IgG: integrating transcriptomic, miRNA, and proteomic landscapes

Borges, J. V. D. S., Passos, L. O., Machado, N. R., do Nascimento, L. A., Fagundes, B. O., Bergamasco, I. S., Moreira, A. L. B., Cilento, N. E., Sanabani, S. S., & Victor, J. R. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08289-6

Advanced glycomics approach for characterization of IgG glycan alterations and immune modulation in traumatic brain injury

Onigbinde, S. B., Solomon, J., Sandilya, V., Daramola, O. E., Fowowe, M., Adeniyi, M., Kobeissy, F. H., Mondello, S., Puccio, A. M., & Mechref, Y. S. (2026) · Analytica Chimica Acta · doi:10.1016/j.aca.2026.345882

Chemoenzymatic synthesis of unusual antibody glycoforms using E. coli expressed human and bovine β-1,4-galactosyltransferase and their mutants

Owitipana, D. N., Harris, D., Yun, H., Zong, G., & Wang, L. (2026) · Carbohydrate Research · doi:10.1016/j.carres.2026.110019

Biological Functions of Glycosylation and Their Application in Glycoengineered Therapeutics

Kubalek, C., Gardiner, S., Heaps, W. P., McCammon, K. M., Talcott, S., Argyle, M., Bundy, B. C., & Corte, D. D. (2026) · ChemEngineering · doi:10.3390/chemengineering10070085

Using chemical synthesis to investigate protein glycosylation: O-mannosylation site specifically modulates the stability and cellulose binding affinity of family 1 carbohydrate binding modules

Drake, M. R. (2014) · CU Scholar (University of Colorado Boulder)

Programmable One-Tube Sialic Acid Derivatization Enables Dual-Mode N -Glycomics of Low-Input Samples

Lu, J., Tursumamat, N., Liu, S., Liu, Q., Li, H., Su, X., Wu, S., Guo, S., Shen, X., Peng, W., et al. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c02757

IgG Glycosylation Patterns May Identify Distinct Clinical Trajectories in Fibromyalgia Patients: A Longitudinal Pilot Study

Kung, L., Nhu, N. T., Yu, Y., Tsai, I., & Kang, J. (2026) · European Journal of Pain · doi:10.1002/ejp.70364

Glycosylation in Quality and Safety of Therapeutic Proteins

Matsumoto, Y., Kim, J., McKenna, K. R., Biel, T. G., Kirshner, S., Falkowski, V. M., & Ju, T. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100163

Glycan-intrinsic monoclonal antibody biomanufacturing

Gyorgypal, A. (2026) · Frontiers in Chemical Engineering · doi:10.3389/fceng.2026.1955792

Solution structure of interleukin-1β bound to a potential therapeutic antibody

Wilkinson, I. C. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)

with a Recombinant IgG Fc Recapitulation of IVIG Anti-Inflammatory Activity

Anthony, R. M. (2008)

Research Highlights

Okoreeh, M. K., & Luo, X. (2026) · Transplantation · doi:10.1097/tp.0000000000005610

The anti-inflammatory activity of IgG is enhanced by co-engagement of type I and II Fc receptors

Jones, A., Marino, A. E., Martynyuk, T., Bournazos, S., & Ravetch, J. V. (2025) · Science · doi:10.1126/science.adv2927 · Cited by 11

Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity

Washburn, N., Schwab, I., Ortiz, D., Bhatnagar, N., Lansing, J. C., Medeiros, A., Tyler, S., Mekala, D., Cochran, E., Sarvaiya, H., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422481112 · Cited by 225

Novel Fc receptors mediating the anti-inflammatory properties of IgG

Ravetch, J. V. (2010)