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The Centrosome in Cells and Organisms
Abstract
Centrosome Center Stage?: The centrosome is a major organizer of the cytoskeleton in animal cells. The precise duplication of this organelle at each cell cycle ensures proper organization of the mitotic apparatus and chromosome segregation. However, centrosomes are dispensable for cell division during some stages of development in mouse and Drosophila . Bornens (p. 422 ) reviews the role of the centrosome in a variety of organisms and discusses how and why they can be dispensed with on occasion. In this vein, Azimzadeh et al. (p. 461 , published online 5 January) now demonstrate that centrosomes in Planarian flatworms, best known for their remarkable regeneration abilities, are completely dispensable for both cell division and development.
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Cites
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Megraw, T. L., Sharkey, J. T., & Nowakowski, R. S. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.04.007 · Cited by 124
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Francia, M. E., & Striepen, B. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3184 · Cited by 301
The roles of evolutionarily conserved functional modules in cilia-related trafficking
Sung, C.-H., & Leroux, M. R. (2013) · Nature Cell Biology · doi:10.1038/ncb2888 · Cited by 186
A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility
Sheu, S.-H., Upadhyayula, S., Dupuy, V., Pang, S., Deng, F., Wan, J., Walpita, D., Pasolli, H. A., Houser, J., Sanchez-Martinez, S., et al. (2022) · Cell · doi:10.1016/j.cell.2022.07.026 · Cited by 162
Retinal disease in ciliopathies: Recent advances with a focus on stem cell-based therapies
Chen, H. Y., Welby, E., Li, T., & Swaroop, A. (2019) · Translational Science of Rare Diseases · doi:10.3233/trd-190038 · Cited by 44
Castellano-Pellicena, I., Morrison, C. G., Bell, M., O’Connor, C., & Tobin, D. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063143 · Cited by 35
Metadata
- Authors
- Bornens, M.
- Venue
- Science
- Published
- 2012-01-27
- Volume
- 335
- Issue
- 6067
- Pages
- 422-426
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2048718074
- Cited by
- 480
- References
- 1
- FWCI
- 19.74
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.