Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

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Dopamine, learning and motivation.

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Channelrhodopsin-2, a directly light-gated cation-selective membrane channel

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Multimodal fast optical interrogation of neural circuitry

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Neuromodulation for obsessive-compulsive disorder

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Activation of mesocorticolimbic dopamine projections initiates cue-induced reinstatement of reward seeking in mice

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The Convergence Model of Brain Reward Circuitry: Implications for Relief of Treatment-Resistant Depression by Deep-Brain Stimulation of the Medial Forebrain Bundle

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Sensory Cues Potentiate VTA Dopamine Mediated Reinforcement

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Dopaminergic Projection from Ventral Tegmental Area to Substantia Nigra Pars Reticulata Mediates Chronic Social Defeat Stress–Induced Hypolocomotion

He, F., Zhang, P., Zhang, Q., Qi, G., Cai, H., Li, T., Li, M., Lu, J., Lin, J., Ming, J., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02522-7 · Cited by 18

Locus of onset and subpopulation specificity of in vivo ethanol effect in the reciprocal ventral tegmental area–nucleus accumbens circuit

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Application of fast-scan cyclic voltammetry for the in vivo characterization of optically evoked dopamine in the olfactory tubercle of the rat brain

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Computational approaches to habits in a model-free world

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Decreases in Cued Reward Seeking After Reward-Paired Inhibition of Mesolimbic Dopamine

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Functional interrogation of neural circuits with virally transmitted optogenetic tools

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Dissecting the neural circuitry of addiction and psychiatric disease with optogenetics

Stuber, G. D. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.102 · Cited by 18

Morphine selectively disinhibits glutamatergic input from mPFC onto dopamine neurons of VTA, inducing reward

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Throwing open the doors of perception: The role of dopamine in visual processing

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NAPE-PLD in the ventral tegmental area regulates reward events, feeding and energy homeostasis

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Drug-induced change in transmitter identity is a shared mechanism generating cognitive deficits

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Optogenetic Modulation and Multi-Electrode Analysis of Cerebellar Networks In Vivo

Kruse, W., Krause, M., Aarse, J., Mark, M. D., Manahan‐Vaughan, D., & Herlitze, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105589 · Cited by 17

Selective lesions of the cholinergic neurons within the posterior pedunculopontine do not alter operant learning or nicotine sensitization

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Shedding Light on the Role of Ventral Tegmental Area Dopamine in Reward

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Selective dopamine D3receptor antagonism significantly attenuates stress‐induced immobility in a rat model of post‐traumatic stress disorder

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Effects of brief inhibition of the ventral tegmental area dopamine neurons on the cocaine seeking during abstinence

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Social Determinants of Inter-Individual Variability and Vulnerability: The Role of Dopamine

Fauré, P., Fayad, S. L., Solié, C., & Reynolds, L. M. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.836343 · Cited by 17

Optogenetics: Novel Tools for Controlling Mammalian Cell Functions with Light

Kushibiki, T., Okawa, S., Hirasawa, T., & Ishihara, M. (2014) · International Journal of Photoenergy · doi:10.1155/2014/895039 · Cited by 17

Midbrain dopaminergic neuron activity across alternating brain states of urethane anaesthetized rat

Walczak, M., & Błasiak, T. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13533 · Cited by 17

Bases neurobiologiques de l’addiction à l’alcool

Naassïla, M. (2018) · La Presse Médicale · doi:10.1016/j.lpm.2017.12.001 · Cited by 17

Review—In Vivo Electrochemical Measurements of Norepinephrine in the Brain: Current Status and Remaining Challenges

Park, J., Bhimani, R. V., & Bass, C. E. (2018) · Journal of The Electrochemical Society · doi:10.1149/2.0091812jes · Cited by 17

Activation of VTA/CeA/mPFC cannabinoid CB1 receptors induced conditioned drug effects via interacting with hippocampal CAMKII-CREB-BDNF signaling pathway in rats

Navabpour, S., Rezayof, A., & Ghasemzadeh, Z. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174417 · Cited by 17

Possible contributions of a novel form of synaptic plasticity inAplysiato reward, memory, and their dysfunctions in mammalian brainPreprint

Hawkins, R. D. (2013) · Learning & Memory · doi:10.1101/lm.031237.113 · Cited by 17

Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner

Harada, M., Capdevila, L. S., Wilhelm, M., Burdakov, D., & Patriarchi, T. (2023) · eLife · doi:10.7554/elife.90158 · Cited by 16

Optimized Fabrication of Carbon-Fiber Microbiosensors for Codetection of Glucose and Dopamine in Brain Tissue

Forderhase, A. G., Ligons, L. A., Norwood, E., McCarty, G. S., & Sombers, L. A. (2024) · ACS Sensors · doi:10.1021/acssensors.4c00527 · Cited by 16

Oppositional and competitive instigation of hippocampal synaptic plasticity by the VTA and locus coeruleus

Hagena, H., & Manahan‐Vaughan, D. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2402356122 · Cited by 16

Modulating the map

Werlen, E., & Jones, M. W. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.03.002 · Cited by 16

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Bimpisidis, Z., König, N., & Wallén‐Mackenzie, Å. (2020) · Journal of Visualized Experiments · doi:10.3791/60867 · Cited by 16

Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling

Pradel, K., Drwiȩga, G., Chrobok, Ł., & Błasiak, T. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.932378 · Cited by 16

Characterization of striatal dopamine projections across striatal subregions in behavioral flexibility

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Stereotaxic Adeno-associated Virus Injection and Cannula Implantation in the Dorsal Raphe Nucleus of Mice

Correia, P. A., Matias, S., & Mainen, Z. F. (2017) · BIO-PROTOCOL · doi:10.21769/bioprotoc.2549 · Cited by 16

A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis

Sanchís, P., Fernández‐Gayol, O., Comes, G., Aguilar, K., Escrig, A., Giralt, M., Palmiter, R. D., & Hidalgo, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01969-0 · Cited by 16

Acetylcholine demixes heterogeneous dopamine signals for learning and moving

Jang, H. J., Ward, R. M., Golden, C. E. M., & Constantinople, C. M. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02227-x · Cited by 20

Temporally Coordinated Deep Brain Stimulation in the Dorsal and Ventral Striatum Synergistically Enhances Associative Learning

Katnani, H. A., Patel, S. R., Kwon, C., Abdel-Aziz, S., Gale, J. T., & Eskandar, E. N. (2016) · Scientific Reports · doi:10.1038/srep18806 · Cited by 15

Learning deficits in rats overexpressing the dopamine transporter

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Clinical applicability of optogenetic gene regulation

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Optogenetic modulation of glutamatergic afferents from the ventral subiculum to the nucleus accumbens: Effects on dopamine function, response vigor and locomotor activity

Lindenbach, D., Vacca, G., Ahn, S., Seamans, J. K., & Phillips, A. G. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114028 · Cited by 15

Optogenetic Activation of the Excitatory Neurons Expressing CaMKIIαin the Ventral Tegmental Area Upregulates the Locomotor Activity of Free Behaving Rats

Guo, S., Chen, S., Zhang, Q., Wang, Y., Xu, K., & Zheng, X. (2014) · BioMed Research International · doi:10.1155/2014/687469 · Cited by 15

Cell death and sexual differentiation of behavior: worms, flies, and mammals

Forger, N. G., & Vries, G. J. D. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.09.006 · Cited by 15

Virogenetic and optogenetic mechanisms to define potential therapeutic targets in psychiatric disorders

Han, M., & Friedman, A. K. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.009 · Cited by 15

Positive reinforcing effect of neurotensin microinjection into the ventral pallidum in conditioned place preference test

Ollmann, T., Péczely, L., László, K., Kovács, A., Gálosi, R., Berente, E., Karádi, Z., & Lénárd, L. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.10.021 · Cited by 15

Perinatal Exposure to Neuregulin-1 Results in Disinhibition of Adult Midbrain Dopaminergic Neurons: Implication in Schizophrenia Modeling

Namba, H., Okubo, T., & Nawa, H. (2016) · Scientific Reports · doi:10.1038/srep22606 · Cited by 15

Psychiatry’s age of enlightenment: optogenetics and the discovery of novel targets for the treatment of psychiatric disorders

Sidor, M. M. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110175 · Cited by 15

New approaches to neural circuits in behaviorPreprint

Garner, A. R., & Mayford, M. R. (2012) · Learning & Memory · doi:10.1101/lm.025049.111 · Cited by 15

Four individually identified paired dopamine neurons signal taste punishment in larval DrosophilaPreprint

Weber, D., Vogt, K., Miroschnikow, A., Pankratz, M. J., & Thum, A. S. (2023) · eLife · doi:10.7554/elife.91387 · Cited by 15

Optogenetic Brain–Computer Interfaces

Tang, F., Yan, F., Zhong, Y., Li, J., Gong, H., & Li, X. (2024) · Bioengineering · doi:10.3390/bioengineering11080821 · Cited by 14

Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety-like behaviors

Borgne, T. L., Nguyen, C., Vicq, É., Jehl, J., Solié, C., Guyon, N., Daussy, L., Gulmez, A., Reynolds, L. M., Mondoloni, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61180-8 · Cited by 14

The striatum and beyond: contributions of the hippocampus to decision making

Wimmer, G. E., & Shohamy, D. (2011) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199600434.003.0013 · Cited by 14

Design and construction of a low-cost nose poke system for rodents

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Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior

Yoo, H., Yang, S. H., Kim, J. Y., Yang, E., Park, H. S., Lee, S. J., Rhyu, I. J., Turecki, G., Lee, H. W., & Kim, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-83310-0 · Cited by 14

Remote Optogenetics Using Up/Down-Conversion Phosphors

Matsubara, T., & Yamashita, T. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.771717 · Cited by 14

The dopamine circuit as a reward-taxis navigation system

Karin, O., & Alon, U. S. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010340 · Cited by 14

Good vibrations switch attention: An affective function for network oscillations in evolutionary simulations

Heerebout, B. T., & Phaf, R. H. (2010) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.10.2.217 · Cited by 14

The Extended Brain: Cyclic Information Flow in a Quantum Physical Realm

Meijer, D. K. F. (2014) · NeuroQuantology · doi:10.14704/nq.2014.12.2.754 · Cited by 14

Striatal dopamine D1 receptors are involved in the dissociation of learning based on reward-magnitude

Rose, J., Schiffer, A., & Güntürkün, O. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.064 · Cited by 14

Enhanced dorsolateral striatal activity in drug use: The role of outcome in stimulus–response associations

Schneck, N., & Vezina, P. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.042 · Cited by 14

Ventral Tegmental Area Dopamine Neurons Firing Model Reveals Prenatal Nicotine Induced Alterations

Dragomir, A., Akay, Y. M., Zhang, D., & Akay, M. (2016) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2016.2636133 · Cited by 14

Optogenetics: What it has uncovered in potential pathways of depression

Cheng, Z., Cui, R., Ge, T., Yang, W., & Li, B. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104596 · Cited by 14

Characterization of kindled VGAT‐Cre mice as a new animal model of temporal lobe epilepsy

Straub, J., Gawda, A., Ravichandran, P., McGrew, B., Nylund, E. O., Kang, J. S., Burke, C. T., Vitko, I., Scott, M. M., Williamson, J., et al. (2020) · Epilepsia · doi:10.1111/epi.16651 · Cited by 14

CHANGE DETECTION, MULTIPLE CONTROLLERS, AND DYNAMIC ENVIRONMENTS: INSIGHTS FROM THE BRAIN

Pearson, J. M., & Platt, M. L. (2012) · Journal of the Experimental Analysis of Behavior · doi:10.1002/jeab.5 · Cited by 14

Modulating dopamine release by optogenetics in transgenic mice reveals terminal dopaminergic dynamics

Lu, Y., Driscoll, N., Ozden, I., Yu, Z., & Nurmikko, A. V. (2015) · Neurophotonics · doi:10.1117/1.nph.2.3.031207 · Cited by 13

Plasticity in the Brainstem: Prenatal and Postnatal Experience Can Alter Laterodorsal Tegmental (LDT) Structure and Function

Kohlmeier, K. A., & Polli, F. S. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00003 · Cited by 13

A Causal Role for the Pedunculopontine Nucleus in Human Instrumental Learning

Skvortsova, V., Palminteri, S., Buot, A., Karachi, C., Welter, M., Grabli, D., & Pessiglione, M. (2020) · Current Biology · doi:10.1016/j.cub.2020.11.042 · Cited by 13

Laterodorsal tegmentum–ventral tegmental area projections encode positive reinforcement signals

Coimbra, B., Domingues, A. V., Soares‐Cunha, C., Correia, R. G., Pinto, L., Sousa, N., & Rodrigues, A. J. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24931 · Cited by 13

All-fiber-transmission photometry for simultaneous optogenetic stimulation and multi-color neuronal activity recording

Qi, Z., Guo, Q., Wang, S., Jia, M., Gao, X., Luo, M., & Fu, L. (2022) · Opto-Electronic Advances · doi:10.29026/oea.2022.210081 · Cited by 13

The circadian neurobiology of reward

Olejniczak, I., Begemann, K., Wilhelm, I., & Oster, H. (2023) · Acta Physiologica · doi:10.1111/apha.13928 · Cited by 13

Real-Time Electrochemical Recording of Dopamine Release under Optogenetic Stimulation

Chiu, W., Lin, C.-M., Tsai, T.-C., Wu, C. W., Tsai, C.-L., Lin, S., & Chen, J.-J. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089293 · Cited by 13

GABAB Receptor Functions in the Mesolimbic Dopamine System

Lalive, A. L., & Lüscher, C. (2016) · Springer eBooks · doi:10.1007/978-3-319-46044-4_8 · Cited by 13

Dopamine-mediated formation of a memory module in the nucleus accumbens for goal-directed navigation

Jung, K., Krüssel, S., Yoo, S., An, M., Burke, B., Schappaugh, N., Choi, Y., Gu, Z., Blackshaw, S., Costa, R. M., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01770-9 · Cited by 14

Dynamic functional connectivity between nucleus accumbens and the central executive network relates to chronic cannabis use

Yoo, H. B., Moya, B. E., & Filbey, F. M. (2020) · Human Brain Mapping · doi:10.1002/hbm.25036 · Cited by 12

Optogenetic neuromodulation with gamma oscillation as a new strategy for Alzheimer disease: a narrative review

Ko, H., & Yoon, S. P. (2022) · Journal of Yeungnam Medical Science · doi:10.12701/jyms.2021.01683 · Cited by 12

Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement

Petter, E. A., Fallon, I. P., Hughes, R. N., Watson, G. D. R., Meck, W. H., Severino, F. P. U., & Yin, H. H. (2023) · eLife · doi:10.7554/elife.83600 · Cited by 12

Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons

Glykos, V., & Fujisawa, S. (2023) · eLife · doi:10.7554/elife.89743 · Cited by 12

Viral vector strategies for investigating midbrain dopamine circuits underlying motivated behaviors

Pinto, D. F. C., & Lammel, S. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.02.006 · Cited by 12

Morphine Reward Promotes Cue-Sensitive Learning: Implication of Dorsal Striatal CREB Activity

Baudonnat, M., Guillou, J., Husson, M., Bohbot, V. D., Schwabe, L., & David, V. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00087 · Cited by 12

The D2-like Dopamine Receptor Agonist Quinpirole Microinjected Into the Ventral Pallidum Dose-Dependently Inhibits the VTA and Induces Place Aversion

Péczely, L., Ollmann, T., László, K., Lénárd, L., & Grace, A. A. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac024 · Cited by 12

Natural VTA activity during NREM sleep influences future exploratory behavior

Harris, J. J., Köllő, M., Erskine, A., Schaefer, A. T., & Burdakov, D. (2022) · iScience · doi:10.1016/j.isci.2022.104396 · Cited by 12

Synaptotagmin-7 Counteracts Short-Term Depression during Phasic Dopamine Release

Kissiwaa, S. A., Lebowitz, J. J., Engeln, K. A., Bowman, A. M., Williams, J. T., & Jackman, S. L. (2024) · eNeuro · doi:10.1523/eneuro.0501-23.2024 · Cited by 12

Modeling Decision-Making Systems in Addiction

Kurth-Nelson, Z. L., & Redish, A. D. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0751-5_6 · Cited by 12

Reward and aversion systems of the brain as a functional unit. Basic mechanisms and functions

Michel, A., Estañol, B., Senties, H., Chiquete, E., Delgado‐García, G. R., & Castillo, G. (2015) · Salud Mental · doi:10.17711/sm.0185-3325.2015.041 · Cited by 12

Functional Interrogation of the AgRP Neural Circuits in Control of Appetite, Body Weight, and Behaviors

Han, Y., Xia, G., & Wu, Q. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1286-1_1 · Cited by 13

Using Optogenetics to Dissect the Neural Circuits Underlying OCD and Related Disorders

Piantadosi, S. C., & Ahmari, S. E. (2015) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-015-0056-3 · Cited by 12

Whither motoneurons?

Brownstone, R. M., & Stuart, D. G. (2011) · Brain Research · doi:10.1016/j.brainres.2011.06.008 · Cited by 12

Optogenetics in Freely Moving Mammals: Dopamine and RewardPreprint

Zhang, F., Tsai, H.-C., Airan, R. D., Stuber, G. D., Adamantidis, A., de Lecea, L., Bonci, A., & Deisseroth, K. A. (2015) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top086330 · Cited by 12

Illuminating anhedonia

Robbins, T. W. (2015) · Science · doi:10.1126/science.aad9698 · Cited by 12

Real-time markerless video tracking of body parts in mice using deep neural networksPreprint

Forys, B. J., Xiao, D., Gupta, P. K., Boyd, J. D., & Murphy, T. H. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/482349 · Cited by 12

Prediction error in dopamine neurons during associative learning

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