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Structural Insight into the Ion-Exchange Mechanism of the Sodium/Calcium Exchanger
Abstract
Maintaining Equilibrium: Na + /Ca 2+ exchangers (NCX) are membrane transporters that maintain the homeostasis of cytosolic Ca 2+ and play an essential role in Ca 2+ signaling. Despite a long history of physiological work and a large body of functional data, the structural basis underlying the ion exchange mechanism of NCX is poorly understood. Liao et al. (p. 686 ; see the Perspective by Abramson et al. ) present a high-resolution crystal structure of an NCX from Methanococcus jannaschii and demonstrate that this archaeal NCX catalyzes Na + /Ca 2+ -exchange reactions similar to its eukaryotic counterpart. The structure clarifies the mechanism of ion exchange proteins and reveals the basis for the stoichiometry, cooperativity, and bidirectionality of the reaction.
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Adams, P. D., Afonine, P. V., Bunkóczi, G., Chen, V. B., Davis, I. W., Echols, N., Headd, J. J., Hung, L.-W., Kapral, G. J., Grosse-Kunstleve, R. W., et al. (2010) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444909052925 · Cited by 23,716
Clapham, D. E. (2007) · Cell · doi:10.1016/j.cell.2007.11.028 · Cited by 4,175
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Noble, D. (2002) · Science · doi:10.1126/science.1069881 · Cited by 622
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Harding, M. M. (2002) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444902003712 · Cited by 279
Na+/Ca2+-K+Exchangers (NCKX):Functional Properties and Physiological Roles
Altimimi, H. F., & Schnetkamp, P. P. M. (2007) · Channels · doi:10.4161/chan.4366 · Cited by 62
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Metadata
- Authors
- Liao, J., Li, H., Zeng, W., Sauer, D. B., Belmares, R., & Jiang, Y.
- Venue
- Science
- Published
- 2012-02-10
- Volume
- 335
- Issue
- 6069
- Pages
- 686-690
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2109523366
- Cited by
- 261
- References
- 6
- FWCI
- 10.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liao, J., Li, H., Zeng, W., Sauer, D. B., Belmares, R., & Jiang, Y. (2012). Structural Insight into the Ion-Exchange Mechanism of the Sodium/Calcium Exchanger. Science. https://doi.org/10.1126/science.1215759
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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