Cited by 186Genetic and Kidney Cyst DiseasesCystic Fibrosis Research AdvancesCellular transport and secretion

The roles of evolutionarily conserved functional modules in cilia-related trafficking

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Sung, Ching-Hwa, Leroux, Michel R.·2013·Nature Cell Biology

Abstract

Cilia are present across most eukaryotic phyla and have diverse sensory and motility roles in animal physiology, cell signalling and development. Their biogenesis and maintenance depend on vesicular and intraciliary (intraflagellar) trafficking pathways that share conserved structural and functional modules. The functional units of the interconnected pathways, which include proteins involved in membrane coating as well as small GTPases and their accessory factors, were first experimentally associated with canonical vesicular trafficking. These components are, however, ancient, having been co-opted by the ancestral eukaryote to establish the ciliary organelle, and their study can inform us about ciliary biology in higher organisms.

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  • Vesicular transport pathways deliver specific receptors or signalling molecules from the Golgi or recycling endosome to the ciliary base, where vesicles are exocytosed.

    “These include vesicular transport pathways that target specific receptors or signalling molecules from the Golgi or recycling endosome to the ciliary base where vesicles are exocytosed 22, 23,”

    From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [22]

    The ‘Vesicular and membrane trafficking for ciliary proteins’ section describes possible routes from the trans-Golgi network to the periciliary membrane, including one via the recycling endosome. ‘Trafficking directly to the periciliary membrane’ says vesicle fusion there is probable, not established; the citing sentence presents that step as definite. Page numbers are unavailable in our copy. (LLM, conf=0.82)

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Authors
Sung, C.-H., & Leroux, M. R.
Affiliations
  • Cornell University (US)
  • Simon Fraser University (CA)
Corresponding author
Leroux, Michel R.
Venue
Nature Cell Biology
Published
2013-12
Volume
15
Issue
12
Pages
1387-1397
ISSN
  • 1465-7392 (ISSN-L)
  • 1476-4679
OpenAlex
W2023459232
Cited by
186
References
150
Citations by year
2026: 3 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 10 · 2021: 12 · 2020: 9 · 2019: 17 · 2018: 18 · 2017: 22 · 2016: 29 · 2015: 30 · 2014: 15 · 2013: 1
FWCI
3.08
Type
journal article
Language
en
Open access
Locations
  • Nature Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • Canadian Institutes of Health Research (123527_1)
  • National Eye Institute (EY11307, R01EY016805, R01EY011307, EY016805)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
cilia, ciliary trafficking, cilia biogenesis, vesicle trafficking, small GTPases, flagella, sensory cilia, motile cilia
MeSH terms
Animals, Cell Membrane, Centrioles, Cilia, Biological Evolution, Flagella, Golgi Apparatus, Humans, Endosomes, Protein Transport, Transport Vesicles, Metabolic Networks and Pathways

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