Synthetic Genetic Polymers Capable of Heredity and Evolution

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Items 101–200 of 728

  1. Fluorescence Sensing Using DNA Aptamers in Cancer Research and Clinical Diagnostics
    Domenica Musumeci, Chiara Platella, Claudia Riccardi, Federica Moccia, Daniela Montesarchio · 2017 · Cancers
  2. Origins of life: a problem for physics, a key issues review
    Walker, Sara Imari · 2017 · Reports on Progress in Physics
  3. Evaluating TNA stability under simulated physiological conditions
    Michelle C. Culbertson, Kartik W. Temburnikar, Sujay P. Sau, Jen-Yu Liao, Saikat Bala, John Charles Chaput · 2016 · Bioorganic & Medicinal Chemistry Letters
  4. Pyrrolidinyl PNA with α/β-Dipeptide Backbone: From Development to Applications
    Tirayut Vilaivan · 2015 · Accounts of Chemical Research
  5. Prebiotic Syntheses of Noncanonical Nucleosides and Nucleotides
    David M. Fialho, Tyler P. Roche, Nicholas V. Hud · 2020 · Chemical Reviews
  6. Selection of 2′-Fluoro-Modified Aptamers with Optimized Properties
    Deepak Thirunavukarasu, Tingjian Chen, Zhixia Liu, Narupat Hongdilokkul, Floyd E. Romesberg · 2017 · Journal of the American Chemical Society
  7. Evolution of a General RNA-Cleaving FANA Enzyme
    Yajun Wang, Arlene K. Ngor, Ali Nikoomanzar, John Charles Chaput · 2018 · Nature Communications
  8. Improving Polymerase Activity with Unnatural Substrates by Sampling Mutations in Homologous Protein Architectures
    Matthew R. Dunn, Carine Otto, Kathryn E. Fenton, John Charles Chaput · 2016 · ACS Chemical Biology
  9. The DNA and RNA sugar–phosphate backbone emerges as the key player. An overview of quantum-chemical, structural biology and simulation studies
    Jiřı́ Šponer, Arnošt Mládek, Judit E. Šponer, Daniel Svozil, Marie Zgarbová, Pavel Banáš, Petr Jurečka, Michal Otyepka · 2012 · Physical Chemistry Chemical Physics
  10. Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker
    Yee‐Wai Cheung, Pascal Röthlisberger, Ariel Méchaly, Patrick Weber, Fabienne Lévi-Acobas, Young Lo, Alvin W. C. Wong, Andrew B. Kinghorn, Ahmed Haouz, G. Paul Savage et al. · 2020 · Proceedings of the National Academy of Sciences
  11. Engineering polymerases for applications in synthetic biology
    Ali Nikoomanzar, Nicholas Chim, Eric J. Yik, John Charles Chaput · 2020 · Quarterly Reviews of Biophysics
  12. The Emerging World of Synthetic Genetics
    John Charles Chaput, Hanyang Yu, Su Zhang · 2012 · Chemistry & Biology
  13. The Toolbox for Modified Aptamers
    Sergey A. Lapa, Alexander V. Chudinov, Edward N. Timofeev · 2015 · Molecular Biotechnology
  14. A reversibly gated protein-transporting membrane channel made of DNA
    Swarup Dey, Adam Dorey, Leeza Abraham, Yongzheng Xing, Irene Zhang, Fei Zhang, Stefan Howorka, Hao Yan · 2022 · Nature Communications
  15. Towards open-ended evolution in self-replicating molecular systems
    Duim, Herman, Otto, Sijbren · 2017 · Beilstein Journal of Organic Chemistry
  16. Simple peptides derived from the ribosomal core potentiate RNA polymerase ribozyme function
    Shunsuke Tagami, James Attwater, Philipp Holliger · 2017 · Nature Chemistry
  17. Liposomal Drug Delivery Systems for Targeted Cancer Therapy: Is Active Targeting the Best Choice?
    Shaghayegh Fathi, Adegboyega K. Oyelere · 2016 · Future Medicinal Chemistry
  18. DNA polymerases and biotechnological applications
    Joos Aschenbrenner, Andreas Marx · 2017 · Current Opinion in Biotechnology
  19. Abiotic synthesis of RNA in water: a common goal of prebiotic chemistry and bottom-up synthetic biology
    Cafferty, Brian J, Hud, Nicholas V · 2014 · Current Opinion in Chemical Biology
  20. Selection platforms for directed evolution in synthetic biology
    Pedro A. G. Tizei, Eszter Csibra, Leticia L. Torres, Vitor Bernardes Pinheiro · 2016 · Biochemical Society Transactions
  21. Controlling monomer-sequence using supramolecular templates
    Niels ten Brummelhuis · 2014 · Polymer Chemistry
  22. Safety by design: Biosafety and biosecurity in the age of synthetic genomics
    Stefan A. Hoffmann, James Diggans, Douglas Michael Densmore, Junbiao Dai, Tom Knight, Emily M LeProust, Jef D. Boeke, Nicole E. Wheeler, Yizhi Cai · 2023 · iScience
  23. The solution structure of double helical arabino nucleic acids (ANA and 2′F-ANA): effect of arabinoses in duplex-hairpin interconversion
    Nerea Martín‐Pintado, Maryam Yahyaee Anzahaee, Ramón Campos‐Olivas, Anne M. Noronha, Christopher James Wilds, Masad José Damha, Carlos González · 2012 · Nucleic Acids Research
  24. Cyanobacteria Produce N-(2-Aminoethyl)Glycine, a Backbone for Peptide Nucleic Acids Which May Have Been the First Genetic Molecules for Life on Earth
    Sandra Anne Banack, James S. Metcalf, Liying Jiang, Derek J. Craighead, Leopold L. Ilag, Paul Alan Cox · 2012 · PLoS ONE
  25. Nanostructures from Synthetic Genetic Polymers
    Alexander I. Taylor, Fabienne Beuron, Sew‐Yeu Peak‐Chew, Edward P. Morris, Piet A. Herdewijn, Philipp Holliger · 2016 · ChemBioChem
  26. Exploring the Chemistry of Genetic Information Storage and Propagation through Polymerase Engineering
    Gillian Houlihan, Sebastian Arangundy‐Franklin, Philipp Holliger · 2017 · Accounts of Chemical Research
  27. A horizon scan of global conservation issues for 2013
    William J. Sutherland, Sarah Bardsley, Mick N. Clout, Michael H. Depledge, Lynn V. Dicks, Liz Fellman, Erica Fleishman, DAVID WINGFIELD GIBBONS, Brandon Keim, Fiona A. Lickorish et al. · 2012 · Trends in Ecology & Evolution
  28. Synthetic Biological Circuits within an Orthogonal Central Dogma
    Alan Costello, Ahmed H. Badran · 2020 · Trends in biotechnology
  29. Recent advances in aptamer discovery, modification and improving performance
    Arezoo Fallah, Abbas Ali Imani Fooladi, Seyed Asghar Havaei, Mahdieh Mahboobi, Hamid Sedighian · 2024 · Biochemistry and Biophysics Reports
  30. Enhancing aptamer function and stability via in vitro selection using modified nucleic acids
    Kirsten N. Meek, Alexandra E. Rangel, Jennifer M. Heemstra · 2016 · Methods
  31. DNA Ligase-Mediated Translation of DNA Into Densely Functionalized Nucleic Acid Polymers
    Ryan Hili, Jia Niu, David R. Liu · 2012 · Journal of the American Chemical Society
  32. Synthesis and biological applications of fluoro-modified nucleic acids
    Fengmin Guo, Qiang Li, Chuanzheng Zhou · 2017 · Organic & Biomolecular Chemistry
  33. Beyond DNA and RNA: The Expanding Toolbox of Synthetic Genetics
    Alexander I. Taylor, Gillian Houlihan, Philipp Holliger · 2019 · Cold Spring Harbor Perspectives in Biology
  34. DNA Polymerase Variants with High Processivity and Accuracy for Encoding and Decoding Locked Nucleic Acid Sequences
    Hidekazu Hoshino, Yuuya Kasahara, Masayasu Kuwahara, Satoshi Obika · 2020 · Journal of the American Chemical Society
  35. In vitro selection of BNA (LNA) aptamers
    Masayasu Kuwahara, Satoshi Obika · 2013 · Artificial DNA PNA & XNA
  36. Mirror-image polymerase chain reaction
    Wenjun Jiang, Baochang Zhang, Chuyao Fan, Min Wang, Jiaxing Wang, Qiang Deng, Xianyu Liu, Chen Ji, Ji‐Shen Zheng, Lei Liu et al. · 2017 · Cell Discovery
  37. Aptamers targeting cell surface proteins
    Masaki Takahashi · 2017 · Biochimie
  38. Xeno-Nucleic Acid (XNA) 2’-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding
    Irani Alves Ferreira‐Bravo, Jeffrey J. DeStefano · 2021 · Viruses
  39. A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing
    Alexander I. Taylor, Christopher J. K. Wan, Maria J. Donde, Sew‐Yeu Peak‐Chew, Philipp Holliger · 2022 · Nature Chemistry
  40. Directed polymerase evolution
    Tingjian Chen, Floyd E. Romesberg · 2013 · FEBS Letters
  41. Phosphonomethyl Oligonucleotides as Backbone-Modified Artificial Genetic Polymers
    Chao Liu, Christopher Cozens, Faten Jaziri, Jef Rozenski, Amandine Maréchal, Shrinivas G. Dumbre, Valérie Pezo, Philippe Marlière, Vitor Bernardes Pinheiro, Elisabetta Groaz et al. · 2018 · Journal of the American Chemical Society
  42. The expanding world of DNA and RNA
    Tingjian Chen, Narupat Hongdilokkul, Zhixia Liu, Deepak Thirunavukarasu, Floyd E. Romesberg · 2016 · Current Opinion in Chemical Biology
  43. Redesigning the Genetic Polymers of Life
    John Charles Chaput · 2021 · Accounts of Chemical Research
  44. Dressed for success – applying chemistry to modulate aptamer functionality
    Fabian Tölle, Günter Mayer · 2012 · Chemical Science
  45. Capillary Electrophoresis–Systematic Evolution of Ligands by Exponential Enrichment Selection of Base- and Sugar-Modified DNA Aptamers: Target Binding Dominated by 2′-O,4′-C-Methylene-Bridged/Locked Nucleic Acid Primer
    Yuuya Kasahara, Yuuta Irisawa, Hiroto Fujita, Aiko Yahara, Hiroaki Ozaki, Satoshi Obika, Masayasu Kuwahara · 2013 · Analytical Chemistry
  46. Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity
    Gillian Houlihan, Sebastian Arangundy‐Franklin, Benjamin T. Porebski, Nithya Subramanian, Alexander I. Taylor, Philipp Holliger · 2020 · Nature Chemistry
  47. 2'-Fluoro-arabinonucleic Acid (FANA): A Versatile Tool for Probing Biomolecular Interactions.
    Roberto El-Khoury, M. Damha · 2021 · Accounts of Chemical Research
  48. An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination
    Yueyao Wang, Yao Wang, Dongfan Song, Xin Sun, Zhe Li, Jiayu Chen, Hanyang Yu · 2021 · Nature Chemistry
  49. A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyethyl)-RNA
    Niklas Freund, Alexander I. Taylor, Sebastian Arangundy‐Franklin, Nithya Subramanian, Sew‐Yeu Peak‐Chew, Amy M. Whitaker, Bret Freudenthal, Mikhail Abramov, Piet A. Herdewijn, Philipp Holliger · 2022 · Nature Chemistry
  50. On the Emergence of RNA
    Ramanarayanan Krishnamurthy · 2015 · Israel Journal of Chemistry
  51. Nucleic acids: function and potential for abiogenesis
    Falk Wachowius, James Attwater, Philipp Holliger · 2017 · Quarterly Reviews of Biophysics
  52. Transport of Nucleoside Triphosphates into Cells by Artificial Molecular Transporters
    Zbigniew Zawada, Ameneh Tatar, Pavle Mocilac, Miloš Buděšı́nský, Tomáš Kraus · 2018 · Angewandte Chemie International Edition
  53. Building Synthetic Cells─From the Technology Infrastructure to Cellular Entities
    Lynn J. Rothschild, Nils J. H. Averesch, Elizabeth A. Strychalski, Felix Moser, John I. Glass, Rolando Perez, Ibrahim O. Yekinni, Brooke Rothschild-Mancinelli, Garrett A. Roberts Kingman, Feilun Wu et al. · 2024 · ACS Synthetic Biology
  54. A general temperature-guided language model to design proteins of enhanced stability and activity
    Fan Jiang, Mingchen Li, Jiajun Dong, Yuanxi Yu, Xinyu Sun, Banghao Wu, Jin Huang, Liqi Kang, Yufeng Pei, Liang Zhang et al. · 2024 · Science Advances
  55. Synthetic Genomics and Synthetic Biology Applications Between Hopes and Concerns
    Harald König, Daniel O. Frank, Reinhard Heil, Christopher Coenen · 2013 · Current Genomics
  56. DNA polymerases engineered by directed evolution to incorporate non-standard nucleotides
    Roberto Laos, J. Michael Thomson, Steven A. Benner · 2014 · Frontiers in Microbiology
  57. Scaffolding along Nucleic Acid Duplexes Using 2′-Amino-Locked Nucleic Acids
    Kira Astakhova, Jesper Wengel · 2014 · Accounts of Chemical Research
  58. Improving aptamer performance with nucleic acid mimics: de novo and post-SELEX approaches
    Ricardo Oliveira, Eva Pinho, Ana Luísa Sousa, Jeffrey J. DeStefano, Nuno F. Azevedo, Carina Almeida · 2021 · Trends in biotechnology
  59. Nucleic acid enzymes based on functionalized nucleosides
    Marcel Hollenstein · 2019 · Current Opinion in Chemical Biology
  60. Directed Evolution of Polymerases To Accept Nucleotides with Nonstandard Hydrogen Bond Patterns
    Roberto Laos, Ryan W. Shaw, Nicole A. Leal, Eric A. Gaucher, Steven A. Benner · 2013 · Biochemistry
  61. Comparing proteins and nucleic acids for next-generation biomolecular engineering
    Genevieve Pugh, Jonathan R. Burns, Stefan Howorka · 2018 · Nature Reviews Chemistry
  62. Biotechnology for secure biocontainment designs in an emerging bioeconomy
    Kathleen L. Arnolds, Lukas R. Dahlin, Lin Ding, Chao Wu, Jianping Yu, Wei Xiong, Cristal Zúñiga, Yo Suzuki, Karsten Zengler, Jeffrey G Linger et al. · 2021 · Current Opinion in Biotechnology
  63. Science Objectives for Flagship-Class Mission Concepts for the Search for Evidence of Life at Enceladus
    Shannon MacKenzie, Marc F. Neveu, Alfonso F. Dávila, Jonathan I. Lunine, Morgan Leigh Cable, C. M. Phillips-Lander, J. L. Eigenbrode, Jack Hunter Waite, Kathleen L. Craft, Jason D. Hofgartner et al. · 2022 · Astrobiology
  64. DNA Extraction and Purification
    Anandika Dhaliwal · 2013 · Materials and Methods
  65. Top-Down Causation and the Rise of Information in the Emergence of Life
    Sara Imari Walker · 2014 · Information
  66. Was a Pyrimidine‐Pyrimidine Base Pair the Ancestor of Watson‐Crick Base Pairs? Insights from a Systematic Approach to the Origin of RNA
    Brian J. Cafferty, Nicholas V. Hud · 2015 · Israel Journal of Chemistry
  67. Selection, Characterization and Application of Artificial DNA Aptamer Containing Appended Bases with Sub-nanomolar Affinity for a Salivary Biomarker
    Hirotaka Minagawa, Kentaro Onodera, Hiroto Fujita, Taiichi Sakamoto, Joe Akitomi, Naoto Kaneko, Ikuo Shiratori, Masayasu Kuwahara, Katsunori Horii, Iwao Waga · 2017 · Scientific Reports
  68. Mapping the affinity landscape of Thrombin-binding aptamers on 2′F-ANA/DNA chimeric G-Quadruplex microarrays
    Jory Lietard, Hala Abou Assi, Irene Gómez‐Pinto, Carlos González, Mark Manuel Somoza, Masad José Damha · 2017 · Nucleic Acids Research
  69. Random-sequence genetic oligomer pools display an innate potential for ligation and recombination
    Hannes Mutschler, Alexander I Taylor, Benjamin T. Porebski, Alice Lightowlers, Gillian Houlihan, Mikhail Abramov, Piet A. Herdewijn, Philipp Holliger · 2018 · eLife
  70. Auxotrophy to Xeno-DNA: an exploration of combinatorial mechanisms for a high-fidelity biosafety system for synthetic biology applications
    Christopher M. Whitford, Saskia Dymek, Denise Kerkhoff, Camilla März, Olga Schmidt, Maximilian Edich, Julian Droste, Boas Pucker, Christian Rückert, Jörn Kalinowski · 2018 · Journal of Biological Engineering
  71. Total chemical synthesis of a thermostable enzyme capable of polymerase chain reaction
    Weiliang Xu, Wenjun Jiang, Jiaxing Wang, Linping Yu, Chen Ji, Xianyu Liu, Lei Liu, Ting F Zhu · 2017 · Cell Discovery
  72. Reverse Transcription of Threose Nucleic Acid by a Naturally Occurring DNA Polymerase
    Matthew R. Dunn, John Charles Chaput · 2016 · ChemBioChem
  73. Structural basis for TNA synthesis by an engineered TNA polymerase
    Nicholas Chim, Changhua Shi, Sujay P. Sau, Ali Nikoomanzar, John Charles Chaput · 2017 · Nature Communications
  74. Click-Particle Display for Base-Modified Aptamer Discovery
    Chelsea K. L. Gordon, Diana Wu, Anusha Pusuluri, Trevor Feagin, Andrew T. Csordas, Michael S. Eisenstein, Craig J. Hawker, Jia Niu, Hyongsok Tom Soh · 2019 · ACS Chemical Biology
  75. Engineering and application of polymerases for synthetic genetics
    Gillian Houlihan, Sebastian Arangundy‐Franklin, Philipp Holliger · 2017 · Current Opinion in Biotechnology
  76. 100th Anniversary of Macromolecular Science Viewpoint: Toward Artificial Life-Supporting Macromolecules
    Jean‐François Lutz · 2020 · ACS Macro Letters
  77. Engineered live bacteria as disease detection and diagnosis tools
    Imen Tanniche, Bahareh Behkam · 2023 · Journal of Biological Engineering
  78. Binary Genetic Cassettes for Selecting XNA‐Templated DNA Synthesis In Vivo
    Valérie Pezo, Feng Wu Liu, Mikhail Abramov, Matheus Froeyen, Piet A. Herdewijn, Philippe Marlière · 2013 · Angewandte Chemie International Edition
  79. The in vitro selection world
    Kenan Jijakli, Basel Khraiwesh, Weiqi Fu, Liming Luo, Amnah Salem Alzahmi, Joseph Koussa, Amphun Chaiboonchoe, Serdal Kırmızıaltın, Laising Yen, Kourosh Salehi‐Ashtiani · 2016 · Methods
  80. 2′,4′-BNA/LNA aptamers: CE-SELEX using a DNA-based library of full-length 2′-O,4′-C-methylene-bridged/linked bicyclic ribonucleotides
    Yuuya Kasahara, Yuuta Irisawa, Hiroaki Ozaki, Satoshi Obika, Masayasu Kuwahara · 2013 · Bioorganic & Medicinal Chemistry Letters
  81. Chiral encoding may provide a simple solution to the origin of life
    Brewer, Ashley, Davis, Anthony P. · 2014 · Nature Chemistry
  82. Directed evolution of artificial enzymes (XNAzymes) from diverse repertoires of synthetic genetic polymers
    Alexander I. Taylor, Philipp Holliger · 2015 · Nature Protocols
  83. XNA ligation using T4 DNA ligase in crowding conditions
    Donaat Kestemont, Marleen Renders, Piotr Leonczak, Mikhail Abramov, Guy Schepers, Vitor Bernardes Pinheiro, Jef Rozenski, Piet A. Herdewijn · 2018 · Chemical Communications
  84. Direct sequencing of 2′-deoxy-2′-fluoroarabinonucleic acid (FANA) using nanopore-induced phase-shift sequencing (NIPSS)
    Shuanghong Yan, Xintong Li, Panke Zhang, Yuqin Wang, Hong‐Yuan Chen, Shuo Huang, Hanyang Yu · 2019 · Chemical Science
  85. Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase
    L.N. Jackson, Nicholas Chim, Changhua Shi, John Charles Chaput · 2019 · Nucleic Acids Research
  86. Digital and Analog Chemical Evolution
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  87. Intestinal Engineered Probiotics as Living Therapeutics: Chassis Selection, Colonization Enhancement, Gene Circuit Design, and Biocontainment
    Yan Huang, Lin Xiaojun, Siyang Yu, Ruiyue Chen, Wei-Zhao Chen · 2022 · ACS Synthetic Biology
  88. Thirty-five years of research into ribozymes and nucleic acid catalysis: where do we stand today?
    Sabine Müller, Bettina Appel, Darko Balke, Robert Hieronymus, Claudia Nübel · 2016 · F1000Research
  89. Aptamers as Therapeutic Agents: Has the Initial Euphoria Subsided?
    Silvana K. Haßel, Günter Mayer · 2019 · Molecular Diagnosis & Therapy
  90. In vitro Selection of Chemically Modified DNAzymes
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  92. A Threose Nucleic Acid Enzyme with RNA Ligase Activity
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  94. Biorecognition: A key to drug-free macromolecular therapeutics
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  95. Towards applications of synthetic genetic polymers in diagnosis and therapy
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  96. The design and engineering of synthetic genomes
    Joshua S. James, Junbiao Dai, Wei Leong Chew, Yizhi Cai · 2024 · Nature Reviews Genetics
  97. Synthetic transitions: towards a new synthesis
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  98. Water-Soluble Supramolecular Polymers of Paired and Stacked Heterocycles: Assembly, Structure, Properties, and a Possible Path to Pre-RNA
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  99. RNA modularity for synthetic biology
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  100. The Use of Xenonucleic Acids Significantly Reduces the In Vivo Drift of Electrochemical Aptamer‐Based Sensors
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