Development of a second-generation antiandrogen for treatment of advanced prostate cancer.
Tran, Chris, Ouk, Samedy, Clegg, Nicola J., Chen, Yu, Watson, Philip A., Arora, Vivek, Wongvipat, John, Smith-Jones, Peter M., Yoo, Dongwon, Kwon, Andrew, Wasielewska, Teresa, Welsbie, Derek, Chen, Charlie Degui, Higano, Celestia S., Beer, Tomasz M., Hung, David T., Scher, Howard I., Jung, Michael E., Sawyers, Charles L.·2009·Science
Cited by (1,000)
Items 301–400 of 1,000
- Rational optimization of a transcription factor activation domain inhibitorBasu, Shaon, Martínez-Cristóbal, Paula, Frigolé-Vivas, Marta, Pesarrodona, Mireia, Lewis, Michael, Szulc, Elzbieta, Bañuelos, C. Adriana, Sánchez-Zarzalejo, Carolina, Bielskutė, Stasė, Zhu, Jiaqi et al. · 2023 · Nature Structural & Molecular Biology
- Combination Therapy with a Second-Generation Androgen Receptor Antagonist and a Metastasis Vaccine Improves Survival in a Spontaneous Prostate Cancer ModelAndressa Ardiani, Benedetto Farsaci, Connie Jo Rogers, Andy Protter, Zhimin Guo, Thomas H. King, David Apelian, James W. Hodge · 2013 · Clinical Cancer Research
- Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration ResistanceShipra Shukla, Joanna Cyrta, Devan A. Murphy, Edward G. Walczak, Leili Ran, Praveen Kumar Agrawal, Yuanyuan Xie, Yuedan Chen, Shangqian Wang, Yu Zhan et al. · 2017 · Cancer Cell
- Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunityWen‐Bing Jin, Leyi Xiao, Mingeum Jeong, Seong-Ji Han, Wen Zhang, Hiroshi Yano, Huiqing Shi, Mohammad Arifuzzaman, Mengze Lyu, Daoming Wang et al. · 2025 · Cell
- Clinical Outcomes of Castration-resistant Prostate Cancer Treatments Administered as Third or Fourth Line Following Failure of Docetaxel and Other Second-line Treatment: Results of an Italian Multicentre StudyOrazio Caffo, Ugo De Giorgi, Lucia Fratino, Daniele Alesini, Vittorina Zagonel, Gaetano Facchini, Donatello Gasparro, Cinzia Ortega, Marcello Tucci, Francesco Verderame et al. · 2014 · European Urology
- Androgen hormone action in prostatic carcinogenesis: stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasisEmily A. Ricke, Karin Williams, Yi‐Fen Lee, Suzana S. Couto, Yuzhuo Z. Wang, Simon W. Hayward, Gerald R. Cunha, William A. Ricke · 2012 · Carcinogenesis
- Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanismSupriya Shah, Whitney J. Carriveau, Jinyang Li, Sydney L. Campbell, Piotr K. Kopinski, Hee‐Woong Lim, Natalie A. Daurio, Sophie Trefely, Kyoung‐Jae Won, Douglas C. Wallace et al. · 2016 · Oncotarget
- The Role of Androgen Receptor Signaling in Ovarian CancerTaichi Mizushima, Hiroshi Miyamoto · 2019 · Cells
- Triple negative breast cancer: special histological types and emerging therapeutic methodsLu Cao, Yun Niu · 2020 · Cancer Biology and Medicine
- Apalutamide, enzalutamide, and darolutamide for non-metastatic castration-resistant prostate cancer: a systematic review and network meta-analysisKeiichiro Mori, Hadi Mostafaei, Benjamin Pradère, Reza Sari Motlagh, Fahad Quhal, Ekaterina Laukhtina, Victor M. Schuettfort, Mohammad M. Abufaraj, Pierre I. Karakiewicz, Takahiro Kimura et al. · 2020 · International Journal of Clinical Oncology
- Enzalutamide response in a panel of prostate cancer cell lines reveals a role for glucocorticoid receptor in enzalutamide resistant diseaseRebecca Lee Smith, Moqing Liu, Tiera A. Liby, Nora Bayani, Elmar Bucher, Kami Chiotti, Daniel S. Derrick, Anne Chauchereau, Laura M. Heiser, Joshi J. Alumkal et al. · 2020 · Scientific Reports
- Cross-resistance and drug sequence in prostate cancerStefan A.J. Buck, Stijn L.W. Koolen, Ron H.J. Mathijssen, Ronald de Wit, Robert J. van Soest · 2021 · Drug Resistance Updates
- Novel targeted therapeutics for metastatic castration-resistant prostate cancerEmmanuel S. Antonarakis, Michael Anthony Carducci, Mario A. Eisenberger · 2009 · Cancer Letters
- Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate CancerSuriyan Ponnusamy, Yali He, Dong‐Jin Hwang, Thirumagal Thiyagarajan, René Houtman, Vera Bocharova, Bobby G. Sumpter, Elias J. Fernandez, Daniel L. Johnson, Ziyun Du et al. · 2019 · Clinical Cancer Research
- Metastatic Hormone-Sensitive Prostate Cancer (mHSPC): Advances and Treatment Strategies in the First-Line SettingKenrick Ng, Shievon Smith, Jonathan Shamash · 2020 · Oncology and Therapy
- Androgen receptor: a potential therapeutic target for glioblastomaNomi Zalcman, Tamar Canello, Haim Ovadia, Hanna Charbit, Bracha Zelikovitch, Anat Mordechai, Yakov Fellig, Stav Rabani, Tal Shahar, Alexander Lossos et al. · 2018 · Oncotarget
- Androgen Receptor, Although Not a Specific Marker For, Is a Novel Target to Suppress Glioma Stem Cells as a Therapeutic Strategy for GlioblastomaNan Zhao, Fei Wang, Shaheen Ahmed, Kan Liu, Chi Zhang, Sahara J. Cathcart, Dominick J. DiMaio, Michael Punsoni, Bingjie Guan, Ping Zhou et al. · 2021 · Frontiers in Oncology
- Integrative Molecular Profiling Reveals Asparagine Synthetase Is a Target in Castration-Resistant Prostate CancerKanishka Sircar, Heng Huang, Limei Hu, David E. Cogdell, Jasreman Dhillon, Vassiliki Tzelepi, Eleni Efstathiou, Ismaël Hervé Koumakpayi, Fred Saad C, Dijun Luo et al. · 2012 · American Journal Of Pathology
- Androgen–glucocorticoid interactions in the era of novel prostate cancer therapySujata Narayanan, Sandy Srinivas, David Feldman · 2015 · Nature Reviews Urology
- Switching and withdrawing hormonal agents for castration-resistant prostate cancerDavid Lorente, Joaquı́n Mateo, Zafeiris Zafeiriou, Alan David Smith, Shahneen Kaur Sandhu, Roberta Ferraldeschi, Johann Sebastian De Bono · 2015 · Nature Reviews Urology
- AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In VivoSarah A. Loddick, Sarah J. Ross, Andrew G. Thomason, David M. Robinson, Graeme E. Walker, Tom P. J. Dunkley, Sandra R. Brave, Nicola Broadbent, Natalie C. Stratton, Dawn Trueman et al. · 2013 · Molecular Cancer Therapeutics
- Alkaline Phosphatase in Metastatic Castration-Resistant Prostate Cancer: Reassessment of an Older BiomarkerDaniel Alexander Heinrich, Øyvind Sverre Bruland, Theresa A. Guise, Hiroyoshi Suzuki, Oliver A. Sartor · 2018 · Future Oncology
- Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate CancerMcClinch, Kimberly, Avelar, Rita A., Callejas, David, Izadmehr, Sudeh, Wiredja, Danica, Perl, Abbey, Sangodkar, Jaya, Kastrinsky, David B., Schlatzer, Daniela, Cooper, Maxwell et al. · 2018 · Cancer Research
- From pathogenesis to prevention of castration resistant prostate cancerHelmut Bonkhoff, Richard R. Berges · 2009 · The Prostate
- Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity MappingJoanna K. Lempiäinen, Einari A. Niskanen, Kaisa‐Mari Launonen, Riikka Lampinen, Helka Göös, Markku T Varjosalo, Jorma J. Palvimo · 2017 · Molecular & Cellular Proteomics
- Small-Molecule Screens: A Gateway to Cancer Therapeutic Agents with Case Studies of Food and Drug Administration–Approved DrugsNathan P. Coussens, John C. Braisted, Tyler Peryea, Gurusingham Sitta Sittampalam, Anton M. Simeonov, Matthew D. Hall · 2017 · Pharmacological Reviews
- A Glutaminase Isoform Switch Drives Therapeutic Resistance and Disease Progression of Prostate CancerLingfan Xu, Yu Yin, Yanjing Li, Xufeng Chen, Yan Chang, Hong Zhang, Juan Liu, James Beasley, Patricia McCaw, Haoyue Zhang et al. · 2020 · Proceedings of the National Academy of Sciences
- Translational and clinical implications of the genetic landscape of prostate cancerDaniel Eidelberg Spratt, Zachary Stephan Zumsteg, Felix Yi-Chung Feng, Scott A. Tomlins · 2016 · Nature Reviews Clinical Oncology
- Understanding Mechanisms of Resistance in Metastatic Castration-resistant Prostate Cancer: The Role of the Androgen ReceptorDerya Tilki, Edward M. Schaeffer, Christopher P. Evans · 2016 · European Urology Focus
- New Developments in the Medical Management of Prostate CancerManish Kohli, Donald J. Tindall · 2009 · Mayo Clinic Proceedings
- Circulating AR copy number and outcome to enzalutamide in docetaxel-treated metastatic castration-resistant prostate cancerSamanta Salvi, Valentina Casadio, Vincenza Conteduca, Cristian Lolli, Giorgia Gurioli, Filippo Martignano, Giuseppe Schepisi, Sara Testoni, Emanuela Scarpi, Dino Amadori et al. · 2016 · Oncotarget
- Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancerRitika Tiwari, Nishat Manzar, Vipul Bhatia, Anjali Yadav, Mushtaq Ahmad Nengroo, Dipak B. Datta, Shannon L. Carskadon, Nilesh Gupta, Michael Sigouros, Francesca Khani et al. · 2020 · Nature Communications
- Castration-Resistant Prostate Cancer: AUA Guideline Amendment 2015William Thomas Lowrance, Bruce J. Roth, Erin Kirkby, Mohammad Hassan Murad, Michael S. Cookson · 2015 · The Journal of Urology
- Androgen metabolism in prostate cancer: from molecular mechanisms to clinical consequencesK-H Chang, Cesar Emilio Ercole, Nima Sharifi · 2014 · British Journal of Cancer
- Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): Head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft modelRobert D. Bruno, Tadas Sean Vasaitis, Lalji K. Gediya, Puranik Purushottamachar, Abhijit M. Godbole, Zeynep Ateş‐Alagöz, Angela M. H. Brodie, Vincent C.O. Njar · 2011 · Steroids
- Imaging Androgen Receptor Signaling with a Radiotracer Targeting Free Prostate-Specific AntigenDavid Ulmert, Michael J. Evans, Jason P. Holland, Samuel L. Rice, John Wongvipat, Kim S. I. Pettersson, Per-Anders Abrahamsson, Peter T. Scardino, Steven M. Larson, Hans G. Lilja et al. · 2012 · Cancer Discovery
- Targeting the N-Terminal Domain of the Androgen Receptor: A New Approach for the Treatment of Advanced Prostate CancerEmmanuel S. Antonarakis, Chandtip Chandhasin, Erica Osbourne, Jun Luo, Marianne D. Sadar, Frank Perabo · 2016 · The Oncologist
- Clinical utility of androgen receptor gene aberrations in circulating cell-free DNA as a biomarker for treatment of castration-resistant prostate cancerTakayuki Sumiyoshi, Kei Mizuno, Toshinari Yamasaki, Yu Miyazaki, Yuki Makino, Kosuke Okasho, Xin Li, Noriaki Utsunomiya, Takayuki Goto, Takashi Kobayashi et al. · 2019 · Scientific Reports
- Metastatic castration‐sensitive prostate cancer: Abiraterone, docetaxel, or…Pedro Coelho Barata, Oliver A. Sartor · 2019 · Cancer
- The androgen receptor/filamin A complex as a target in prostate cancer microenvironmentMarzia Di Donato, Alice Zamagni, Giovanni Galasso, Erika Di Zazzo, Pia Giovannelli, Maria Vittoria Barone, Michele Zanoni, Roberta Gunelli, Matteo Costantini, Ferdinando Auricchio et al. · 2021 · Cell Death and Disease
- Extracellular Matrix in Synthetic Hydrogel‐Based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 InhibitorsMatthew J. Mosquera, Sungwoong Kim, Rohan Bareja, Zhou Fang, Shuangyi Cai, Heng Pan, Muhammad Imran Asad, M. Laura Martín, Michael Sigouros, Florencia P. Madorsky Rowdo et al. · 2021 · Advanced Materials
- Androgen deprivation therapy sensitizes prostate cancer cells to T-cell killing through androgen receptor dependent modulation of the apoptotic pathwayAndressa Ardiani, Sofia R. Gameiro, Anna R. Kwilas, Renee Nicole Donahue, James W. Hodge · 2014 · Oncotarget
- siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate CancerYoshiaki Yamamoto, Paulo J.C. Lin, Eliana Beraldi, Fan Zhang, Yoshihisa Kawai, Jeffrey Leong, Hidemasa Katsumi, Ladan Fazli, Robert Fraser, Pieter R. Cullis et al. · 2015 · Clinical Cancer Research
- Minireview: Androgen Metabolism in Castration-Resistant Prostate CancerNima Sharifi · 2013 · Molecular Endocrinology
- Multivalent Peptidomimetic Conjugates: A Versatile Platform for Modulating Androgen Receptor ActivityPaul M. Levine, Keren Imberg-Kazdan, Michael J. Garabedian, Kent Kirshenbaum · 2012 · Journal of the American Chemical Society
- Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyondSimon Linder, Henk G. van der Poel, Andries Marinus Bergman, Wilbert T. Zwart, Stefan Preković · 2018 · Endocrine Related Cancer
- Rezvilutamide versus bicalutamide in combination with androgen-deprivation therapy in patients with high-volume, metastatic, hormone-sensitive prostate cancer (CHART): a randomised, open-label, phase 3 trialWeijie Gu, Weiqing Han, Hong Luo, Fangjian Zhou, Dalin He, Lulin Ma, Hongqian Guo, Chang Yin Liang, Tie Chong, Jun Jiang et al. · 2022 · The Lancet Oncology
- The Crucial Role of AR-V7 in Enzalutamide-Resistance of Castration-Resistant Prostate CancerZeyuan Zheng, Jinxin Li, Yankuo Liu, Zhiyuan Shi, Zuodong Xuan, Kunao Yang, Chunlan Xu, Yang Bai, Meiling Fu, Qiaohong Xiao et al. · 2022 · Cancers
- miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and SrcXu-Bao Shi, Ai‐Hong Ma, Lingru Xue, Meimei Li, Hao Gia Nguyen, Joy C. Yang, Clifford G. Tepper, Regina F. Gandour‐Edwards, Christopher P. Evans, Hsing-Jien Kung et al. · 2015 · Cancer Research
- A New Avenue toward Androgen Receptor Pan-antagonists: C2 Sterically Hindered Substitution of Hydroxy-propanamidesAndrea Guerrini, Anna Tesei, Claudia Ferroni, Giulia Paganelli, Alice Zamagni, Silvia Carloni, Marzia Di Donato, Gabriella Castoria, Carlo Leonetti, Manuela Porru et al. · 2014 · Journal of Medicinal Chemistry
- Cancer-Associated Fibroblasts Modify the Response of Prostate Cancer Cells to Androgen and Anti-Androgens in Three-Dimensional Spheroid CultureTheresa Eder, Anja Weber, Hannes Neuwirt, Georg Grünbacher, Christian Ploner, Helmut Klocker, Natalie Sampson, Iris Elisabeth Eder · 2016 · International Journal of Molecular Sciences
- Mechanisms and biotechnological applications of transcription factorsHehe He, Yang Mingfei, Siyu Li, Gaoyang Zhang, Zhongyang Ding, Liang N. Zhang, Guiyang Shi, Youran Li · 2023 · Synthetic and Systems Biotechnology
- Androgen Receptor Rearrangement and Splicing Variants in Resistance to Endocrine Therapies in Prostate CancerYeung Ho, Scott M. Dehm · 2017 · Endocrinology
- Molecular Imaging in Cancer Drug DevelopmentStijn J.H. Waaijer, Iris C. Kok, Bertha Eisses, Carolina Pia Schroder, Mathilde Jalving, Adrienne H. Brouwers, Marjolijn N. Lub–de Hooge, Elisabeth G.E. de Vries · 2018 · Journal of Nuclear Medicine
- Structure and Function of the Nuclear Receptor Superfamily and Current Targeted Therapies of Prostate CancerBaylee A. Porter, Maria Antonia Ortiz, Gennady Bratslavsky, Leszek Kotula · 2019 · Cancers
- Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasisHyun Ho Han, Yan Wang, Josué Curto, Sreeharsha Gurrapu, Sara Laudato, Alekya Rumandla, Goutam Chakraborty, Xiaobo Wang, Hong Chen, Yan Jiang et al. · 2022 · Cell Reports
- Targeting Alternative Sites on the Androgen Receptor to Treat Castration-Resistant Prostate CancerNada Lallous, Kush Dalal, Artem R Cherkasov, Paul S. Rennie · 2013 · International Journal of Molecular Sciences
- Cotargeting Androgen Receptor and Clusterin Delays Castrate-Resistant Prostate Cancer Progression by Inhibiting Adaptive Stress Response and AR StabilityHiroaki Matsumoto, Yoshiaki Yamamoto, Masaki Shiota, Hidetoshi Kuruma, Eliana Beraldi, Hideyasu Matsuyama, Amina Zoubeidi, Martin Edwin Gleave · 2013 · Cancer Research
- Inhibitors of the PI3K/Akt/mTOR Pathway in Prostate Cancer Chemoprevention and InterventionNazanin Momeni Roudsari, Naser‐Aldin Lashgari, Saeideh Momtaz, Shaghayegh Abaft, Fatemeh Jamali, Pardis Safaiepour, Kiyana Narimisa, Gloria Jackson, Anusha Bishayee, Nima Rezaei et al. · 2021 · Pharmaceutics
- Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor AntagonistsChuangxing Guo, Angelica Linton, Susan E. Kephart, Martha A. Ornelas, Mason Pairish, Javier González, Samantha E. Greasley, Asako Nagata, Benjamin J. Burke, Martin P. Edwards et al. · 2011 · Journal of Medicinal Chemistry
- Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing TwistD Ruan, Jinrong He, Chien‐Feng Li, H-J Lee, J Liu, H-K Lin, Chia‐Hsin Chan · 2017 · Oncogene
- Overcoming Chemotherapy Resistance in Prostate CancerRavi Amrit Madan, Sumanta Kumar Pal, Oliver A. Sartor, William L. Dahut · 2011 · Clinical Cancer Research
- Mini-review: Foldosome regulation of androgen receptor action in prostate cancerLaia Querol Cano, Derek N. Lavery, Charlotte Lynne Bevan · 2013 · Molecular and Cellular Endocrinology
- MUC1 oncoprotein is a druggable target in human prostate cancer cellsMaya Datt Joshi, Rehan Ahmad, Yin Li, Deepak Bushan Raina, Hasan N. Rajabi, Glenn J. Bubley, Surender M. Kharbanda, Donald W. Kufe · 2009 · Molecular Cancer Therapeutics
- Elucidating the modes of action for bioactive compounds in a cell-specific manner by large-scale chemically-induced transcriptomicsM Iwata, Ryusuke Sawada, Hiroaki Iwata, Masaaki Kotera, Yoshihiro Yamanishi · 2017 · Scientific Reports
- Targeting Androgen Receptor in Treating HER2 Positive Breast CancerLicai He, Zhuanyun Du, Xusheng Xiong, Hua Ma, Zhenfeng Zhu, Hongwei Gao, Jiawei Cao, Tong Li, Hongzhi Li, Kaiyan Yang et al. · 2017 · Scientific Reports
- Epigenetic Therapy with Panobinostat Combined with Bicalutamide Rechallenge in Castration-Resistant Prostate CancerAnna C. Ferrari, Joshi J. Alumkal, Mark N. Stein, Mary‐Ellen Taplin, James S. Babb, Ethan S. Barnett, Alejandro Gómez-Pinillos, Xiaomei Liu, Dirk F. Moore, Robert S. DiPaola et al. · 2018 · Clinical Cancer Research
- Skeletal metastases and impact of anticancer and bone-targeted agents in patients with castration-resistant prostate cancerFrancesca Vignani, Valentina Bertaglia, Consuelo Buttigliero, Marcello Tucci, Giorgio V. Scagliotti, Massimo Di Maïo · 2016 · Cancer Treatment Reviews
- The evolving role of immune cells in prostate cancerChao Wang, Yan Zhang, Wei‐Qiang Gao · 2021 · Cancer Letters
- Androgen receptor mutations for precision medicine in prostate cancerMasaki Shiota, Shusuke Akamatsu, Shigehiro Tsukahara, Shohei Nagakawa, Takashi Matsumoto, Masatoshi Eto · 2022 · Endocrine Related Cancer
- Enzalutamide After Docetaxel and Abiraterone Therapy in Metastatic Castration-Resistant Prostate CancerSebastian Christoph Schmid, Alexander Geith, Alena Böker, Robert Tauber, Anna Katharina Seitz, Markus Antonius Kuczyk, Christoph A. J. von Klot, Jürgen E. Gschwend, Axel S. Merseburger, Margitta M. Retz · 2014 · Advances in Therapy
- Targeting 5α-reductase for prostate cancer prevention and treatmentLucas P. Nacusi, Donald J. Tindall · 2011 · Nature Reviews Urology
- Progression of metastatic castrate-resistant prostate cancer: impact of therapeutic intervention in the post-docetaxel spaceOliver A. Sartor · 2011 · Journal of Hematology & Oncology
- Progress in emerging therapies for advanced prostate cancerStéphane Marie. Oudard · 2012 · Cancer Treatment Reviews
- Bioactive nanotherapeutic trends to combat triple negative breast cancerPallabita Chowdhury, Upasana Ghosh, Kamalika Samanta, Meena Jaggi, Subhash C. Chauhan, Murali Mohan Yallapu · 2021 · Bioactive Materials
- Identification of a Potent Antiandrogen that Targets the BF3 Site of the Androgen Receptor and Inhibits Enzalutamide-Resistant Prostate CancerRavi S. N. Munuganti, Mohamed D.H. Hassona, Eric Leblanc, Kate Frewin, Kriti Singh, Dennis Ma, Fuqiang Ban, Michael Hsing, Hans H. Adomat, Nada Lallous et al. · 2014 · Chemistry & Biology
- Recent developments in antiandrogens and selective androgen receptor modulatorsBernard Haendler, Arwed Cleve · 2011 · Molecular and Cellular Endocrinology
- Androgen Receptor: A Complex Therapeutic Target for Breast CancerRamesh Narayanan, James T. Dalton · 2016 · Cancers
- The androgen receptor regulates a druggable translational regulon in advanced prostate cancerYuzhen Liu, Jessie L. Horn, Kalyan Banda, Asha Z. Goodman, Yiting Lim, Sujata Jana, Sonali Arora, Alexandre A. Germanos, Lexiaochuan Wen, William R. Hardin et al. · 2019 · Science Translational Medicine
- Discovering the hidden messages within cell trajectories using a deep learning approach for in vitro evaluation of cancer drug treatmentsArianna Mencattini, Davide Di Giuseppe, Maria Colomba Comes, Paola Casti, Francesca Corsi, Francesca Romana Bertani, Lina Ghibelli, Luca Businaro, C. Di Natale, Maria Carla Parrini et al. · 2020 · Scientific Reports
- CircRNA-UCK2 increased TET1 inhibits proliferation and invasion of prostate cancer cells via sponge miRNA-767-5pZhendong Xiang, Chengdang Xu, Gang Wu, Bo Liu, Denglong Wu · 2019 · Open Medicine
- Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancerChaping Cheng, Jinming Wang, Penghui Xu, Kai Zhang, Zhixiang Xin, Huifang Zhao, Zhongzhong Ji, Man Zhang, Deng Wang, Yuman He et al. · 2022 · Nature Cancer
- Targeting androgen receptor degradation with PROTACs from bench to bedsideXiaojuan Jia, Xin Han · 2022 · Biomedicine & Pharmacotherapy
- Enzalutamide for the treatment of metastatic castration-resistant prostate cancerAlejo Rodríguez‐Vida, Simon Chowdhury, Cora Nanette Sternberg, Sarah Maria Rudman, Myria Galazi · 2015 · Drug Design Development and Therapy
- Selectively Targeting Prostate Cancer with Antiandrogen Equipped Histone Deacetylase InhibitorsBerkley E. Gryder, Michelle J. Akbashev, Michael Kenneth Rood, Eric D. Raftery, Warren M. Meyers, Paulette Dillard, Shafiq A. Khan, Adegboyega K. Oyelere · 2013 · ACS Chemical Biology
- PARP-1 regulates epithelial-mesenchymal transition (EMT) in prostate tumorigenesisHong Pu, Craig Horbinski, Patrick Joseph Hensley, Emily A. Matuszak, Timothy H. Atkinson, Natasha Kyprianou · 2014 · Carcinogenesis
- Molecules targeting the androgen receptor (AR) signaling axis beyond the AR‐Ligand binding domainN. G. R. Dayan Elshan, Matthew B. Rettig, Michael E. Jung · 2018 · Medicinal Research Reviews
- The role of adrenal derived androgens in castration resistant prostate cancerMonique Barnard, Elahe A. Mostaghel, Richard Joseph Auchus, Karl‐Heinz Storbeck · 2019 · The Journal of Steroid Biochemistry and Molecular Biology
- Overview of the latest treatments for castration-resistant prostate cancerMohamed Bishr, Fred Saad C · 2013 · Nature Reviews Urology
- Handling smart environment devices, data and services at the semantic level with the FI-WARE core platformFano Ramparany, Fermín Galán Márquez, Javier Soriano, Tarek Elsaleh · 2014 · IEEE International Conference on Big Data (BigData)
- Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancersJohn W. Phillips, Yang Pan, Brandon L. Tsai, Zhijie Xie, Levon Demirdjian, Wen Xiao, Harry Taegyun Yang, Yida Zhang, Chia Ho Lin, Donghui Cheng et al. · 2020 · Proceedings of the National Academy of Sciences
- A novel prostate cancer therapeutic strategy using icaritin-activated arylhydrocarbon-receptor to co-target androgen receptor and its splice variantsFeng Sun, Inthrani Raja Indran, Zhi Wei Zhang, M.H.Eileen Tan, Yu Li, Z.L.Ryan Lim, Rui Hua, Chong Yang, F.-F. Soon, Jun Li et al. · 2015 · Carcinogenesis
- Metastatic castration-resistant prostate cancer (CRPC): preclinical and clinical evidence for the sequential use of novel therapeuticsDeborah Mukherji, Aurelius Gabriel Omlin, Carmel Jo Pezaro, Ali I. Shamseddine, Johann Sebastian De Bono · 2014 · Cancer and Metastasis Reviews
- Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53- deficiency-driven castration-resistant prostate cancerLei Wang, Ji Wang, Hua Xiong, Fengxia Wu, Tian Lan, Yingjie Zhang, Xiaolan Guo, Huanan Wang, Mohammad Saleem, Cheng Jiang et al. · 2016 · EBioMedicine
- Combination of palbociclib with enzalutamide shows in vitro activity in RB proficient and androgen receptor positive triple negative breast cancer cellsChun‐Yu Liu, Ka-Yi Lau, Chia‐Chi Hsu, Ji-Lin Chen, Chia-Han Lee, Tzu‐Ting Huang, Yi‐Ting Chen, Chun-Teng Huang, Po‐Han Lin, Ling‐Ming Tseng · 2017 · PLoS ONE
- Therapeutic advances in hormone-dependent cancers: focus on prostate, breast and ovarian cancersMichael A. Ulm, Arvind V. Ramesh, Keely May McNamara, Suriyan Ponnusamy, Hironobu Sasano, Ramesh Narayanan · 2019 · Endocrine Connections
- Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancerMo Chen, Adegoke O. Adeniji, Barry M. Twenter, Jeffrey D. Winkler, David W. Christianson, T.M. Penning · 2012 · Bioorganic & Medicinal Chemistry Letters
- Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivityHiromitsu Kawata, Nobuyuki Ishikura, Miho Watanabe, Ayako Nishimoto-Kakiuchi, Toshiaki Tsunenari, Yuko Aoki · 2010 · The Prostate
- Second-Generation Androgen Receptor Antagonists as Hormonal Therapeutics for Three Forms of Prostate CancerPravien S. Rajaram, Alyssa Rivera, Kevin Muthima, Nicholas Olveda, Hubert Muchalski, Qiao‐Hong Chen · 2020 · Molecules
- Tracking the expression of therapeutic protein targets in rare cells by antibody-mediated nanoparticle labelling and magnetic sortingMahmoud Labib, Zongjie Wang, Sharif Uddin Ahmed, Reza M. Mohamadi, Bill T. V. Duong, Brenda J. Green, Edward Hartley Sargent, Shana O. Kelley · 2020 · Nature Biomedical Engineering