The DOI matches its Crossref record.
Secreted Peptide Dilp8 Coordinates Drosophila Tissue Growth with Developmental Timing
Abstract
Small But Perfectly Formed: The imaginal discs of Drosophila represent defined larval tissues that give rise to the subsequent adult appendages. These tissues regenerate in response to damage. When the imaginal discs are injured or show tumor growth, they signal to the rest of the larval animal to slow down growth and delay morphogenesis. Garelli et al. (p. 579 ) and Colombani et al. (p. 582 ) now show that an insulin-like peptide, termed Dilp8, is secreted into the hemolymph (insect “blood”) and participates in the communication between growing organs and the endocrine system to adjust the growth program and maturation time. This collaboration ensures that adults attain the normal size and maintain appropriate proportions and symmetry.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Drosophila neuroblasts: a model for stem cell biology
Homem, C. C. F., & Knoblich, J. A. (2012) · Development · doi:10.1242/dev.080515 · Cited by 476
Eat to reproduce: a key role for the insulin signaling pathway in adult insects
Badisco, L., Van Wielendaele, P., & Vanden Broeck, J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00202 · Cited by 173
Kapan, N., Lushchak, O. V., Luo, J., & Nässel, D. R. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1097-z · Cited by 169
The transcriptional response to tumorigenic polarity loss in Drosophila
Bunker, B. D., Nellimoottil, T. T., Boileau, R. M., Classen, A. K., & Bilder, D. (2015) · eLife · doi:10.7554/elife.03189 · Cited by 114
Cell non-autonomous regulation of health and longevity
Miller, H. A., Dean, E. S., Pletcher, S. D., & Leiser, S. F. (2020) · eLife · doi:10.7554/elife.62659 · Cited by 102
Metadata
- Authors
- Colombani, J., Andersen, D. S., & Léopold, P.
- Venue
- Science
- Published
- 2012-05-04
- Volume
- 336
- Issue
- 6081
- Pages
- 582-585
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1964195906
- Cited by
- 521
- References
- 0
- FWCI
- 17.66
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Secreted Peptide Dilp8 Coordinates Drosophila Tissue Growth with Developmental Timing. https://app.cochat.ai/papers/10.1126/science.1216689
- The paper
- Colombani, J., Andersen, D. S., & Léopold, P. (2012). Secreted Peptide Dilp8 Coordinates Drosophila Tissue Growth with Developmental Timing. Science. https://doi.org/10.1126/science.1216689
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
