The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum
Open accessAbstract
Protein folding in the endoplasmic reticulum is a complex process whose malfunction is implicated in disease and aging. By using the cell's endogenous sensor (the unfolded protein response), we identified several hundred yeast genes with roles in endoplasmic reticulum folding and systematically characterized their functional interdependencies by measuring unfolded protein response levels in double mutants. This strategy revealed multiple conserved factors critical for endoplasmic reticulum folding, including an intimate dependence on the later secretory pathway, a previously uncharacterized six-protein transmembrane complex, and a co-chaperone complex that delivers tail-anchored proteins to their membrane insertion machinery. The use of a quantitative reporter in a comprehensive screen followed by systematic analysis of genetic dependencies should be broadly applicable to functional dissection of complex cellular processes from yeast to human.
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Cites
Functional profiling of the Saccharomyces cerevisiae genome
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Self-citationFunctional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis
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Roles of N-Linked Glycans in the Endoplasmic Reticulum
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Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise
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Self-citationSchuldiner, M., Collins, S. R., Thompson, N. J., Denic, V., Bhamidipati, A., Punna, T., Ihmels, J., Andrews, B., Boone, C., Greenblatt, J. F., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.031 · Cited by 870
Self-citationToward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae
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Self-citationModular epistasis in yeast metabolism
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A regulatory link between ER-associated protein degradation and the unfolded-protein response
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A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances
Hein, M. Y., Hubner, N. C., Poser, I., Cox, J., Nagaraj, N., Toyoda, Y., Gak, I. A., Weisswange, I., Mansfeld, J., Buchholz, F., et al. (2015) · Cell · doi:10.1016/j.cell.2015.09.053 · Cited by 1,270
Adamson, B., Norman, T. M., Jost, M., Cho, M. Y., Nuñez, J. K., Chen, Y., Villalta, J. E., Gilbert, L. A., Horlbeck, M. A., Hein, M. Y., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.048 · Cited by 1,193
Self-citationLipid landscapes and pipelines in membrane homeostasis
Holthuis, J. C. M., & Menon, A. K. (2014) · Nature · doi:10.1038/nature13474 · Cited by 901
Endoplasmic reticulum-mitochondrial contactology: structure and signaling functions
Csordás, G., Weaver, D., & Hajnóczky, G. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.009 · Cited by 625
Metadata
- Authors
- Jonikas, M. C., Collins, S. R., Denic, V., Oh, E., Quan, E. M., Schmid, V., Weibezahn, J., Schwappach, B., Walter, P., Weissman, J. S., & Schuldiner, M.
- Venue
- Science
- Published
- 2009-03-27
- Volume
- 323
- Issue
- 5922
- Pages
- 1693-1697
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2133992568
- Cited by
- 740
- References
- 10
- FWCI
- 20.65
- Type
- journal article
- Language
- en
- Open access
- green
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