The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
Open accessAbstract
α-Synuclein and Aging: Transgenic α-synuclein can reverse the otherwise lethal neurodegeneration of cysteine string protein-α knockout mice via changes in SNARE proteins, which mediate synaptic vesicle release. Using experiments with purified recombinant proteins, triple αβγ-synuclein knockout mice, and studies of mouse aging, Burré et al. (p. 1663 , published online 26 August) now demonstrate that α-synuclein directly interacts with the SNARE protein synaptobrevin and functions as a catalyst for SNARE-complex assembly. The role of synucleins is fully dispensable in young animals, but becomes essential late in life, which suggests that α-synuclein maintains normal synaptic function during aging.
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Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
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Membrane Fusion: Grappling with SNARE and SM Proteins
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Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
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Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease
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Self-citationCASK Functions as a Mg2+-independent neurexin kinase
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Cited by
Hallmarks of neurodegenerative diseases
Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789
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-Synuclein in Parkinson's Disease
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Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
Südhof, T. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.022 · Cited by 1,197
Self-citationAutophagy and apoptosis dysfunction in neurodegenerative disorders
Ghavami, S., Shojaei, S., Yeganeh, B., Ande, S. R., Jangamreddy, J. R., Mehrpour, M., Christoffersson, J., Chaabane, W., Moghadam, A. R., Kashani, H. H., et al. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.10.004 · Cited by 1,039
Metadata
- Authors
- Burré, J., Sharma, M., Tsetsenis, T., Buchman, V., Etherton, M. R., & Südhof, T. C.
- Venue
- Science
- Published
- 2010-09-24
- Volume
- 329
- Issue
- 5999
- Pages
- 1663-1667
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990473626
- Cited by
- 1,812
- References
- 13
- FWCI
- 34.43
- Type
- journal article
- Language
- en
- Open access
- green
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