The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
How the Noninflammasome NLRs Function in the Innate Immune System
Open accessAbstract
NLR (nucleotide-binding domain, leucine-rich repeat–containing) proteins have rapidly emerged as central regulators of immunity and inflammation with demonstrated relevance to human diseases. Much attention has focused on the ability of several NLRs to activate the inflammasome complex and drive proteolytic processing of inflammatory cytokines; however, NLRs also regulate important inflammasome-independent functions in the immune system. We discuss several of these functions, including the regulation of canonical and noncanonical NF-κB activation, mitogen-activated protein kinase activation, cytokine and chemokine production, antimicrobial reactive oxygen species production, type I interferon production, and ribonuclease L activity. We also explore the mechanistic basis of these functions and describe current challenges in the field.
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Cites
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VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
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Cited by
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Wen, H., Gris, D., Lei, Y., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P.-Y. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,698
Self-citationThe Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
Davis, B. K., Wen, H., & Ting, J. P.-Y. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101405 · Cited by 1,618
Self-citationDeoxynivalenol: mechanisms of action, human exposure, and toxicological relevance
Pestka, J. J. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0579-8 · Cited by 1,015
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Self-citationThe airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
Metadata
- Authors
- Ting, J. P. Y., Duncan, J. A., & Lei, Y.
- Venue
- Science
- Published
- 2010-01-15
- Volume
- 327
- Issue
- 5963
- Pages
- 286-290
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2094129507
- Cited by
- 287
- References
- 49
- FWCI
- 16.30
- Type
- journal article
- Language
- en
- Open access
- green
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