Synthetic Genetic Polymers Capable of Heredity and Evolution

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Items 401–500 of 728

  1. How To Quantify a Genetic Firewall? A Polarity‐Based Metric for Genetic Code Engineering
    Markus R. Schmidt, Vladimir Kubyshkin · 2020 · ChemBioChem
  2. Tightly linked morpholino-nucleoside chimeras: new, compact cationic oligonucleotide analogues
    Nóra Debreczeni, Miklós Bege, Mihály Herczeg, Ilona Bereczki, Gyula Batta, Pál Herczegh, Anikó Borbás · 2021 · Organic & Biomolecular Chemistry
  3. Transport of Nucleoside Triphosphates into Cells by Artificial Molecular Transporters
    Zbigniew Zawada, Ameneh Tatar, Pavle Mocilac, Miloš Buděšı́nský, Tomáš Kraus · 2018 · Angewandte Chemie
  4. Efficient synthesis and replication of diverse sequence libraries composed of biostable nucleic acid analogues
    John R. D. Hervey, Niklas Freund, Gillian Houlihan, Gurpreet Dhaliwal, Philipp Holliger, Alexander I. Taylor · 2022 · RSC Chemical Biology
  5. Highly Parallelized Screening of Functionally Enhanced XNA Aptamers in Uniform Hydrogel Particles
    Eric J. Yik, Esau L. Medina, Brian M. Paegel, John Charles Chaput · 2023 · ACS Synthetic Biology
  6. Orthogonal Synthesis of Xeno Nucleic Acids
    Guillaume Fiers, Dalila Chouikhi, Laurence Oswald, Abdelaziz Al Ouahabi, Delphine Chan‐Seng, Laurence Charles, Jean‐François Lutz · 2016 · Chemistry - A European Journal
  7. Expanding the chemical repertoire of aptamers
    Usman Akhtar, Weisi He, Cécile Gasse, Julian A. Tanner, Marcel Hollenstein · 2025 · Trends in Chemistry
  8. Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution
    Camille Samson, Pierre Legrand, Mustafa Tekpinar, Jef Rozenski, Mikhail Abramov, Philipp Holliger, Vitor Bernardes Pinheiro, Piet A. Herdewijn, Marc H. Delarue · 2020 · Biomolecules
  9. Synthesis and Biochemical Characterization of Tricyclothymidine Triphosphate (tc‐TTP)
    Marcel Hollenstein, Christian J. Leumann · 2014 · ChemBioChem
  10. Double-headed nucleotides as xeno nucleic acids: information storage and polymerase recognition
    Kasper M. Beck, Marie B. Krogh, Mick Hornum, Paul T. Ludford, Yitzhak Tor, Poul Nielsen · 2020 · Organic & Biomolecular Chemistry
  11. Selection of M2+‐Independent RNA‐Cleaving DNAzymes with Side‐Chains Mimicking Arginine and Lysine
    S. Paul, Antonio A. W. L. Wong, Leo T. Liu, David M. Perrin · 2021 · ChemBioChem
  12. Synthesis of DNA fragments containing 2′-deoxy-4′-selenonucleoside units using DNA polymerases: comparison of dNTPs with O, S and Se at the 4′-position in replication
    Noriko S. Tarashima, T. Sumitomo, Hidenori Ando, K. Furukawa, Tatsuhiro Ishida, Noriaki Minakawa · 2015 · Organic & Biomolecular Chemistry
  13. High‐Throughput Bead‐Based Identification of Structure‐Switching Aptamer Beacons
    Simon G. Trevino, Matthew Levy · 2014 · ChemBioChem
  14. A polymerase engineered for bisulfite sequencing
    Doug Millar, Yonka Christova, Philipp Holliger · 2015 · Nucleic Acids Research
  15. Whole-body scanning PCR; a highly sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides
    Julien A. Boos, David W. Kirk, Mari-Luz Piccolotto, Werner Zuercher, Sandro Gfeller, Philippe Neuner, Andre Dattler, William L. Wishart, Fabian Von Arx, Michael B. Beverly et al. · 2013 · Nucleic Acids Research
  16. Engineering human PrimPol into an efficient RNA-dependent-DNA primase/polymerase
    Rubén Agudo, Patricia A. Calvo, María I. Martínez-Jiménez, Luis Blanco · 2017 · Nucleic Acids Research
  17. Was ist XNA?
    John Charles Chaput, Piet A. Herdewijn · 2019 · Angewandte Chemie
  18. Folding and Duplex Formation in Sequence-Defined Aniline Benzaldehyde Oligoarylacetylenes
    Kyle R. Strom, Jack W. Szostak · 2022 · Journal of the American Chemical Society
  19. Synthesis, Reverse Transcription, Replication, and Inter-Transcription of 2′-Modified Nucleic Acids with Evolved Thermophilic Polymerases: Efforts toward Multidimensional Expansion of the Central Dogma
    Yanjia Qin, Xingyun Ma, Rui Xin Tao, Yuhui Du, Tingjian Chen · 2023 · ACS Synthetic Biology
  20. The clinical potential of l -oligonucleotides: challenges and opportunities
    Victoria Shearer, Chen‐Hsu Yu, Xuan Han, Jonathan T. Sczepanski · 2024 · Chemical Science
  21. Walking over 4 Gya: Chemical Evolution from Photochemistry to Mineral and Organic Chemistries Leading to an RNA World
    Kunio Kawamura, Marie‐Christine Maurel · 2017 · Origins of Life and Evolution of Biospheres
  22. Synthetische Biologie – die Synthese der Biologie
    Simon Ausländer, David Ausländer, Martin Fussenegger · 2016 · Angewandte Chemie
  23. DNA Nanotechnology for Building Sensors, Nanopores and Ion-Channels
    Kerstin Göpfrich, Ulrich F. Keyser · 2019 · Advances in experimental medicine and biology
  24. Dependence of click-SELEX performance on the nature and average number of modified nucleotides
    Julia Siegl, Olga Plückthun, Günter Mayer · 2022 · RSC Chemical Biology
  25. Selection of RNA‐Cleaving TNA Enzymes for Cellular Mg2+ Imaging
    Mingmei Gao, Dongying Wei, Siqi Chen, Bohe Qin, Yueyao Wang, Zhe Li, Hanyang Yu · 2022 · ChemBioChem
  26. Chemical biology: DNA's new alphabet
    Roberta Kwok · 2012 · Nature
  27. Improving Biocontainment with Synthetic Biology: Beyond Physical Containment
    Markus R. Schmidt, Lei Pei · 2015 · Springer protocols handbooks/Springer protocols
  28. Luminescent pyrenyl-GNA nucleosides: synthesis, photophysics and confocal microscopy studies in cancer HeLa cells
    Joanna Skiba, Aleksandra Kowalczyk, Marta A. Fik, Magdalena Gapińska, Damian Trzybiński, Krzysztof Woźniak, Valerije Vrček, Rafał Czerwieniec, Konrad Kowalski · 2019 · Photochemical & Photobiological Sciences
  29. Efficient construction of a stable linear gene based on a TNA loop modified primer pair for gene delivery
    Xuehe Lu, Xiaohui Wu, Tiantian Wu, Lin Han, Jianbing Liu, Baoquan Ding · 2020 · Chemical Communications
  30. How Synthetic Biology Will Reconsider Natural Bioluminescence and Its Applications
    Benjamin Reeve, Theo Sanderson, Tom Ellis, Paul S. Freemont · 2014 · Advances in biochemical engineering, biotechnology
  31. Probing the Backbone Topology of DNA: Synthesis and Properties of 7′,5′‐Bicyclo‐DNA
    Damien Evéquoz, Christian J. Leumann · 2017 · Chemistry - A European Journal
  32. Chimeric XNA: An Unconventional Design for Orthogonal Informational Systems
    Tim C. Efthymiou, Jesse V. Gavette, Matthias Stoop, Francesco De Riccardis, Matheus Froeyen, Piet A. Herdewijn, Ramanarayanan Krishnamurthy · 2018 · Chemistry - A European Journal
  33. Origins of Life: A Problem for Physics
    Sara Imari Walker · 2017 · arXiv (Cornell University)
  34. Beneath the XNA world: Tools and targets to build novel biology
    Paola Handal-Marquez, Anupama Anupama, Valérie Pezo, Philippe Marlière, Piet A. Herdewijn, Vitor Bernardes Pinheiro · 2020 · Current Opinion in Systems Biology
  35. Exploring molecular biology in sequence space: The road to next-generation single-molecule biophysics
    Ivo Severins, Chirlmin Joo, John van Noort · 2022 · Molecular Cell
  36. Functional nucleic acids with synthetic sugar or nucleobase moieties
    Ze Zhang, Siqi Chen, Zhe Li, Hanyang Yu · 2023 · Advanced Agrochem
  37. An In Vitro Selection Protocol for Threose Nucleic Acid (TNA) Using DNA Display
    Matthew R. Dunn, John Charles Chaput · 2014 · Current Protocols in Nucleic Acid Chemistry
  38. Astroecology, cosmo-ecology, and the future of life
    Michael N. Mautner · 2014 · Acta Societatis Botanicorum Poloniae
  39. Materials for the Onset. A story of necessity and chance.
    Ernesto Di Mauro · 2013 · Frontiers in bioscience
  40. Molecular Dynamics of Double Stranded Xylo-Nucleic Acid
    Amutha Ramaswamy, Daryna Smyrnova, Matheus Froeyen, Mohitosh Maiti, Piet A. Herdewijn, Arnout Jozef Ceulemans · 2017 · Journal of Chemical Theory and Computation
  41. Reprint of: Non Canonical Genetic Material
    Elena Eremeeva, Piet A. Herdewijn · 2019 · Current Opinion in Biotechnology
  42. Electron transfer characteristics of 2′-deoxy-2′-fluoro-arabinonucleic acid, a nucleic acid with enhanced chemical stability
    Ruijie D. Teo, Kiriko Terai, Agostino Migliore, David N. Beratan · 2018 · Physical Chemistry Chemical Physics
  43. What Is a Scientific Theory?
    Carol E. Cleland · 2019 · Cambridge University Press eBooks
  44. Expanded genetic alphabet increases structural and chemical diversity of six-letter DNA for high-affinity protein-targeting aptamers
    Kazuhiro Sawada, Michiko Kimoto, Ken‐ichiro Matsunaga, Hui Pen Tan, Ryu Takayanagi, Fumiya K. Sano, Yutaro Shuto, Hisato Hirano, Tsukasa Kusakizako, Yuzuru Itoh et al. · 2025 · Nature Communications
  45. Structural insights into the morpholino nucleic acid/RNA duplex using the new XNA builder Ducque in a molecular modeling pipeline
    Jérôme Rihon, Charles‐Alexandre Mattelaer, Rinaldo W. Montalvão, Matheus Froeyen, Vitor Bernardes Pinheiro, Eveline Lescrinier · 2024 · Nucleic Acids Research
  46. Targeting PCSK9 as a key player in lipid metabolism: exploiting the therapeutic and biosensing potential of aptamers
    Maryam Mahjoubin‐Tehran, Samaneh Rezaei, Raul Dias Santos, Tannaz Jamialahmadi, Wael A. Almahmeed, Amirhossein Sahebkar · 2024 · Lipids in Health and Disease
  47. How Many Biochemistries Are Available To Build a Cell?
    Carlos G. Acevedo‐Rocha, Dirk Schulze‐Makuch · 2015 · ChemBioChem
  48. The Readout of Base‐Pair Information in Adenine–Thymine α‐ D ‐Arabinonucleosides
    Shiliang He, Hang Zhao, Xiurong Guo, Xiaoping Xu, Xinglong Zhou, Jiang Liu, Zhihua Xing, Ling Ye, Lu Jiang, Qianming Chen et al. · 2014 · Chemistry - A European Journal
  49. Quantifying the Performance of Micro-Compartmentalized Directed Evolution Protocols
    Adèle Dramé-Maigné, Anton S. Zadorin, Iaroslava Golovkova, Yannick Rondelez · 2020 · Life
  50. Directed evolution of colE1 plasmid replication compatibility: a fast tractable tunable model for investigating biological orthogonality
    Santiago Chaillou, Pinelopi Eleftheria Stamou, Leticia L. Torres, Ana B. Riesco, Warren Hazelton, Vitor Bernardes Pinheiro · 2022 · Nucleic Acids Research
  51. Aptamers in hematological malignancies and their potential therapeutic implications
    Wanyan Ouyang, Ziqiang Yu, Xiaohong Zhao, Shiyun Lu, Zhi Wang · 2016 · Critical Reviews in Oncology/Hematology
  52. Design and Discovery of New Combinations of Mutant DNA Polymerases and Modified DNA Substrates
    Sydney L. Rosenblum, Aurora G. Weiden, Eliza L. Lewis, Alexie L. Ogonowsky, Hannah E. Chia, Susanna E. Barrett, Mira D. Liu, Aaron M. Leconte · 2017 · ChemBioChem
  53. 1,1′‐Bis(thymine)ferrocene Nucleoside: Synthesis and Study of Its Stereoselective Formation
    Yuriy A. Anisimov, Sebastian Saloman, Alexander Hildebrandt, Heinrich Lang, Damian Trzybiński, Krzysztof Woźniak, Davor Šakić, Valerije Vrček, Konrad Kowalski · 2017 · ChemPlusChem
  54. Evolutionary Outcomes of Diversely Functionalized Aptamers Isolated from in Vitro Evolution
    Dehui Kong, Matina Movahedi, Yasaman Mahdavi‐Amiri, Wayland Yeung, Tristan R. Tiburcio, Dickson Chen, Ryan Hili · 2019 · ACS Synthetic Biology
  55. The sweet allure of XNA
    Fintan R. Steele, Larry Gold · 2012 · Nature Biotechnology
  56. A novel helper phage for HaloTag-mediated co-display of enzyme and substrate on phage
    Wouter Delespaul, Yves Peeters, Piet A. Herdewijn, Johan Robben · 2015 · Biochemical and Biophysical Research Communications
  57. Selection of aptamers for AMACR detection from DNA libraries with different primers
    Deng‐Kai Yang, Chia‐Fu Chou, Lin‐Chi Chen · 2018 · RSC Advances
  58. Kinetic analysis of N -alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases
    Marleen Renders, Shrinivas G. Dumbre, Mikhail Abramov, Donaat Kestemont, Lia Margamuljana, Eric Largy, Christopher Cozens, Julie Vandenameele, Vitor Bernardes Pinheiro, Dominique Toye et al. · 2019 · Nucleic Acids Research
  59. Engineering-driven biological insights into DNA polymerase mechanism
    Vitor Bernardes Pinheiro · 2018 · Current Opinion in Biotechnology
  60. Defining the Field of Sequence‐Controlled Polymers
    Jean‐François Lutz · 2017 · Wiley eBooks
  61. Structural insights into a DNA polymerase reading the xeno nucleic acid HNA
    Cédric Gutfreund, Karin Betz, Mikhail Abramov, Frédérick Coosemans, Philipp Holliger, Piet A. Herdewijn, Andreas Marx · 2024 · Nucleic Acids Research
  62. Measuring XNA polymerase fidelity in a hydrogel particle format
    Esau L. Medina, John Charles Chaput · 2025 · Nucleic Acids Research
  63. Current and emerging opportunities in biological medium‐based computing and digital data storage
    Devasier Bennet, Tuan Vo‐Dinh, Frédéric Zenhausern · 2021 · Nano Select
  64. Reciprocal Nucleopeptides as the Ancestral Darwinian Self-Replicator
    Eleanor F. Banwell, Bernard M. A. G. Piette, Anne Taormina C, Jonathan G. Heddle · 2017 · Molecular Biology and Evolution
  65. Compartmentalized Self‐Replication for Evolution of a DNA Polymerase
    Zhanar Abil, Andrew D. Ellington · 2018 · Current Protocols in Chemical Biology
  66. Unraveling the salt tolerance of Phi29 DNA polymerase using compartmentalized self-replication and microfluidics platform
    Yaping Sun, Danny Hsu Ko, Jie Gao, Kang Fu, Yaping Gao, Zhang Qiwen, Salem Baldi, Tao Hong, Igor Ivanov, Yun He et al. · 2023 · Frontiers in Microbiology
  67. XNA Synthesis and Reverse Transcription by Engineered Thermophilic Polymerases
    Christopher Cozens, Vitor Bernardes Pinheiro · 2018 · Current Protocols in Chemical Biology
  68. 2′-Deoxy-2′-fluoro-arabinonucleic acid: a valid alternative to DNA for biotechnological applications using charge transport
    Ruijie D. Teo, Elizabeth R. Smithwick, Agostino Migliore · 2019 · Physical Chemistry Chemical Physics
  69. Enzymatic synthesis of biphenyl-DNA oligonucleotides
    Pascal Röthlisberger, Fabienne Lévi-Acobas, Christian J. Leumann, Marcel Hollenstein · 2020 · Bioorganic & Medicinal Chemistry
  70. Synthesis and polymerase recognition of a pyrrolocytidine TNA triphosphate
    Hui Mei, Yajun Wang, Eric J. Yik, John Charles Chaput · 2020 · Biopolymers
  71. Protein Purification
    Caroline Ritchie · 2012 · Materials and Methods
  72. Mutant polymerases capable of 2′ fluoro-modified nucleic acid synthesis and amplification with improved accuracy
    Trevor A. Christensen, Kristi Y. Lee, Simone Z. P. Gottlieb, Mikayla B. Carrier, Aaron M. Leconte · 2022 · RSC Chemical Biology
  73. Incorporation of 4′-C-aminomethyl-2′-O-methylthymidine into DNA by thermophilic DNA polymerases
    Ganesh N. Nawale, Kiran R. Gore, Claudia Höbartner, Pushpangadan Indira Pradeepkumar · 2012 · Chemical Communications
  74. Directed evolution of enzymes
    Fábio K. Tamaki · 2020 · Emerging Topics in Life Sciences
  75. DNA-based plasmonic nanostructures and their optical and biomedical applications
    Shengbo Liu, Yingxu Shang, Yunfei Jiao, Na Li, Baoquan Ding · 2021 · Nanotechnology
  76. Split–Combine Click-SELEX Reveals Ligands Recognizing the Transplant Rejection Biomarker CXCL9
    Julia Siegl, Christoph Nikolin, Ngoc Linh Phung, Stefanie Thoms, Cornelia A. Blume, Günter Mayer · 2022 · ACS Chemical Biology
  77. “Click handle”-modified 2′-deoxy-2′-fluoroarabino nucleic acid as a synthetic genetic polymer capable of post-polymerization functionalization
    Kevin Wu, Christopher J. A. Skrodzki, Qiwen Su, Jennifer S Lin, Jia Niu · 2022 · Chemical Science
  78. Parameterizing the Binding Properties of XNA Aptamers Isolated from a Low Stringency Selection
    Nandini Kundu, Cailen M. McCloskey, Mohammad Hajjar, John Charles Chaput · 2023 · Biochemistry
  79. Ein universeller Zugang zu Nucleobasen‐modifizierten Aptameren
    Fabian Tölle, Gerhard Markus Brändle, Daniel Matzner, Günter Mayer · 2015 · Angewandte Chemie
  80. A contamination assessment of the CI carbonaceous meteorite Orgueil using a DNA ‐directed approach
    Joost W. Aerts, Andreas Elsaesser, Wilfred F. M. Röling, P. Ehrenfreund · 2016 · Meteoritics and Planetary Science
  81. Versatility of threose nucleic acids: synthesis, properties, and applications in chemical biology and biomedical advancements
    Dick Yan Tam, Pan Li, Ling Sum Liu, Fei Wang, Hoi Man Leung, Pik Kwan Lo · 2024 · Chemical Communications
  82. A solid-phase enzymatic synthesis platform for the facile production of 2′-fluoroarabinonucleic acid (FANA) and chimeric XNA oligonucleotides using an evolved XNA polymerase
    Binliang Zhang, Yuhui Du, Jingxing Zhang, Xingyun Ma, Yanjia Qin, Rui Tao, Minglan Luo, Jing Wu, Leping Sun, Gan Zhu et al. · 2025 · Nucleic Acids Research
  83. Machine learning-driven molecular engineering of nucleic acids
    Qien Shi, Hui Lv, Fei Wang, Chunhai Fan, Mingqiang Li · 2026 · Chemical Society Reviews
  84. Direct Detection of Lyme Borrelia: Recent Advancement and Use of Aptamer Technology
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  85. Exploring the molecular aspect and updating evolutionary approaches to the DNA polymerase enzymes for biotechnological needs: A comprehensive review
    Said Laatri, Soufiane El Khayari, Zidane Qriouet · 2024 · International Journal of Biological Macromolecules
  86. Synthesis and enzymatic incorporation of α-l-threofuranosyl adenine triphosphate (tATP)
    Su Zhang, John Charles Chaput · 2013 · Bioorganic & Medicinal Chemistry Letters
  87. Impact of bPNA Backbone Structural Constraints and Composition on Triplex Hybridization with DNA
    Oliver Munyaradzi, Sarah R. Rundell, Dennis T.-Y. Bong · 2022 · ChemBioChem
  88. A Partial Answer to the Question Posed by David A. Hughes, PhD, in the Article: “What is in the so-called COVID-19 ‘Vaccines’? Part 1: Evidence of a Global Crime Against Humanity”
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  89. A Nucleic Acid Sequence That is Catalytically Active in Both RNA and TNA Backbones
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  90. Acyclic butyl nucleic acid (BuNA): a novel scaffold for A-switch
    Vipin Kumar, Venkitasamy Kesavan · 2013 · RSC Advances
  91. Reflections of a Darwinian Engineer
    Gerald F. Joyce · 2015 · Journal of Molecular Evolution
  92. Efficient Heritable Gene Expression Readily Evolves in RNA Pools
    Michael Yarus · 2017 · Journal of Molecular Evolution
  93. Synthetic Biology
    David P. Clark, Nanette J. Pazdernik · 2015 · Elsevier eBooks
  94. Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid
    Mohammad Hajjar, Nicholas Chim, Chao Liu, Piet A. Herdewijn, John Charles Chaput · 2022 · Nucleic Acids Research
  95. Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying
    Noam Prywes, Yale S. Michaels, Ayan Pal, Seung Soo Oh, Jack W. Szostak · 2016 · Chemical Communications
  96. Enzymatic Synthesis Using Polymerases of Modified Nucleic Acids and Genes
    Elena Eremeeva, Piet A. Herdewijn · 2018
  97. Pluralism or unity in biology: could microbes hold the secret to life?
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  98. Inhibition of SARS-CoV-2 infection in human airway epithelium with a xeno-nucleic acid aptamer
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  99. Advancing the enzymatic toolkit for 2′-fluoro arabino nucleic acid (FANA) manipulation: phosphorylation, ligation, replication, and templating RNA transcription
    Yingyu Liu, Jun Wang, Yashu Wu, Yajun Wang · 2024 · Chemical Science
  100. Rapid evolution of a highly efficient RNA polymerase by homologous recombination
    Esau L. Medina, Victoria A. Maola, Mohammad Hajjar, Grace K. Ko, Ethan J. Ho, Alexandria R. Horton, Nicholas Chim, John Charles Chaput · 2026 · Nature Chemical Biology