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Halofuginone Inhibits T H 17 Cell Differentiation by Activating the Amino Acid Starvation Response
Open accessAbstract
Starving T Cells: The T H 17 lineage of CD4 + helper T cells, characterized by the ability to secrete IL-17, is an important mediator of inflammation and autoimmunity. Dampening the responses of these cells or inhibiting their differentiation is of great therapeutic interest. Sundrud et al. (p. 1334 ; see the Perspective by Blander and Amsen ) now show that the small molecule halofuginone inhibits the differentiation of T H 17 cells but not other CD4 + T cell helper lineages both in vitro and in a mouse model of multiple sclerosis. This selective inhibition was mediated by activation of the amino acid starvation response. Amino acid depletion mimicked the effects of halofuginone, whereas excess amino acids rescued T H 17 differentiation. The results highlight the importance of amino acid metabolism in regulating inflammation.
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Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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TH17 cells in development: an updated view of their molecular identity and genetic programming
Dong, C. (2008) · Nature reviews. Immunology · doi:10.1038/nri2295 · Cited by 1,064
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Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803
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Metadata
- Authors
- Sundrud, M. S., Koralov, S. B., Feuerer, M., Calado, D. P., Kozhaya, A. E., Rhule-Smith, A., Lefebvre, R. E., Unutmaz, D., Mazitschek, R., Waldner, H., Whitman, M., Keller, T., & Rao, A.
- Venue
- Science
- Published
- 2009-06-05
- Volume
- 324
- Issue
- 5932
- Pages
- 1334-1338
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2116289946
- Cited by
- 421
- References
- 6
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Halofuginone Inhibits T H 17 Cell Differentiation by Activating the Amino Acid Starvation Response. https://app.cochat.ai/papers/10.1126/science.1172638
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- Sundrud, M. S., Koralov, S. B., Feuerer, M., Calado, D. P., Kozhaya, A. E., Rhule-Smith, A., Lefebvre, R. E., Unutmaz, D., Mazitschek, R., Waldner, H., Whitman, M., Keller, T., & Rao, A. (2009). Halofuginone Inhibits T H 17 Cell Differentiation by Activating the Amino Acid Starvation Response. Science. https://doi.org/10.1126/science.1172638
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
