Cited by 173Neurobiology and Insect Physiology ResearchReproductive biology and impacts on aquatic speciesInvertebrate Immune Response Mechanisms

Eat to reproduce: a key role for the insulin signaling pathway in adult insects

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Badisco, Liesbeth, Van Wielendaele, Pieter, Vanden Broeck, Jozef·2013·Frontiers in Physiology

Abstract

Insects, like all heterotrophic organisms, acquire from their food the nutrients that are essential for anabolic processes that lead to growth (larval stages) or reproduction (adult stage). In adult females, this nutritional input is processed and results in a very specific output, i.e., the production of fully developed eggs ready for fertilization and deposition. An important role in this input-output transition is attributed to the insulin signaling pathway (ISP). The ISP is considered to act as a sensor of the organism's nutritional status and to stimulate the progression of anabolic events when the status is positive. In several insect species belonging to different orders, the ISP has been demonstrated to positively control vitellogenesis and oocyte growth. Whether or not ISP acts herein via a mediator action of lipophilic insect hormones (ecdysteroids and juvenile hormone) remains debatable and might be differently controlled in different insect orders. Most likely, insulin-related peptides, ecdysteroids and juvenile hormone are involved in a complex regulatory network, in which they mutually influence each other and in which the insect's nutritional status is a crucial determinant of the network's output. The current review will present an overview of the regulatory role of the ISP in female insect reproduction and its interaction with other pathways involving nutrients, lipophilic hormones and neuropeptides.

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  • Beta-ecdysone is reported to inhibit NF-kB activation in a cancer cell line.

    “Mechanistically, βEcd is reported to promote muscle cell growth via insulin and PI3K/Akt signaling and is reported to inhibit NF-kB activation in a cancer cell line [21, 25, 27, 61].”
  • Beta-ecdysone is reported to promote muscle cell growth via insulin and PI3K/Akt signaling.

    “Mechanistically, βEcd is reported to promote muscle cell growth via insulin and PI3K/Akt signaling and is reported to inhibit NF-kB activation in a cancer cell line [21, 25, 27, 61].”

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  1. Riehle M. A. Brown M. R. (2002). Insulin receptor expression during development and a reproductive cycle in the ovary of the mosquito Aedes aegypti. Cell Tissue Res. 308, 409– 420 10.1016/S0965-1748(99)00084-3 12107434 · DOI

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Authors
Badisco, L., Van Wielendaele, P., & Vanden Broeck, J.
Affiliations
KU Leuven (BE)
Venue
Frontiers in Physiology
Published
2013
Volume
4
Pages
202-202
ISSN
1664-042X (ISSN-L)
OpenAlex
W1987168916
Cited by
173
References
199
Citations by year
2026: 17 · 2025: 16 · 2024: 10 · 2023: 17 · 2022: 17 · 2021: 23 · 2020: 16 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 6 · 2015: 12 · 2014: 7 · 2013: 1
FWCI
4.25
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Physiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lirias (KU Leuven) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Fonds Wetenschappelijk Onderzoek (GOA/11/02)
  • KU Leuven (GOA/11/02)
  • Vlaamse regering
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
  • Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
Keywords
insulin signaling pathway, insect reproduction, vitellogenesis, oocyte growth, nutritional status, ecdysteroids, juvenile hormone, insulin-like peptides, neuropeptides, female reproduction, egg production, nutrient regulation

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