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Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex

Wang, Fei, Zhu, Jun, Zhu, Hong, Zhang, Qi, Lin, Zhanmin, Hu, Hailan·2011·Science

DOI 10.1126/science.1209951

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Abstract

Dominance hierarchy has a profound impact on animals' survival, health, and reproductive success, but its neural circuit mechanism is virtually unknown. We found that dominance ranking in mice is transitive, relatively stable, and highly correlates among multiple behavior measures. Recording from layer V pyramidal neurons of the medial prefrontal cortex (mPFC) showed higher strength of excitatory synaptic inputs in mice with higher ranking, as compared with their subordinate cage mates. Furthermore, molecular manipulations that resulted in an increase and decrease in the synaptic efficacy in dorsal mPFC neurons caused an upward and downward movement in the social rank, respectively. These results provide direct evidence for mPFC's involvement in social hierarchy and suggest that social rank is plastic and can be tuned by altering synaptic strength in mPFC pyramidal cells.

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Authors: Wang, F., Zhu, J., Zhu, H., Zhang, Q., Lin, Z., & Hu, H.
Affiliations: Chinese Academy of Sciences (CN)
ORCID: Wang, Fei
Zhu, Hong
Zhang, Qi
Lin, Zhanmin
Hu, Hailan
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2011-11-04
Volume: 334
Issue: 6056
Pages: 693-697
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1209951
OpenAlex: W1997195741
Cited by: 528
References: 34
Citations by year: 2026: 43 · 2025: 63 · 2024: 56 · 2023: 51 · 2022: 43 · 2021: 42 · 2020: 41 · 2019: 37 · 2018: 42 · 2017: 24 · 2016: 24 · 2015: 17 · 2014: 23 · 2013: 8 · 2012: 13
FWCI: 5.96
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: social dominance hierarchy, social rank, medial prefrontal cortex, synaptic efficacy, excitatory synaptic input, layer 5 pyramidal neurons, dorsomedial prefrontal cortex, mice
MeSH terms: Animals, Hierarchy, Social, Male, Synaptic Transmission, Social Dominance, Prefrontal Cortex, Pyramidal Cells, Mice

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Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex

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