ER Stress Controls Iron Metabolism Through Induction of Hepcidin

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Items 101–200 of 310

  1. Hepatic Xbp1 Gene Deletion Promotes Endoplasmic Reticulum Stress-induced Liver Injury and Apoptosis
    Shantel Olivares, Anne S. Henkel · 2015 · Journal of Biological Chemistry
  2. The new role of poly (rC)-binding proteins as iron transport chaperones: Proteins that could couple with inter-organelle interactions to safely traffic iron
    Izumi Yanatori, Des Raymond Richardson, Shinya Toyokuni, Fumio Kishi · 2020 · Biochimica et Biophysica Acta (BBA) - General Subjects
  3. Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice
    Giada Sebastiani, Kostas Pantopoulos · 2011 · Metallomics
  4. Latin American Association for the Study of the Liver (LAASL) Clinical Practice Guidelines: Management of Hepatocellular Carcinoma
    Nahúm Méndez‐Sánchez, Ezequiel Ridruejo, Ângelo Alves de Mattos, Norberto Carlos Chávez-Tapia, Rodrigo Zapata, Raymundo Paraná, Ricardo Mastaï, Edna Strauss, Luis Gonzalo Guevara-Casallas, Jorge R Daruich et al. · 2014 · Annals of Hepatology
  5. Mutant HFE H63D Protein Is Associated with Prolonged Endoplasmic Reticulum Stress and Increased Neuronal Vulnerability
    Yiting Liu, Sang Yong Lee, Elizabeth B. Neely, Wint Nandar, Mthabisi Moyo, Zachary Simmons, James R. Connor · 2011 · Journal of Biological Chemistry
  6. Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1α localization in erythroblasts
    Renella, Raffaele, Roberts, Nigel A., Brown, Jill M., De Gobbi, Marco, Bird, Louise E., Hassanali, Tasneem, Sharpe, Jacqueline A., Sloane-Stanley, Jacqueline, Ferguson, David J. P., Cordell, Jacqueline et al. · 2011 · Blood
  7. Parasite‐induced ER stress response in hepatocytes facilitates Plasmodium liver stage infection
    Patricia Inácio, Vanessa Zuzarte‐Luís, Margarida T. Grilo Ruivo, Brie Falkard, Nagarjuna Nagaraj, Koos Rooijers, Matthias Mann, Gunnar Rudolf Mair, David Armand Fidock, Maria M. Mota · 2015 · EMBO Reports
  8. Iron status in athletic females, a shift in perspective on an old paradigm
    Claire Evelyn Badenhorst, Kazushige Goto, Wendy J. O’Brien, Stacy T. Sims · 2021 · Journal of Sports Sciences
  9. Transcriptional regulation of apolipoprotein A-IV by the transcription factor CREBH
    Xu Xu, Jong‐Gil Park, Jae‐Seon So, Kyu Yeon Hur, Ann–Hwee Lee · 2014 · Journal of Lipid Research
  10. Diagnostic and therapeutic implications of the association between ferritin level and severity of nonalcoholic fatty liver disease
    Luca V. C. Valenti · 2012 · World Journal of Gastroenterology
  11. Lipocalin-2 Promotes Endoplasmic Reticulum Stress and Proliferation by Augmenting Intracellular Iron in Human Pulmonary Arterial Smooth Muscle Cells
    Guoliang Wang, Shenghua Liu, Li Wang, Liukun Meng, Chuan-Jue Cui, Hao Zhang, Shengshou Hu, Ning Ma, Yingjie Wei · 2017 · International Journal of Biological Sciences
  12. Role of hepcidin‐ferroportin axis in the pathophysiology, diagnosis, and treatment of anemia of chronic inflammation
    Arielle L. Langer, Yelena Z. Ginzburg · 2017 · Hemodialysis International
  13. Functional interaction of endoplasmic reticulum stress and hepatitis B virus in the pathogenesis of liver diseases
    So Young Kim, Yi Yi Kyaw, JaeHun Cheong · 2017 · World Journal of Gastroenterology
  14. Iron and inflammation – the gut reaction
    Smriti Verma, Bobby J. Cherayil · 2017 · Metallomics
  15. Role of Endoplasmic Reticulum Stress and Unfolded Protein Responses in Health and Diseases
    Abbas Ali Mahdi, Syed Husain Mustafa Rizvi, Arshiya Parveen · 2015 · Indian Journal of Clinical Biochemistry
  16. Nucleic acid oxidative damage in Alzheimer's disease—explained by the hepcidin-ferroportin neuronal iron overload hypothesis?
    Tim Hofer, George L. Perry · 2016 · Journal of Trace Elements in Medicine and Biology
  17. N-linked glycosylation is required for optimal proteolytic activation of membrane-bound transcription factor CREB-H
    Chi‐Ping Chan, To-Yuen Mak, King‐Tung Chin, Irene Oi‐Lin Ng, Dong‐Yan Jin · 2010 · Journal of Cell Science
  18. Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in Mice
    Anne S. Henkel, Brian E. LeCuyer, Shantel Olivares, Richard M. Green · 2016 · Cellular and Molecular Gastroenterology and Hepatology
  19. Hepcidin expression by human monocytes in response to adhesion and pro-inflammatory cytokines
    Xiaolan Zhang, Brad H. Rovin · 2010 · Biochimica et Biophysica Acta (BBA) - General Subjects
  20. Iron redistribution as a therapeutic strategy for treating diseases of localized iron accumulationThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.
    Or Kakhlon, William V. Breuer, Arnold Münnich, Zvi Ioav Cabantchik · 2010 · Canadian Journal of Physiology and Pharmacology
  21. Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption
    Henry K. Bayele, Sara Balesaria, Surjit Kaila Srai · 2015 · Free Radical Biology and Medicine
  22. Iron at the Interface of Hepatocellular Carcinoma
    Rossana Paganoni, André Lechel, Maja Vujić Spasić · 2021 · International Journal of Molecular Sciences
  23. Dietary Iron Concentration May Influence Aging Process by Altering Oxidative Stress in Tissues of Adult Rats
    Lorena Fernandes Arruda, Sandra Fernandes Arruda, Natália Aboudib Campos, Fernando Fortes de Valência, Egle Machado de Almeida Siqueira · 2013 · PLoS ONE
  24. Hepcidin resistance in dysmetabolic iron overload
    Raffaela Rametta, Paola Dongiovanni, Serena Pelusi, Paolo Francione, Federica Iuculano, Vittorio Natale Borroni, Erika Fatta, Annalisa Castagna, Domenico Girelli, Silvia Rossana Fargion et al. · 2016 · Liver International
  25. Energy deficit increases hepcidin and exacerbates declines in dietary iron absorption following strenuous physical activity: a randomized-controlled cross-over trial
    Stephen R. Hennigar, James P. McClung, Adrienne Hatch‐McChesney, Jillian T. Allen, Marques A. Wilson, Christopher T. Carrigan, Nancy E. Murphy, Hilde K. Teien, Svein Martini, Jess A. Gwin et al. · 2020 · American Journal of Clinical Nutrition
  26. Pretreatment with CO-releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways
    Da-Yong Shin, Jihwa Chung, Yeonsoo Joe, Hyun‐Ock Pae, Ki Churl Chang, Gyeong Jae Cho, Stefan W. Ryter, Hun‐Taeg Chung · 2012 · Blood
  27. Curcumin Differentially Regulates Endoplasmic Reticulum Stress through Transcriptional Corepressor SMILE (Small Heterodimer Partner-interacting Leucine Zipper Protein)-mediated Inhibition of CREBH (cAMP Responsive Element-binding Protein H)
    Jagannath Misra, Dipanjan Chanda, Don‐Kyu Kim, Tiangang Li, Seung‐Hoi Koo, Sung-Hoon Back, John Y.L. Chiang, Hueng‐Sik Choi · 2011 · Journal of Biological Chemistry
  28. Hepatic Cannabinoid Receptor Type 1 Mediates Alcohol-Induced Regulation of Bile Acid Enzyme Genes Expression Via CREBH
    Dipanjan Chanda, Yong-Hoon Kim, Tiangang Li, Jagannath Misra, Don-Kyu Kim, Jung Ran Kim, Joseph Kwon, Won‐Il Jeong, Sung-Hoon Ahn, Tae‐Sik Park et al. · 2013 · PLoS ONE
  29. Review article: iron disturbances in chronic liver diseases other than haemochromatosis – pathogenic, prognostic, and therapeutic implications
    Albert J. Czaja · 2019 · Alimentary Pharmacology & Therapeutics
  30. An Orchestrated Program Regulating Secretory Pathway Genes and Cargos by the Transmembrane Transcription Factor CREB‐H
    Sónia Barbosa, Giovanna Fasanella, Suzanne Carreira, Marta Llarena, Rebecca Fox, Cristina Barreca, Deborah J. Andrew, Peter O’Hare · 2012 · Traffic
  31. Non-Transferrin-Bound Iron in the Spotlight: Novel Mechanistic Insights into the Vasculotoxic and Atherosclerotic Effect of Iron
    Francesca Vinchi · 2021 · Antioxidants and Redox Signaling
  32. The role of CREB-H transcription factor in triglyceride metabolism
    Ann–Hwee Lee · 2012 · Current Opinion in Lipidology
  33. Histone Deacetylase 3 Inhibitor Suppresses Hepatitis C Virus Replication by Regulating Apo-A1 and LEAP-1 Expression
    Yuan Zhou, Qian Wang, Qi Yang, Jielin Tang, Chonghui Xu, Dong-wei Gai, Xinwen Chen, Jizheng Chen · 2018 · Virologica Sinica
  34. Unraveling Mechanisms Regulating Systemic Iron Homeostasis
    Karin E. Finberg · 2011 · Hematology
  35. Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice
    Kenta Hino, Atsushi Saito, Rie Asada, Soshi Kanemoto, Kazunori Imaizumi · 2014 · PLoS ONE
  36. Activation of Cannabinoid Receptor Type 1 (Cb1r) Disrupts Hepatic Insulin Receptor Signaling via Cyclic AMP-response Element-binding Protein H (Crebh)-mediated Induction of Lipin1 Gene
    Dipanjan Chanda, Yong‐Hoon Kim, Don‐Kyu Kim, Minwoo Lee, Su-Yeon Lee, Tae‐Sik Park, Seung‐Hoi Koo, Chul‐Ho Lee, Hueng‐Sik Choi · 2012 · Journal of Biological Chemistry
  37. The transcription factors CREBH, PPARa, and FOXO1 as critical hepatic mediators of diet-induced metabolic dysregulation
    Zhao Yang, Katherine Roth, Manisha Agarwal, Wanqing Liu, Michael C. Petriello · 2021 · The Journal of Nutritional Biochemistry
  38. Xenobiotic Perturbation of ER Stress and the Unfolded Protein Response
    Marc A. Lafleur, James L. Stevens, Jeffrey W. Lawrence · 2013 · Toxicologic Pathology
  39. Hepcidin contributes to Swedish mutant APP-induced osteoclastogenesis and trabecular bone loss
    Hao-Han Guo, Lei Xiong, Jin‐Xiu Pan, Daehoon Lee, Kevin Liu, Xiao Ren, Bo Wang, Xiao Yang, Shun Cui, Lin Mei et al. · 2021 · Bone Research
  40. Ectopic clotting factor VIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma
    Audrey Kapelanski‐Lamoureux, Zhouji Chen, Zu‐Hua Gao, Ruishu Deng, Anthoula Lazaris, Cynthia Lebeaupin, Lisa Giles, Jyoti Dhar Malhotra, Jing Yong, Chenhui Zou et al. · 2022 · Molecular Therapy
  41. Iron Absorption: Molecular and Pathophysiological Aspects
    Margherita Correnti, Elena Gammella, Gaetano Cairo, Stefania Recalcati · 2024 · Metabolites
  42. The Unfolded Protein Response in Lung Disease
    Stefan John Marciniak, David Ron · 2010 · Proceedings of the American Thoracic Society
  43. Transcriptional regulation of secretory capacity by bZip transcription factors
    Rebecca M. Fox, Deborah J. Andrew · 2014 · Frontiers in Biology
  44. CHOP induces apoptosis by affecting brain iron metabolism in rats with subarachnoid hemorrhage
    Jun Zhao, Xiang Xiang, Hongxia Zhang, Dengzhi Jiang, Yidan Liang, Wang Qing, Liu Liu, Qing Chuan Zhao, Zhaohui He · 2017 · Experimental Neurology
  45. Hepcidin as a key iron regulator mediates glucotoxicity-induced pancreatic β-cell dysfunction
    Tingting Shu, Zhigang Lv, Yuchun Xie, Jun‐Ming Tang, Xuhua Mao · 2019 · Endocrine Connections
  46. Gestational diabetes mellitus affects placental iron homeostasis: Mechanism and clinical implications
    Jonas Zaugg, Hassan Melhem, Xiao Bo Huang, Małgorzata Wegner, Marc U. Baumann, Daniel Surbek, Meike Körner, Christiane Albrecht · 2020 · The FASEB Journal
  47. Hepcidin and Iron Metabolism in Experimental Liver Injury
    Steven A. Bloomer, Kyle E. Brown · 2021 · American Journal Of Pathology
  48. Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease
    Schaefer, Benedikt, Haschka, David, Finkenstedt, Armin, Petersen, Britt-Sabina, Theurl, Igor, Henninger, Benjamin, Janecke, Andreas R., Wang, Chia-Yu, Lin, Herbert Y., Veits, Lothar et al. · 2015 · Human Molecular Genetics
  49. Inflammation and ER stress downregulate BDH2 expression and dysregulate intracellular iron in macrophages
    Zughaier, Susu M., Stauffer, Brandon B., McCarty, Nael A. · 2014 · Journal of Immunology Research
  50. HBx induces the proliferation of hepatocellular carcinoma cells via AP1 over-expressed as a result of ER stress
    Hyun Kook Cho, So Young Kim, Yi Yi Kyaw, Aye Aye Win, Seung‐Hoi Koo, Hyeong-Hoe Kim, JaeHun Cheong · 2014 · Biochemical Journal
  51. The SMAD Pathway Is Required for Hepcidin Response During Endoplasmic Reticulum Stress
    Susanna Canali, Chiara Vecchi, Cinzia Garuti, Giuliana Montosi, Jodie L. Babitt, Antonello Pietrangelo · 2016 · Endocrinology
  52. Recombinant human lactoferrin attenuates the progression of hepatosteatosis and hepatocellular death by regulating iron and lipid homeostasis in ob / ob mice
    Chuang Guo, Xue Han, Tian Guo, Wei Zhang, Wen-Qiang Xuan, Yan-Tao Ren, Di Wang, Yan-Hong Chen, Yuhan Meng, Huiling Gao et al. · 2020 · Food & Function
  53. Critical role of CREBH‐mediated induction of transforming growth factor β2 by hepatitis C virus infection in fibrogenic responses in hepatic stellate cells
    Takeshi Chida, Masahiko Ito, Kenji Nakashima, Yumi Kanegae, Takuya Aoshima, Shuji Takabayashi, Kazuhito Kawata, Yoshimi Nakagawa, Masahiro Yamamoto, Hitoshi Shimano et al. · 2017 · Hepatology
  54. Iron and oxygen sensing: a tale of 2 interacting elements?
    Robert James Simpson, Andrew Tristan McKie · 2014 · Metallomics
  55. Obesity Promotes Alterations in Iron Recycling
    Marta Citelli, Thaís Fonte‐Faria, Vany Nascimento-Silva, Mariana Renovato‐Martins, Raphael Alves da Silva, Aderval Severino Luna, Simone Silva, Christina Barja‐Fidalgo · 2015 · Nutrients
  56. The smell of renal protection against chronic kidney disease: Hydrogen sulfide offers a potential stinky remedy
    George Johnson Dugbartey · 2017 · Pharmacological Reports
  57. Bovine serum albumin-stabilized gold nanoclusters as a fluorescent probe for determination of ferrous ion in cerebrospinal fluids via the Fenton reaction
    Si Yang, Zhongyao Jiang, Zhenzhen Chen, Lili Tong, Jun Lü, Jiahui Wang · 2015 · Microchimica Acta
  58. Cancer: Tumor Iron Metabolism, Mitochondrial Dysfunction and Tumor Immunosuppression; “A Tight Partnership—Was Warburg Correct?”
    Robert Lange Elliott, Jonathan F. Head · 2012 · Journal of Cancer Therapy
  59. Mechanisms of Hepatocyte Detoxification
    Niviann M. Blondet, Donald J. Messner, Kris V. Kowdley, Karen F. Murray · 2018 · Elsevier eBooks
  60. Hepcidin as a Prospective Individualized Biomarker for Individuals at Risk of Low Energy Availability
    Claire Evelyn Badenhorst, Katherine Elizabeth Black, Wendy J. O’Brien · 2019 · International Journal of Sport Nutrition and Exercise Metabolism
  61. 20 years of Hepcidin: How far we have come
    Silvia Colucci, Oriana Marques, Sandro Altamura · 2021 · Seminars in Hematology
  62. Endoplasmic reticulum stress and angiogenesis: is there an interaction between them?
    Annelies Paridaens, Debby Laukens, Yves‐Paul Vandewynckel, Stéphanie Coulon, Hans Van Vlierberghe, Anja M. Geerts, Isabelle O. Colle · 2014 · Liver International
  63. The Unfolded Protein Response in a Pair of Sensory Neurons Promotes Entry of C. elegans into Dauer Diapause
    Warakorn Kulalert, Dennis H. Kim · 2013 · Current Biology
  64. Carbon monoxide, a reaction product of heme oxygenase-1, suppresses the expression of C-reactive protein by endoplasmic reticulum stress through modulation of the unfolded protein response
    Jihwa Chung, Da-Yong Shin, Min Zheng, Yeonsoo Joe, Hyun‐Ock Pae, Stefan W. Ryter, Hun‐Taeg Chung · 2011 · Molecular Immunology
  65. Lipogenic SREBP-1a/c transcription factors activate expression of the iron regulator hepcidin, revealing cross-talk between lipid and iron metabolisms
    Alus M. Xiaoli, Ziyi Song, Fajun Yang · 2019 · Journal of Biological Chemistry
  66. Correlates of serum hepcidin levels and its association with cardiovascular disease in an elderly general population
    Raimund Pechlaner, Stefan Julia Kiechl, Manuel Mayr, Peter Santer, Siegfried Weger, David Haschka, Sukhvinder S. Bansal, Johann Willeit, Günter Weiß · 2015 · Clinical Chemistry and Laboratory Medicine (CCLM)
  67. The Effect of Alcohol and Hydrogen Peroxide on Liver Hepcidin Gene Expression in Mice Lacking Antioxidant Enzymes, Glutathione Peroxidase-1 or Catalase
    Duygu Dee Harrison-Findik, Sizhao Lu · 2015 · Biomolecules
  68. Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin
    Pattaraporn Thepsuwan, Asmita Bhattacharya, Zhenfeng Song, Stephen W. Hippleheuser, Shaobin Feng, Xiaoqiong Wei, Nupur Kanti Das, Mariana Sierra, Juncheng Wei, Deyu Fang et al. · 2023 · Proceedings of the National Academy of Sciences
  69. Iron metabolism and regulation by neutrophil gelatinase-associated lipocalin in cardiomyopathy
    Yee Kwan Chan, Hye Kyoung Sung, Gary Sweeney · 2015 · Clinical Science
  70. Interplay between innate immunity and iron metabolism after acute pancreatitis
    Shayal K. Chand, Ruma G. Singh, Sayali A. Pendharkar, Sakina H. Bharmal, Maxim S. Petrov · 2017 · Cytokine
  71. GATA-4 transcription factor regulates hepatic hepcidin expression
    Marie‐Laure Island, Nadia Fatih, Patricia Leroyer, Pierre Brissot, Olivier Loréal · 2011 · Biochemical Journal
  72. Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis
    Rachel P. L. van Swelm, Madelon Vos, Frank Verhoeven, Frank Thévenod, Dorine W. Swinkels · 2018 · Cell Death and Disease
  73. Novel CREB3L3 Nonsense Mutation in a Family With Dominant Hypertriglyceridemia
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  74. Chlorine Induces the Unfolded Protein Response in Murine Lungs and Skin
    Changzhao Li, Zhiping Weng, Stephen F. Doran, Ritesh K. Srivastava, Farrukh Afaq, Sadis Matalon, Mohammad Athar · 2013 · American Journal of Respiratory Cell and Molecular Biology
  75. Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin
    Paul Joseph Schmidt, Nancy C. Andrews, Mark D. Fleming · 2010 · Blood
  76. Toll-like receptor signalling in liver disease: ER stress the missing link?
    Matthew W. Lawless, Catherine M. Greene · 2012 · Cytokine
  77. Signaling pathways regulating hepcidin
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  78. Melatonin modifies cellular stress in the liver of septic mice by reducing reactive oxygen species and increasing the unfolded protein response
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  79. β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H
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  80. Mechanisms of Hepatocyte Detoxification
    Donald J. Messner, Karen F. Murray, Kris V. Kowdley · 2012 · Elsevier eBooks
  81. Toosendanin induced hepatotoxicity via triggering PERK-eIF2α-ATF4 mediated ferroptosis
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  82. Foxo1 is an iron-responsive transcriptional factor regulating systemic iron homeostasis
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  83. ER Stress and Iron Homeostasis: A New Frontier for the UPR
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  84. Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathways
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  85. No evidence of a genetic causal relationship between ankylosing spondylitis and iron homeostasis: A two-sample Mendelian randomization study
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  86. Pathophysiology of Iron Homeostasis during Inflammatory States
    Bobby J. Cherayil · 2015 · The Journal of Pediatrics
  87. Acute Acetaminophen Intoxication Leads to Hepatic Iron Loading by Decreased Hepcidin Synthesis
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  88. Ceramide Induces Human Hepcidin Gene Transcription through JAK/STAT3 Pathway
    Sizhao Lu, Sathish Kumar Natarajan, Justin L. Mott, Kusum K. Kharbanda, Duygu Dee Harrison-Findik · 2016 · PLoS ONE
  89. Orphan Nuclear Receptor Errγ Induces C-Reactive Protein Gene Expression through Induction of ER-Bound Bzip Transmembrane Transcription Factor CREBH
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  90. JNK facilitates IL-1β-induced hepcidin transcription via JunB activation
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  91. The small molecule ferristatin II induces hepatic hepcidin expression in vivo and in vitro
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  92. Hepatic X‐Box Binding Protein 1 and Unfolded Protein Response Is Impaired in Weanling Mice With Resultant Hepatic Injury
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  93. Intracellular labile iron is a key regulator of hepcidin expression and iron metabolism
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  94. Dietary fat level affects tissue iron levels but not the iron regulatory gene HAMP in rats
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  95. bZIP transmembrane transcription factor CREBH: Potential role in non-alcoholic fatty liver disease (Review)
    MIN WANG, Shui-Ping Zhao, MINGYUE TAN · 2015 · Molecular Medicine Reports
  96. Adenine alleviates iron overload by cAMP/PKA mediated hepatic hepcidin in mice
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  97. Endoplasmic reticulum stress at the forefront of fatty liver diseases and cancer
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  98. Plasmodium’s fight for survival: escaping elimination while acquiring nutrients
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  99. Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation
    Kazuyoshi Ohta, Masahiko Ito, Takeshi Chida, Kenji Nakashima, Satoshi Sakai, Yumi Kanegae, Hideya Kawasaki, Takuya Aoshima, Shuji Takabayashi, Hirotaka Takahashi et al. · 2023 · PLoS Pathogens
  100. Nutritional Modulation of Hepcidin in the Treatment of Various Anemic States
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