Development of a second-generation antiandrogen for treatment of advanced prostate cancer.

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Items 301–400 of 1,000

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    Basu, Shaon, Martínez-Cristóbal, Paula, Frigolé-Vivas, Marta, Pesarrodona, Mireia, Lewis, Michael, Szulc, Elzbieta, Bañuelos, C. Adriana, Sánchez-Zarzalejo, Carolina, Bielskutė, Stasė, Zhu, Jiaqi et al. · 2023 · Nature Structural & Molecular Biology
  2. Combination Therapy with a Second-Generation Androgen Receptor Antagonist and a Metastasis Vaccine Improves Survival in a Spontaneous Prostate Cancer Model
    Andressa Ardiani, Benedetto Farsaci, Connie Jo Rogers, Andy Protter, Zhimin Guo, Thomas H. King, David Apelian, James W. Hodge · 2013 · Clinical Cancer Research
  3. Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance
    Shipra Shukla, Joanna Cyrta, Devan A. Murphy, Edward G. Walczak, Leili Ran, Praveen Kumar Agrawal, Yuanyuan Xie, Yuedan Chen, Shangqian Wang, Yu Zhan et al. · 2017 · Cancer Cell
  4. Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity
    Wen‐Bing Jin, Leyi Xiao, Mingeum Jeong, Seong-Ji Han, Wen Zhang, Hiroshi Yano, Huiqing Shi, Mohammad Arifuzzaman, Mengze Lyu, Daoming Wang et al. · 2025 · Cell
  5. Clinical Outcomes of Castration-resistant Prostate Cancer Treatments Administered as Third or Fourth Line Following Failure of Docetaxel and Other Second-line Treatment: Results of an Italian Multicentre Study
    Orazio Caffo, Ugo De Giorgi, Lucia Fratino, Daniele Alesini, Vittorina Zagonel, Gaetano Facchini, Donatello Gasparro, Cinzia Ortega, Marcello Tucci, Francesco Verderame et al. · 2014 · European Urology
  6. Androgen hormone action in prostatic carcinogenesis: stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasis
    Emily A. Ricke, Karin Williams, Yi‐Fen Lee, Suzana S. Couto, Yuzhuo Z. Wang, Simon W. Hayward, Gerald R. Cunha, William A. Ricke · 2012 · Carcinogenesis
  7. Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism
    Supriya Shah, Whitney J. Carriveau, Jinyang Li, Sydney L. Campbell, Piotr K. Kopinski, Hee‐Woong Lim, Natalie A. Daurio, Sophie Trefely, Kyoung‐Jae Won, Douglas C. Wallace et al. · 2016 · Oncotarget
  8. The Role of Androgen Receptor Signaling in Ovarian Cancer
    Taichi Mizushima, Hiroshi Miyamoto · 2019 · Cells
  9. Triple negative breast cancer: special histological types and emerging therapeutic methods
    Lu Cao, Yun Niu · 2020 · Cancer Biology and Medicine
  10. Apalutamide, enzalutamide, and darolutamide for non-metastatic castration-resistant prostate cancer: a systematic review and network meta-analysis
    Keiichiro Mori, Hadi Mostafaei, Benjamin Pradère, Reza Sari Motlagh, Fahad Quhal, Ekaterina Laukhtina, Victor M. Schuettfort, Mohammad M. Abufaraj, Pierre I. Karakiewicz, Takahiro Kimura et al. · 2020 · International Journal of Clinical Oncology
  11. Enzalutamide response in a panel of prostate cancer cell lines reveals a role for glucocorticoid receptor in enzalutamide resistant disease
    Rebecca Lee Smith, Moqing Liu, Tiera A. Liby, Nora Bayani, Elmar Bucher, Kami Chiotti, Daniel S. Derrick, Anne Chauchereau, Laura M. Heiser, Joshi J. Alumkal et al. · 2020 · Scientific Reports
  12. Cross-resistance and drug sequence in prostate cancer
    Stefan A.J. Buck, Stijn L.W. Koolen, Ron H.J. Mathijssen, Ronald de Wit, Robert J. van Soest · 2021 · Drug Resistance Updates
  13. Novel targeted therapeutics for metastatic castration-resistant prostate cancer
    Emmanuel S. Antonarakis, Michael Anthony Carducci, Mario A. Eisenberger · 2009 · Cancer Letters
  14. Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer
    Suriyan Ponnusamy, Yali He, Dong‐Jin Hwang, Thirumagal Thiyagarajan, René Houtman, Vera Bocharova, Bobby G. Sumpter, Elias J. Fernandez, Daniel L. Johnson, Ziyun Du et al. · 2019 · Clinical Cancer Research
  15. Metastatic Hormone-Sensitive Prostate Cancer (mHSPC): Advances and Treatment Strategies in the First-Line Setting
    Kenrick Ng, Shievon Smith, Jonathan Shamash · 2020 · Oncology and Therapy
  16. Androgen receptor: a potential therapeutic target for glioblastoma
    Nomi Zalcman, Tamar Canello, Haim Ovadia, Hanna Charbit, Bracha Zelikovitch, Anat Mordechai, Yakov Fellig, Stav Rabani, Tal Shahar, Alexander Lossos et al. · 2018 · Oncotarget
  17. Androgen Receptor, Although Not a Specific Marker For, Is a Novel Target to Suppress Glioma Stem Cells as a Therapeutic Strategy for Glioblastoma
    Nan Zhao, Fei Wang, Shaheen Ahmed, Kan Liu, Chi Zhang, Sahara J. Cathcart, Dominick J. DiMaio, Michael Punsoni, Bingjie Guan, Ping Zhou et al. · 2021 · Frontiers in Oncology
  18. Integrative Molecular Profiling Reveals Asparagine Synthetase Is a Target in Castration-Resistant Prostate Cancer
    Kanishka Sircar, Heng Huang, Limei Hu, David E. Cogdell, Jasreman Dhillon, Vassiliki Tzelepi, Eleni Efstathiou, Ismaël Hervé Koumakpayi, Fred Saad C, Dijun Luo et al. · 2012 · American Journal Of Pathology
  19. Androgen–glucocorticoid interactions in the era of novel prostate cancer therapy
    Sujata Narayanan, Sandy Srinivas, David Feldman · 2015 · Nature Reviews Urology
  20. Switching and withdrawing hormonal agents for castration-resistant prostate cancer
    David Lorente, Joaquı́n Mateo, Zafeiris Zafeiriou, Alan David Smith, Shahneen Kaur Sandhu, Roberta Ferraldeschi, Johann Sebastian De Bono · 2015 · Nature Reviews Urology
  21. AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo
    Sarah A. Loddick, Sarah J. Ross, Andrew G. Thomason, David M. Robinson, Graeme E. Walker, Tom P. J. Dunkley, Sandra R. Brave, Nicola Broadbent, Natalie C. Stratton, Dawn Trueman et al. · 2013 · Molecular Cancer Therapeutics
  22. Alkaline Phosphatase in Metastatic Castration-Resistant Prostate Cancer: Reassessment of an Older Biomarker
    Daniel Alexander Heinrich, Øyvind Sverre Bruland, Theresa A. Guise, Hiroyoshi Suzuki, Oliver A. Sartor · 2018 · Future Oncology
  23. Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer
    McClinch, Kimberly, Avelar, Rita A., Callejas, David, Izadmehr, Sudeh, Wiredja, Danica, Perl, Abbey, Sangodkar, Jaya, Kastrinsky, David B., Schlatzer, Daniela, Cooper, Maxwell et al. · 2018 · Cancer Research
  24. From pathogenesis to prevention of castration resistant prostate cancer
    Helmut Bonkhoff, Richard R. Berges · 2009 · The Prostate
  25. Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping
    Joanna K. Lempiäinen, Einari A. Niskanen, Kaisa‐Mari Launonen, Riikka Lampinen, Helka Göös, Markku T Varjosalo, Jorma J. Palvimo · 2017 · Molecular & Cellular Proteomics
  26. Small-Molecule Screens: A Gateway to Cancer Therapeutic Agents with Case Studies of Food and Drug Administration–Approved Drugs
    Nathan P. Coussens, John C. Braisted, Tyler Peryea, Gurusingham Sitta Sittampalam, Anton M. Simeonov, Matthew D. Hall · 2017 · Pharmacological Reviews
  27. A Glutaminase Isoform Switch Drives Therapeutic Resistance and Disease Progression of Prostate Cancer
    Lingfan Xu, Yu Yin, Yanjing Li, Xufeng Chen, Yan Chang, Hong Zhang, Juan Liu, James Beasley, Patricia McCaw, Haoyue Zhang et al. · 2020 · Proceedings of the National Academy of Sciences
  28. Translational and clinical implications of the genetic landscape of prostate cancer
    Daniel Eidelberg Spratt, Zachary Stephan Zumsteg, Felix Yi-Chung Feng, Scott A. Tomlins · 2016 · Nature Reviews Clinical Oncology
  29. Understanding Mechanisms of Resistance in Metastatic Castration-resistant Prostate Cancer: The Role of the Androgen Receptor
    Derya Tilki, Edward M. Schaeffer, Christopher P. Evans · 2016 · European Urology Focus
  30. New Developments in the Medical Management of Prostate Cancer
    Manish Kohli, Donald J. Tindall · 2009 · Mayo Clinic Proceedings
  31. Circulating AR copy number and outcome to enzalutamide in docetaxel-treated metastatic castration-resistant prostate cancer
    Samanta Salvi, Valentina Casadio, Vincenza Conteduca, Cristian Lolli, Giorgia Gurioli, Filippo Martignano, Giuseppe Schepisi, Sara Testoni, Emanuela Scarpi, Dino Amadori et al. · 2016 · Oncotarget
  32. Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer
    Ritika Tiwari, Nishat Manzar, Vipul Bhatia, Anjali Yadav, Mushtaq Ahmad Nengroo, Dipak B. Datta, Shannon L. Carskadon, Nilesh Gupta, Michael Sigouros, Francesca Khani et al. · 2020 · Nature Communications
  33. Castration-Resistant Prostate Cancer: AUA Guideline Amendment 2015
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    K-H Chang, Cesar Emilio Ercole, Nima Sharifi · 2014 · British Journal of Cancer
  35. Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): Head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model
    Robert D. Bruno, Tadas Sean Vasaitis, Lalji K. Gediya, Puranik Purushottamachar, Abhijit M. Godbole, Zeynep Ateş‐Alagöz, Angela M. H. Brodie, Vincent C.O. Njar · 2011 · Steroids
  36. Imaging Androgen Receptor Signaling with a Radiotracer Targeting Free Prostate-Specific Antigen
    David Ulmert, Michael J. Evans, Jason P. Holland, Samuel L. Rice, John Wongvipat, Kim S. I. Pettersson, Per-Anders Abrahamsson, Peter T. Scardino, Steven M. Larson, Hans G. Lilja et al. · 2012 · Cancer Discovery
  37. Targeting the N-Terminal Domain of the Androgen Receptor: A New Approach for the Treatment of Advanced Prostate Cancer
    Emmanuel S. Antonarakis, Chandtip Chandhasin, Erica Osbourne, Jun Luo, Marianne D. Sadar, Frank Perabo · 2016 · The Oncologist
  38. Clinical utility of androgen receptor gene aberrations in circulating cell-free DNA as a biomarker for treatment of castration-resistant prostate cancer
    Takayuki Sumiyoshi, Kei Mizuno, Toshinari Yamasaki, Yu Miyazaki, Yuki Makino, Kosuke Okasho, Xin Li, Noriaki Utsunomiya, Takayuki Goto, Takashi Kobayashi et al. · 2019 · Scientific Reports
  39. Metastatic castration‐sensitive prostate cancer: Abiraterone, docetaxel, or…
    Pedro Coelho Barata, Oliver A. Sartor · 2019 · Cancer
  40. The androgen receptor/filamin A complex as a target in prostate cancer microenvironment
    Marzia Di Donato, Alice Zamagni, Giovanni Galasso, Erika Di Zazzo, Pia Giovannelli, Maria Vittoria Barone, Michele Zanoni, Roberta Gunelli, Matteo Costantini, Ferdinando Auricchio et al. · 2021 · Cell Death and Disease
  41. Extracellular Matrix in Synthetic Hydrogel‐Based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 Inhibitors
    Matthew J. Mosquera, Sungwoong Kim, Rohan Bareja, Zhou Fang, Shuangyi Cai, Heng Pan, Muhammad Imran Asad, M. Laura Martín, Michael Sigouros, Florencia P. Madorsky Rowdo et al. · 2021 · Advanced Materials
  42. Androgen deprivation therapy sensitizes prostate cancer cells to T-cell killing through androgen receptor dependent modulation of the apoptotic pathway
    Andressa Ardiani, Sofia R. Gameiro, Anna R. Kwilas, Renee Nicole Donahue, James W. Hodge · 2014 · Oncotarget
  43. siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer
    Yoshiaki Yamamoto, Paulo J.C. Lin, Eliana Beraldi, Fan Zhang, Yoshihisa Kawai, Jeffrey Leong, Hidemasa Katsumi, Ladan Fazli, Robert Fraser, Pieter R. Cullis et al. · 2015 · Clinical Cancer Research
  44. Minireview: Androgen Metabolism in Castration-Resistant Prostate Cancer
    Nima Sharifi · 2013 · Molecular Endocrinology
  45. Multivalent Peptidomimetic Conjugates: A Versatile Platform for Modulating Androgen Receptor Activity
    Paul M. Levine, Keren Imberg-Kazdan, Michael J. Garabedian, Kent Kirshenbaum · 2012 · Journal of the American Chemical Society
  46. Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond
    Simon Linder, Henk G. van der Poel, Andries Marinus Bergman, Wilbert T. Zwart, Stefan Preković · 2018 · Endocrine Related Cancer
  47. Rezvilutamide versus bicalutamide in combination with androgen-deprivation therapy in patients with high-volume, metastatic, hormone-sensitive prostate cancer (CHART): a randomised, open-label, phase 3 trial
    Weijie Gu, Weiqing Han, Hong Luo, Fangjian Zhou, Dalin He, Lulin Ma, Hongqian Guo, Chang Yin Liang, Tie Chong, Jun Jiang et al. · 2022 · The Lancet Oncology
  48. The Crucial Role of AR-V7 in Enzalutamide-Resistance of Castration-Resistant Prostate Cancer
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  49. miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src
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  50. A New Avenue toward Androgen Receptor Pan-antagonists: C2 Sterically Hindered Substitution of Hydroxy-propanamides
    Andrea Guerrini, Anna Tesei, Claudia Ferroni, Giulia Paganelli, Alice Zamagni, Silvia Carloni, Marzia Di Donato, Gabriella Castoria, Carlo Leonetti, Manuela Porru et al. · 2014 · Journal of Medicinal Chemistry
  51. Cancer-Associated Fibroblasts Modify the Response of Prostate Cancer Cells to Androgen and Anti-Androgens in Three-Dimensional Spheroid Culture
    Theresa Eder, Anja Weber, Hannes Neuwirt, Georg Grünbacher, Christian Ploner, Helmut Klocker, Natalie Sampson, Iris Elisabeth Eder · 2016 · International Journal of Molecular Sciences
  52. Mechanisms and biotechnological applications of transcription factors
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  53. Androgen Receptor Rearrangement and Splicing Variants in Resistance to Endocrine Therapies in Prostate Cancer
    Yeung Ho, Scott M. Dehm · 2017 · Endocrinology
  54. Molecular Imaging in Cancer Drug Development
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  55. Structure and Function of the Nuclear Receptor Superfamily and Current Targeted Therapies of Prostate Cancer
    Baylee A. Porter, Maria Antonia Ortiz, Gennady Bratslavsky, Leszek Kotula · 2019 · Cancers
  56. Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis
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  57. Targeting Alternative Sites on the Androgen Receptor to Treat Castration-Resistant Prostate Cancer
    Nada Lallous, Kush Dalal, Artem R Cherkasov, Paul S. Rennie · 2013 · International Journal of Molecular Sciences
  58. Cotargeting Androgen Receptor and Clusterin Delays Castrate-Resistant Prostate Cancer Progression by Inhibiting Adaptive Stress Response and AR Stability
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  60. Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor Antagonists
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  61. Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing Twist
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  63. Mini-review: Foldosome regulation of androgen receptor action in prostate cancer
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  64. MUC1 oncoprotein is a druggable target in human prostate cancer cells
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  91. Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers
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  94. Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53- deficiency-driven castration-resistant prostate cancer
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  95. Combination of palbociclib with enzalutamide shows in vitro activity in RB proficient and androgen receptor positive triple negative breast cancer cells
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  99. Second-Generation Androgen Receptor Antagonists as Hormonal Therapeutics for Three Forms of Prostate Cancer
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  100. Tracking the expression of therapeutic protein targets in rare cells by antibody-mediated nanoparticle labelling and magnetic sorting
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