Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

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Dopamine, learning and motivation.

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Channelrhodopsin-2, a directly light-gated cation-selective membrane channel

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Drug abuse: hedonic homeostatic dysregulation

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The mesolimbic dopamine reward circuit in depression

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Dopamine neuron systems in the brain: An update

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Multimodal fast optical interrogation of neural circuitry

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Frequency- and State-Dependent Network Effects of Electrical Stimulation Targeting the Ventral Tegmental Area in Macaques

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Biophotonic Strategies of Measurement and Stimulation of the Cranial and the Extracranial Lymphatic Drainage Function

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A hindbrain dopaminergic neural circuit prevents weight gain by reinforcing food satiation

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Neuropeptides in Cancer: Friend and Foe?

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Utility of genetically modified mice for understanding the neurobiology of substance use disorders

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Optogenetics in psychiatric diseases

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Chronic ethanol exposure increases inhibition of optically targeted phasic dopamine release in the nucleus accumbens core and medial shell ex vivo

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Optogenetics in the behaving rat: integration of diverse new technologies in a vital animal model

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Dissociable contributions of phasic dopamine activity to reward and prediction

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Overview on Research and Clinical Applications of Optogenetics

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Dopamine release in the nucleus accumbens is altered following traumatic brain injury

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Biophysical Properties of Somatic and Axonal Voltage-Gated Sodium Channels in Midbrain Dopaminergic Neurons

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Altered baseline and amphetamine-mediated behavioral profiles in dopamine transporter Cre (DAT-Ires-Cre) mice compared to tyrosine hydroxylase Cre (TH-Cre) mice

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Allostatic Changes in the cAMP System Drive Opioid-Induced Adaptation in Striatal Dopamine Signaling

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Terminal effects of optogenetic stimulation on dopamine dynamics in rat striatum

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Striatal Dopamine Signals and Reward Learning

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Optical suppression of drug-evoked phasic dopamine release

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Genetically encoded probes for optical imaging of brain electrical activity

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Optogenetic Modulation of Intracellular Signalling and Transcription: Focus on Neuronal Plasticity

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Cognitive representations of intracranial self-stimulation of midbrain dopamine neurons depend on stimulation frequency

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Mouse Models of Depression

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Neurotrapping: cellular screens to identify the neural substrates of behavior in Drosophila

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A Guide to Creating and Testing New INTRSECT Constructs

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Adaptive Changes in the Central Control of Energy Homeostasis Occur in Response to Variations in Energy Status

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Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation

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Orexin/hypocretin plays a role in the response to physiological disequilibrium

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Back to the Future: Circuit-testing TS & OCD

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Causal Mechanisms Driving Visual Cortical Plasticity and Perceptual Learning in Primates

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Shedding Light on Social Reward Circuitry: (Un)common Blueprints in Humans and Rodents

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Dopamine neurons do not constitute an obligatory stage in the final common path for the evaluation and pursuit of brain stimulation reward

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Reward prediction error in learning-related behaviors

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Studying cerebellar circuits by remote control of selected neuronal types with GABA-A receptors

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Mapping the Brain-Wide Network Effects by Optogenetic Activation of the Corpus Callosum

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Simultaneous voltammetric detection of glucose and lactate fluctuations in rat striatum evoked by electrical stimulation of the midbrain

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Electrophysiological evidence for functionally distinct neuronal populations in the human substantia nigra

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Optogenetic activation of GABAergic neurons in the nucleus accumbens decreases the activity of the ventral pallidum and the expression of cocaine-context-associated memory

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Integrating Optogenetic and Pharmacological Approaches to Study Neural Circuit Function: Current Applications and Future Directions

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Rethinking dopamine as generalized prediction errorPreprint

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Molecular Mechanisms of Cannabis Signaling in the Brain

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Application of optogenetics and in vivo imaging approaches for elucidating the neurobiology of addiction

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Linking Across Levels of Computation in Model-Based Cognitive Neuroscience

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A Direct Neurokinin B Projection from the Arcuate Nucleus Regulates Magnocellular Vasopressin Cells of the Supraoptic Nucleus

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Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology

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CCKergic Tufted Cells Differentially Drive Two Anatomically Segregated Inhibitory Circuits in the Mouse Olfactory Bulb

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Analysis of individual differences in neurofeedback training illuminates successful self-regulation of the dopaminergic midbrain

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Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice

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Endocannabinoid-Dependent Modulation of Phasic Dopamine Signaling Encodes External and Internal Reward-Predictive Cues

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Stimulus-Preceding Negativity (SPN) and Attention to Rewards

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Short-term plasticity in glomerular inhibitory circuits shapes olfactory bulb output

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Changes in the Honeybee Antioxidant System after 12 h of Exposure to Electromagnetic Field Frequency of 50 Hz and Variable Intensity

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Food reward depends on TLR4 activation in dopaminergic neurons

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Evaluation of the hypothesis that phasic dopamine constitutes a cached-value signal

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Micro- and nano-technologies to probe the mechano-biology of the brain

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Chronically dysregulated corticosterone impairs dopaminergic transmission in the dorsomedial striatum by sex-divergent mechanisms

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Dopamine transients encode reward prediction errors independent of learning rates

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Optogenetics as a neuromodulation tool in cognitive neuroscience

Pama, E. A. C., Colzato, L. S., & Hommel, B. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00610 · Cited by 22

The strength of aversive and appetitive associations and maladaptive behaviors

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Phasic Stimulation of Midbrain Dopamine Neuron Activity Reduces Salt Consumption

Sandhu, E., Fernando, A. B. P., Irvine, E. E., Tossell, K., Kokkinou, M., Glegola, J. A., Smith, M. A., Howes, O. D., Withers, D. J., & Ungless, M. A. (2018) · eNeuro · doi:10.1523/eneuro.0064-18.2018 · Cited by 22

GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization

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The past, present and future of light-gated ion channels and optogenetics

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Current Perspectives on the Neurobiology of Drug Addiction: A Focus on Genetics and Factors Regulating Gene Expression

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Heterogeneity of the midbrain dopamine system

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Targeting mitochondrial dynamics of morphine-responsive dopaminergic neurons ameliorates opiate withdrawal

Jiang, C., Huang, H., Yang, X., Le, Q., Liu, X., Ma, L., & Wang, F. (2024) · Journal of Clinical Investigation · doi:10.1172/jci171995 · Cited by 21

Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans

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Coordinating brain-distributed network activities in memory resistant to extinction

Clarke-Williams, C. J., Lopes‐dos‐Santos, V., Lefèvre, L., Brizee, D., Causse, A. A., Rothaermel, R., Hartwich, K., Perestenko, P. V., Toth, R. A., McNamara, C. G., et al. (2024) · Cell · doi:10.1016/j.cell.2023.12.018 · Cited by 21

Different adaptations of dopamine release in Nucleus Accumbens shell and core of individual alcohol drinking groups of mice

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Neural Circuitries between the Brain and Peripheral Solid Tumors

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Differential activation of accumbens shell and core dopamine by sucrose reinforcement with nose poking and with lever pressing

Bassareo, V., Cucca, F., Frau, R., & Chiara, G. D. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.08.006 · Cited by 20

A magnetic rotary optical fiber connector for optogenetic experiments in freely moving animals

Klorig, D. C., & Godwin, D. W. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.02.013 · Cited by 20

The reward value of sucrose in leptin-deficient obese mice

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Off the Beaten Path: Drug Addiction and the Pontine Laterodorsal Tegmentum

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Effects of D1 receptor knockout on fear and reward learning

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Reward and value coding by dopamine neurons in non-human primates

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Photoperiod Impacts Nucleus Accumbens Dopamine Dynamics

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Gene Targeting in Neuroendocrinology

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Midbrain dopaminergic inputs gate amygdala intercalated cell clusters by distinct and cooperative mechanisms in male mice

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Targeted Optical Neural Stimulation: A New Era for Personalized Medicine

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The deep cerebellar nuclei to striatum disynaptic connection contributes to skilled forelimb movement

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Awake or Sleeping? Maybe Both… A Review of Sleep-Related Dissociative States

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Neural mechanisms underlying uninstructed orofacial movements during reward-based learning behaviors

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Glutamate release from astrocyte cell-line GL261 via alterations in the intracellular ion environment

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