Cdk5rap2 exposes the centrosomal root of microcephaly syndromes
Open accessAbstract
Autosomal recessive primary microcephaly (MCPH) is characterized by small brain size as a result of deficient neuron production in the developing cerebral cortex. Although MCPH is a rare disease, the questions surrounding its etiology strike at the core of stem cell biology. The seven genes implicated in MCPH all encode centrosomal proteins and disruption of the MCPH gene Cdk5rap2 in mice revealed its role in neural progenitor proliferation and in maintaining normal centriole replication control. We discuss here the impact that centrosome regulation has upon neural progenitors in the developing brain. We integrate the impact of centriole replication defects with the functions of Cdk5rap2 and other MCPH proteins, propose mechanisms for progenitor loss in MCPH, and discuss links to two other microcephaly syndromes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Centrosome-related proteins are overrepresented in studies on the microcephaly phenotype in humans.
“centrosome-related proteins are overrepresented in studies on the microcephaly phenotype in humans70.”
From A catalog of single nucleotide changes distinguishing modern humans from archaic hominins (2019) · cites this paper as [70]
The centrosome-cilium interface is critical for early brain development.
“The centrosome-cilium interface is known to be critical for early brain development”
From A catalog of single nucleotide changes distinguishing modern humans from archaic hominins (2019) · cites this paper as [70]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130 · see citing works
The primary cilium: a signalling centre during vertebrate development
Goetz, S. C., & Anderson, K. V. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2774 · Cited by 1,824 · see citing works
Evolution of the neocortex: a perspective from developmental biology
Rakic, P. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2719 · Cited by 1,565 · see citing works
A mechanism linking extra centrosomes to chromosomal instability
Ganem, N. J., Godinho, S. A., & Pellman, D. S. (2009) · Nature · doi:10.1038/nature08136 · Cited by 1,427 · see citing works
Centrioles, Centrosomes, and Cilia in Health and Disease
Nigg, E. A., & Raff, J. W. (2009) · Cell · doi:10.1016/j.cell.2009.10.036 · Cited by 898 · see citing works
Ruzankina, Y., Pinzon‐Guzman, C., Asare, A., Ong, T., Pontano, L. L., Cotsarelis, G., Zediak, V. P., Velez, M., Bhandoola, A., & Brown, E. J. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.03.002 · Cited by 780 · see citing works
Basto, R., Lau, J., Vinogradova, T. M., Gardiol, A., Woods, C. G., Khodjakov, A. L., & Raff, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.05.025 · Cited by 686 · see citing works
The Primary Cilium as a Complex Signaling Center
Berbari, N. F., O'Connor, A. K., Haycraft, C. J., & Yoder, B. K. (2009) · Current Biology · doi:10.1016/j.cub.2009.05.025 · Cited by 621 · see citing works
Centrosome biogenesis and function: centrosomics brings new understanding
Bettencourt‐Dias, M., & Glover, D. M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2180 · Cited by 583 · see citing works
A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size
Bond, J., Roberts, E., Springell, K., Lizarraga, S., Scott, S., Higgins, J. W., Hampshire, D. J., Morrison, E. E., Leal, G. F., Silva, E. O., et al. (2005) · Nature Genetics · doi:10.1038/ng1539 · Cited by 564 · see citing works
Centrosome Amplification Can Initiate Tumorigenesis in Flies
Basto, R., Brunk, K., Vinadogrova, T., Peel, N., Franz, A., Khodjakov, A. L., & Raff, J. W. (2008) · Cell · doi:10.1016/j.cell.2008.05.039 · Cited by 562 · see citing works
Asymmetric Inheritance of Mother Versus Daughter Centrosome in Stem Cell Division
Yamashita, Y. M., Mahowald, A. P., Perlin, J. R., & Fuller, M. T. (2007) · Science · doi:10.1126/science.1134910 · Cited by 561 · see citing works
Cep164, a novel centriole appendage protein required for primary cilium formation
Graser, S., Stierhof, Y., Lavoie, S., Gassner, O., Lamla, S., Clech, M. L., & Nigg, E. A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200707181 · Cited by 517 · see citing works
Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations
Bilgüvar, K., Öztürk, A. K., Louvi, A., Kwan, K. Y., Choi, M., Tatlı, B., Yalnızoğlu, D., Tüysüz, B., Çağlayan, A. O., Gökben, S., et al. (2010) · Nature · doi:10.1038/nature09327 · Cited by 503 · see citing works
Konno, D., Shioi, G., Shitamukai, A., Mori, A., Kiyonari, H., Miyata, T., & Matsuzaki, F. (2007) · Nature Cell Biology · doi:10.1038/ncb1673 · Cited by 502 · see citing works
Asymmetric centrosome inheritance maintains neural progenitors in the neocortex
Wang, X., Tsai, J., Imai, J. H., Lian, W.-N., Vallee, R. B., & Shi, S. (2009) · Nature · doi:10.1038/nature08435 · Cited by 477 · see citing works
Spindle orientation during asymmetric cell division
Siller, K. H., & Doe, C. Q. (2009) · Nature Cell Biology · doi:10.1038/ncb0409-365 · Cited by 474 · see citing works
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells
Fish, J. L., Kosodo, Y., Enard, W., Pääbo, S., & Huttner, W. B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604066103 · Cited by 421 · see citing works
Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis
Noctor, S. C., Martínez‐Cerdeño, V., & Kriegstein, A. R. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21669 · Cited by 415 · see citing works
Primary microcephaly: do all roads lead to Rome?
Thornton, G., & Woods, C. G. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.09.011 · Cited by 396 · see citing works
Mutations in the Pericentrin ( PCNT ) Gene Cause Primordial Dwarfism
Rauch, A. M., Thiel, C. T., Schindler, D., Wick, U., Crow, Y. J., Ekici, A. B., van Essen, A. J., Goecke, T. O., Al‐Gazali, L., Chrzańowska, K., et al. (2008) · Science · doi:10.1126/science.1151174 · Cited by 396 · see citing works
Mitotic Spindle Regulation by Nde1 Controls Cerebral Cortical Size
Feng, Y., & Walsh, C. A. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.023 · Cited by 353 · see citing works
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling
Griffith, E., Walker, S., Martin, C.-A., Vagnarelli, P., Stiff, T., Vernay, B., Sanna, N. A., Saggar, A., Hamel, B. C. J., Earnshaw, W. C., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.80 · Cited by 301 · see citing works
Polo Kinase and Separase Regulate the Mitotic Licensing of Centriole Duplication in Human Cells
Tsou, M.-F. B., Wang, W., George, K. A., Uryu, K., Stearns, T., & Jallepalli, P. V. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.07.015 · Cited by 300 · see citing works
WDR62 is associated with the spindle pole and is mutated in human microcephaly
Nicholas, A. K., Khurshid, M., Désir, J., Carvalho, O. P., Cox, J. J., Thornton, G., Kausar, R., Ansar, M., Ahmad, W., Verloès, A., et al. (2010) · Nature Genetics · doi:10.1038/ng.682 · Cited by 297 · see citing works
Yu, T. W., Mochida, G. H., Tischfield, D. J., Sgaier, S. K., Flores‐Sarnat, L., Sergi, C. M., Topçu, M., McDonald, M., Barry, B. J., Felie, J. M., et al. (2010) · Nature Genetics · doi:10.1038/ng.683 · Cited by 294 · see citing works
Rebollo, E., Sampaio, P., Januschke, J., Llamazares, S., Varmark, H., & González, C. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.01.021 · Cited by 291 · see citing works
Asterless is a scaffold for the onset of centriole assembly
Dzhindzhev, N. S., Yu, Q. D., Weiskopf, K., Tzolovsky, G., Cunha‐Ferreira, I., Riparbelli, M. G., Rodrigues-Martins, A., Bettencourt‐Dias, M., Callaini, G., & Glover, D. M. (2010) · Nature · doi:10.1038/nature09445 · Cited by 284 · see citing works
Cep152 interacts with Plk4 and is required for centriole duplication
Hatch, E. M., Kulukian, A., Holland, A. J., Cleveland, D. W., & Stearns, T. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201006049 · Cited by 284 · see citing works
Fong, K.-W., Choi, Y.-K., Rattner, J. B., & Qi, R. Z. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-04-0371 · Cited by 283 · see citing works
Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome
Cizmecioglu, O., Arnold, M., Bahtz, R., Settele, F., Ehret, L., Haselmann-Weiß, U., Antony, C., & Hoffmann, I. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201007107 · Cited by 277 · see citing works
CDK5RAP2 stimulates microtubule nucleation by the γ-tubulin ring complex
Choi, Y.-K., Liu, P., Sze, S. K., Dai, C., & Qi, R. Z. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201007030 · Cited by 273 · see citing works
Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors
Lizarraga, S. B., Margossian, S. P., Harris, M. H., Campagna, D. R., Han, A., Blevins, S., Mudbhary, R., Barker, J. E., Walsh, C. A., & Fleming, M. D. (2010) · Development · doi:10.1242/dev.040410 · Cited by 270 · see citing works
A role for a novel centrosome cycle in asymmetric cell division
Rusan, N. M., & Peifer, M. A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200612140 · Cited by 255 · see citing works
Farkas, L. M., & Huttner, W. Β. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.09.008 · Cited by 247 · see citing works
Morin, X., Jaouen, F., & Durbec, P. L. (2007) · Nature Neuroscience · doi:10.1038/nn1984 · Cited by 245 · see citing works
Mutations in STIL, Encoding a Pericentriolar and Centrosomal Protein, Cause Primary Microcephaly
Kumar, A., Girimaji, S. C., Duvvari, M. R., & Blanton, S. H. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.01.017 · Cited by 231 · see citing works
CEP152 is a genome maintenance protein disrupted in Seckel syndrome
Kalay, E., Yigit, G., Aslan, Y., Brown, K. E., Pohl, E., Bicknell, L. S., Kayserili, H., Li, Y., Tüysüz, B., Nürnberg, G., et al. (2010) · Nature Genetics · doi:10.1038/ng.725 · Cited by 228 · see citing works
Zygotic development without functional mitotic centrosomes
Megraw, T. L., Kao, L.-R., & Kaufman, T. C. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00017-3 · Cited by 226 · see citing works
Self-citationHaren, L., Stearns, T., & Lüders, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005976 · Cited by 222 · see citing works
Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion
Graser, S., Stierhof, Y., & Nigg, E. A. (2007) · Journal of Cell Science · doi:10.1242/jcs.020248 · Cited by 218 · see citing works
Many roads lead to primary autosomal recessive microcephaly
Kaindl, A. M., Passemard, S., Kumar, P., Kraemer, N., Issa, L., Zwirner, A., Gérard, B., Verloès, A., Mani, S., & Gressèns, P. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.11.002 · Cited by 208 · see citing works
Mutations in Centrosomal Protein CEP152 in Primary Microcephaly Families Linked to MCPH4
Guernsey, D. L., Jiang, H., Hussin, J., Arnold, M., Bouyakdan, K., Perry, S., Babineau-Sturk, T., Beis, J., Dumas, N., Evans, S. C., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.06.003 · Cited by 200 · see citing works
Drosophila neuroblasts retain the daughter centrosome
Januschke, J., Llamazares, S., Reina, J., & González, C. (2011) · Nature Communications · doi:10.1038/ncomms1245 · Cited by 196 · see citing works
Pulvers, J. N., Bryk, J., Fish, J. L., Wilsch‐Bräuninger, M., Arai, Y., Schreier, D., Naumann, R., Helppi, J., Habermann, B. H., Vogt, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010494107 · Cited by 194 · see citing works
Pericentrin in cellular function and disease
Delaval, B., & Doxsey, S. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200908114 · Cited by 191 · see citing works
Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells
González, C. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2103 · Cited by 189 · see citing works
Imai, F., Hirai, S.-I., Akimoto, K., Koyama, H., Miyata, T., Ogawa, M., Noguchi, S., Sasaoka, T., Noda, T., & Ohno, S. (2006) · Development · doi:10.1242/dev.02330 · Cited by 178 · see citing works
Buchman, J. J., Tseng, H.-C., Zhou, Y., Frank, C. L., Xie, Z., & Tsai, L. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.036 · Cited by 177 · see citing works
Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway
Alderton, G. K., Joenje, H., Varon, R., Børglum, A. D., Jeggo, P. A., & O’Driscoll, M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh335 · Cited by 177 · see citing works
Regulation of mitotic entry by microcephalin and its overlap with ATR signalling
Alderton, G. K., Galbiati, L., Griffith, E., Surinya, K. H., Neitzel, H., Jackson, A. P., Jeggo, P. A., & O’Driscoll, M. (2006) · Nature Cell Biology · doi:10.1038/ncb1431 · Cited by 168 · see citing works
Drosophila asterless and Vertebrate Cep152 Are Orthologs Essential for Centriole Duplication
Blachon, S., Gopalakrishnan, J., Omori, Y., Polyanovsky, A. D., Church, A., Nicastro, D., Malicki, J. J., & Avidor‐Reiss, T. (2008) · Genetics · doi:10.1534/genetics.108.095141 · Cited by 167 · see citing works
Centrioles Regulate Centrosome Size by Controlling the Rate of Cnn Incorporation into the PCM
Conduit, P. T., Brunk, K., Dobbelaere, J., Dix, C. I., Lucas, E. P., & Raff, J. W. (2010) · Current Biology · doi:10.1016/j.cub.2010.11.011 · Cited by 167 · see citing works
Novel CENPJ mutation causes Seckel syndrome
Aldosari, M., Shaheen, R., Çolak, D., & Alkuraya, F. S. (2010) · Journal of Medical Genetics · doi:10.1136/jmg.2009.076646 · Cited by 164 · see citing works
Conduit, P. T., & Raff, J. W. (2010) · Current Biology · doi:10.1016/j.cub.2010.11.055 · Cited by 164 · see citing works
Neurogenesis and asymmetric cell division
Zhong, W., & Chia, W. N. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.05.002 · Cited by 163 · see citing works
CDK5RAP2 Regulates Centriole Engagement and Cohesion in Mice
Barrera, J. A., Kao, L.-R., Hammer, R. E., Seemann, J., Fuchs, J. L., & Megraw, T. L. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.05.017 · Cited by 162 · see citing works
Self-citationCytoskeletal genes regulating brain size
Bond, J., & Woods, C. G. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.11.004 · Cited by 150 · see citing works
Role of primary cilia in brain development and cancer
Han, Y.-G., & Álvarez-Buylla, A. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.12.002 · Cited by 149 · see citing works
Conserved Motif of CDK5RAP2 Mediates Its Localization to Centrosomes and the Golgi Complex
Wang, Z., Wu, T., Shi, L., Zhang, L., Zheng, W., Qu, J. Y., Niu, R., & Qi, R. Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.105965 · Cited by 132 · see citing works
Lucas, E. P., & Raff, J. W. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704081 · Cited by 126 · see citing works
Asymmetric centrosome behavior and the mechanisms of stem cell division
Yamashita, Y. M., & Fuller, M. T. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200707083 · Cited by 121 · see citing works
CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response
Barr, A. R., Kilmartin, J. V., & Gergely, F. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200912163 · Cited by 120 · see citing works
DNA damage induces Chk1‐dependent centrosome amplification
Bourke, E., Dodson, H., Merdes, A., Cuffe, L., Zachos, G., Walker, M., Gillespie, D. A., & Morrison, C. G. (2007) · EMBO Reports · doi:10.1038/sj.embor.7400962 · Cited by 120 · see citing works
Willems, M., Geneviève, D., Borck, G., Baumann, C., Baujat, G., Bieth, É., Edery, P., Farra, C., Gerard, M., Héron, D., et al. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2009.067298 · Cited by 113 · see citing works
Structure meets function—Centrosomes, genome maintenance and the DNA damage response
Löffler, H., Lukas, J., Bártek, J., & Krämer, A. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.06.008 · Cited by 108 · see citing works
Liang, Y., Gao, H., Lin, S., Peng, G., Huang, X., Zhang, P., Goss, J. A., Brunicardi, F. C., Multani, A. S., Chang, S. S., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000826 · Cited by 106 · see citing works
Tarui, T., Takahashi, T., Nowakowski, R. S., Hayes, N. L., Bhide, P. G., & Caviness, V. S. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi017 · Cited by 106 · see citing works
Self-citationZhang, J., & Megraw, T. L. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-05-0474 · Cited by 104 · see citing works
Self-citationJanuschke, J., & González, C. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200905024 · Cited by 101 · see citing works
A clinical and molecular genetic study of 112 Iranian families with primary microcephaly
Darvish, H., Esmaeeli, S., Monajemi, G. B., Mohseni, M., Firouzabadi, S. G., Abedini, S. S., Bahman, I., Jamali, P., Azimi, S., Mojahedi, F., et al. (2010) · Journal of Medical Genetics · doi:10.1136/jmg.2009.076398 · Cited by 96 · see citing works
Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1
Tibelius, A., Marhold, J., Zentgraf, H., Heilig, C. E., Neitzel, H., Ducommun, B., Rauch, A. M., Ho, A. D., Bártek, J., & Krämer, A. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200810159 · Cited by 94 · see citing works
Ab ovo or de novo? Mechanisms of Centriole Duplication
Lončarek, J., & Khodjakov, A. L. (2009) · Molecules and Cells · doi:10.1007/s10059-009-0017-z · Cited by 81 · see citing works
Jeffers, L. J., Coull, B. J., Stack, S. J., & Morrison, C. G. (2007) · Oncogene · doi:10.1038/sj.onc.1210595 · Cited by 80 · see citing works
Fong, K.-W., Hau, S.-Y., Kho, Y. S., Jia, Y., He, L., & Qi, R. Z. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-01-0009 · Cited by 67 · see citing works
Spindle regulation in neural precursors of flies and mammals
Buchman, J. J., & Tsai, L. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2058 · Cited by 60 · see citing works
Inanç, B., Dodson, H., & Morrison, C. G. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-02-0124 · Cited by 58 · see citing works
Samejima, I., Miller, V. J., Groocock, L., & Sawin, K. E. (2008) · Journal of Cell Science · doi:10.1242/jcs.038414 · Cited by 58 · see citing works
Fission Yeast Mto1 Regulates Diversity of Cytoplasmic Microtubule Organizing Centers
Samejima, I., Miller, V. J., Rincón, S. A., & Sawin, K. E. (2010) · Current Biology · doi:10.1016/j.cub.2010.10.006 · Cited by 57 · see citing works
Emerging Connection Between Centrosome and DNA Repair Machinery
Shimada, M., & Komatsu, K. (2009) · Journal of Radiation Research · doi:10.1269/jrr.09039 · Cited by 56 · see citing works
Trimborn, M., Ghani, M., Walther, D. J., Dopatka, M., Dutrannoy, V., Busche, A., Meyer, F. I., Nowak, S., Nowak, J., Zabel, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009242 · Cited by 53 · see citing works
Lee, S., & Rhee, K. (2010) · Cell Cycle · doi:10.4161/cc.9.4.10667 · Cited by 49 · see citing works
CDK5RAP2 is required for spindle checkpoint function
Zhang, X., Liu, D., Lv, S., Wang, H., Zhong, X., Liu, B., Wang, B., Liao, J., Li, J., Pfeifer, G. P., et al. (2009) · Cell Cycle · doi:10.4161/cc.8.8.8205 · Cited by 48 · see citing works
A Tale of Too Many Centrosomes
Açılan, C., & Saunders, W. S. (2008) · Cell · doi:10.1016/j.cell.2008.08.007 · Cited by 40 · see citing works
Histogenetic Processes Leading to the Laminated Neocortex: Migration Is Only a Part of the Story
Caviness, V. S., Bhide, P. G., & Nowakowski, R. S. (2007) · Developmental Neuroscience · doi:10.1159/000109854 · Cited by 39 · see citing works
Self-citationPiane, M., Monica, M. D., Piatelli, G., Lulli, P., Lonardo, F., Chessa, L., & Scarano, G. (2009) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33035 · Cited by 34 · see citing works
MCPH1/BRIT1 limits ionizing radiation-induced centrosome amplification
Brown, J. A. L., Bourke, E., Liptrot, C. H., Dockery, P., & Morrison, C. G. (2010) · Oncogene · doi:10.1038/onc.2010.302 · Cited by 32 · see citing works
Neural stem cells: the need for a proper orientation
Lesage, B., Gutiérrez, I. L., Martı́, E., & González, C. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.04.013 · Cited by 30 · see citing works
Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans
Fujimori, A., Yaoi, T., Ogi, H., Wang, B. H., Suetomi, K., Sekine, E., Yu, D., Kato, T. A., Takahashi, S., Okayasu, R., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.02.149 · Cited by 30 · see citing works
High incidence, early onset of histiocytic sarcomas in mice with Hertwig's anemia
Barker, J. E., Deveau, S. A., Compton, S. T., Fancher, K. S., & Eppig, J. T. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.06.021 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cerebral organoids model human brain development and microcephaly
Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372 · see citing works
Taverna, E., Götz, M., & Huttner, W. Β. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155801 · Cited by 737 · see citing works
Centrosome function and assembly in animal cells
Conduit, P. T., Wainman, A., & Raff, J. W. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4062 · Cited by 565 · see citing works
The Centrosome in Cells and Organisms
Bornens, M. (2012) · Science · doi:10.1126/science.1209037 · Cited by 480 · see citing works
Growth and folding of the mammalian cerebral cortex: from molecules to malformations
Sun, T., & Hevner, R. F. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3707 · Cited by 471 · see citing works
The Genetics of Primary Microcephaly
Jayaraman, D., Bae, B.-I., & Walsh, C. A. (2018) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083117-021441 · Cited by 277 · see citing works
Centrosome amplification causes microcephaly
Marthiens, V., Rujano, M. A., Pennetier, C., Tessier, S., Paul‐Gilloteaux, P., & Basto, R. (2013) · Nature Cell Biology · doi:10.1038/ncb2746 · Cited by 262 · see citing works
Molecular genetics of human primary microcephaly: an overview
Faheem, M., Naseer, M. I., Rasool, M., Chaudhary, A., Kumosani, T., Ilyas, A. M., Pushparaj, P. N., Ahmed, F., Algahtani, H. A., Al-Qahtani, M. H., et al. (2015) · BMC Medical Genomics · doi:10.1186/1755-8794-8-s1-s4 · Cited by 234 · see citing works
Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication
Sonnen, K. F., Gabryjonczyk, A.-M., Anselm, E., Stierhof, Y., & Nigg, E. A. (2013) · Journal of Cell Science · doi:10.1242/jcs.129502 · Cited by 236 · see citing works
Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis
Joukov, V., & Nicolo, A. D. (2018) · Science Signaling · doi:10.1126/scisignal.aar4195 · Cited by 208 · see citing works
Lee, C., Bendriem, R. M., Wu, W. W., & Shen, R. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0362-8 · Cited by 198 · see citing works
Zhang, W., Yang, S.-L., Yang, M., Herrlinger, S. A., Shao, Q., Collar, J. L., Fierro, E., Shi, Y., Liu, A., Lü, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10497-2 · Cited by 190 · see citing works
Spindle orientation in mammalian cerebral cortical development
Lancaster, M. A., & Knoblich, J. A. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.04.003 · Cited by 158 · see citing works
Chen, J.-F., Zhang, Y., Wilde, J. J., Hansen, K. C., Lai, F., & Niswander, L. A. (2014) · Nature Communications · doi:10.1038/ncomms4885 · Cited by 153 · see citing works
Jayaraman, D., Kodani, A., Gonzalez, D. M., Mancias, J. D., Mochida, G. H., Vagnoni, C., Johnson, J. R., Krogan, N. J., Harper, J. W., Reiter, J. F., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.056 · Cited by 146 · see citing works
Small organelle, big responsibility: the role of centrosomes in development and disease
Chavali, P. L., Pütz, M., & Gergely, F. V. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0468 · Cited by 150 · see citing works
Amorphous no more: subdiffraction view of the pericentriolar material architecture
Mennella, V., Agard, D. A., Huang, B., & Pelletier, L. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.10.001 · Cited by 148 · see citing works
+TIPs: SxIPping along microtubule ends
Kumar, P., & Wittmann, T. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.05.005 · Cited by 146 · see citing works
Zhang, X., Ling, J., Barcia, G., Jing, L., Wu, J., Barry, B. J., Mochida, G. H., Hill, R. S., Weimer, J. M., Stein, Q., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.03.003 · Cited by 133 · see citing works
A molecular mechanism of mitotic centrosome assembly in Drosophila
Conduit, P. T., Richens, J. H., Wainman, A., Holder, J. W., Vicente, C. C., Pratt, M. B., Dix, C. I., Novak, Z. A., Dobbie, I. M., Schermelleh, L., et al. (2014) · eLife · doi:10.7554/elife.03399 · Cited by 133 · see citing works
OSVZ progenitors in the human cortex: an updated perspective on neurodevelopmental disease
Ostrem, B. E. L., Lui, J. H., Wang, X., & Kriegstein, A. R. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.03.006 · Cited by 130 · see citing works
ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination
Capecchi, M. R., & Pozner, A. (2015) · Nature Communications · doi:10.1038/ncomms9763 · Cited by 114 · see citing works
Molecular and Cellular Basis of Autosomal Recessive Primary Microcephaly
Barbelanne, M., & Tsang, W. Y. (2014) · BioMed Research International · doi:10.1155/2014/547986 · Cited by 109 · see citing works
A catalog of single nucleotide changes distinguishing modern humans from archaic hominins
Kuhlwilm, M., & Boeckx, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-44877-x · Cited by 108 · see citing works
Mitotic spindle (DIS)orientation and DISease: Cause or consequence?
Noatynska, A., Gotta, M., & Meraldi, P. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201209015 · Cited by 108 · see citing works
The Centrosome and the Primary Cilium: The Yin and Yang of a Hybrid Organelle
Joukov, V., & Nicolo, A. D. (2019) · Cells · doi:10.3390/cells8070701 · Cited by 106 · see citing works
Human centrosome organization and function in interphase and mitosis
Vásquez‐Limeta, A., & Lončarek, J. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.03.020 · Cited by 103 · see citing works
Cottee, M. A., Muschalik, N., Wong, Y. L., Johnson, C. M., Johnson, S., Andreeva, A. E., Oegema, K., Lea, S. M., Raff, J. W., & van Breugel, M. (2013) · eLife · doi:10.7554/elife.01071 · Cited by 101 · see citing works
Scarpa, E., Finet, C., Blanchard, G. B., & Sanson, B. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.10.029 · Cited by 93 · see citing works
ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules
Gai, M., Bianchi, F. T., Vagnoni, C., Vernı̀, F., Bonaccorsi, S., Pasquero, S., Berto, G. E., Sgrò, F., Chiotto, A. M. A., Annaratone, L., et al. (2016) · EMBO Reports · doi:10.15252/embr.201541823 · Cited by 84 · see citing works
Bogoyevitch, M. A., Yeap, Y. Y. C., Qu, Z., Ngoei, K. R. W., Yip, Y. Y., Zhao, T. T., Heng, J. I., & Ng, D. C. H. (2012) · Journal of Cell Science · doi:10.1242/jcs.107326 · Cited by 79 · see citing works
Magini, P., Smits, D. J., Vandervore, L. V., Schot, R., Columbaro, M., Kasteleijn, E., van der Ent, M., Palombo, F., Lequin, M. H., Dremmen, M. H. G., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.08.006 · Cited by 80 · see citing works
Cell Division Modes and Cleavage Planes of Neural Progenitors during Mammalian Cortical DevelopmentPreprint
Matsuzaki, F., & Shitamukai, A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a015719 · Cited by 72 · see citing works
Poulton, J. S., Cuningham, J. C., & Peifer, M. A. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.08.007 · Cited by 74 · see citing works
Neocortex expansion in development and evolution — from cell biology to single genes
Wilsch‐Bräuninger, M., Florio, M., & Huttner, W. Β. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.05.004 · Cited by 73 · see citing works
PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2
Hanafusa, H., Kedashiro, S., Tezuka, M., Funatsu, M., Usami, S., Toyoshima, F., & Matsumoto, K. (2015) · Nature Cell Biology · doi:10.1038/ncb3204 · Cited by 70 · see citing works
Nair, A. R., Singh, P. A., Salvador-Garcia, D., Rodríguez-Crespo, D., Egger, B., & Cabernard, C. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.097 · Cited by 59 · see citing works
DNA damage response in microcephaly development of MCPH1 mouse model
Zhou, Z., Tapias, A., Bruhn, C., Gruber, R., Sukchev, M., & Wang, Z. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.04.017 · Cited by 63 · see citing works
Kristensen, U., Epanchintsev, A., Rauschendorf, M., Laugel, V., Stevnsner, T., Bohr, V. A., Coin, F., & Egly, J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220071110 · Cited by 61 · see citing works
Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved
Komarasamy, T. V., Adnan, N. A. A., James, W., & Balasubramaniam, V. R. M. T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.773191 · Cited by 59 · see citing works
Seabury, C. M., Dowd, S. E., Seabury, P. M., Raudsepp, T., Brightsmith, D. J., Liboriussen, P., Halley, Y., Fisher, C. A., Owens, E. K., Viswanathan, G. G., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062415 · Cited by 56 · see citing works
Autosomal Recessive Primary Microcephaly: Not Just a Small Brain
Zaqout, S., & Kaindl, A. M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.784700 · Cited by 54 · see citing works
Centrosome Remodelling in Evolution
Ito, D., & Bettencourt‐Dias, M. (2018) · Cells · doi:10.3390/cells7070071 · Cited by 55 · see citing works
Paronett, E. M., Meechan, D. W., Karpinski, B. A., LaMantia, A.-S., & Maynard, T. M. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu285 · Cited by 54 · see citing works
The Centrosomal E3 Ubiquitin Ligase FBXO31-SCF Regulates Neuronal Morphogenesis and Migration
Vadhvani, M., Schwedhelm‐Domeyer, N., Mukherjee, C., & Stegmüller, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057530 · Cited by 54 · see citing works
Brain Organoids—A Bottom-Up Approach for Studying Human Neurodevelopment
Karzbrun, E., & Reiner, O. (2019) · Bioengineering · doi:10.3390/bioengineering6010009 · Cited by 45 · see citing works
Farag, H. G., Froehler, S., Oexle, K., Ravindran, E., Schindler, D., Staab, T., Huebner, A., Kraemer, N., Chen, W., & Kaindl, A. M. (2013) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-8-178 · Cited by 44 · see citing works
Tungadi, E. A., Ito, A., Kiyomitsu, T., & Goshima, G. (2017) · Journal of Cell Science · doi:10.1242/jcs.203703 · Cited by 36 · see citing works
The case for DUF1220 domain dosage as a primary contributor to anthropoid brain expansion
Keeney, J., Dumas, L., & Sikela, J. M. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00427 · Cited by 37 · see citing works
When fate follows age: unequal centrosomes in asymmetric cell division
Reina, J., & González, C. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0466 · Cited by 40 · see citing works
Centrosome and spindle assembly checkpoint loss leads to neural apoptosis and reduced brain size
Poulton, J. S., Cuningham, J. C., & Peifer, M. A. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201607022 · Cited by 39 · see citing works
The genetics of congenitally small brains
Duerinckx, S., & Abramowicz, M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.09.015 · Cited by 38 · see citing works
Issa, L., Kraemer, N., Rickert, C. H., Sifringer, M., Ninnemann, O., Stoltenburg, G., & Kaindl, A. M. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs212 · Cited by 37 · see citing works
Issa, L., Mueller, K., Seufert, K., Kraemer, N., Rosenkötter, H., Ninnemann, O., Buob, M., Kaindl, A. M., & Morris-Rosendahl, D. J. (2013) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-8-59 · Cited by 37 · see citing works
Zheng, Y., Mennella, V., Marks, S., Wildonger, J., Elnagdi, E., Agard, D. A., & Megraw, T. L. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-09-0655 · Cited by 34 · see citing works
Self-citationPericentrin-mediated SAS-6 recruitment promotes centriole assembly
Ito, D., Zitouni, S., Jana, S. C., Duarte, P., Surkont, J., Carvalho-Santos, Z., Pereira‐Leal, J. B., Ferreira, M. G., & Bettencourt‐Dias, M. (2019) · eLife · doi:10.7554/elife.41418 · Cited by 33 · see citing works
Development of the cerebral cortex and the effect of the intrauterine environment
Quezada, S., Castillo-Meléndez, M., Walker, D. W., & Tolcos, M. (2018) · The Journal of Physiology · doi:10.1113/jp277151 · Cited by 35 · see citing works
Heterogeneous clinical phenotypes and cerebral malformations reflected by rotatin cellular dynamics
Vandervore, L. V., Schot, R., Kasteleijn, E., Oegema, R., Stouffs, K., Gheldof, A., Grochowska, M. M., van der Sterre, M. L. T., van Unen, L., Wilke, M., et al. (2019) · Brain · doi:10.1093/brain/awz045 · Cited by 32 · see citing works
Emerging roles of centrosome cohesion
Dang, H., & Schiebel, E. (2022) · Open Biology · doi:10.1098/rsob.220229 · Cited by 29 · see citing works
Nasser, H., Vera, L., Elmaleh, M., Steindl, K., Létard, P., Teissier, N., Ernault, A., Guimiot, F., Afenjar, A., Moutard, M. L., et al. (2020) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2019-106474 · Cited by 28 · see citing works
Takitoh, T., Kumamoto, K., Wang, C.-C., Sato, M., Toba, S., Wynshaw-Boris, A. J., & Hirotsune, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5664-11.2012 · Cited by 28 · see citing works
Pylro, V. S., de Oliveira, F. S., Morais, D., Cuadros-Orellana, S., Pais, F. S.-M., Medeiros, J. D., Geraldo, J. A., Gilbert, J. A., Volpini, Â. C., & Fernandes, G. R. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004817 · Cited by 25 · see citing works
Duerinckx, S., Jacquemin, V., Drunat, S., Vial, Y., Passemard, S., Perazzolo, C., Massart, A., Soblet, J., Racapé, J., Desmyter, L., et al. (2019) · Human Mutation · doi:10.1002/humu.23948 · Cited by 25 · see citing works
An updated view on the centrosome as a cell cycle regulator
Lin, M., Xie, S., & Chan, K. Y. (2022) · Cell Division · doi:10.1186/s13008-022-00077-0 · Cited by 24 · see citing works
Rutherford, E. L., & Lowery, L. A. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.10.012 · Cited by 24 · see citing works
Quezada, S., van de Looij, Y., Hale, N., Rana, S., Sizonenko, S. V., Gilchrist, C. P., Castillo-Meléndez, M., Tolcos, M., & Walker, D. W. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa171 · Cited by 26 · see citing works
Kerzendorfer, C., Colnaghi, R., Abramowicz, I., Carpenter, G., & O’Driscoll, M. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.04.016 · Cited by 23 · see citing works
CDK5RAP2 Is Required to Maintain the Germ Cell Pool during Embryonic Development
Zaqout, S., Bessa, P., Krämer, N., Stoltenburg, G., & Kaindl, A. M. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.01.002 · Cited by 23 · see citing works
The Evolutionary Biology of Human Neurodevelopment
Crespi, B. J., & Leach, E. (2015) · Wiley eBooks · doi:10.1002/9781118524756.ch9 · Cited by 21 · see citing works
Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
Pilaz, L., & Silver, D. L. (2014) · Journal of Visualized Experiments · doi:10.3791/51298 · Cited by 20 · see citing works
Zhou, X., Zhi, Y., Yu, J., & Xu, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051691 · Cited by 20 · see citing works
Xu, Q., Zhang, Y., Xiong, X., Huang, Y., Salisbury, J. L., Hu, J., & Ling, K. (2014) · Journal of Cell Science · doi:10.1242/jcs.141465 · Cited by 19 · see citing works
Aurora B kinase activity is regulated by SET/TAF1 on Sgo2 at the inner centromere
Asai, Y., Fukuchi, K., Tanno, Y., Koitabashi-Kiyozuka, S., Kiyozuka, T., Noda, Y., Matsumura, R., Koizumi, T., Watanabe, A., Nagata, K., et al. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201811060 · Cited by 19 · see citing works
Du, Z., Zang, Z., Luo, J., Liu, T., Yang, L., Cai, Y., Wang, L., Zhang, D., Zhao, J., Gao, J., et al. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131379 · Cited by 18 · see citing works
Loss of CDK5RAP2 affects neural but not non-neural mESC differentiation into cardiomyocytes
Kraemer, N., Ravindran, E., Zaqout, S., Neubert, G., Schindler, D., Ninnemann, O., Gräf, R., Seiler, A. E. M., & Kaindl, A. M. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1044169 · Cited by 16 · see citing works
González‐Martínez, J., Cwetsch, A. W., Martínez‐Alonso, D., López-Sainz, L. R., Almagro, J., Melati, A., Gómez, J., Pérez‐Martínez, M., Megı́as, D., Boskovic, J., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.146364 · Cited by 15 · see citing works
Estrogen regulation of microcephaly genes and evolution of brain sexual dimorphism in primates
Shi, L., Lin, Q., & Su, B. (2015) · BMC Evolutionary Biology · doi:10.1186/s12862-015-0398-x · Cited by 15 · see citing works
Tubgcp3 Is Required for Retinal Progenitor Cell Proliferation During Zebrafish Development
Li, G., Jin, D., & Zhong, T. P. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00126 · Cited by 14 · see citing works
Buchwalter, R. A., Ogden, S. C., York, S. B., Sun, L. J., Zheng, C., Hammack, C., Cheng, Y., Chen, J. V., Cone, A. S., Meckes, D. G., et al. (2021) · Cells · doi:10.3390/cells10123335 · Cited by 13 · see citing works
Self-citationThe impact of TP53 activation and apoptosis in primary hereditary microcephaly
Iegiani, G., Ferraro, A., Pallavicini, G., & Cunto, F. D. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1220010 · Cited by 12 · see citing works
Neuronal stem cells in the central nervous system and in human diseases
Wu, Q., & Wang, X. (2012) · Protein & Cell · doi:10.1007/s13238-012-2930-8 · Cited by 12 · see citing works
Ravindran, E., Jühlen, R., Vieira-Vieira, C. H., Ha, T., Salzberg, Y., Fichtman, B., Becker, L., Martins, N., Picker‐Minh, S., Bessa, P., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab160 · Cited by 12 · see citing works
Radial glial cells organize the central nervous system via microtubule dependant processes
Nulty, J. M., Alsaffar, M., & Barry, D. (2015) · Brain Research · doi:10.1016/j.brainres.2015.08.027 · Cited by 11 · see citing works
Congenital microcephaly‐linked CDK5RAP2 affects eye development
Zaqout, S., Ravindran, E., Stoltenburg, G., & Kaindl, A. M. (2019) · Annals of Human Genetics · doi:10.1111/ahg.12343 · Cited by 10 · see citing works
WDR62 regulates mouse oocyte meiotic maturation related to p-JNK and H3K9 trimethylation
Wang, Y., Chen, C., Ahmad, M. J., Chen, F., Ding, Z., Yang, S.-J., Chen, Y., Duan, Z., Liu, M., Liang, A., et al. (2022) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2022.106169 · Cited by 9 · see citing works
Shiri, F., Rakhshani-morad, S., Samzadeh‐Kermani, A., & Karimi, P. (2016) · Medicinal Chemistry Research · doi:10.1007/s00044-016-1638-3 · Cited by 9 · see citing works
Centrosome in Cell Division, Development and Disease
Buchwalter, R. A., Chen, J. V., Zheng, Y., & Megraw, T. L. (2016) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0020872 · Cited by 9 · see citing works
Self-citationLi, M. H., Arndt, K., Das, S., Weiss, E. M., Wu, Y., Gwal, K., Shekdar, K. V., & Zackai, E. H. (2015) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36975 · Cited by 8 · see citing works
Wang, Y., Jiao, X., Chen, F., Wu, D., Ding, Z., Miao, Y., & Huo, L. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.111773 · Cited by 8 · see citing works
Morozov, Y. M., & RAKIC, P. T. (2024) · Cerebral Cortex · doi:10.1093/cercor/bhae293 · Cited by 7 · see citing works
LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2
Hanafusa, H., & Matsumoto, K. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1093446 · Cited by 5 · see citing works
Exploring microcephaly and human brain evolution
Murray, J., & Jackson, A. P. (2012) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2012.04330.x · Cited by 5 · see citing works
Dharmadhikari, A. V., Abad, M. A., Khan, S., Maroofian, R., Sands, T. T., Ullah, F., Samejima, I., Shen, Y., Wear, M. A., Moore, K. E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56876-w · Cited by 6 · see citing works
Kang, D., Shin, B., Kim, G., Hea, J. H., Sung, Y. H., & Rhee, K. (2024) · The FASEB Journal · doi:10.1096/fj.202401541r · Cited by 3 · see citing works
Malekshahi, Z., Mahmoudi, M., Akhlaghi, M., Garshasbi, M., Jamshidi, A., Poursani, S., Mostafaei, S., & Nicknam, M. H. (2017) · Egyptian Journal of Medical Human Genetics · doi:10.1016/j.ejmhg.2017.06.002 · Cited by 3 · see citing works
Morris, M. J., Yeap, Y. Y. C., Chen, C., Millard, S. S., Pagan, J. K., & Ng, D. C. H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.01.601630 · Cited by 3 · see citing works
Rios, M. U., Stachera, W. E., Familiari, N. E., Brito, C., Surrey, T., & Woodruff, J. B. (2025) · Journal of Cell Science · doi:10.1242/jcs.264121 · Cited by 2 · see citing works
Shintomi, M., Shiratori, M., Negishi, L., & Terada, Y. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.094 · Cited by 2 · see citing works
Emerging Methods in Modeling Brain Development and Disease with Human Pluripotent Stem Cells
Allen, G. E., Dhanda, A. S., & Julian, L. M. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2409-8_20 · Cited by 2 · see citing works
Uzquiano, A., & Francis, F. (2019) · Brain · doi:10.1093/brain/awz048 · Cited by 2 · see citing works
- Authors
- Megraw, T. L., Sharkey, J. T., & Nowakowski, R. S.
- Affiliations
- Florida State University (US)
- Corresponding author
- Megraw, Timothy L.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 21
- Issue
- 8
- Pages
- 470-480
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC3371655
- OpenAlex
- W2073555909
- Cited by
- 124
- References
- 90
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 9 · 2019: 14 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 11 · 2014: 14 · 2013: 13 · 2012: 11
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (GM068756, R01GM068756)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- CDK5RAP2, primary microcephaly, centriole replication, neural progenitor proliferation, cortical development, centrosomal proteins, mouse model
- MeSH terms
- Animals, Humans, Microcephaly, Microtubule-Associated Proteins, Spindle Apparatus, Nerve Tissue Proteins, Centrosome, Intracellular Signaling Peptides and Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review