KLF Family Members Regulate Intrinsic Axon Regeneration Ability
Open accessAbstract
Containing Neuronal Exuberance: In rats and mice, around the time of birth, neurons of the central nervous system switch from a growth mode and lose their ability to regenerate. Studying retinal ganglion cells of the rat, Moore et al. (p. 298 ; see the Perspective by Subang and Richardson ) identified a gene, Krüppel-like factor-4 ( KLF4 ), that seems to contribute to the switch. The KLF4 gene belongs to a family of related transcription factors that possess repressive or enhancing effects on axon growth. The combinatorial effect of this family of transcription factors before and after birth may fine-tune the ability of the neurons to extend axons.
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Klf4 can repress rather than promote axonal growth.
“Because Klf4 can repress rather than promote axonal growth24, we tested a dual-cistron of only Oct4 and Sox2 and observed no regenerative effect.”
From Reprogramming to recover youthful epigenetic information and restore vision (2020) · cites this paper as [24]
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- Authors
- Moore, D. L., Blackmore, M. G., Hu, Y., Kaestner, K. H., Bixby, J. L., Lemmon, V. P., & Goldberg, J. L.
- Affiliations
- University of Miami (US)
- University of Pennsylvania (US)
- Corresponding author
- Moore, Darcie L.
- Blackmore, Murray G.
- Goldberg, Jeffrey L.
- ORCID
- Venue
- Science
- Published
- 2009-10-09
- Volume
- 326
- Issue
- 5950
- Pages
- 298-301
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2882032
- OpenAlex
- W4247333492
- Cited by
- 714
- References
- 40
- Citations by year
- 2026: 24 · 2025: 41 · 2024: 41 · 2023: 47 · 2022: 47 · 2021: 47 · 2020: 54 · 2019: 35 · 2018: 42 · 2017: 43 · 2016: 51 · 2015: 42 · 2014: 38 · 2013: 42 · 2012: 45
- FWCI
- 16.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (R03EY016790, P30EY014801)
- National Institute of Neurological Disorders and Stroke (T32 NS07492, T32NS007459, T32NS007492, R01NS061348, R01NS059866)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- Krüppel-like factors, KLF4, axon regeneration, axon growth, retinal ganglion cells, optic nerve injury, transcriptional repression, central nervous system neurons, developmental gene expression, postnatal gene expression
- MeSH terms
- Kruppel-Like Factor 4, Animals, Axons, Cell Count, Cell Survival, Cells, Cultured, Hippocampus, Nerve Crush, Nerve Regeneration, Neurons, Retinal Ganglion Cells, Transcription, Genetic, Transfection, Down-Regulation, Up-Regulation, Neurites, Optic Nerve Injuries, Growth Cones, Mice, Rats, Kruppel-Like Transcription Factors, Gene Knockout Techniques
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