The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis
Open accessAbstract
During chemotaxis, activation of the small guanosine triphosphatase Rac is spatially regulated to organize the extension of membrane protrusions in the direction of migration. In neutrophils, Rac activation is primarily mediated by DOCK2, an atypical guanine nucleotide exchange factor. Upon stimulation, we found that DOCK2 rapidly translocated to the plasma membrane in a phosphatidylinositol 3,4,5-trisphosphate–dependent manner. However, subsequent accumulation of DOCK2 at the leading edge required phospholipase D–mediated synthesis of phosphatidic acid, which stabilized DOCK2 there by means of interaction with a polybasic amino acid cluster, resulting in increased local actin polymerization. When this interaction was blocked, neutrophils failed to form leading edges properly and exhibited defects in chemotaxis. Thus, intracellular DOCK2 dynamics are sequentially regulated by distinct phospholipids to localize Rac activation during neutrophil chemotaxis.
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Cites
Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling
Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., & Chen, J. (2001) · Science · doi:10.1126/science.1066015 · Cited by 1,055
Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex
Brugnera, E., Haney, L., Grimsley, C., Lu, M., Walk, S. F., Tosello-Trampont, A.-C., Macara, I. G., Madhani, H., Fink, G. R., & Ravichandran, K. S. (2002) · Nature Cell Biology · doi:10.1038/ncb824 · Cited by 576
Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration
Fukui, Y., Hashimoto, O., Sanui, T., Oono, T., Koga, H., Abe, M., Inayoshi, A., Noda, M., Oike, M., Shirai, T., et al. (2001) · Nature · doi:10.1038/35090591 · Cited by 449
Self-citation
Cited by
ADF/Cofilin: a functional node in cell biology
Bernstein, B. W., & Bamburg, J. R. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.01.001 · Cited by 704
Harada, Y., Tanaka, Y., Terasawa, M., Pieczyk, M., Habiro, K., Katakai, T., Hanawa-Suetsugu, K., Kukimoto-Niino, M., Nishizaki, T., Shirouzu, M., et al. (2012) · Blood · doi:10.1182/blood-2012-01-407098 · Cited by 236
Self-citationDock-family exchange factors in cell migration and disease
Gadea, G., & Blangy, A. (2014) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2014.06.003 · Cited by 217
Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections
Dobbs, K., Domínguez Conde, C., Zhang, S.-Y., Parolini, S., Audry, M., Chou, J., Haapaniemi, E., Keles, S., Bilic, I., Okada, S., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1413462 · Cited by 201
Insights into the biological functions of Dock family guanine nucleotide exchange factors
Laurin, M., & Côté, J.-F. (2014) · Genes & Development · doi:10.1101/gad.236349.113 · Cited by 160
Metadata
- Authors
- Nishikimi, A., Fukuhara, H., Su, W., Hongu, T., Takasuga, S., Mihara, H., Cao, Q., Sanematsu, F., Kanai, M., Hasegawa, H., Tanaka, Y., Shibasaki, M., Kanaho, Y., Sasaki, T., Frohman, M. A., & Fukui, Y.
- Venue
- Science
- Published
- 2009-04-17
- Volume
- 324
- Issue
- 5925
- Pages
- 384-387
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024765629
- Cited by
- 267
- References
- 3
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Nishikimi, A., Fukuhara, H., Su, W., Hongu, T., Takasuga, S., Mihara, H., Cao, Q., Sanematsu, F., Kanai, M., Hasegawa, H., Tanaka, Y., Shibasaki, M., Kanaho, Y., Sasaki, T., Frohman, M. A., & Fukui, Y. (2009). Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis. Science. https://doi.org/10.1126/science.1170179
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