The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion
Open accessAbstract
Trans–SNAP receptor (SNARE, where SNAP is defined as soluble NSF attachment protein, and NSF is defined as N -ethylmaleimide–sensitive factor) complexes catalyze synaptic vesicle fusion and bind complexin, but the function of complexin binding to SNARE complexes remains unclear. Here we show that in neuronal synapses, complexin simultaneously suppressed spontaneous fusion and activated fast calcium ion–evoked fusion. The dual function of complexin required SNARE binding and also involved distinct amino-terminal sequences of complexin that localize to the point where trans-SNARE complexes insert into the fusing membranes, suggesting that complexin controls the force that trans-SNARE complexes apply onto the fusing membranes. Consistent with this hypothesis, a mutation in the membrane insertion sequence of the v-SNARE synaptobrevin/vesicle-associated membrane protein (VAMP) phenocopied the complexin loss-of-function state without impairing complexin binding to SNARE complexes. Thus, complexin probably activates and clamps the force transfer from assembled trans-SNARE complexes onto fusing membranes.
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Cites
SNAREs — engines for membrane fusion
Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635
Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse
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Self-citationSynaptotagmin I functions as a calcium regulator of release probability
Fernández-Chacón, R., Königstorfer, A., Gerber, S. H., García, J., Matos, M. F., Stevens, C. F., Brose, N., Rizo, J., Rosenmund, C., & Südhof, T. C. (2001) · Nature · doi:10.1038/35065004 · Cited by 961
SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice
Schoch, S., Deák, F., Königstorfer, A., Mozhayeva, M., Sara, Y., Südhof, T. C., & Kavalali, E. T. (2001) · Science · doi:10.1126/science.1064335 · Cited by 662
Self-citationComplexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release
Reim, K., Mansour, M., Varoqueaux, F., McMahon, H. T., Südhof, T. C., Brose, N., & Rosenmund, C. (2001) · Cell · doi:10.1016/s0092-8674(01)00192-1 · Cited by 499
A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis
Tang, J., Maximov, A., Shin, O.-H., Dai, H., Rizo, J., & Südhof, T. C. (2006) · Cell · doi:10.1016/j.cell.2006.08.030 · Cited by 463
Self-citationThree-Dimensional Structure of the Complexin/SNARE Complex
Chen, X., Tomchick, D. R., Kovrigin, E., Araç, D., Machius, M., Südhof, T. C., & Rizo, J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00583-4 · Cited by 450
A Clamping Mechanism Involved in SNARE-Dependent Exocytosis
Giraudo, C. G., Eng, W. S., Melia, T. J., & Rothman, J. E. (2006) · Science · doi:10.1126/science.1129450 · Cited by 368
A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth
Huntwork, S., & Littleton, J. T. (2007) · Nature Neuroscience · doi:10.1038/nn1980 · Cited by 290
Synaptotagmin I Functions as a Calcium Sensor to Synchronize Neurotransmitter Release
Yoshihara, M., & Littleton, J. T. (2002) · Neuron · doi:10.1016/s0896-6273(02)01065-6 · Cited by 285
Cited by
Membrane Fusion: Grappling with SNARE and SM Proteins
Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
Südhof, T. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.022 · Cited by 1,197
Self-citationSkeletal muscle: A review of molecular structure and function, in health and disease
Mukund, K., & Subramaniam, S. (2020) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1462 · Cited by 664
Calcium Control of Neurotransmitter Release
Sudhof, T. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a011353 · Cited by 502
Molecular Mechanisms for Synchronous, Asynchronous, and Spontaneous Neurotransmitter Release
Kaeser, P. S., & Regehr, W. G. (2014) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170338 · Cited by 447
Metadata
- Authors
- Maximov, A., Tang, J., Yang, X., Pang, Z. P., & Südhof, T. C.
- Venue
- Science
- Published
- 2009-01-23
- Volume
- 323
- Issue
- 5913
- Pages
- 516-521
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2009639277
- Cited by
- 338
- References
- 22
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- green
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