The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Synthetic Gene Networks That Count
Open accessAbstract
One, Two, Three: Synthetic biologists take much of their inspiration from computing and electrical engineering, attempting to gain programmability in cells using analogous genetic circuits. Friedland et al. (p. 1199 ; see the Perspective by Smolke ) have constructed complementary Escherichia coli synthetic gene networks that keep track of prior molecular events to function as counters. These modular devices count up to three induction events over a range of frequencies and could be extended to higher numbers. Similar devices may find application in multi-event processes of cell biology, bioengineering, and, potentially, therapeutics.
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Citations
Cites
A synthetic oscillatory network of transcriptional regulators
Elowitz, M. B., & Leibler, S. (2000) · Nature · doi:10.1038/35002125 · Cited by 4,630
Construction of a genetic toggle switch in Escherichia coli
Gardner, T. S., Cantor, C. R., & Collins, J. J. (2000) · Nature · doi:10.1038/35002131 · Cited by 4,268
Self-citationA synthetic multicellular system for programmed pattern formation
Basu, S., Gerchman, Y., Collins, C. H., Arnold, F. H., & Weiss, R. (2005) · Nature · doi:10.1038/nature03461 · Cited by 1,154
A fast, robust and tunable synthetic gene oscillator
Stricker, J., Cookson, S., Bennett, M. R., Mather, W. H., Tsimring, L. S., & Hasty, J. (2008) · Nature · doi:10.1038/nature07389 · Cited by 1,112
Andersen, J. B., Sternberg, C., Poulsen, L. K., Bjørn, S. P., Givskov, M., & Molin, S. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.6.2240-2246.1998 · Cited by 1,033
Dispersing biofilms with engineered enzymatic bacteriophage
Lu, T. K., & Collins, J. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704624104 · Cited by 895
Self-citationNoise Propagation in Gene Networks
Pedraza, J. M., & van Oudenaarden, A. (2005) · Science · doi:10.1126/science.1109090 · Cited by 805
Engineering Escherichia coli to see light
Levskaya, A., Chevalier, A. A., Tabor, J. J., Simpson, Z. B., Lavery, L. A., Levy, M., Davidson, E. A., Scouras, A., Ellington, A. D., Marcotte, E. M., et al. (2005) · Nature · doi:10.1038/nature04405 · Cited by 624
Programmable cells: Interfacing natural and engineered gene networks
Kobayashi, H., Kærn, M., Araki, M., Chung, K., Gardner, T. S., Cantor, C. R., & Collins, J. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402940101 · Cited by 602
Self-citationEngineered riboregulators enable post-transcriptional control of gene expression
Isaacs, F. J., Dwyer, D. J., Ding, C., Pervouchine, D. D., Cantor, C. R., & Collins, J. J. (2004) · Nature Biotechnology · doi:10.1038/nbt986 · Cited by 554
Self-citation
Cited by
Automated design of synthetic ribosome binding sites to control protein expression
Salis, H. M., Mirsky, E. A., & Voigt, C. A. (2009) · Nature Biotechnology · doi:10.1038/nbt.1568 · Cited by 1,844
A synchronized quorum of genetic clocks
Danino, T., Mondragón-Palomino, O., Tsimring, L., & Hasty, J. (2010) · Nature · doi:10.1038/nature08753 · Cited by 992
Programmable bacteria induce durable tumor regression and systemic antitumor immunity
Chowdhury, S., Castro, S., Coker, C., Hinchliffe, T. E., Arpaia, N., & Danino, T. (2019) · Nature Medicine · doi:10.1038/s41591-019-0498-z · Cited by 724
Synthetic circuits integrating logic and memory in living cells
Siuti, P., Yazbek, J., & Lu, T. K. (2013) · Nature Biotechnology · doi:10.1038/nbt.2510 · Cited by 531
Self-citationMolecular Digital Data Storage Using DNA
Ceze, L., Nivala, J., & Strauss, K. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0125-3 · Cited by 551
Metadata
- Authors
- Friedland, A. E., Lu, T. K., Wang, X., Shi, D., Church, G., & Collins, J. J.
- Venue
- Science
- Published
- 2009-05-29
- Volume
- 324
- Issue
- 5931
- Pages
- 1199-1202
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2121987905
- Cited by
- 587
- References
- 30
- FWCI
- 17.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Friedland, A. E., Lu, T. K., Wang, X., Shi, D., Church, G., & Collins, J. J. (2009). Synthetic Gene Networks That Count. Science. https://doi.org/10.1126/science.1172005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
