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Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism
Open accessAbstract
Threonine Required: Embryonic stem (ES) cells divide rapidly, raising the possibility that they might exist in a metabolic state that facilitates rapid growth. By monitoring the abundance of common metabolites in mouse ES cells, Wang et al. (p. 435 ; published online 9 July) found altered levels of metabolites involved in carbon metabolism. Measurement of messenger RNA levels revealed unusually high expression of the gene encoding threonine dehydrogenase. In addition, in growth experiments, mouse ES cells were critically dependent on the amino acid threonine.
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Cited by
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Ducker, G. S., & Rabinowitz, J. D. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.009 · Cited by 2,239
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Metadata
- Authors
- Wang, J., Alexander, P., Wu, L., Hammer, R., Cleaver, O., & McKnight, S. L.
- Venue
- Science
- Published
- 2009-07-24
- Volume
- 325
- Issue
- 5939
- Pages
- 435-439
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2020072016
- Cited by
- 364
- References
- 0
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, J., Alexander, P., Wu, L., Hammer, R., Cleaver, O., & McKnight, S. L. (2009). Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism. Science. https://doi.org/10.1126/science.1173288
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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