The roles of evolutionarily conserved functional modules in cilia-related trafficking
Open accessAbstract
Cilia are present across most eukaryotic phyla and have diverse sensory and motility roles in animal physiology, cell signalling and development. Their biogenesis and maintenance depend on vesicular and intraciliary (intraflagellar) trafficking pathways that share conserved structural and functional modules. The functional units of the interconnected pathways, which include proteins involved in membrane coating as well as small GTPases and their accessory factors, were first experimentally associated with canonical vesicular trafficking. These components are, however, ancient, having been co-opted by the ancestral eukaryote to establish the ciliary organelle, and their study can inform us about ciliary biology in higher organisms.
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Vesicular transport pathways deliver specific receptors or signalling molecules from the Golgi or recycling endosome to the ciliary base, where vesicles are exocytosed.
“These include vesicular transport pathways that target specific receptors or signalling molecules from the Golgi or recycling endosome to the ciliary base where vesicles are exocytosed 22, 23,”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [22]
The ‘Vesicular and membrane trafficking for ciliary proteins’ section describes possible routes from the trans-Golgi network to the periciliary membrane, including one via the recycling endosome. ‘Trafficking directly to the periciliary membrane’ says vesicle fusion there is probable, not established; the citing sentence presents that step as definite. Page numbers are unavailable in our copy. (LLM, conf=0.82)
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THE DEVELOPMENT OF BASAL BODIES AND FLAGELLA IN ALLOMYCES ARBUSCULUS
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Flagged first, then by citations
Cited by
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Self-citation
- Authors
- Sung, C.-H., & Leroux, M. R.
- Affiliations
- Cornell University (US)
- Simon Fraser University (CA)
- Corresponding author
- Leroux, Michel R.
- Venue
- Nature Cell Biology
- Published
- 2013-12
- Volume
- 15
- Issue
- 12
- Pages
- 1387-1397
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC4016715
- OpenAlex
- W2023459232
- Cited by
- 186
- References
- 150
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 10 · 2021: 12 · 2020: 9 · 2019: 17 · 2018: 18 · 2017: 22 · 2016: 29 · 2015: 30 · 2014: 15 · 2013: 1
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Canadian Institutes of Health Research (123527_1)
- National Eye Institute (EY11307, R01EY016805, R01EY011307, EY016805)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- cilia, ciliary trafficking, cilia biogenesis, vesicle trafficking, small GTPases, flagella, sensory cilia, motile cilia
- MeSH terms
- Animals, Cell Membrane, Centrioles, Cilia, Biological Evolution, Flagella, Golgi Apparatus, Humans, Endosomes, Protein Transport, Transport Vesicles, Metabolic Networks and Pathways
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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