The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium
Open accessAbstract
Garnering Information on Granulomas: In tuberculosis, the tuberculous granuloma has been viewed traditionally as a host-protective structure that serves to “wall off” mycobacteria. However, recent work in the zebrafish embryo showed that mycobacteria convert the nascent granuloma into a vehicle for bacterial expansion and dissemination. Thus, intercepting granuloma formation could provide a strategy for treating tuberculosis, an urgent public health goal in light of the epidemic of extensively drug-resistant tuberculosis. Now Volkman et al. (p. 466 , published online 10 December; see the Perspective by Agarwal and Bishai ) present the molecular pathway by which mycobacteria induce granulomas in zebrafish. Inhibition of this pathway attenuates infection by reducing granuloma formation, suggesting a therapeutic target for tuberculosis treatment.
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Hsu, T., Hingley-Wilson, S. M., Chen, B., Chen, M., Dai, A. Z., Morin, P. M., Marks, C. B., Padiyar, J., Goulding, C., Gingery, M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1635213100 · Cited by 731
Le Guellec, D., Morvan-Dubois, G., & Sire, J.-Y. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.15272388 · Cited by 286
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Petrie, T. A., Strand, N. S., Tsung-Yang, C., Rabinowitz, J. S., & Moon, R. T. (2014) · Development · doi:10.1242/dev.098459 · Cited by 365
Yang, C.-T., Cambier, C. J., Davis, J. M., Hall, C. J., Crosier, P. S., & Ramakrishnan, L. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.07.009 · Cited by 293
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Tubo, N. J., & Jenkins, M. K. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00097-13 · Cited by 105
Animal Models of Tuberculosis: Zebrafish
van Leeuwen, L. M., van der Sar, A. M., & Bitter, W. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a018580 · Cited by 53
Metadata
- Authors
- Volkman, H. E., Pozos, T. C., Zheng, J., Davis, J. M., Rawls, J. F., & Ramakrishnan, L.
- Venue
- Science
- Published
- 2010-01-22
- Volume
- 327
- Issue
- 5964
- Pages
- 466-469
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2071723955
- Cited by
- 448
- References
- 2
- FWCI
- 23.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
