Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention
Open accessAbstract
More than one-third of all people are estimated to experience mild to severe cognitive impairment as they age. Acetylcholine (ACh) levels in the brain diminish with aging, and nicotinic ACh receptor (nAChR) stimulation is known to enhance cognitive performance. The prefrontal cortex (PFC) is involved in a range of cognitive functions and is thought to mediate attentional focus. We found that mice carrying nAChR β2-subunit deletions have impaired attention performance. Efficient lentiviral vector-mediated reexpression of functional β2-subunit-containing nAChRs in PFC neurons of the prelimbic area (PrL) completely restored the attentional deficit but did not affect impulsive and motivational behavior. Our findings show that β2-subunit expression in the PrL PFC is sufficient for endogenous nAChR-mediated cholinergic regulation of attentional performance.
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Genetic deletion of α4β2 nicotinic receptors in the mPFC impairs visual attention.
“while genetic deletion of these receptors in the mPFC impairs visual attention (Guillem et al., 2011)”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Guillem et al., 2011
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- Authors
- Guillem, K., Bloem, B., Poorthuis, R. B., Loos, M., Smit, A. B., Maskos, U., Spijker, S., & Mansvelder, H. D.
- Affiliations
- Amsterdam Neuroscience (NL)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Bloem, Bernard
- Poorthuis, Rogier B.
- Spijker, Sabine
- Mansvelder, Huibert D.
- ORCID
- Venue
- Science
- Published
- 2011-08-12
- Volume
- 333
- Issue
- 6044
- Pages
- 888-891
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021755555
- Cited by
- 191
- References
- 28
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 11 · 2023: 7 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 17 · 2017: 15 · 2016: 16 · 2015: 13 · 2014: 28 · 2013: 21 · 2012: 16
- FWCI
- 9.73
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- other-oa
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion)
- HAL (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotinic acetylcholine receptors, medial prefrontal cortex, attention, cholinergic modulation, cognitive aging, acetylcholine, attention deficits, impulsive behavior, motivation
- MeSH terms
- Acetylcholine, Animals, Attention, Behavior, Animal, Cognition, Male, Motivation, Neurons, Reaction Time, Receptors, Nicotinic, Transduction, Genetic, Gene Deletion, Prefrontal Cortex, Mice, Knockout, Patch-Clamp Techniques, Mice
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