The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project
Open accessAbstract
From Genome to Regulatory Networks: For biologists, having a genome in hand is only the beginning—much more investigation is still needed to characterize how the genome is used to help to produce a functional organism (see the Perspective by Blaxter ). In this vein, Gerstein et al. (p. 1775 ) summarize for the Caenorhabditis elegans genome, and The modENCODE Consortium (p. 1787 ) summarize for the Drosophila melanogaster genome, full transcriptome analyses over developmental stages, genome-wide identification of transcription factor binding sites, and high-resolution maps of chromatin organization. Both studies identified regions of the nematode and fly genomes that show highly occupied targets (or HOT) regions where DNA was bound by more than 15 of the transcription factors analyzed and the expression of related genes were characterized. Overall, the studies provide insights into the organization, structure, and function of the two genomes and provide basic information needed to guide and correlate both focused and genome-wide studies.
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Cites
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Cited by
Spatial reconstruction of single-cell gene expression data
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BackgroundMethodInfluentialChIP-seq guidelines and practices of the ENCODE and modENCODE consortia
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Metadata
- Authors
- Gerstein, M. B., Lu, Z. J., Van Nostrand, E. L., Cheng, C., Arshinoff, B. I., Liu, T., Yip, K. Y., Robilotto, R., Rechtsteiner, A., Ikegami, K., Alves, P., Chateigner, A., Perry, M., Morris, M., Auerbach, R. K., Feng, X., Leng, J., Vielle, A., Niu, W., Rhrissorrakrai, K., Agarwal, A., Alexander, R. P., Barber, G., Brdlik, C. M., Brennan, J., Brouillet, J. J., Carr, A., Cheung, M.-S., Clawson, H., Contrino, S., Dannenberg, L. O., Dernburg, A. F., Desai, A., Dick, L., Dosé, A. C., Du, J., Egelhofer, T., Ercan, S., Euskirchen, G., Ewing, B., Feingold, E. A., Gassmann, R., Good, P. J., Green, P., Gullier, F., Gutwein, M., Guyer, M. S., Habegger, L., Han, T., Henikoff, J. G., Henz, S. R., Hinrichs, A., Holster, H., Hyman, T., Iniguez, A. L., Janette, J., Jensen, M., Kato, M., Kent, W. J., Kephart, E., Khivansara, V., Khurana, E., Kim, J. K., Kolasinska-Zwierz, P., Lai, E. C., Latorre, I., Leahey, A., Lewis, S., Lloyd, P., Lochovsky, L., Lowdon, R. F., Lubling, Y., Lyne, R., MacCoss, M., Mackowiak, S. D., Mangone, M., McKay, S., Mecenas, D., Merrihew, G., Miller, D. M., Muroyama, A., Murray, J. I., Ooi, S.-L., Pham, H., Phippen, T., Preston, E. A., Rajewsky, N., Rätsch, G., Rosenbaum, H., Rozowsky, J., Rutherford, K., Ruzanov, P., Sarov, M., Sasidharan, R., Sboner, A., Scheid, P., Segal, E., Shin, H., Shou, C., Slack, F. J., Slightam, C., Smith, R., Spencer, W. C., Stinson, E. O., Taing, S., Takasaki, T., Vafeados, D., Voronina, K., Wang, G., Washington, N. L., Whittle, C. M., Wu, B., Yan, K.-K., Zeller, G., Zha, Z., Zhong, M., Zhou, X., modENCODE Consortium, Ahringer, J., Strome, S., Gunsalus, K. C., Micklem, G., Liu, X. S., Reinke, V., Kim, S. K., Hillier, L. W., Henikoff, S., Piano, F., Snyder, M., Stein, L., Lieb, J. D., & Waterston, R. H.
- Venue
- Science
- Published
- 2010-12-24
- Volume
- 330
- Issue
- 6012
- Pages
- 1775-1787
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2148966035
- Cited by
- 955
- References
- 9
- FWCI
- 34.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Gerstein, M. B., Lu, Z. J., Van Nostrand, E. L., Cheng, C., Arshinoff, B. I., Liu, T., Yip, K. Y., Robilotto, R., Rechtsteiner, A., Ikegami, K., Alves, P., Chateigner, A., Perry, M., Morris, M., Auerbach, R. K., Feng, X., Leng, J., Vielle, A., Niu, W., . . . Waterston, R. H. (2010). Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project. Science. https://doi.org/10.1126/science.1196914
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