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Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation

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The Impact of Glycosylation on the Biological Function and Structure of Human Immunoglobulins

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Divergent Immunoglobulin G Subclass Activity Through Selective Fc Receptor Binding

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Anti-inflammatory Activity of IVIG Mediated Through the Inhibitory Fc Receptor

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From Systemic T Cell Self-Reactivity to Organ-Specific Autoimmune Disease via Immunoglobulins

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A Two-Amino Acid Change in the Hemagglutinin of the 1918 Influenza Virus Abolishes Transmission

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Higher levels of sialylated Fc glycans in immunoglobulin G molecules can adversely impact functionality

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Influenza Virus Receptor Specificity and Cell Tropism in Mouse and Human Airway Epithelial Cells

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Effects of Sialic Acid Linkage on Antibody-Fragment Crystallizable Receptor Binding and Antibody Dependent Cytotoxicity Depend on Levels of Fucosylation/Bisecting

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Fcγ receptor biology and systemic lupus erythematosus

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Tumor necrosis factor-α –308G/A gene polymorphism in Egyptian children with immune thrombocytopenic purpura

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Efficient Chemoenzymatic Synthesis of N‐Glycans with a β1,4‐Galactosylated Bisecting GlcNAc Motif

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Recent advances in antibody glycoengineering for the gain of functions

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The future of immunoglobulin therapy: An overview of the 2nd international workshop on natural antibodies in health and disease

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The structure and role of lactone intermediates in linkage-specific sialic acid derivatization reactions

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Case Report: COVID-19 Vaccination Associated Fulminant Myocarditis

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Viral and Host Biomarkers of HIV Remission Post Treatment Interruption

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Harnessing IgG Fc glycosylation for clinical benefit

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Pathobiont-driven antibody sialylation through IL-10 undermines vaccination

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Expression and function of the inhibitory Fcγ‐receptor in CIDP

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Aberrant glycosylation of the anti-Thomsen-Friedenreich glycotope immunoglobulin G in gastric cancer patients

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Antibody‐mediated sialidase activity in blood serum of patients with multiple myeloma

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Can glycoprofiling be helpful in detecting prostate cancer?

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Functional role of carbohydrate residues in human immunoglobulin G and therapeutic monoclonal antibodies

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Intravenous Immunoglobulin in Pediatric Rheumatology: When to Use It and What Is the Evidence

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Targeting IgG in Arthritis: Disease Pathways and Therapeutic Avenues

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Capillary (Gel) Electrophoresis-Based Methods for Immunoglobulin (G) Glycosylation Analysis

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New Opportunities in Glycan Engineering for Therapeutic Proteins

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Should development of Alzheimer¿s disease-specific intravenous immunoglobulin be considered?

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Light-Induced Histidine Adducts to an IgG1 Molecule Via Oxidized Histidine Residue and the Potential Impact of Polysorbate-20 Concentration

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Antibody Engineering

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Cell-based glycoengineering for production of homogeneous and specific glycoform-enriched antibodies with improved effector functions

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Immunoglobulin Glycosylation – An Unexploited Potential for Immunomodulatory Strategies in Farm Animals

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Novel data analysis tool for semiquantitative LC-MS-MS2 profiling of N-glycans

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Myasthenia Gravis Treatment Updates

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State-of-the-Art Glycomics Technologies in Glycobiotechnology

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Systems Glycobiology: Immunoglobulin G Glycans as Biomarkers and Functional Effectors in Aging and Diseases

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Current views on N-glycolylneuraminic acid in therapeutic recombinant proteins

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Targeting B cells and autoantibodies in the therapy of autoimmune diseases

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Molecular and Cellular Pathways of Immunoglobulin G Activity In Vivo

Nimmerjahn, F. (2014) · ISRN Immunology · doi:10.1155/2014/524081 · Cited by 14

Protein destabilizing agents induce polyreactivity and enhanced immunomodulatory activity in IVIg preparations

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Fractionation of Fab glycosylated immunoglobulin G with concanavalin A chromatography unveils new structural properties of the molecule

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IVIG efficacy in CIDP patients is not associated with terminal complement inhibition

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Using the K/BxN mouse model of endogenous, chronic, rheumatoid arthritis for the evaluation of potential immunoglobulin-based therapeutic agents, including IVIg and Fc-μTP-L309C, a recombinant IgG1 Fc hexamer

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Engineered Fc-glycosylation switch to eliminate antibody effector function

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An open-label dosing study to evaluate the safety and effects of a dietary plant-derived polysaccharide supplement on the N-glycosylation status of serum glycoproteins in healthy subjects

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Isotype Selection and Fc Engineering: Design and Construction of Fit-for-Purpose Therapeutic Antibodies

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Identification of serum glycobiomarkers for Hepatocellular Carcinoma using lectin microarrays

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Sialyltransferase and Neuraminidase Levels/Ratios and Sialic Acid Levels in Peripheral Blood B Cells Correlate with Measures of Disease Activity in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Pilot Study

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Emerging immunotherapies for autoimmune kidney disease

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The Role and Function of Fcγ Receptors on Myeloid Cells

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Production of recombinant human IgG1 Fc with beneficial N-glycosylation pattern for anti-inflammatory activity using genome-edited chickens

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Rapid Glycopeptide Enrichment Using Cellulose Hydrophilic Interaction/Reversed-Phase StageTips

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IgG glycosylation in autoimmune diseases

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Sweet Rules: Linking Glycosylation to Antibody Function

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Human IgG Subclasses Differ in the Structural Elements of Their N -Glycosylation

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Going Native: Synthesis of Glycoproteins and Glycopeptides via Native Linkages To Study Glycan-Specific Roles in the Immune System

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Efficient HCD-pd-EThcD approach for N-glycan mapping of therapeutic antibodies at intact glycopeptide level

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Aptamer-based Biosensors: Promising Sensing Technology for Diabetes Diagnosis in Biological Fluids

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Engineering the supernatural: monoclonal antibodies for challenging infectious diseases

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Enhancement of glycosylation by stable co-expression of two sialylation-related enzymes on Chinese hamster ovary cells

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Enhancement of fucosylated N-glycan isomer separation with an ultrahigh column temperature in porous graphitic carbon liquid chromatography-mass spectrometry

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Virus Infection of the Heart – Unmet Therapeutic Needs

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Insertion of N-terminal hinge glycosylation enhances interactions of the Fc region of human IgG1 monomers with glycan-dependent receptors and blocks hemagglutination by the influenza virus

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The anti-inflammatory activity of IgG is enhanced by co-engagement of type I and II Fc receptors

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Methadone use is associated with increased levels of sCD14, immune activation, and inflammation during suppressed HIV infection

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Two N-terminally truncated variants of human β-galactoside α2,6 sialyltransferase I with distinct properties for in vitro protein glycosylation

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The role of ACPAs in at-risk individuals: Early targeting of the bone and joints

Schett, G. A. (2017) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2017.09.015 · Cited by 11

O-GalNAcylation of RANTES Improves Its Properties as a Human Immunodeficiency Virus Type 1 Entry Inhibitor

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Antibody bivalency improves antiviral efficacy by inhibiting virion release independently of Fc gamma receptors

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PGLYRP1-mIgG2a-Fc inhibits macrophage activation via AKT/NF-κB signaling and protects against fatal lung injury during bacterial infection

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Protection from experimental autoimmune encephalomyelitis by polyclonal IgG requires adjuvant-induced inflammation

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Effects of Galactosylation in Immunoglobulin G from All-Atom Molecular Dynamics Simulations

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Possible role of β-galactosidase in rheumatoid arthritis

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Heat-induced stress modulates cell surface glycans and membrane lipids of coral symbionts

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Enhanced Bacterial α(2,6)-Sialyltransferase Reaction through an Inhibition of Its Inherent Sialidase Activity by Dephosphorylation of Cytidine-5'-Monophosphate

Kang, J., Lim, S.-J., Kwon, O., Lee, S., Kim, H. H., & Oh, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133739 · Cited by 10

Neuraminidase Inhibitor Zanamivir Ameliorates Collagen-Induced Arthritis

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Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors

Crowley, A. R., Osei‐Owusu, N. Y., Dekkers, G., Gao, W., Wuhrer, M., Magnani, D. M., Reimann, K. A., Pincus, S. H., Vidarsson, G., & Ackerman, M. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.754710 · Cited by 11

Stimulatory Effect of CMV Immunoglobulin on Innate Immunity and on the Immunogenicity of CMV Antigens

Deml, L., Hüber, C. M., Barabas, S., Spindler, T., Cozzi, E., & Grossi, P. (2021) · Transplantation Direct · doi:10.1097/txd.0000000000001236 · Cited by 10

Extracellular vesicles of Trypanosoma cruzi and immune complexes they form with sialylated and non-sialylated IgGs increase small peritoneal macrophage subpopulation and elicit different cytokines profiles

Cornet-Gómez, A., Moreira, L. R., Gómez-Samblás, M., & Osuna, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1215913 · Cited by 10

Application of Quality by Design Paradigm to the Manufacture of Protein Therapeutics

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Evaluation of IVIG response in relation to Th1/Th2 cytokines in pediatricm immune thrombocytopenia

Chen, Y., Zhou, Y., Zhao, N., Zhang, Y., Xu, W., & Tang, Y. (2019) · Cytokine · doi:10.1016/j.cyto.2019.05.014 · Cited by 10

A CD209 ligand and a sialidase inhibitor differentially modulate adipose tissue and liver macrophage populations and steatosis in mice on the Methionine and Choline-Deficient (MCD) diet

Pilling, D., Karhadkar, T. R., & Gomer, R. H. (2020) · PLoS ONE · doi:10.1371/journal.pone.0244762 · Cited by 11

A Toolbox of Potential Immune-Related Therapies for Inflammatory Cardiomyopathy

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Inhibitory Fc-Gamma IIb Receptor Signaling Induced by Multivalent IgG-Fc Is Dependent on Sialylation

Beneduce, C., Nguyen, S. A., Washburn, N., Schaeck, J. J., Meccariello, R., Holte, K., Ortiz, D., Manning, A. M., Bosques, C. J., & Kurtagic, E. (2023) · Cells · doi:10.3390/cells12172130 · Cited by 10

Direct Glycan Analysis of Biological Samples and Intact Glycoproteins by Integrating Machine Learning-Driven Surface-Enhanced Raman Scattering and Boronic Acid Arrays

Hu, Q., & Wu, H. (2024) · ACS Measurement Science Au · doi:10.1021/acsmeasuresciau.4c00014 · Cited by 9

IgG N-glycosylation contributes to different severities of insulin resistance: implications for 3P medical approaches

Chen, X., Balmer, L. A., Lin, K., Cao, W., Huang, Z., Chen, X., Song, M., & Chen, Y. (2025) · The EPMA Journal · doi:10.1007/s13167-025-00410-x · Cited by 9

Isomeric Separation of α2,3/α2,6-Linked 2-Aminobenzamide (2AB)-Labeled Sialoglycopeptides by C18-LC-MS/MS

Jiang, P., Huang, Y., Reyes, C. D. G., Zhong, J., & Mechref, Y. S. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c03118 · Cited by 9

Primary immune deficiencies

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CD40-activated B cells from patients with systemic lupus erythematosus can be modulated by therapeutic immunoglobulins in vitro

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Mgat2 ablation in the myeloid lineage leads to defective glycoantigen T cell responses

Ryan, S. O., Leal, S. M., Abbott, D. W., Pearlman, E. M., & Cobb, B. A. (2013) · Glycobiology · doi:10.1093/glycob/cwt107 · Cited by 9

Sialic Acid Derivatization for the Rapid Subclass- and Sialic Acid Linkage-Specific MALDI-TOF-MS Analysis of IgG Fc-Glycopeptides

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Efficient Assembly of Quantum Dots with Homogenous Glycans Derived from Natural N-Linked Glycoproteins

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Total Synthesis of a Partial Structure from Arabinogalactan and Its Application for Allergy Prevention

Krumb, M., Jäger, M., Voss, A., Immig, L., Peters, K., Kowalczyk, D., Bufe, A., Opatz, T., Holst, O., Vogel, C., et al. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202002287 · Cited by 9

Interferons and other cytokines, genetics and beyond in COVID-19 and autoimmunity

Opdenakker, G., & Damme, J. V. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.01.004 · Cited by 9

Analytical comparability assessment on glycosylation of ziv-aflibercept and the biosimilar candidate.

Shen, Z.-D., Wang, Y.-H., Xu, H.-R., Zhang, Q., Sha, C.-J., Sun, B.-P., & Li, Q. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.03.020 · Cited by 11

Mass spectrometry-based analysis of IgG glycosylation and its applications

Liu, X., Sun, Z., Li, Z., Zhang, Y., & Lu, H. (2022) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2022.116799 · Cited by 9

Emerging glycobiology tools: A renaissance in accessibility

Oswald, D. M., & Cobb, B. A. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.04.010 · Cited by 9

Immunoglobulin G Glycosylation Changes in Aging and Other Inflammatory Conditions

Dall’Olio, F., & Malagolini, N. (2021) · Experientia supplementum · doi:10.1007/978-3-030-76912-3_10 · Cited by 9

Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life

Leeuw, E. D., Justesen, J. F., Bosteels, C., Debeuf, N., Vanheerswynghels, M., Jonckheere, L., Wolf, C. D., Wayenberg, A., Damme, K. F. A. V., Vanhee, S., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adz4626 · Cited by 8

Role of ST6GAL1 and ST6GAL2 in subversion of cellular signaling during enteroaggregative Escherichia coli infection of human intestinal epithelial cell lines

Chandel, S., Joon, A., Kaur, S., & Ghosh, S. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-12321-2 · Cited by 8

Impact of estrogen on IgG glycosylation and serum protein glycosylation in a murine model of healthy postmenopause

Gupta, P., Sághy, T., Nordqvist, J., Nilsson, J. A., Carlsten, H., Horkeby, K., Henning, P., & Engdahl, C. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1243942 · Cited by 8

An exploratory trial of intravenous immunoglobulin therapy for idiopathic pulmonary fibrosis: a preliminary multicenter report

Enomoto, N., Chida, K., Suda, T., Kaida, Y., Taniguchi, M., Azuma, A., Hayashi, H., Ogura, T., Kitamura, H., Yamaguchi, O., et al. (2015) · The Clinical Respiratory Journal · doi:10.1111/crj.12281 · Cited by 8

Glycosylation des autoanticorps au cours des maladies auto-immunes

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Massive immune response against IVIg interferes with response against other antigens in mice: A new mode of action?

Sordé, L., Spindeldreher, S., Palmer, E., & Karle, A. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186046 · Cited by 8

GM-CSF and IL-4 are not involved in IVIG-mediated amelioration of ITP in mice: a role for IL-11 cannot be ruled out

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Sex effect on the correlation of immunoglobulin G glycosylation with rheumatoid arthritis disease activity

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with a Recombinant IgG Fc Recapitulation of IVIG Anti-Inflammatory Activity

Anthony, R. M. (2008)

Research Highlights

Okoreeh, M. K., & Luo, X. (2026) · Transplantation · doi:10.1097/tp.0000000000005610

The anti-inflammatory activity of IgG is enhanced by co-engagement of type I and II Fc receptors

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Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity

Washburn, N., Schwab, I., Ortiz, D., Bhatnagar, N., Lansing, J. C., Medeiros, A., Tyler, S., Mekala, D., Cochran, E., Sarvaiya, H., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422481112 · Cited by 225

Novel Fc receptors mediating the anti-inflammatory properties of IgG

Ravetch, J. V. (2010)