The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Fast Vesicle Fusion in Living Cells Requires at Least Three SNARE Complexes
Open accessAbstract
Three's the Charm: The molecular machinery mediating membrane fusion during secretion from a cell requires a complex of so-called SNARE protein that forms a coiled bundle of four parallel α-helices. Mohrmann et al. (p. 502 , published online 16 September) developed an elegant approach to find out how many SNARE complexes are required to promote secretion of individual secretory vesicles in living chromaffin cells by titrating the ratio of wild-type and mutant SNARE proteins expressed. For fast synchronous release, a minimum of three SNARE complexes per vesicle were required. Fewer SNARE complexes resulted in slower release.
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Cites
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417
Differential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23
Sørensen, J. B., Nagy, G., Varoqueaux, F., Nehring, R. B., Brose, N., Wilson, M. C., & Neher, E. (2003) · Cell · doi:10.1016/s0092-8674(03)00477-x · Cited by 364
Self-citation
Cited by
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
Südhof, T. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.022 · Cited by 1,197
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins
Wilhelm, B. G., Mandad, S., Truckenbrodt, S., Kröhnert, K., Schäfer, C., Rammner, B., Koo, S. J., Claßen, G. A., Krauss, M., Haucke, V., et al. (2014) · Science · doi:10.1126/science.1252884 · Cited by 770
The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?
Rizo, J., & Südhof, T. C. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155818 · Cited by 386
Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling
Verweij, F. J., Bebelman, M. P., Jimenez, C. R., Garcia-Vallejo, J. J., Janssen, H., Neefjes, J., Knol, J. C., de Goeij-de Haas, R., Piersma, S. R., Baglio, S. R., et al. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201703206 · Cited by 359
Self-citationThe Synaptic Vesicle Release Machinery
Rizo, J., & Xu, J. (2015) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-060414-034057 · Cited by 339
Metadata
- Authors
- Mohrmann, R., de Wit, H., Verhage, M., Neher, E., & Sørensen, J. B.
- Venue
- Science
- Published
- 2010-10-22
- Volume
- 330
- Issue
- 6003
- Pages
- 502-505
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2019594298
- Cited by
- 319
- References
- 2
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- green
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