Cited by 124Neurogenesis and neuroplasticity mechanismsMicrotubule and mitosis dynamicsFetal and Pediatric Neurological Disorders

Cdk5rap2 exposes the centrosomal root of microcephaly syndromes

Open access
Megraw, Timothy L., Sharkey, James T., Nowakowski, Richard S.·2011·Trends in Cell Biology

Abstract

Autosomal recessive primary microcephaly (MCPH) is characterized by small brain size as a result of deficient neuron production in the developing cerebral cortex. Although MCPH is a rare disease, the questions surrounding its etiology strike at the core of stem cell biology. The seven genes implicated in MCPH all encode centrosomal proteins and disruption of the MCPH gene Cdk5rap2 in mice revealed its role in neural progenitor proliferation and in maintaining normal centriole replication control. We discuss here the impact that centrosome regulation has upon neural progenitors in the developing brain. We integrate the impact of centriole replication defects with the functions of Cdk5rap2 and other MCPH proteins, propose mechanisms for progenitor loss in MCPH, and discuss links to two other microcephaly syndromes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.tcb.2011.04.007

Cites

90 of 90 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Megraw, T. L., Sharkey, J. T., & Nowakowski, R. S.
Affiliations
Florida State University (US)
Corresponding author
Megraw, Timothy L.
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2011-08
Volume
21
Issue
8
Pages
470-480
ISSN
0962-8924 (ISSN-L)
OpenAlex
W2073555909
Cited by
124
References
90
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 9 · 2019: 14 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 11 · 2014: 14 · 2013: 13 · 2012: 11
FWCI
1.04
Type
journal article
Language
en
Open access
Locations
  • Trends in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of General Medical Sciences (GM068756, R01GM068756)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords
CDK5RAP2, primary microcephaly, centriole replication, neural progenitor proliferation, cortical development, centrosomal proteins, mouse model
MeSH terms
Animals, Humans, Microcephaly, Microtubule-Associated Proteins, Spindle Apparatus, Nerve Tissue Proteins, Centrosome, Intracellular Signaling Peptides and Proteins, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review