The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.
The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?
Abstract
Neurotransmitter release is governed by proteins that have homo-logs in most types of intracellular membrane fusion, including the Sec1/Munc18 protein Munc18-1 and the SNARE proteins syntaxin-1, synaptobrevin/VAMP, and SNAP-25. The SNAREs initiate fusion by forming tight SNARE complexes that bring the vesicle and plasma membranes together. SNARE maintenance in a functional state depends on two chaperone systems (Hsc70/αCSP/SGT and synuclein); defects in these systems lead to neurodegeneration. Munc18-1 binds to an autoinhibitory closed conformation of syntaxin-1, gating formation of SNARE complexes, and also binds to SNARE complexes, which likely underlies the crucial function of Munc18-1 in membrane fusion by an as-yet unclear mechanism. Syntaxin-1 opening is mediated by Munc13s through their MUN domain, which is homologous to diverse tethering factors and may also have a general role in fusion. MUN domain activity is likely modulated in diverse presynaptic plasticity processes that depend on Ca(2+) and RIM proteins, among others.
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Cites
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Self-citationSNAREpins: Minimal Machinery for Membrane Fusion
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The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones
Imig, C., Min, S.-W., Krinner, S., Arancillo, M., Rosenmund, C., Südhof, T. C., Rhee, J., Brose, N., & Cooper, B. H. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.009 · Cited by 389
Self-citationThe Synaptic Vesicle Release Machinery
Rizo, J., & Xu, J. (2015) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-060414-034057 · Cited by 339
Self-citationThe biogenesis of lysosomes and lysosome-related organelles
Luzio, J. P., Hackmann, Y., Dieckmann, N. M. G., & Griffiths, G. M. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016840 · Cited by 330
Metadata
- Authors
- Rizo, J., & Südhof, T. C.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2012-11-10
- Volume
- 28
- Issue
- 1
- Pages
- 279-308
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2159529647
- Cited by
- 386
- References
- 196
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rizo, J., & Südhof, T. C. (2012). The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged? Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev-cellbio-101011-155818
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