The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
Open accessAbstract
Maintaining Mutual Ignorance: Our gut is colonized by trillions of bacteria that do not activate the immune system because of careful compartmentalization. Such compartmentalization means that our immune system is “ignorant” of these microbes and thus it has been proposed that loss of compartmentalization might result in an immune response to the colonizing bacteria. Microorganisms are sensed by cells that express pattern recognition receptors, such as Toll-like receptors, which recognize patterns specific to those microbes. Slack et al. (p. 617 ) show that Toll-like receptor–dependent signaling is required to maintain compartmentalization of bacteria to the gut of mice. In the absence of Toll-dependent signaling, intestinal bacteria disseminated throughout the body and the mice mounted a high-titer antibody response against them. This antibody response was of great functional importance because, despite the loss of systemic ignorance to intestinal microbes, the mice were tolerant of the bacteria. Thus, in the absence of innate immunity, the adaptive immune system can compensate so that host and bacterial mutualism can be maintained.
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Cites
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Self-citationPyogenic Bacterial Infections in Humans with MyD88 Deficiency
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Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Self-citationHost Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy
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Role of the gut microbiota in immunity and inflammatory disease
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Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
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Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Markle, J. G. M., Frank, D. N., Mortin-Toth, S., Robertson, C. E., Feazel, L. M., Rolle-Kampczyk, U., von Bergen, M., McCoy, K. D., Macpherson, A. J., & Danska, J. S. (2013) · Science · doi:10.1126/science.1233521 · Cited by 2,025
Self-citation
Metadata
- Authors
- Slack, E., Hapfelmeier, S., Stecher, B., Velykoredko, Y., Stoel, M., Lawson, M. A. E., Geuking, M. B., Beutler, B., Tedder, T. F., Hardt, W.-D., Bercik, P., Verdu, E. F., McCoy, K. D., & Macpherson, A. J.
- Venue
- Science
- Published
- 2009-07-31
- Volume
- 325
- Issue
- 5940
- Pages
- 617-620
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005507128
- Cited by
- 503
- References
- 25
- FWCI
- 18.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Slack, E., Hapfelmeier, S., Stecher, B., Velykoredko, Y., Stoel, M., Lawson, M. A. E., Geuking, M. B., Beutler, B., Tedder, T. F., Hardt, W.-D., Bercik, P., Verdu, E. F., McCoy, K. D., & Macpherson, A. J. (2009). Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism. Science. https://doi.org/10.1126/science.1172747
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
