Colony formation of C57BL/6J mice in visible burrow system: identification of eusocial behaviors in a background strain for genetic animal models of autism
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Deficits in social interaction are primary characteristics of autism, which has strong genetic components. Genetically manipulated mouse models may provide a useful research tool to advance the investigation of genes associated with autism. To identify these genes using mouse models, behavioral assays for social relationships in the background strains must be developed. The present study examined colony formation in groups of one male and three female mice (Experiment 1) and, groups of three male mice (Experiment 2) of the C57BL/6J strain in a semi-natural visible burrow system. For adult mixed-sex colonies, 4-h observations during both the dark and light cycles for 15 days demonstrated day-dependent increases in huddling together in the chamber accompanied by decreased frequencies of active social behaviors. Sequential analyses of social interactions indicated that approaches to the back of the approached animal typically elicited flight, while approaches to the front of the approached animal failed to do so. This was seen for female to female, and for female to male approaches, as well as male to female approaches, strongly counterindicating a view that rear approach/flight specifically reflects female responsivirity to unwanted male sexual approach. For adult male colonies, similar protocols found that these social behaviors were similar to those of adult mixed-sex colonies. These findings suggest two potentially useful measures of eusocial behavior in mice, of possible value for genetic mouse models of autism; that is, huddling together and approaches to the front but not the back, of conspecifics.
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Observations of mice colonies in a visible burrow system have shown that approach toward the back of a conspecific more often induces flight than approach to the front and thus may reflect an offensive motivation.
“Observations of mice colonies in a visible burrow system have shown that approach toward the back of a conspecific more often induces flight than approach to the front and thus may reflect an offensive motivation”
From Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors (2020) · cites this paper as Arakawa et al., 2007
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- Authors
- ARAKAWA, H., BLANCHARD, D., & BLANCHARD, R.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- Corresponding author
- ARAKAWA, H
- ORCID
- ARAKAWA, H
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2007-01-10
- Volume
- 176
- Issue
- 1
- Pages
- 27-39
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC3264663
- OpenAlex
- W1998247620
- Cited by
- 86
- References
- 64
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 6
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Japan Society for the Promotion of Science
- National Institute of Neurological Disorders and Stroke (U54NS039406)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Keywords
- autism spectrum disorder, C57BL/6J mice, colony formation, social interaction, huddling, approach behavior, escape behavior, genetic mouse models
- MeSH terms
- Animals, Autistic Disorder, Behavior, Animal, Circadian Rhythm, Cooperative Behavior, Disease Models, Animal, Female, Group Processes, Male, Mice, Inbred C57BL, Population Dynamics, Reference Values, Social Behavior, Behavioral Research, Mice
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