The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.
Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex
Abstract
Dominance hierarchy has a profound impact on animals' survival, health, and reproductive success, but its neural circuit mechanism is virtually unknown. We found that dominance ranking in mice is transitive, relatively stable, and highly correlates among multiple behavior measures. Recording from layer V pyramidal neurons of the medial prefrontal cortex (mPFC) showed higher strength of excitatory synaptic inputs in mice with higher ranking, as compared with their subordinate cage mates. Furthermore, molecular manipulations that resulted in an increase and decrease in the synaptic efficacy in dorsal mPFC neurons caused an upward and downward movement in the social rank, respectively. These results provide direct evidence for mPFC's involvement in social hierarchy and suggest that social rank is plastic and can be tuned by altering synaptic strength in mPFC pyramidal cells.
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“while in mice, altering synaptic efficacy in the mPFC is sufficient to promote a change in social rank (Wang et al., 2011).”
From Dorsal raphe dopamine neurons represent the experience of social isolation (2016) · cites this paper as Wang et al., 2011
In the citing paper
“Keeping this limitation in mind, social dominance can be reliably found in mice kept in captivity.This is true both for laboratory mice 72,92,96,135,136 and wild ones.80,137”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [136]
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“In some studies the subordinates form linear hierarchies, 136,138,141 while in others ranking is more despotic.80,97,142”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [136]
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Metadata
- Authors
- Wang, F., Zhu, J., Zhu, H., Zhang, Q., Lin, Z., & Hu, H.
- Affiliations
- Chinese Academy of Sciences (CN)
- Venue
- Science
- Published
- 2011-11-04
- Volume
- 334
- Issue
- 6056
- Pages
- 693-697
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997195741
- Cited by
- 528
- References
- 34
- Citations by year
- 2026: 43 · 2025: 63 · 2024: 56 · 2023: 51 · 2022: 43 · 2021: 42 · 2020: 41 · 2019: 37 · 2018: 42 · 2017: 24 · 2016: 24 · 2015: 17 · 2014: 23 · 2013: 8 · 2012: 13
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- social dominance hierarchy, social rank, medial prefrontal cortex, synaptic efficacy, excitatory synaptic input, layer 5 pyramidal neurons, dorsomedial prefrontal cortex, mice
- MeSH terms
- Animals, Hierarchy, Social, Male, Synaptic Transmission, Social Dominance, Prefrontal Cortex, Pyramidal Cells, Mice
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