Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576 · see citing works

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

Wildin, R. S., Ramsdell, F., Peake, J., Faravelli, F., Casanova, J., Buist, N. R. M., Levy‐Lahad, E., Mazzella, M., Goulet, O., Perroni, L., et al. (2001) · Nature Genetics · doi:10.1038/83707 · Cited by 1,916 · see citing works

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

Sun, C., Hall, J. A., Blank, R. B., Bouladoux, N. J., Oukka, M., Mora, J. R., & Belkaid, Y. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070602 · Cited by 1,880 · see citing works

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

Shevach, E. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.010 · Cited by 1,754 · see citing works

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

Zhou, X., Bailey-Bucktrout, S. L., Jeker, L. T., Peñaranda, C., Martínez‐Llordella, M., Ashby, M., Nakayama, M., Rosenthal, W. L., & Bluestone, J. A. (2009) · Nature Immunology · doi:10.1038/ni.1774 · Cited by 1,374 · see citing works

Inducing and expanding regulatory T cell populations by foreign antigen

Kretschmer, K., Apostolou, I., Hawiger, D., Khazaie, K., Nussenzweig, M. C., & von Boehmer, H. (2005) · Nature Immunology · doi:10.1038/ni1265 · Cited by 1,240 · see citing works

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

Yang, X. O., Nurieva, R., Martínez, G., Kang, H. S., Chung, Y., Pappu, B. P., Shah, B., Chang, S. H., Schluns, K. S., Watowich, S. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.007 · Cited by 1,129 · see citing works

Foxp3-dependent programme of regulatory T-cell differentiation

Gavin, M. A., Rasmussen, J. P., Fontenot, J. D., Vasta, V., Manganiello, V. C., Beavo, J. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05543 · Cited by 1,127 · see citing works

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

de Lafaille, M. A. C., & Lafaille, J. J. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.002 · Cited by 1,057 · see citing works

The ikaros gene is required for the development of all lymphoid lineages

Georgopoulos, K., Bigby, M., Wang, J.-H., Molnar, A., Wu, P., Winandy, S., & Sharpe, A. (1994) · Cell · doi:10.1016/0092-8674(94)90407-3 · Cited by 985 · see citing works

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

Allan, S. E., Crome, S. Q., Crellin, N. K., Passerini, L., Steiner, T. S., Bacchetta, R., Roncarolo, M. G., & Levings, M. K. (2007) · International Immunology · doi:10.1093/intimm/dxm014 · Cited by 872 · cited 1× · see citing works

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

Zheng, Y., Josefowicz, S. Z., Kas, A., Chu, T.-T., Gavin, M. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05563 · Cited by 835 · see citing works

Induction of FOXP3 expression in naive human CD4+FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype

Tran, D. Q., Ramsey, H. E., & Shevach, E. M. (2007) · Blood · doi:10.1182/blood-2007-06-094656 · Cited by 738 · see citing works

Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β

Xu, L., Kitani, A., Fuss, I. J., & Strober, W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6725 · Cited by 733 · see citing works

In Vivo Instruction of Suppressor Commitment in Naive T Cells

Apostolou, I., & von Boehmer, H. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040249 · Cited by 728 · see citing works

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

Hsieh, C., Liang, Y., Tyznik, A. J., Self, S. G., Liggitt, D., & Rudensky, A. Y. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.009 · Cited by 719 · see citing works

Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature.

Hill, J., Feuerer, M., Tash, K., Haxhinasto, S., Perez, J., Melamed, R., Mathis, D., & Benoist, C. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.010 · Cited by 671 · see citing works

A Two-Step Process for Thymic Regulatory T Cell Development

Lio, C. J., & Hsieh, C. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.021 · Cited by 663 · see citing works

Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation

Wang, J., Nichogiannopoulou, A., Wu, L. J., Sun, L., Sharpe, A. H., Bigby, M. E., & Georgopoulos, K. (1996) · Immunity · doi:10.1016/s1074-7613(00)80269-1 · Cited by 614 · see citing works

Ikaros DNA-Binding Proteins Direct Formation of Chromatin Remodeling Complexes in Lymphocytes

Kim, J., Sif, S., Jones, B., Jackson, A., Koipally, J., Heller, E., Winandy, S., Viel, A., Sawyer, A., Ikeda, T., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80034-5 · Cited by 587 · see citing works

Control of Regulatory T Cell Lineage Commitment and Maintenance

Josefowicz, S. Z., & Rudensky, A. Y. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.009 · Cited by 572 · see citing works

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma

Winandy, S., Wu, P. W., & Georgopoulos, K. (1995) · Cell · doi:10.1016/0092-8674(95)90170-1 · Cited by 527 · see citing works

Heterogeneity of natural Foxp3 + T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

Komatsu, N., Mariotti‐Ferrandiz, E., Wang, Y., MALISSEN, B., Waldmann, H., & Hori, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811556106 · Cited by 521 · see citing works

Oral tolerance in the absence of naturally occurring Tregs

Mucida, D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24487 · Cited by 498 · see citing works

Regulatory T cell development in the absence of functional Foxp3

Lin, W. X., Haribhai, D., Relland, L. M., Truong, N., Carlson, M. R. J., Williams, C. B., & Chatila, T. A. (2007) · Nature Immunology · doi:10.1038/ni1445 · Cited by 485 · see citing works

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

Brusko, T. M., Putnam, A. L., & Bluestone, J. A. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00637.x · Cited by 374 · see citing works

Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

Morgan, B., Sun, L., Avitahl, N., Andrikopoulos, K., Ikeda, T., Gonzales, E., Wu, P., Neben, S., & Georgopoulos, K. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.2004 · Cited by 367 · see citing works

Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis

Sugimoto, N., Oida, T., Hirota, K., Nakamura, K., Nomura, T., Uchiyama, T., & Sakaguchi, S. (2006) · International Immunology · doi:10.1093/intimm/dxl060 · Cited by 366 · see citing works

Eos Mediates Foxp3-Dependent Gene Silencing in CD4 + Regulatory T Cells

Pan, F., Yu, H., Dang, E. V., Barbi, J. J., Pan, X., Grosso, J. F., Jinasena, D., Sharma, S. M., McCadden, E., Getnet, D., et al. (2009) · Science · doi:10.1126/science.1176077 · Cited by 335 · see citing works

Aiolos Regulates B Cell Activation and Maturation to Effector State

Wang, J.-H., Avitahl, N., Cariappa, A., Friedrich, C., Ikeda, T., Renold, A., Andrikopoulos, K., Liang, L., Pillai, S., Morgan, B. A., et al. (1998) · Immunity · doi:10.1016/s1074-7613(00)80637-8 · Cited by 321 · see citing works

Origin and T Cell Receptor Diversity of Foxp3+CD4+CD25+ T Cells

Pacholczyk, R., Ignatowicz, H., Kraj, P. J., & Ignatowicz, L. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.016 · Cited by 317 · see citing works

Activation requirements for the induction of CD4+CD25+ T cell suppressor function

Thornton, A. M., Piccirillo, C. A., & Shevach, E. M. (2004) · European Journal of Immunology · doi:10.1002/eji.200324455 · Cited by 297 · see citing works

Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatinPreprint

Hahm, K., Cobb, B. S., McCarty, A., Brown, K. E., Klug, C. A., Lee, R., Akashi, K., Weissman, I. L., Fisher, A. G., & Smale, S. T. (1998) · Genes & Development · doi:10.1101/gad.12.6.782 · Cited by 253 · see citing works

Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors

Kelley, C. M., Ikeda, T., Koipally, J., Avitahl, N., Wu, L., Georgopoulos, K., & Morgan, B. A. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70202-7 · Cited by 231 · see citing works

Antigen-specific peripheral shaping of the natural regulatory T cell population

Lathrop, S. K., Santacruz, N. A., Pham, D., Luo, J. R., & Hsieh, C. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081359 · Cited by 188 · see citing works

Adaptation of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory CD4+ T Cells

Wong, J., Obst, R., Correia‐Neves, M., Losyev, G., Mathis, D. J., & Benoist, C. O. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.7032 · Cited by 183 · see citing works

Predominant Interaction of Both Ikaros and Helios with the NuRD Complex in Immature Thymocytes

Sridharan, R., & Smale, S. T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702541200 · Cited by 130 · see citing works

Back to the Thymus: Peripheral T Cells Come Home

Hale, J., & Fink, P. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.87 · Cited by 98 · see citing works

Distinct Subsets of FoxP3+ Regulatory T Cells Participate in the Control of Immune Responses

Stephens, G. L., Andersson, J., & Shevach, E. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6901 · Cited by 97 · see citing works

Ikaros Enforces the Costimulatory Requirement for <i>IL2</i> Gene Expression and Is Required for Anergy Induction in CD4+ T Lymphocytes

Thomas, R. M., Chunder, N., Chen, C., Umetsu, S. E., Winandy, S., & Wells, A. D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7305 · Cited by 91 · see citing works

Helios Deficiency Has Minimal Impact on T Cell Development and function

Cai, Q., Dierich, A., Oulad‐Abdelghani, M., Chan, S. H., & Kastner, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901407 · Cited by 79 · see citing works

Effects of Cyclosporine on Transplant Tolerance: The Role of IL‐2

Kang, H. G., Zhang, D., Degauque, N., Mariat, C., Alexopoulos, S. P., & Zheng, X. X. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.01881.x · Cited by 67 · see citing works

A Key Role for TGF-β Signaling to T Cells in the Long-Term Acceptance of Allografts

Daley, S. R., Ma, J., Adams, E., Cobbold, S. P., & Waldmann, H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3648 · Cited by 62 · see citing works

Ikaros-Family Proteins: In Search of Molecular Functions During Lymphocyte Development

Cobb, B. S., & Smale, S. T. (2005) · Springer eBooks · doi:10.1007/3-540-26363-2_3 · Cited by 43 · see citing works

Erratum: Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaos at centromeric heterochromatin (Genes and Development (1998) 12 (782-796))

Hahm, K., Cobb, B. S., McCarty, A., Brown, K. E., Klug, C. A., Lee, R., Akashi, K., Wiessman, I. L., Fisher, A. G., & Smale, S. T. (1998) · Genes & Development · Cited by 34 · see citing works

Subtractive Cloning: New Genes for Studying Inflammatory Disorders

Rebrikov, D. V., Desai, S., Kogan, Y. N., Thornton, A. M., & Diatchenko, L. B. (2002) · Annals of Periodontology · doi:10.1902/annals.2002.7.1.17 · Cited by 10 · see citing works

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T _reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works

Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872 · see citing works

Foxp3+ follicular regulatory T cells control the germinal center response

Linterman, M. A., Pierson, W., Lee, S. K., Kallies, A., Kawamoto, S., Rayner, T. F., Srivastava, M., Divekar, D. P., Beaton, L., Hogan, J. J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2425 · Cited by 1,292 · see citing works

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

Chung, Y., Tanaka, S., Chu, F., Nurieva, R. I., Martinez, G. J., Rawal, S., Wang, Y.-H., Lim, H., Reynolds, J. M., Zhou, X.-H., et al. (2011) · Nature Medicine · doi:10.1038/nm.2426 · Cited by 1,120 · see citing works

Peripheral education of the immune system by colonic commensal microbiota

Lathrop, S. K., Bloom, S. M., Rao, S. M., Nutsch, K., Lio, C.-W., Santacruz, N., Peterson, D. A., Stappenbeck, T. S., & Hsieh, C.-S. (2011) · Nature · doi:10.1038/nature10434 · Cited by 1,034 · see citing works

The alarmin IL-33 promotes regulatory T-cell function in the intestine

Schiering, C., Krausgruber, T., Chomka, A., Fröhlich, A., Adelmann, K., Wohlfert, E. A., Pott, J., Griseri, T., Bollrath, J., Hegazy, A. N., et al. (2014) · Nature · doi:10.1038/nature13577 · Cited by 1,007 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 982 · see citing works

Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria.

Hadis, U., Wahl, B., Schulz, O., Hardtke-Wolenski, M., Schippers, A., Wagner, N., Müller, W., Sparwasser, T., Förster, R., & Pabst, O. (2011) · Immunity · doi:10.1016/j.immuni.2011.01.016 · Cited by 893 · see citing works

The microbiota regulates type 2 immunity through RORγt ⁺ T cells

Ohnmacht, C., Park, J.-H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., et al. (2015) · Science · doi:10.1126/science.aac4263 · Cited by 863 · see citing works

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

Geuking, M. B., Cahenzli, J., Lawson, M. A. E., Ng, D. C. K., Slack, E., Hapfelmeier, S., McCoy, K. D., & Macpherson, A. J. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.021 · Cited by 840 · see citing works

The immunosuppressive tumour network: myeloid‐derived suppressor cells, regulatory T cells and natural killer T cells

Lindau, D., Gielen, P. R., Kroesen, M., Wesseling, P., & Adema, G. J. (2012) · Immunology · doi:10.1111/imm.12036 · Cited by 817 · see citing works

The microbiome in infectious disease and inflammation

Honda, K., & Littman, D. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074937 · Cited by 791 · see citing works

Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases

Buckner, J. H. (2010) · Nature reviews. Immunology · doi:10.1038/nri2889 · Cited by 790 · see citing works

The genomic landscape of hypodiploid acute lymphoblastic leukemia

Holmfeldt, L., Wei, L., Díaz-Flores, E., Walsh, M. F., Zhang, J., Ding, L., Payne-Turner, D., Churchman, M. L., Andersson, A., Chen, S.-C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2532 · Cited by 722 · see citing works

Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

Wing, J. B., Tanaka, A., & Sakaguchi, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.020 · Cited by 726 · see citing works

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

Ito, M., Komai, K., Mise-Omata, S., Iizuka-Koga, M., Noguchi, Y., Kondo, T., Sakai, R., Matsuo, K., Nakayama, T., Yoshie, O., et al. (2019) · Nature · doi:10.1038/s41586-018-0824-5 · Cited by 784 · see citing works

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

Yadav, M., Louvet, C., Davini, D., Gardner, J. M., Martinez-Llordella, M., Bailey-Bucktrout, S., Anthony, B. A., Sverdrup, F. M., Head, R., Kuster, D. J., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120822 · Cited by 649 · see citing works

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells

Weiss, J. M., Bilate, A. M., Gobert, M., Ding, Y., Curotto de Lafaille, M. A., Parkhurst, C. N., Xiong, H., Dolpady, J., Frey, A. B., Ruocco, M. G., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120914 · Cited by 621 · see citing works

Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells

Miyao, T., Floess, S., Setoguchi, R., Luche, H., Fehling, H. J., Waldmann, H., Huehn, J., & Hori, S. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.012 · Cited by 612 · see citing works

tTregs, pTregs, and iTregs: similarities and differences

Shevach, E. M., & Thornton, A. M. (2014) · Immunological Reviews · doi:10.1111/imr.12160 · Cited by 609 · see citing works

Peripheral CD4+ T‐cell differentiation regulated by networks of cytokines and transcription factors

Zhu, J., & Paul, W. E. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00951.x · Cited by 596 · see citing works

IRF4 Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation

Persson, E. K., Uronen‐Hansson, H., Semmrich, M., Rivollier, A., Hägerbrand, K., Marsal, J., Guðjónsson, S., Håkansson, U., Reizis, B., Kotarsky, K., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.009 · Cited by 591 · see citing works

Induced CD4⁺Foxp3⁺Regulatory T Cells in Immune Tolerance

Bilate, A. M., & Lafaille, J. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075043 · Cited by 569 · see citing works

Development and maintenance of intestinal regulatory T cells

Tanoue, T., Atarashi, K., & Honda, K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.36 · Cited by 553 · see citing works

Tissue Tregs

Panduro, M., Benoist, C., & Mathis, D. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095948 · Cited by 536 · see citing works

Epigenetic Modification and Antibody-Dependent Expansion of Memory-like NK Cells in Human Cytomegalovirus-Infected Individuals

Lee, J., Zhang, T., Hwang, I., Kim, A., Nitschke, L., Kim, M. J., Scott, J. M., Kamimura, Y., Lanier, L. L., & Kim, S. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.013 · Cited by 554 · see citing works

Liver-resident NK cells confer adaptive immunity in skin-contact inflammation

Peng, H. C., Jiang, X., Chen, Y., Sojka, D. K., Wei, H., Gao, X., Sun, R., Yokoyama, W. M., & Tian, Z. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66381 · Cited by 546 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies *

Cossarizza, A., Chang, H., Radbruch, A., Akdiş, M., Andrä, I., Annunziato, F., Bächer, P., Barnaba, V., Battistini, L., Bauer, W. M., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201646632 · Cited by 572 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works

Pregnancy imprints regulatory memory that sustains anergy to fetal antigen

Rowe, J. H., Ertelt, J. M., Xin, L., & Way, S. S. (2012) · Nature · doi:10.1038/nature11462 · Cited by 523 · see citing works

Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)

Syed, A., Garcia, M. A., Lyu, S., Bucayu, R., Kohli, A., Ishida, S., Berglund, J. P., Tsai, M. M., Maecker, H. T., O’Riordan, G., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.12.1037 · Cited by 488 · see citing works

Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface

Yang, F., Zheng, Q., & Jin, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02317 · Cited by 480 · see citing works

Selection of regulatory T cells in the thymus

Hsieh, C., Lee, H., & Lio, C. J. (2012) · Nature reviews. Immunology · doi:10.1038/nri3155 · Cited by 476 · see citing works

Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation

Yang, B.-H., Hagemann, S., Mamareli, P., Lauer, U., Hoffmann, U., Beckstette, M., Föhse, L., Prinz, I., Pezoldt, J., Suerbaum, S., et al. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.74 · Cited by 435 · see citing works

The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature

deLeeuw, R., Kost, S., Kakal, J., & Nelson, B. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-3216 · Cited by 444 · see citing works

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

Kim, H.-J., Barnitz, R. A., Kreslavsky, T., Brown, F. D., Moffett, H., Lemieux, M. E., Kaygusuz, Y., Meissner, T., Holderried, T. A. W., Chan, S., et al. (2015) · Science · doi:10.1126/science.aad0616 · Cited by 441 · see citing works

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

Serrels, A., Lund, T., Serrels, B., Byron, A., McPherson, R. C., von Kriegsheim, A., Gómez-Cuadrado, L., Canel, M., Muir, M., Ring, J. E., et al. (2015) · Cell · doi:10.1016/j.cell.2015.09.001 · Cited by 407 · see citing works

Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses

Hilligan, K. L., & Ronchese, F. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0465-0 · Cited by 433 · see citing works

Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

McClymont, S. A., Putnam, A. L., Lee, M. R., Esensten, J. H., Liu, W., Hulme, M. A., Hoffmüller, U., Baron, U., Olek, S., Bluestone, J. A., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003099 · Cited by 428 · see citing works

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

Duhen, T., Duhen, R., Lanzavecchia, A., Sallusto, F., & Campbell, D. J. (2012) · Blood · doi:10.1182/blood-2011-11-392324 · Cited by 413 · see citing works

Homeostatic control of regulatory T cell diversity

Liston, A., & Gray, D. H. D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3605 · Cited by 428 · see citing works

Intestinal Commensal Microbes as Immune Modulators

Ivanov, I. I., & Honda, K. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.09.009 · Cited by 425 · see citing works

Umbilical cord blood–derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

Brunstein, C. G., Miller, J. S., McKenna, D. H., Hippen, K. L., DeFor, T. E., Sumstad, D., Curtsinger, J., Verneris, M. R., MacMillan, M. L., Levine, B. L., et al. (2015) · Blood · doi:10.1182/blood-2015-06-653667 · Cited by 416 · see citing works

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

Smigiel, K. S., Richards, E. A., Srivastava, S., Thomas, K. R., Dudda, J. C., Klonowski, K. D., & Campbell, D. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131142 · Cited by 406 · see citing works

Helios Expression Is a Marker of T Cell Activation and Proliferation

Akimova, T., Beier, U. H., Wang, L., Levine, M. H., & Hancock, W. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024226 · Cited by 389 · see citing works

Intrinsic and extrinsic control of peripheral T‐cell tolerance by costimulatory molecules of the CD28/ B7 family

Bour‐Jordan, H., Esensten, J. H., Martinez‐Llordella, M., Penaranda, C., Stumpf, M., & Bluestone, J. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01011.x · Cited by 391 · see citing works

Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy

Abdel-Gadir, A., Victor, E. S., Gerber, G. K., Rivas, M. N., Wang, S., Harb, H., Wang, L., Li, N., Crestani, E., Spielman, S. C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0461-z · Cited by 392 · see citing works

Regulatory T cells in allergic diseases

Rivas, M. N., & Chatila, T. A. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.06.003 · Cited by 378 · see citing works

Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

Kolodin, D., van Panhuys, N., Li, C., Magnuson, A. M., Cipolletta, D., Miller, C. M., Wagers, A., Germain, R. N., Benoist, C., & Mathis, D. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.03.005 · Cited by 365 · see citing works

Regulatory T Cell Reprogramming toward a Th2-Cell-like Lineage Impairs Oral Tolerance and Promotes Food Allergy

Rivas, M. N., Burton, O. T., Wise, P. M., Charbonnier, L., Georgiev, P., Oettgen, H. C., Rachid, R. A., & Chatila, T. A. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.004 · Cited by 375 · see citing works

CD4 T Helper Cell Subsets and Related Human Immunological Disorders

Zhu, X., & Zhu, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218011 · Cited by 380 · see citing works

Regulation of Adaptive Immunity; The Role of Interleukin-10

Ng, T. H. S., Britton, G. J., Hill, E. V., Verhagen, J., Burton, B. R., & Wraith, D. C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00129 · Cited by 354 · see citing works

Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus

von Spee-Mayer, C., Siegert, E., Abdirama, D., Rose, A., Klaus, A., Alexander, T., Enghard, P., Sawitzki, B., Hiepe, F., Radbruch, A., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2015-207776 · Cited by 351 · see citing works

Regulatory T cells in nonlymphoid tissues

Burzyn, D., Benoist, C. O., & Mathis, D. J. (2013) · Nature Immunology · doi:10.1038/ni.2683 · Cited by 342 · see citing works

Human FoxP3+ regulatory T cells in systemic autoimmune diseases

Miyara, M., Gorochov, G., Ehrenstein, M. R., Musset, L., Sakaguchi, S., & Amoura, Z. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.05.004 · Cited by 342 · see citing works

From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation

Bacchetta, R., Barzaghi, F., & Roncarolo, M. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13011 · Cited by 338 · see citing works

Aryl Hydrocarbon Receptor Control of Adaptive Immunity

Quintana, F. J., & Sherr, D. H. (2013) · Pharmacological Reviews · doi:10.1124/pr.113.007823 · Cited by 336 · see citing works

Regulatory T Cell Development

Savage, P. A., Klawon, D. E. J., & Miller, C. H. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-100219-020937 · Cited by 321 · see citing works

Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy

Eller, K., Kirsch, A. H., Wolf, A. M., Sopper, S., Tagwerker, A., Stanzl, U., Wolf, D. G. F., Patsch, W., Rosenkranz, A. R., & Eller, P. (2011) · Diabetes · doi:10.2337/db11-0358 · Cited by 318 · see citing works

T-cell Dysfunction in Glioblastoma: Applying a New Framework

Woroniecka, K. I., Rhodin, K. E., Chongsathidkiet, P., Keith, K. A., & Fecci, P. E. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0047 · Cited by 316 · see citing works

Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells

Gottschalk, R. A., Corse, E., & Allison, J. P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102964 · Cited by 310 · see citing works

The role of decidual immune cells on human pregnancy.

Liu, S., Diao, L., Huang, C., Li, Y., Zeng, Y., & Kwak-Kim, J. (2017) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2017.10.045 · Cited by 279 · see citing works

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development

Lei, Y. L., Ripen, A. M., Ishimaru, N., Ohigashi, I., Nagasawa, T., Jeker, L. T., Bösl, M. R., Holländer, G. A., Hayashi, Y., Malefyt, R. D. W., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102327 · Cited by 308 · see citing works

Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation–polyendocrinopathy–enteropathy–X-linked–like syndrome

Uzel, G., Sampaio, E. P., Lawrence, M. G., Hsu, A. P., Hackett, M. J., Dorsey, M. J., Noel, R. J., Verbsky, J. W., Freeman, A. F., Janssen, E., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.11.054 · Cited by 301 · see citing works

A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells

Fu, W., Ergün, A., Lu, T., Hill, J. A., Haxhinasto, S. A., Fassett, M. S., Gazit, R., Adoro, S., Glimcher, L. H., Chan, S. H., et al. (2012) · Nature Immunology · doi:10.1038/ni.2420 · Cited by 299 · see citing works

CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers Game

Long, S. A., & Buckner, J. H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003224 · Cited by 294 · see citing works

Plasticity of Human CD4 T Cell Subsets

Geginat, J., Paroni, M., Maglie, S., Alfen, J. S., Kastirr, I., Gruarin, P., Simone, M. C. D., Pagani, M., & Abrignani, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00630 · Cited by 289 · see citing works

FOXP3+ regulatory T cells and their functional regulation

Li, Z., Li, D., Tsun, A., & Li, B. (2015) · Cellular &amp; Molecular Immunology · doi:10.1038/cmi.2015.10 · Cited by 290 · see citing works

A cellular and molecular view of T helper 17 cell plasticity in autoimmunity

Stadhouders, R., Lubberts, E., & Hendriks, R. W. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.12.007 · Cited by 289 · see citing works

Role of regulatory T cells in psoriasis pathogenesis and treatment

Nußbaum, L., Chen, Y. L., & Ogg, G. S. (2020) · British Journal of Dermatology · doi:10.1111/bjd.19380 · Cited by 283 · see citing works

The anti-inflammatory mechanisms of Hsp70

Borges, T. J., Wieten, L., van Herwijnen, M. J. C., Broere, F., van der Zee, R., Bonorino, C., & van Eden, W. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00095 · Cited by 276 · see citing works

Peripherally Induced Tregs – Role in Immune Homeostasis and Autoimmunity

Yadav, M., Stephan, S. R., & Bluestone, J. A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00232 · Cited by 274 · see citing works

Adaptive immune education by gut microbiota antigens

Zhao, Q. S., & Elson, C. O. (2018) · Immunology · doi:10.1111/imm.12896 · Cited by 272 · see citing works

Th17 plasticity and its relevance to inflammatory bowel disease

Ueno, A., Jeffery, L. E., Kobayashi, T., Hibi∥, T., Ghosh, S. K., & Jijon, H. B. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.12.004 · Cited by 263 · see citing works

Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs

Hui, S. P., Sheng, D. Z., Sugimoto, K., González-Rajal, Á., Nakagawa, S., Hesselson, D., & Kikuchi, K. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.11.010 · Cited by 269 · see citing works

TGF-β: the sword, the wand, and the shield of FOXP3+ regulatory T cells

Tran, D. Q. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjr033 · Cited by 265 · see citing works

Emerging Functions of Regulatory T Cells in Tissue Homeostasis

Sharma, A., & Rudra, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00883 · Cited by 263 · see citing works

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226

Fuhrman, C. A., Yeh, W.-I., Seay, H. R., Lakshmi, P. S., Chopra, G., Zhang, L., Perry, D. J., McClymont, S., Yadav, M., Lopez, M.-C., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402381 · Cited by 262 · see citing works

Regulatory T cells in systemic lupus erythematosus

Ohl, K., & Tenbrock, K. (2014) · European Journal of Immunology · doi:10.1002/eji.201344280 · Cited by 262 · see citing works

Aiolos promotes TH17 differentiation by directly silencing Il2 expression

Quintana, F. J., Jin, H., Burns, E. J., Nadeau, M., Yeste, A., Kumar, D., Rangachari, M., Zhu, C. Y., Xiao, S., Seavitt, J., et al. (2012) · Nature Immunology · doi:10.1038/ni.2363 · Cited by 250 · see citing works

T Regulatory Cells and Priming the Suppressive Tumor Microenvironment

Paluskievicz, C., Cao, X., Abdi, R., Zheng, P., Liu, Y., & Bromberg, J. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02453 · Cited by 252 · see citing works

Natural and Induced T Regulatory Cells in Cancer

Adeegbe, D. O., & Nishikawa, H. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00190 · Cited by 248 · see citing works

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells

Halim, T. Y. F., Rana, B. M. J., Walker, J. A., Kerscher, B., Knolle, M. D., Jolin, H. E., Serrão, E. M., Haim-Vilmovsky, L., Teichmann, S. A., Rodewald, H.-R., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.003 · Cited by 249 · see citing works

The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications

Zeng, C., Shi, X., Zhang, B., Liu, H., Zhang, L., Ding, W., & Zhao, Y. X. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0816-5 · Cited by 248 · see citing works

Regulatory T Cells: the Many Faces of Foxp3

Georgiev, P., Charbonnier, L., & Chatila, T. A. (2019) · Journal of Clinical Immunology · doi:10.1007/s10875-019-00684-7 · Cited by 242 · see citing works

Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy

Roy, S., Bag, A. K., Singh, R. K., Talmadge, J. E., Batra, S. K., & Datta, K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01228 · Cited by 237 · see citing works

CD4 + T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion

Legoux, F. P., Lim, J., Cauley, A. W., Dikiy, S., Ertelt, J. M., Mariani, T. J., Sparwasser, T. D., Way, S. S., & Moon, J. J. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.011 · Cited by 238 · see citing works

Neuropilin 1: function and therapeutic potential in cancer

Chaudhary, B., Khaled, Y. S., Ammori, B. J., & Elkord, E. (2014) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-013-1500-0 · Cited by 233 · see citing works

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection

Leeansyah, E., Svärd, J., Dias, J., Buggert, M., Nyström, J., Quigley, M. F., Moll, M., Sönnerborg, A. B., Nowak, P., & Sandberg, J. K. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005072 · Cited by 234 · see citing works

Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation

Klein, L., Robey, E. A., & Hsieh, C.-S. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-018-0083-6 · Cited by 214 · see citing works

A Unique Population of Regulatory T Cells in Heart Potentiates Cardiac Protection From Myocardial Infarction

Xia, N., Lu, Y., Gu, M., Li, N., Liu, M., Jiao, J., Zhu, Z., Li, J., Li, D., Tang, T., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.046789 · Cited by 229 · see citing works

Generation and Function of Induced Regulatory T Cells

Schmitt, E. G., & Williams, C. B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00152 · Cited by 229 · see citing works

The Interplay Between Monocytes/Macrophages and CD4+ T Cell Subsets in Rheumatoid Arthritis

Roberts, C. A., Dickinson, A. K., & Taams, L. S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00571 · Cited by 227 · see citing works

CD 4+ T‐cell subsets in intestinal inflammation

Shale, M., Schiering, C., & Powrie, F. M. (2013) · Immunological Reviews · doi:10.1111/imr.12039 · Cited by 222 · see citing works

Critical role of all - trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions

Lu, L., Lan, Q., Li, Z., Zhou, X., Gu, J., Li, Q., Wang, J., Chen, M., Liu, Y., Shen, Y., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408780111 · Cited by 225 · see citing works

Rationale for anti-GITR cancer immunotherapy

Knee, D. A., Hewes, B., & Brogdon, J. L. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.06.028 · Cited by 221 · see citing works

Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling

Zhao, J., Lloyd, C. M., & Noble, A. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.76 · Cited by 221 · see citing works

Helios+ and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans

Himmel, M. E., MacDonald, K. G., Garcia, R. V., Steiner, T. S., & Levings, M. K. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201379 · Cited by 217 · see citing works

Comment on “Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells”

Verhagen, J., & Wraith, D. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1090105 · Cited by 100 · see citing works

Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells

Gottschalk, R. A., Corse, E., & Allison, J. P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102964 · Cited by 310 · see citing works

Response to Comment on “Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells”

Gottschalk, R. A., Corse, E., & Allison, J. P. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1290034 · Cited by 4 · see citing works

Helios: still behind the clouds

Thornton, A. M., & Shevach, E. M. (2019) · Immunology · doi:10.1111/imm.13115 · Cited by 101 · see citing works

Helios expression defines two distinct populations of Foxp3+ regulatory T cells

Thornton, A. M., Kilaru, G., Burr, P., Rieder, S. A., Muljo, S. A., & Shevach, E. M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.196.supp.125.6 · Cited by 7 · see citing works