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Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations
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The hypoexcitability induced by tau pathology is different from the hyperactivity induced by APP or PSEN mutations, which increases Aβ pathology in AD.
“The hypoexcitability induced by tau pathology is different from the hyperactivity induced by APP or PSEN mutations88–90, which increases Aβ pathology in AD.”
From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [90]
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Metadata
- Authors
- Tu, H., Nelson, O., Bezprozvanny, A., Wang, Z., Lee, S.-F., Hao, Y.-H., Serneels, L., De Strooper, B., Yu, G., & Bezprozvanny, I.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 126
- Issue
- 5
- Pages
- 981-993
- ISSN
- 0092-8674
- Cited by
- 616
- References
- 1
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2547 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
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