Cited by 191Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention

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Guillem, Karine, Bloem, Bernard, Poorthuis, Rogier B., Loos, Maarten, Smit, August B., Maskos, Uwe, Spijker, Sabine, Mansvelder, Huibert D.·2011·Science

Abstract

More than one-third of all people are estimated to experience mild to severe cognitive impairment as they age. Acetylcholine (ACh) levels in the brain diminish with aging, and nicotinic ACh receptor (nAChR) stimulation is known to enhance cognitive performance. The prefrontal cortex (PFC) is involved in a range of cognitive functions and is thought to mediate attentional focus. We found that mice carrying nAChR β2-subunit deletions have impaired attention performance. Efficient lentiviral vector-mediated reexpression of functional β2-subunit-containing nAChRs in PFC neurons of the prelimbic area (PrL) completely restored the attentional deficit but did not affect impulsive and motivational behavior. Our findings show that β2-subunit expression in the PrL PFC is sufficient for endogenous nAChR-mediated cholinergic regulation of attentional performance.

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Crossref · 10.1126/science.1207079

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Authors
Guillem, K., Bloem, B., Poorthuis, R. B., Loos, M., Smit, A. B., Maskos, U., Spijker, S., & Mansvelder, H. D.
Affiliations
  • Amsterdam Neuroscience (NL)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
  • Bloem, Bernard
  • Poorthuis, Rogier B.
  • Spijker, Sabine
  • Mansvelder, Huibert D.
Venue
Science
Published
2011-08-12
Volume
333
Issue
6044
Pages
888-891
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2021755555
Cited by
191
References
28
Citations by year
2026: 4 · 2025: 4 · 2024: 11 · 2023: 7 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 17 · 2017: 15 · 2016: 16 · 2015: 13 · 2014: 28 · 2013: 21 · 2012: 16
FWCI
9.73
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • VU Research Portal (publishedVersion)
  • HAL (submittedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
Japan Society for the Promotion of Science
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
nicotinic acetylcholine receptors, medial prefrontal cortex, attention, cholinergic modulation, cognitive aging, acetylcholine, attention deficits, impulsive behavior, motivation
MeSH terms
Acetylcholine, Animals, Attention, Behavior, Animal, Cognition, Male, Motivation, Neurons, Reaction Time, Receptors, Nicotinic, Transduction, Genetic, Gene Deletion, Prefrontal Cortex, Mice, Knockout, Patch-Clamp Techniques, Mice

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