Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., & Glabe, C. G. (2003) · Science · doi:10.1126/science.1079469 · Cited by 4,064

Boosting slow oscillations during sleep potentiates memory

Marshall, L., Helgadóttir, H., Mölle, M., & Born, J. (2006) · Nature · doi:10.1038/nature05278 · Cited by 1,792

Coordinated memory replay in the visual cortex and hippocampus during sleep

Ji, D., & Wilson, M. A. (2007) · Nature Neuroscience · doi:10.1038/nn1825 · Cited by 1,669

Dynamics of ongoing activity: explanation of the large variability in evoked cortical responses

Arieli, A., Sterkin, A., Grinvald, A., & Aertsen, A. (1996) · Science · doi:10.1126/science.273.5283.1868 · Cited by 1,660

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of alzheimer’s disease.

Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653

APP Processing and Synaptic Function

Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., & Malinow, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00124-7 · Cited by 1,644

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

Shankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., & Sabatini, B. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4970-06.2007 · Cited by 1,592

Regulation of NMDA receptor trafficking by amyloid-β

Snyder, E. M., Nong, Y., Almeida, C. G., Paul, S., Moran, T., Choi, E. Y., Nairn, A. C., Salter, M. W., Lombroso, P. J., Gouras, G. K., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1503 · Cited by 1,561

In vivo two-photon calcium imaging of neuronal networks

Stosiek, C., Garaschuk, O., Holthoff, K., & Konnerth, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1232232100 · Cited by 1,341

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123

AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss

Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.035 · Cited by 1,042

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

Meyer-Luehmann, M., Spires-Jones, T. L., Prada, C., Garcia-Alloza, M., de Calignon, A., Rozkalne, A., Koenigsknecht-Talboo, J., Holtzman, D. M., Bacskai, B. J., & Hyman, B. T. (2008) · Nature · doi:10.1038/nature06616 · Cited by 987

Positron Emission Tomography in Evaluation of Dementia

Silverman, D. H. S., Small, G. W., Chang, C. Y., Lu, C. S., de Aburto, M. A. K., Chen, W., Czernin, J. G., Rapoport, S. I., Pietrini, P., Alexander, G. E., et al. (2001) · JAMA · doi:10.1001/jama.286.17.2120 · Cited by 960

Inflammatory processes in Alzheimer's disease

Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

Jacobsen, J. S., Wu, C.-C., Redwine, J. M., Comery, T. A., Arias, R., Bowlby, M., Martone, R., Morrison, J. H., Pangalos, M. N., Reinhart, P. H., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600948103 · Cited by 701

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease

Davies, C. A., Mann, D. M. A., Sumpter, P. Q., & Yates, P. O. (1987) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(87)90057-8 · Cited by 628

Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

Tu, H., Nelson, O., Bezprozvanny, A., Wang, Z., Lee, S.-F., Hao, Y.-H., Serneels, L., De Strooper, B., Yu, G., & Bezprozvanny, I. (2006) · Cell · doi:10.1016/j.cell.2006.06.059 · Cited by 616

Aβ plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks

Kuchibhotla, K. V., Goldman, S. T., Lattarulo, C. R., Wu, H.-Y., Hyman, B. T., & Bacskai, B. J. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.008 · Cited by 614

Incidence and Predictors of Seizures in Patients with Alzheimer's Disease

Amatniek, J. C., Hauser, W. A., del Castillo–Castañeda, C., Jacobs, D. M., Marder, K. S., Bell, K. L., Albert, M., Brandt, J., & Stern, Y. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00554.x · Cited by 592

Imaging input and output of neocortical networks in vivo

Kerr, J. N. D., Greenberg, D., & Helmchen, F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506029102 · Cited by 474

Visualizing the Cortical Representation of Whisker Touch: Voltage-Sensitive Dye Imaging in Freely Moving Mice

Ferezou, I., Bolea, S., & Petersen, C. C. H. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.043 · Cited by 466

Targeted bulk-loading of fluorescent indicators for two-photon brain imaging in vivo

Garaschuk, O., Milos, R., & Konnerth, A. (2006) · Nature Protocols · doi:10.1038/nprot.2006.58 · Cited by 235

Familial Alzheimer disease–linked mutations specifically disrupt Ca2+ leak function of presenilin 1

Nelson, O. L., Tu, H., Lei, T., Bentahir, M., Strooper, B. D., & Борисович, Б. И. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30447 · Cited by 226

The Functional Microarchitecture of the Mouse Barrel Cortex

Sato, T., Gray, N. W., Mainen, Z. F., & Svoboda, K. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050189 · Cited by 226

AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice

Chang, E. H., Savage, M. J., Flood, D. G., Thomas, J. M., Levy, R. B., Mahadomrongkul, V., Shirao, T., Aoki, C., & Huerta, P. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507313103 · Cited by 225

Stimulus dependence of two-state fluctuations of membrane potential in cat visual cortex

Anderson, J. S., Lampl, I., Reichova, I., Carandini, M., & Ferster, D. (2000) · Nature Neuroscience · doi:10.1038/75797 · Cited by 219

Amyloid β Oligomers (Aβ 1–42 Globulomer) Suppress Spontaneous Synaptic Activity by Inhibition of P/Q-Type Calcium Currents

Nimmrich, V., Grimm, C., Draguhn, A., Barghorn, S., Lehmann, A., Schoemaker, H., Hillen, H., Gross, G., Ebert, U., & Bruehl, C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4771-07.2008 · Cited by 210

Growth Arrest of Individual Senile Plaques in a Model of Alzheimer's Disease Observed byIn VivoMultiphoton Microscopy

Christie, R. H., Bacskai, B. J., Zipfel, W. R., Williams, R. M., Kajdasz, S. T., Webb, W. W., & Hyman, B. T. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00858.2001 · Cited by 197

Cerebral Amyloid Induces Aberrant Axonal Sprouting and Ectopic Terminal Formation in Amyloid Precursor Protein Transgenic Mice

Phinney, A. L., Deller, T., Stalder, M., Calhoun, M. E., Frotscher, M., Sommer, B., Staufenbiel, M., & Jucker, M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08552.1999 · Cited by 188

Various Dendritic Abnormalities Are Associated with Fibrillar Amyloid Deposits in Alzheimer's Disease

Grutzendler, J., Helmin, K. A., Tsai, J., & Gan, W. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.003 · Cited by 143

Prevalence and Causes of Seizures at the Time of Diagnosis of Probable Alzheimer’s Disease

Lozsádi, D. A., & Larner, A. J. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000093664 · Cited by 131

Functional activation imaging in aging and dementia

Prvulovic, D., van de Ven, V. G., Sack, A. T., Maurer, K., & Linden, D. E. J. (2005) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.06.006 · Cited by 108

Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease

Wirths, O., Breyhan, H., Schäfer, S., Roth, C., & Bayer, T. A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.12.004 · Cited by 97

In vivo calcium imaging of the aging and diseased brain

Eichhoff, G., Busche, M. A., & Garaschuk, O. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-007-0709-6 · Cited by 59

Excitotoxic hippocampal lesions disrupt allocentric spatial learning in mice: effects of strain and task demands

Arns, M. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00103-5 · Cited by 41

Alzheimer disease

Knopman, D. S., Amieva, H., Petersen, R. C., Chételat, G., Holtzman, D. M., Hyman, B. T., Nixon, R. A., & Jones, D. T. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00269-y · Cited by 2,606

The Amyloid-β Pathway in Alzheimer’s Disease

Hampel, H., Hardy, J., Blennow, K., Chen, C., Perry, G., Kim, S. H., Villemagne, V. L., Aisen, P., Vendruscolo, M., Iwatsubo, T., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01249-0 · Cited by 1,952

Experience-dependent structural synaptic plasticity in the mammalian brain

Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

Ittner, L. M., Ke, Y. D., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wölfing, H., Chieng, B. C., Christie, M. J., Napier, I. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.036 · Cited by 1,821

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651

S3‐02‐03: Selective increase in neuronal activity in the vicinity of amyloid plaques in a mouse model of Alzheimer's disease

Garaschuk, O. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.05.383

Mechanisms Underlying Neuronal “hyperactivity” in a Mouse Model of Alzheimer's Disease

Brawek, B., Eichhoff, G., & Garaschuk, O. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2009.12.018

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease

Busche, M. A., Chen, X., Henning, H. A., Reichwald, J., Staufenbiel, M., Sakmann, B., & Konnerth, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206171109 · Cited by 715

Investigation of neuronal activity in a murine model of Alzheimer’s disease using in vivo two-photon calcium imaging

Korzhova, V. (2019) · doi:10.5282/edoc.24895

Neuronal hyperactivity--A key defect in Alzheimer’s disease?

Busche, M. A., & Konnerth, A. (2015) · BioEssays · doi:10.1002/bies.201500004 · Cited by 266