Multiscale Evolutionary Dynamics of Host-Associated Microbiomes
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The composite members of the microbiota face a range of selective pressures and must adapt to persist in the host. We highlight recent work characterizing the evolution and transfer of genetic information across nested scales of host-associated microbiota, which enable resilience to biotic and abiotic perturbations. At the strain level, we consider the preservation and diversification of adaptive information in progeny lineages. At the community level, we consider genetic exchange between distinct microbes in the ecosystem. Finally, we frame microbiomes as open systems subject to acquisition of novel information from foreign ecosystems through invasion by outsider microbes.
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Bacterial pathogens accumulate mutations to compete with resident microbiome and host factors when entering the host intestines.
“Extensive studies proved bacterial pathogens accumulate mutations to compete with resident microbiome and host factors when entering the host intestines.23,24”
From Gut microbiota drives structural variation of exogenous probiotics to enhance colonization (2025) · cites this paper as [24]
The review’s “Pathogen evolution during infection” section reports adaptive mutations in pathogens during infection, while “Evolution in gut bacterial populations” describes mutations in E. coli introduced into mouse guts. It does not establish that bacterial pathogens entering the intestines accumulate mutations specifically to compete with both resident microbes and host factors; the cited pathogen examples concern cystic-fibrosis infections. (LLM, conf=0.85)
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МІКРОБІОТА ЛЮДЕЙ ТА ТВАРИН: ВПЛИВ ФІЗИЧНОЇ АКТИВНОСТІ ТА ДІЄТИ
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Coadaptation mechanism of the gut microbiota and human organism to physical loading
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- Authors
- Ferreiro, A., Crook, N., Gasparrini, A. J., & Dantas, G.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Dantas, Gautam
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 172
- Issue
- 6
- Pages
- 1216-1227
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC5846202
- OpenAlex
- W2792874068
- Cited by
- 127
- References
- 91
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 15 · 2023: 9 · 2022: 24 · 2021: 30 · 2020: 16 · 2019: 10 · 2018: 4
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Edward Mallinckrodt, Jr. Foundation
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases
- Eunice Kennedy Shriver National Institute of Child Health & Human Development
- National Institutes of Health (R01GM099538, R01AI123394, R01HD092414)
- Washington University
- NIDDK Pediatric Gastroenterology Research Training Program
- NIH (T32 DK077653)
- NIGMS (T32 GM007067)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- host-associated microbiota, microbiome evolution, horizontal gene transfer, microbial invasion, microbiome resilience, host-microbe interactions
- MeSH terms
- Animals, Humans, Genetic Variation, Ecosystem, Evolution, Molecular, Gene Transfer, Horizontal, Metagenome, Host Specificity, Microbiota
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