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Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity
Open accessAbstract
Chronic yeast infections in the absence of other infections result from genetic deficiencies in proinflammatory host responses.
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In the citing paper
“IL-17-mediated immunity is central to mucocutaneous host defense against fungi such as C. albicans and Malassezia [10,99,100].”
From Host–Candida auris interactions in the skin (2026) · cites this paper as [99]
Experimental — accuracy not yet measuredIn the citing paper
“analysis of Th17 cells in different tissue sites has revealed that Th17 cells may exhibit distinct transcriptional profiles associated with either homeostatic or pathogenic functions”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [43]
In the citing paper
“intestinal non-pathogenic/homeostatic Th17 cells specific for segmented filamentous bacteria (SFB) have a transcriptome that differs markedly from the pro-inflammatory Th17 cells elicited by Helicobacter hepaticus (H. hepaticus) in mice defective for induced intestinal Treg cells”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [43]
In the citing paper
“In the Il10−/− model of colitis, in which IL-10-deficient mice develop spontaneous microbiota-dependent colitis, Th17 cells were identified as the main immune population mediating the inflammatory immune response [43, 133].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [43]
In the citing paper
“In Helicobacter hepaticus- dependent colitis, pathobiont-specific inflammatory Th17 cells are major mediators of intestinal inflammation [43].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [43]
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Cites
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Orf Infection in a Patient with Stat1 Gain-of-Function
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“Mutations in several immune response genes have been associated with susceptibility to chronic mucocutaneous candidiasis in human families (14, 17, 36, 48), and several have been verified in murine models.”
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“Defects in the IL17 axis, however, are known to cause chronic mucocutaneous candidiasis (21, 22), which do not show any involvement of the dental/skeletal system whatsoever and hence IL17 deficiency as the cause for the dental/ skeletal defects in HIES seems unlikely.”
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Chronic Mucocutaneous Candidiasis in an Adolescent Boy Due to a Novel Mutation in TRAF3IP2
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“The need to elucidate the function of the receptor subunits comes from the evidence that IL-17RA or IL-17RC mutations have been also described in human fungal infections (52, 53).”
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Cytokines and cytokine receptors
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“CMC patients have been identified with mutations in the IL-17 receptor A or with IL-17F deficiency [20], whereas a majority of families with autosomal-dominant CMC displays a gain of function mutation in the STAT-1 signal transduction molecule, leading to defective Th17 responses [21,22].”
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“In contrast, IL-17F deficiency partially displays antifungal activity [63].”
BackgroundIκBζ is an essential mediator of immunity to oropharyngeal candidiasis
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“staphylococci to cause invasive infections (trauma, surgery); individuals with implants that serve as a protective niche for staphylococci; and individuals with diminished innate immune defenses, most importantly patients with reduced opsonophagocytic killing of bacteria, which is mediated by neutrophil granulocytes (…”
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Self-citationC/EBPβ Promotes Immunity to Oral Candidiasis through Regulation of β-Defensins
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“Humans with mutations in the IL17RA gene have been identified with CMC [7].”
BackgroundRecent advances in understanding the pathophysiology of primary T cell immunodeficiencies
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“…that IL-17A contributes to host defense and to the expression of antimicrobial peptides; 46,80,81 however, absence of IL-17A has not been associated with infection or autoimmune manifestations, 80 suggesting that inhibition of IL-17 has a low potential for adverse effects on the immune system.”
BackgroundHuman gain-of-function STAT1 mutation disturbs IL-17 immunity in mice
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“albicans dermatitis during the neonatal period (120), although the involvement of IL-17-producing γδ T cells in host defense was not known.”
BackgroundSecukinumab (AIN457) for the treatment of psoriasis
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“In this sense, genetic deficiency in IL-17RA in humans gives rise to chronic mucocutaneous infections by Candida albicans, and to a lesser extent to Staphylococcus aureus [50].”
BackgroundBoisson, B. (2020) · Human Genetics · doi:10.1007/s00439-020-02111-z · Cited by 23
Human MALT1 deficiency and predisposition to infections
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Life before seventeen: cloning of the IL-17 receptor
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“Similarly, individuals with inherited defects in IL-17F, IL-17RA, or STAT3 (required for Th17 differentiation) also exhibit mucosal candidiasis and cutaneous staphylococcal infections (42, 43), consistent with prior mouse studies (44–47).”
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“Indeed, defects in several components of the Th17 pathway, ranging from the signaling molecules (CARD9, STAT1, STAT3) to the cytokines involved (IL-17), have been linked to chronic mucocutaneous candidiasis [23,45].”
BackgroundBiological and synthetic target DMARDs in psoriatic arthritis
Silvagni, E., Bortoluzzi, A., Ciancìo, G., & Govoni, M. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104473 · Cited by 22
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“CD4 T helper (Th) cells producing IL-17A and possibly other cytokines (IL22, G-CSF, IL-17F) are involved in the regulation of inflammation by inducing pro-inflammatory cytokines(7) and in the defense against certain fungi (Candida albicans).(8) IL-10-producing T cells, often called Tr1 T cells, were defined in mice by…”
BackgroundChronic Candidiasis in Children
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Act Locally, Act Globally—Microbiota, Barriers, and Cytokines in Atherosclerosis
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“A point of concern is the finding that patients with deficiencies in the IL-17 pathway have a high risk of developing chronic mucocutaneous candidiasis.(36) In the phase II trial and in the open-label extension study no cases of fungal infections were reported.”
BackgroundMekki, N., Ben‐Mustapha, I., Liu, L., BOUSSOFARA, L., Okada, S., Cypowyj, S., Ghariani, N., Saïdi, W., DENGUEZLI, M., Casanova, J., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.480 · Cited by 21
Self-citationHost genetic susceptibility to mycetoma
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“Chronic mucocutaneous candidiasis (CMC) is a monogenetic immunodeficiency of cellmediated immunity that develops as a consequence of defects in IL-17 and IL-22 immunity required for defence against fungal infections [43].”
BackgroundSuchodolski, J., Derkacz, D., Bernat, P., & Krasowska, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-86012-9 · Cited by 21
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“albicans in humans was established in patients with chronic mucocutaneous candidiasis, with five genetic etiologies: (i) autosomal recessive deficiency in the IL-17 receptor A [34], (ii) autosomal dominant deficiency of IL-17F [34], (iii) autosomal dominant gain of STAT1 activity [35], (iv) mutation of ACT1 [36], or (…”
BackgroundMartínez‐Martínez, L., Martínez-Saavedra, M. T., Fuentes‐Prior, P., Barnadas, M. A., Rubiales, M. V., Noda, J., Badell, I., Rodríguez‐Gallego, C., & Calle-Martin, O. D. L. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.09.014 · Cited by 20
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“aureus infections in patients with hyper-IgE syndrome [23, 24], atopic dermatitis [25], and mucocutaneous candidiasis [26].”
BackgroundSalivary cytokine profile in elders with Candida‐related denture stomatitis
Pesee, S., & Arpornsuwan, T. (2013) · Gerodontology · doi:10.1111/ger.12064 · Cited by 22
Klicznik, M. M., Benedetti, A., Gail, L. M., Varkhande, S. R., Holly, R., Laimer, M., Stoecklinger, A., Sir, A., Reitsamer, R., Neuper, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-67430-7 · Cited by 20
Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs
Aggor, F. E. Y., Bertolini, M., Coleman, B. M., Taylor, T. C., Ponde, N. O., & Gaffen, S. L. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012302 · Cited by 20
Primary Immunodeficiency Diseases
Hernandez-Trujillo, V. P., Scalchunes, C., Hernandez-Trujillo, H. S., Boyle, J. M., Williams, P. V., Boyle, M., & Orange, J. S. (2015) · Clinical Pediatrics · doi:10.1177/0009922815574079 · Cited by 22
Fagundes, B. O., de Sousa, T. R., & Victor, J. R. (2022) · International Journal of Dermatology · doi:10.1111/ijd.16364 · Cited by 21
A gut-oral microbiome–driven axis controls oropharyngeal candidiasis through retinoic acid
Aggor, F. E. Y., Bertolini, M., Zhou, C., Taylor, T. C., Abbott, D. A., Musgrove, J., Bruno, V. M., Hand, T. W., & Gaffen, S. L. (2022) · JCI Insight · doi:10.1172/jci.insight.160348 · Cited by 20
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Eslami, N., Tavakol, M., Mesdaghi, M., Gharegozlou, M. J., Casanova, J., Puel, A., Okada, S., Arshi, S., Bemanian, M. H., Fallahpour, M., et al. (2017) · Acta Microbiologica et Immunologica Hungarica · doi:10.1556/030.64.2017.014 · Cited by 19
Self-citationHost Defenses to Fungal Pathogens
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The Goldilocks model of immune symbiosis with Mycobacteria and Candida colonizers
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Key molecules in the differentiation and commitment program of T helper 17 (Th17) cells up-to-date
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Insights from human studies into the host defense against candidiasis
Filler, S. G. (2011) · Cytokine · doi:10.1016/j.cyto.2011.09.018 · Cited by 19
“The receptor encoded by this gene was not detectable on the patient’s cells, and his fibroblasts did not respond to IL-17A, IL-17F, or an IL-17A/F heterodimer [27].”
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Fungus-Specific CD4 T Cells as Specific Sensors for Identification of Pulmonary Fungal Infections
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Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Psoriasis
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Physiological roles of human interleukin‐17 family
Liu, Y., Ouyang, Y., You, W., Liu, W., Cheng, Y., Mai, X., & Shen, Z. (2023) · Experimental Dermatology · doi:10.1111/exd.14964 · Cited by 22
“34–37 Interestingly, a similar phenomenon can be observed in animal studies whereby mouse models with IL-17 deficiency, have a severely impaired defence reaction in skin and mucous membranes to Candida albicans infection, confirming the involvement of IL-17 in the resistance to Candida albicans .”
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“AD IL-17F 46 and AR IL-17RA, 46,47 IL-17RC, 48 and ACT1 deficiency 49–54 are classified as causative for iCMC.”
BackgroundGuo, T., Huo, Y., Zhu, W., Xu, F., Liu, C., Liu, N., Cao, M., Cui, B., & Ning, G. (2012) · Gene · doi:10.1016/j.gene.2012.10.021 · Cited by 18
Skin Mycobiome of Psoriasis Patients is Retained during Treatment with TNF and IL-17 Inhibitors
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“, chronic mucocutaneous candidiasis) [10].”
Hemdan, N. Y. A., El-Saad, A. M. A., & Sack, U. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/374769 · Cited by 18
“Moreover, studies on nucleotide oligomerization domain knockout mice (Nod1−/− and Nod2−/−) demonstrated that this “early” TH17 response was Nod1- and Nod2-dependent, and hence they have been given the name innate (i)TH17 cells [35].”
BackgroundChronic mucocutaneous candidiasis, a case study and literature review
Khosravi, A., Mansouri, P., Saffarian, Z., Vahedi, G., & Nikaein, D. (2018) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2018.02.004 · Cited by 18
Wu, U., Olivier, K. N., Kuhns, D. B., Fink, D. L., Sampaio, E. P., Zelazny, A. M., Shallom, S. J., Marciano, B. E., Lionakis, M. S., & Holland, S. M. (2019) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofz484 · Cited by 18
“It has been well described that inborn errors of IL-17 immunity contribute to chronic mucocutaneous candidiasis (CMC) [28], which was absent in our patients.”
BackgroundγδT17/γδTreg cell subsets: a new paradigm for asthma treatment
Yao, Y., Qin, C., Yang, C., & Huang, T.-X. (2021) · Journal of Asthma · doi:10.1080/02770903.2021.1980585 · Cited by 18
“Furthermore, the IL-17A and IL-17F absence or mutations in their signaling pathway lead to chronic mucocutaneous candidiasis, and they are particularly important for control of mucocutaneous infections in humans (65,66).”
Background
Metadata
- Authors
- Puel, A., Cypowyj, S., Bustamante, J., Wright, J. F., Liu, L., Lim, H. K., Migaud, M., Israel, L., Chrabieh, M., Audry, M., Gumbleton, M., Toulon, A., Bodemer, C., El-Baghdadi, J., Whitters, M., Paradis, T., Brooks, J., Collins, M., Wolfman, N. M., Al-Muhsen, S., Galicchio, M., Abel, L., Picard, C., & Casanova, J.-L.
- Affiliations
- Inserm (FR)
- Rockefeller University (US)
- Pfizer (United States) (US)
- Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, U980, and University Paris Descartes, Necker Medical School, 75015 Paris, France.
- SUNY Upstate Medical University (US)
- Hôpital Necker-Enfants Malades (FR)
- Unit of Genetics, Military Hospital of Instruction Mohamed V, Rabat 10000, Morocco.
- Prince Naif Center for Immunology Research, Department of Pediatrics, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.
- Victor J. Vilela Children’s Hospital, Rosario, Santa Fe 2000, Argentina.
- Corresponding author
- Puel, Anne
- Cypowyj, Sophie
- Abel, Laurent
- Casanova, Jean-Laurent
- ORCID
- Venue
- Science
- Published
- 2011-04
- Volume
- 332
- Issue
- 6025
- Pages
- 65-68
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3070042
- OpenAlex
- W2034453891
- Cited by
- 1,056
- References
- 30
- Citations by year
- 2026: 26 · 2025: 35 · 2024: 29 · 2023: 54 · 2022: 52 · 2021: 64 · 2020: 76 · 2019: 57 · 2018: 67 · 2017: 84 · 2016: 81 · 2015: 76 · 2014: 94 · 2013: 95 · 2012: 103
- FWCI
- 49.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Center for Research Resources (UL1RR024143)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- chronic mucocutaneous candidiasis, IL-17A, Candida albicans, primary immunodeficiency, autosomal recessive inheritance, autosomal dominant inheritance
- MeSH terms
- Candida albicans, Candidiasis, Chronic Mucocutaneous, Child, Child, Preschool, Female, Genes, Dominant, Genes, Recessive, Humans, Male, Molecular Sequence Data, Mutation, Pedigree, Signal Transduction, Interleukin-17, Receptors, Interleukin-17, Th17 Cells
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