Kuo, Calvin J.

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science

Muscle Physiology and DisordersWnt/β-catenin signaling in development and cancer

Cited by 1,564

Organoid modeling of the tumor immune microenvironment

Neal, J. T., Li, X., Zhu, J., Giangarra, V., Grzeskowiak, C. L., Ju, J., Liu, I. H., Chiou, S.-H., Salahudeen, A. A., Smith, A. R., et al. (2018) · Cell

Cancer Immunotherapy and Biomarkers3D Printing in Biomedical Research

Cited by 1,556

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

Ootani, A., Li, X., Sangiorgi, E., Ho, Q. T., Ueno, H., Toda, S., Sugihara, H., Fujimoto, K., Weissman, I. L., Capecchi, M. R., et al. (2009) · Nature Medicine

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

Cited by 906

VEGF is necessary for exercise‐induced adult hippocampal neurogenesis

Fabel, K., Fabel, K., Tam, B., Kaufer, D., Baiker, A., Simmons, N., Kuo, C. J., & Palmer, T. D. (2003) · European Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 861

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

Rosenbluh, J., Nijhawan, D., Cox, A. G., Li, X., Neal, J. T., Schafer, E. J., Zack, T. I., Wang, X., Tsherniak, A., Schinzel, A. C., et al. (2012) · Cell

Hippo pathway signaling and YAP/TAZWnt/β-catenin signaling in development and cancer

Cited by 757

Augmented Wnt signaling in a mammalian model of accelerated aging

Liu, H., Fergusson, M. M., Castilho, R. M., Liu, J., Cao, L., Chen, J., Malide, D., Rovira, I. I., Schimel, D., Kuo, C. J., et al. (2007) · Science

Wnt/β-catenin signaling in development and cancerTelomeres, Telomerase, and Senescence

Cited by 755

Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis

Daneman, R., Agalliu, D., Zhou, L., Kuhnert, F., Kuo, C. J., & Barres, B. A. (2009) · Proceedings of the National Academy of Sciences

Barrier Structure and Function StudiesAngiogenesis and VEGF in Cancer

Cited by 753

Apc Tumor Suppressor Gene Is the “Zonation-Keeper” of Mouse Liver

Benhamouche, S., Decaens, T., Godard, C., Chambrey, R., Rickman, D. S., Moinard, C., Vasseur-Cognet, M., Kuo, C. J., Kahn, A., Perret, C., et al. (2006) · Developmental Cell

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 543

Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions

Co, J. Y., Margalef-Català, M., Li, X., Mah, A. T., Kuo, C. J., Monack, D. M., & Amieva, M. R. (2019) · Cell Reports

Salmonella and Campylobacter epidemiologyEscherichia coli research studies

Cited by 488

Oligodendrocyte precursors migrate along vasculature in the developing nervous system

Tsai, H.-H., Niu, J., Munji, R., Davalos, D., Chang, J., Zhang, H., Tien, A.-C., Kuo, C. J., Chan, J. R., Daneman, R., et al. (2016) · Science

Neurogenesis and neuroplasticity mechanismsBarrier Structure and Function Studies

Cited by 483

Progenitor identification and SARS-CoV-2 infection in human distal lung organoids

Salahudeen, A. A., Choi, S. S., Rustagi, A., Zhu, J., van Unen, V., de la O, S. M., Flynn, R. A., Margalef-Català, M., Santos, A. J. M., Ju, J., et al. (2020) · Nature

SARS-CoV-2 and COVID-19 ResearchNeonatal Respiratory Health Research

Cited by 416

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Janda, C. Y., Dang, L. T., You, C., Chang, J., de Lau, W., Zhong, Z. A., Yan, K. S., Marecic, O., Siepe, D., Li, X., et al. (2017) · Nature

Wnt/β-catenin signaling in development and cancerHedgehog Signaling Pathway Studies

Cited by 403

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

Furman, D., Chang, J., Lartigue, L., Bolen, C. R., Haddad, F., Gaudilliere, B., Ganio, E. A., Fragiadakis, G. K., Spitzer, M. H., Douchet, I., et al. (2017) · Nature Medicine

Inflammasome and immune disordersGenetics, Aging, and Longevity in Model Organisms

Cited by 389

CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities

Han, K., Pierce, S. E., Li, A., Spees, K., Anderson, G. R., Seoane, J. A., Lo, Y.-H., Dubreuil, M., Olivas, M., Kamber, R. A., et al. (2020) · Nature

CRISPR and Genetic EngineeringCancer Genomics and Diagnostics

Cited by 311

Essential Regulation of CNS Angiogenesis by the Orphan G Protein–Coupled Receptor GPR124

Kuhnert, F., Mancuso, M. R., Shamloo, A., Wang, H.-T., Choksi, V., Florek, M., Su, H., Fruttiger, M., Young, W. L., Heilshorn, S. C., et al. (2010) · Science

Angiogenesis and VEGF in CancerBarrier Structure and Function Studies

Cited by 301

AXL Is an Essential Factor and Therapeutic Target for Metastatic Ovarian Cancer

Rankin, E. B., Fuh, K. C., Taylor, T. E., Krieg, A. J., Musser, M., Yuan, J., Wei, K., Kuo, C. J., Longacre, T. A., & Giaccia, A. J. (2010) · Cancer Research

Ovarian cancer diagnosis and treatmentCancer Cells and Metastasis

Cited by 229

An expanded universe of cancer targets

Hahn, W. C., Bader, J. S., Braun, T. P., Califano, A., Clemons, P. A., Druker, B. J., Ewald, A. J., Fu, H., Jagu, S., Kemp, C. J., et al. (2021) · Cell

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 213

A nomenclature for intestinal in vitro cultures

Stelzner, M., Helmrath, M., Dunn, J. C. Y., Henning, S. J., Houchen, C. W., Kuo, C., Lynch, J., Li, L., Magness, S. T., Martin, M. G., et al. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Digestive system and related healthCancer Cells and Metastasis

Cited by 195

Applications of organoids for cancer biology and precision medicine

Lo, Y.-H., Karlsson, K., & Kuo, C. J. (2020) · Nature Cancer

Cancer Cells and Metastasis3D Printing in Biomedical Research

Cited by 182

A CRISPR/Cas9-Engineered ARID1A -Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Lo, Y.-H., Kolahi, K. S., Du, Y., Chang, C.-Y., Krokhotin, A., Nair, A., Sobba, W. D., Karlsson, K., Jones, S. J., Longacre, T. A., et al. (2021) · Cancer Discovery

Chromatin Remodeling and CancerCRISPR and Genetic Engineering

Cited by 174

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

Miao, Y., Ha, A., de Lau, W., Yuki, K., Santos, A. J. M., You, C., Geurts, M. H., Puschhof, J., Pleguezuelos-Manzano, C., Peng, W. C., et al. (2020) · Cell Stem Cell

Wnt/β-catenin signaling in development and cancerHedgehog Signaling Pathway Studies

Cited by 151

Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening

Du, Y., Li, X., Niu, Q., Mo, X., Qui, M., Ma, T., Kuo, C. J., & Fu, H. (2020) · Journal of Molecular Cell Biology

3D Printing in Biomedical ResearchCancer Cells and Metastasis

Cited by 125

Deterministic evolution and stringent selection during preneoplasia

Karlsson, K., Przybilla, M. J., Kotler, E., Khan, A., Xu, H., Karagyozova, K., Sockell, A., Wong, W. H., Liu, K., Mah, A., et al. (2023) · Nature

Cancer Genomics and DiagnosticsEvolution and Genetic Dynamics

Cited by 83

Inhibition of VEGF (Vascular Endothelial Growth Factor)-A or its Receptor Activity Suppresses Experimental Aneurysm Progression in the Aortic Elastase Infusion Model

Xu, B., Iida, Y., Glover, K. J., Ge, Y., Wang, Y., Xuan, H., Hu, X., Tanaka, H., Wang, W., Fujimura, N., et al. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology

Aortic aneurysm repair treatmentsConnective tissue disorders research

Cited by 73