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Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

Tu, Huiping, Nelson, Omar, Bezprozvanny, Arseny, Wang, Zhengnan, Lee, Sheu-Fen, Hao, Yi-Heng, Serneels, Lutgarde, De Strooper, Bart, Yu, Gang, Bezprozvanny, Ilya·2006·Cell

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Crossref · 10.1016/j.cell.2006.06.059

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  • The hypoexcitability induced by tau pathology is different from the hyperactivity induced by APP or PSEN mutations, which increases Aβ pathology in AD.

    “The hypoexcitability induced by tau pathology is different from the hyperactivity induced by APP or PSEN mutations88–90, which increases Aβ pathology in AD.”

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Research works printed but not linked: 40

  1. Annaert, 1999, Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons, J. Cell Biol., 147, 277, 10.1083/jcb.147.2.277 · DOI
  2. Arispe, 1993, Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum, Proc. Natl. Acad. Sci. USA, 90, 567, 10.1073/pnas.90.2.567 · DOI
  3. Begley, 1999, Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice, J. Neurochem., 72, 1030, 10.1046/j.1471-4159.1999.0721030.x · DOI
  4. Camello, 2002, Calcium leak from intracellular stores–the enigma of calcium signalling, Cell Calcium, 32, 355, 10.1016/S0143416002001926 · DOI
  5. Cedazo-Minguez, 2002, The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations, J. Biol. Chem., 277, 36646, 10.1074/jbc.M112117200 · DOI
  6. De Strooper, 1998, Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein, Nature, 391, 387, 10.1038/34910 · DOI · Paper page
  7. Herms, 2003, Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein, J. Biol. Chem., 278, 2484, 10.1074/jbc.M206769200 · DOI
  8. Herreman, 2000, Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells, Nat. Cell Biol., 2, 461, 10.1038/35017105 · DOI
  9. Hofer, 1999, Measurement of free [Ca2+] changes in agonist-sensitive internal stores using compartmentalized fluorescent indicators, Methods Mol. Biol., 114, 249
  10. Ito, 1994, Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease, Proc. Natl. Acad. Sci. USA, 91, 534, 10.1073/pnas.91.2.534 · DOI
  11. Kasri, 2006, Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca(2+) content in presenilin double knock-out cells, Cell Calcium, 40, 41, 10.1016/j.ceca.2006.03.005 · DOI
  12. Khachaturian, 1989, Calcium, membranes, aging, and Alzheimer's disease. Introduction and overview, Ann. N Y Acad. Sci., 568, 1, 10.1111/j.1749-6632.1989.tb12485.x · DOI
  13. LaFerla, 2002, Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease, Nat. Rev. Neurosci., 3, 862, 10.1038/nrn960 · DOI
  14. Laudon, 2005, A nine-transmembrane domain topology for presenilin 1, J. Biol. Chem., 280, 35352, 10.1074/jbc.M507217200 · DOI
  15. Leissring, 1999, Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals, J. Biol. Chem., 274, 32535, 10.1074/jbc.274.46.32535 · DOI
  16. Leissring, 1999, Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes, J. Neurochem., 72, 1061
  17. Leissring, 2001, Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling, Neurobiol. Dis., 8, 469, 10.1006/nbdi.2001.0382 · DOI
  18. Leissring, 2002, A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP, Proc. Natl. Acad. Sci. USA, 99, 4697, 10.1073/pnas.072033799 · DOI
  19. Lomax, 2002, Basal and physiological Ca(2+) leak from the endoplasmic reticulum of pancreatic acinar cells. Second messenger-activated channels and translocons, J. Biol. Chem., 277, 26479, 10.1074/jbc.M201845200 · DOI
  20. Mattson, 2000, Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders, Trends Neurosci., 23, 222, 10.1016/S0166-2236(00)01548-4 · DOI
  21. Nyabi, 2003, Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin, J. Biol. Chem., 278, 43430, 10.1074/jbc.M306957200 · DOI
  22. Oakes, 2005, Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum, Proc. Natl. Acad. Sci. USA, 102, 105, 10.1073/pnas.0408352102 · DOI
  23. Pinton, 2000, Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells, J. Cell Biol., 148, 857, 10.1083/jcb.148.5.857 · DOI
  24. Ris, 2003, Capacitative calcium entry induces hippocampal long term potentiation in the absence of presenilin-1, J. Biol. Chem., 278, 44393, 10.1074/jbc.M300971200 · DOI
  25. Schneider, 2001, Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation, J. Biol. Chem., 276, 11539, 10.1074/jbc.M010977200 · DOI
  26. Serneels, 2005, Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo, Proc. Natl. Acad. Sci. USA, 102, 1719, 10.1073/pnas.0408901102 · DOI
  27. Shah, 2005, Nicastrin functions as a gamma-secretase-substrate receptor, Cell, 122, 435, 10.1016/j.cell.2005.05.022 · DOI
  28. Smith, 2005, Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals, Cell Calcium, 38, 427, 10.1016/j.ceca.2005.06.021 · DOI
  29. Stutzmann, 2004, Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability, J. Neurosci., 24, 508, 10.1523/JNEUROSCI.4386-03.2004 · DOI
  30. Stutzmann, 2006, Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice, J. Neurosci., 26, 5180, 10.1523/JNEUROSCI.0739-06.2006 · DOI
  31. Takeda, 2005, Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling, FASEB J., 19, 2069, 10.1096/fj.05-3744fje · DOI
  32. Tandon, 2002, The presenilins, Genome Biol., 3, 10.1186/gb-2002-3-11-reviews3014 · DOI
  33. Tang, 2003, Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1, Neuron, 39, 227, 10.1016/S0896-6273(03)00366-0 · DOI
  34. Tu, 2005, Modulation of mammalian inositol 1,4,5-trisphosphate receptor isoforms by calcium: a role of calcium sensor region, Biophys. J., 88, 1056, 10.1529/biophysj.104.049601 · DOI
  35. Tu, 2005, Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms, Biophys. J., 88, 1046, 10.1529/biophysj.104.049593 · DOI
  36. Van Coppenolle, 2004, Ribosome-translocon complex mediates calcium leakage from endoplasmic reticulum stores, J. Cell Sci., 117, 4135, 10.1242/jcs.01274 · DOI
  37. Wolfe, 1999, Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity, Nature, 398, 513, 10.1038/19077 · DOI
  38. Woodbury, 1990, Nystatin-induced liposome fusion: a versatile approach to ion channel reconstitution into planar bilayers, Biophys. J., 58, 833, 10.1016/S0006-3495(90)82429-2 · DOI
  39. Yoo, 2000, Presenilin-mediated modulation of capacitative calcium entry, Neuron, 27, 561, 10.1016/S0896-6273(00)00066-0 · DOI
  40. Zweifach, 1993, The mitogen-regulated calcium current of T lymphocytes is activated by depletion of intracellular calcium stores, Proc. Natl. Acad. Sci. USA, 90, 6295, 10.1073/pnas.90.13.6295 · DOI

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Metadata

Authors
Tu, H., Nelson, O., Bezprozvanny, A., Wang, Z., Lee, S.-F., Hao, Y.-H., Serneels, L., De Strooper, B., Yu, G., & Bezprozvanny, I.
Venue
Cell
Publisher
Elsevier BV
Published
2006-09
Volume
126
Issue
5
Pages
981-993
ISSN
0092-8674
Cited by
616
References
1
Language
en

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