Cited by 302Angiogenesis and VEGF in CancerBarrier Structure and Function StudiesNeurogenesis and neuroplasticity mechanisms

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Essential Regulation of CNS Angiogenesis by the Orphan G Protein–Coupled Receptor GPR124

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Kuhnert, Frank, Mancuso, Michael R., Shamloo, Amir, Wang, Hsiao-Ting, Choksi, Vir, Florek, Mareike, Su, Hua, Fruttiger, Marcus, Young, William L., Heilshorn, Sarah C., Kuo, Calvin J.·2010·Science

DOI 10.1126/science.1196554PMC PMC3099479

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Abstract

The orphan G protein-coupled receptor (GPCR) GPR124/tumor endothelial marker 5 is highly expressed in central nervous system (CNS) endothelium. Here, we show that complete null or endothelial-specific GPR124 deletion resulted in embryonic lethality from CNS-specific angiogenesis arrest in forebrain and neural tube. Conversely, GPR124 overexpression throughout all adult vascular beds produced CNS-specific hyperproliferative vascular malformations. In vivo, GPR124 functioned cell-autonomously in endothelium to regulate sprouting, migration, and developmental expression of the blood-brain barrier marker Glut1, whereas in vitro, GPR124 mediated Cdc42-dependent directional migration to forebrain-derived, vascular endothelial growth factor-independent cues. Our results demonstrate CNS-specific angiogenesis regulation by an endothelial receptor and illuminate functions of the poorly understood adhesion GPCR subfamily. Further, the functional tropism of GPR124 marks this receptor as a therapeutic target for CNS-related vascular pathologies.

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Authors: Kuhnert, F., Mancuso, M. R., Shamloo, A., Wang, H.-T., Choksi, V., Florek, M., Su, H., Fruttiger, M., Young, W. L., Heilshorn, S. C., & Kuo, C. J.
Affiliations: Stanford Medicine (US)
Stanford University (US)
University of California, San Francisco (US)
University College London (GB)
Corresponding author: Kuo, Calvin J.
ORCID: Kuhnert, Frank
Mancuso, Michael R.
Shamloo, Amir
Florek, Mareike
Su, Hua
Fruttiger, Marcus
Heilshorn, Sarah C.
Kuo, Calvin J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2010-11-12
Volume: 330
Issue: 6006
Pages: 985-989
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1196554
PMC: PMC3099479
OpenAlex: W2115716038
Cited by: 301
References: 32
Citations by year: 2026: 11 · 2025: 16 · 2024: 17 · 2023: 16 · 2022: 29 · 2021: 23 · 2020: 17 · 2019: 21 · 2018: 18 · 2017: 20 · 2016: 20 · 2015: 19 · 2014: 22 · 2013: 16 · 2012: 20
FWCI: 6.78
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: National Institutes of Health (5r21ns058600-02, 1dp2od006477-01)
National Heart, Lung, and Blood Institute (R01HL074267)
National Cancer Institute (R01CA095654, T32CA009302)
National Institute of General Medical Sciences (T32GM007365, GM 07365)
National Institute of Neurological Disorders and Stroke (1R21 NS058600, P01NS044155, R01NS027713, R01NS052830, P01 NS 44155, R01NS064517, R01-NS 27713, R21 NS058600, R21NS070153)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: GPR124, orphan G protein-coupled receptor, adhesion GPCRs, endothelial cells, embryonic lethality, neural tube, forebrain, vascular malformations, Cdc42, endothelial cell migration, sprouting angiogenesis, blood-brain barrier, GLUT1
MeSH terms: Animals, Blood Vessels, Blood-Brain Barrier, Cell Movement, Endothelium, Vascular, Mesencephalon, Mice, Transgenic, Rhombencephalon, Telencephalon, Prosencephalon, Gene Deletion, Mice, Knockout, Neovascularization, Physiologic, Endothelial Cells, Receptors, G-Protein-Coupled, Embryonic Development, Glucose Transporter Type 1, Mice, Neural Tube

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Essential Regulation of CNS Angiogenesis by the Orphan G Protein–Coupled Receptor GPR124

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