The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Single-Molecule Fluorescence Experiments Determine Protein Folding Transition Path Times
Open accessAbstract
A Fraction of Folding: An energy barrier has to be crossed as a protein transforms between folded and unfolded states. Molecular dynamic simulations have observed sharp transitions, with barrier crossing times of less than a microsecond, a fraction of the total folding time; however, this time range has been inaccessible to single-molecule experiments. Chung et al. (p. 981 ) described single-molecule fluorescence experiments that allowed measurement of the transition-path time for a fast-folding protein and to reduce the upper bound for a slow-folding protein. Although the folding rates differed by a factor of 10,000, the transition-path times differ by less than a factor of 5, pointing to energy landscape theory for the explanation.
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Cites
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Cited by
Identification of slow molecular order parameters for Markov model construction
Pérez-Hernández, G., Paul, F., Giorgino, T., De Fabritiis, G., & Noé, F. (2013) · The Journal of Chemical Physics · doi:10.1063/1.4811489 · Cited by 990
“Rare conformational transitions can be explicitly traced by either single-molecule experiments [70, 88, 17, 44] or by high-throughput molecular dynamics simulations, either realized with few long trajectories [84, 48] or with many shorter trajectories [92, 11, 67, 13, 77, 12].”
BackgroundFluorescence Enhancement at Docking Sites of DNA-Directed Self-Assembled Nanoantennas
Acuna, G. P., Möller, F. M., Holzmeister, P., Beater, S., Lalkens, B., & Tinnefeld, P. (2012) · Science · doi:10.1126/science.1228638 · Cited by 698
Nuclear magnetic resonance detection and spectroscopy of single proteins using quantum logic
Lovchinsky, I., Sushkov, A. O., Urbach, E., de Leon, N. P., Choi, S., De Greve, K., Evans, R., Gertner, R., Bersin, E., Müller, C., et al. (2016) · Science · doi:10.1126/science.aad8022 · Cited by 536
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Metadata
- Authors
- Chung, H. S., McHale, K., Louis, J. M., & Eaton, W. A.
- Venue
- Science
- Published
- 2012-02-24
- Volume
- 335
- Issue
- 6071
- Pages
- 981-984
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2150614072
- Cited by
- 414
- References
- 32
- FWCI
- 15.22
- Type
- journal article
- Language
- en
- Open access
- green
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