ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Cramer, Paige E., Cirrito, John R., Wesson, Daniel W., Lee, C. Y. Daniel, Karlo, J. Colleen, Zinn, Adriana E., Casali, Brad T., Restivo, Jessica L., Goebel, Whitney D., James, Michael J., Brunden, Kurt R., Wilson, Donald A., Landreth, Gary E.·2012·Science
Cited by (1,000)
Items 901–1,000 of 1,000
- Analytical methods for bexarotene determination: a comparative review of chromatographic techniques through the lens of green chemistryKanaka Parvathi Kannaiah, Hemraj Sharma, Hemanth Kumar Chanduluru, Rita Keshishian, Reem Hasan Obaydo · 2026 · Green Chemistry Letters and Reviews
- 1α,25-Dihydroxyvitamin D3 and Resolvins Improve Immunity to Amyloid-β in Patients with Alzheimer’s DiseaseMilan Fiala, Rachel E. Weitzman · 2014 · Elsevier eBooks
- Rational design and virtual screening identify mimetics of the RXR agonist valerenic acidLaura Isigkeit, Annette Kärcher, Gustave Adouvi, Silvia Arifi, Daniel Merk · 2024 · ChemMedChem
- Bexarotene Induce Differentiation of Myeloid-Derived Suppressor Cells through Arg-1 Signalling PathwayHaozhou Wang, Yinan Guo, Xiaodong Zhang, Xiaoguang Zhou · 2024 · Transplantation Proceedings
- Activation of retinoid X receptors protects retinal neurons and pigment epithelial cells from BMAA-induced deathTamara B. Soto, Paula Estefanía Tenconi, Edgardo D. Buzzi, Leonardo Dionisio, Melina V. Mateos, Nora P. Rotstein, Guillermo F. Spitzmaul, Luis E. Politi, Olga Lorena German · 2024 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Dementia-Related Features in Longitudinal MRI: Tracking Keypoints over TimeElisabeth Stühler, Michael R. Berthold · 2014 · Lecture notes in computer science
- Brain Single-Cell Transcriptional Responses to Bexarotene-Activated RXR in an Alzheimer’s Disease ModelCarolina Saibro Girardi, Lu Yi, Nicholas Francis Fitz, Daniel Pens Gelain, Iliya M. Lefterov, Radosveta P. Koldamova · 2026 · International Journal of Molecular Sciences
- Computational Drug Discovery in Patients with Endometriosis-Induced Infertility via Text Mining and Biomedical DatabasesYingying Lin, Zhiwei Chen, Jianping Huang, Jiaoning Fang, Yuanjie Qi, Li Huitong Xie, Hua Li, Li Chen · 2022 · Clinical and Experimental Obstetrics & Gynecology
- Worming Our Way to Alzheimer’s Disease Drug DiscoverySangeetha V. Iyer, Jonathan T. Pierce-Shimomura · 2013 · Biological Psychiatry
- Therapeutic Links between Alzheimer’s Disease and Brain Cancer: Drug Discovery ConsequencesJean‐Louis Kraus · 2013 · ChemMedChem
- The Relationship Between Astrocyte-mediated Metabolism of β-Amyloid Protein and Pathogenesis of The Early Stages of Alzheimer′s Disease*Lu yi Lin, Shujun Xu, Qinwen Wang · 2012 · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
- Contemporary Approaches for Pharmacological Intervention of Abundant Neurodegenerative DisordersСергей Олегович Бачурин · 2015 · Journal of Nanomedicine & Biotherapeutic Discovery
- Hypothesis: Entrapment of lipoprotein particles in the brain causes Alzheimer’s diseaseDelphine Boche, James A. R. Nicoll · 2021 · Free Neuropathology
- Tracking the insidious course of Alzheimer's disease2012 · Nature Medicine
- Navigating the Landscape of Alzheimer's Disease: From Epidemiology to Drug Re-purposingKarishma Rathi, Ritesh P. Bhole, Prachi Bansode, Nayan Motghare · 2024 · Advances in Pharmacology and Pharmacy
- Molecular Basis of Neurodegeneration: Lessons from Alzheimer’s and Parkinson’s DiseasesJuan Manuel Zolezzi, Sussy Bastias Candia, Nibaldo C. Inestrosa · 2019 · IntechOpen eBooks
- Fluorine-18 (18F)-labeled retinoid x receptor (RXR) partial agonist whose tissue transferability is affected by other RXR ligandsYuta Takamura, Osamu Shibahara, Masaki Watanabe, Michiko Fujihara, Shoya Yamada, Masaru Akehi, Takanori Sasaki, Hiroyuki Hirano, Hiroki Kakuta · 2019 · Bioorganic & Medicinal Chemistry
- Methods to Assess Activity and Potency of Rexinoids Using Rapid Luciferase-Based Assays: A Case Study with NEt-TMNPeter W. Jurutka, Carl E. Wagner · 2019 · Methods in molecular biology
- Studies cast doubt on cancer drug as Alzheimer's treatmentHelen M. Shen · 2013 · Nature
- Alternative activationKristen S. Young, Sean William Fanning · 2023 · eLife
- Why freshwater hydra does not get Alzheimer’s diseaseAlexander N. Khokhlov · 2023 · Vestnik Moskovskogo universiteta Seria 16 Biologia
- Potential treatment of Alzheimer’s disease astrocyte pathology based on nuclear lipid regulationMasato Komai, Nobumasa Takasugi · 2024 · Neural Regeneration Research
- Protein misfolding and neurodegeneration: Mechanisms, implications, and therapeutic strategiesAsma Shah, Tharini Karthikeyan, Sheema Hashem, Rakesh Kumar, Ajaz Ahmad Bhat, Muzafar Ahmad Macha · 2025 · Advances in protein chemistry and structural biology
- An Iodinated BODIPY-Based Probe for the Selective Mapping and Disassembly of Amyloid-β Aggregates In VivoMingguang Zhu, Lijun Ma, Ran Liu, Fanghui Liang, Zixuan Zhang, Guoyang Zhang, Yulong Jin, Xuefei Wang, Zhuo Wang · 2026 · Analytical Chemistry
- Impact of Variation in APOE on Rheumatoid Arthritis, Psoriasis, and Psoriatic Arthritis: Sequencing and Genotyping in General Population CohortsKatrine Laura Rasmussen, Jiao Luo, S. Pors Nielsen, Børge Grønne Nordestgaard, Anne Tybjærg‐Hansen, Ruth Frikke‐Schmidt · 2026 · ACR Open Rheumatology
- Atherosclerosis and dementia - causal aspects and preventive potentialIda Juul Rasmussen, Jiao Luo, Katrine Laura Rasmussen, Emilie Westerlin Kjeldsen, Lucia Sanchez Schneider, Nicolai Sandau, Jesper Qvist Thomassen, Ruth Frikke‐Schmidt · 2026 · Atherosclerosis
- Apolipoprotein E in Alzheimer's disease: A review of APOE receptors, signalling pathways and therapeutic opportunitiesJ. Saravanan, Vigneshwaran Easwaran, Divakar Selvaraj, Venkatesh Gunasekaran, V. Soumya, M. Thiruselvi, M. Laxmana Prasanth, Siddharth Singh, C. Ellaiyarasu, P. Karthik Rai et al. · 2026 · Molecular and Cellular Neuroscience
- Acitretin shows promising potential in Alzheimer’s disease: retinoid-driven modulation of amyloid processing, neuroinflammation, and translational prospectsVarun Sharma, Kanika Vashisht, Garima Choudhary, Vaishali Choudhay, Vandana Bhatia, Mahendra Singh Ashawat, Ashish Baldi, Shiv Kumar Kushawaha · 2026 · Inflammopharmacology
- Does perturbed adaptive myelination contribute to cognitive dysfunction in Alzheimer’s disease?Charles ffrench‐Constant · 2026 · PLoS Biology
- Clearing away Alzheimer's diseaseDarran M. Yates · 2012 · Nature reviews. Neuroscience
- Translationale Forschung in der Geriatrie?Leo Cornelius Bollheimer, Dorothee Volkert, Tobias Bertsch, Jürgen Martin Bauer, Jochen Klucken, Cornel Christian Sieber, Reinhard Büttner · 2012 · Zeitschrift für Gerontologie und Geriatrie
- Evidence based computational drug repositioning candidate screening pipeline design: Case StudyQian Zhu, Hongfang Liu, Yuji Zhang, Jiabei Wang · 2014 · IEEE International Conference on Systems Biology
- Ausgewählte altersbedingte ErkrankungenChristian Behl, Christine Ziegler · 2015 · Springer eBooks
- Comprehensive Overview of Alzheimer’s Disease Neurodegeneration, from Amyloid-β to Neuroinflammatory ModulationJuan Manuel Zolezzi, Nibaldo C. Inestrosa · 2017 · InTech eBooks
- Time-Resolved In Situ AFM Measurement of Growth Rates of Aβ40 FibrilsPeter G. Vekilov, Peter Guy Wolynes · 2022 · Methods in molecular biology
- A Biomimetic Multiparametric Assay to Characterise Anti-Amyloid DrugsWilly Smeralda, Marc Since, Sophie Corvaisier, Dimitri Fayolle, Julien Cardin, Sylvain Duprey, Jean‐Pierre Jourdan, Christophe Cullin, Aurélie Malzert‐Fréon · 2023 · International Journal of Molecular Sciences
- An Investigation of the Inflammatory Landscape in the Brain and Bone Marrow of the APP/PS1 MouseKishore Chittimalli, Stephen Adkins, Sanjay Arora, Jagdish Singh, Yagna P. R. Jarajapu · 2024 · Journal of Alzheimer s Disease Reports
- Current Therapeutic Options and Repurposed Drugs for NeurodegenerationSuneela Sunil Dhaneshwar, Mohammad Aadil Bhat, Anuradha Singh, Supriya Roy · 2024 · BENTHAM SCIENCE PUBLISHERS eBooks
- Receptor agonist/antagonist-incorporated anticancer nanodrugs: Design, materials, and strategiesShi-Jie Hao, Shun‐Yu Wu, Yun-Kai Chang, Fu‐Gen Wu · 2024 · Materials Today
- Distinct functional modes of SUMOylation for retinoid X receptor alphaWai-Ping Lee, Sarita Jena, Edna Patricia Rodriguez, Sinead P. O'Donovan, Carl E. Wagner, Peter W. Jurutka, Paul D. Thompson · 2015 · Biochemical and Biophysical Research Communications
- Advances in Therapies and Scope for Personalized Medicine in Alzheimer’s DiseaseHosakere N Ravishankar, A. K. Dutta, Alisha G. Lewis, Amogh Mohan · 2016 · Personalized Medicine
- Methods to Generate an Array of Novel Rexinoids by SAR on a Potent Retinoid X Receptor Agonist: A Case Study with NEt-TMNCarl E. Wagner, Peter W. Jurutka · 2019 · Methods in molecular biology
- The future of dementia prevention and treatment strategies里 直行 · 2020 · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics
- Radiopharmaceutical Discovery with 11CO2-Fixation Methods Inspired by Green ChemistryBenjamin H. Rotstein, Neil Vasdev · 2021 · Methods in pharmacology and toxicology
- Effects of C-Terminal-Ethyl-Esterification in a Snake-Venom-Based Peptide Against the Neurotoxicity of Acrolein in PC12 CellsCarolina Petri Bernardes, Neife Aparecida Guinaim dos Santos, Tássia R. Costa, Danilo L. Menaldo, F Sisti, Martin K. Amstalden, Diego Luís Ribeiro, Lusânia Maria Greggi Antunes, Suely Vilela Sampaio, Antonio Cardozo dos Santos · 2023 · International Journal of Peptide Research and Therapeutics
- PAK1 in Alzheimer’s and Huntington’s DiseasesQiu‐Lan Ma, Fusheng Yang, Sally Ann Frautschy, Greg M. Cole · 2013 · Elsevier eBooks
- The aging synapse: Synaptic proteome changes in mouse models of agingMarlene J. Végh · 2012 · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)
- Bexarotene treatment does not clear β-Amyloid in an AD mouse model and Beagle dogsIna C. Tesseur, Adrian C. Lo, Anouk Roberfroid, Sofie Dietvorst, Bianca Van Broeck, Marianne Borgers, Harrie J. M. Gijsen, Diederik Moechars, Marc H. Mercken, John A. Kemp et al. · 2013 · Molecular Neurodegeneration
- High Throughput Discovery, Metabolism and Disposition of Chemopreventive Agents using Mass SpectrometryLian Chen · 2013 · Figshare
- Synaptic modifications in hippocampal CA3 pyramidal cells in an Alzheimer's mouse modelPei Zhang · 2018 · eDiss (Georg-August-Universität Göttingen)
- Current and Prospective Treatments for Alzheimer's Disease (and Other Neurodegenerative Diseases)Steve Pedrini, Mike Morici, Ralph Nigel Martins · 2019 · Wiley eBooks
- Serum Metabolites Associated with Brain Amyloid Beta Deposition, Cognitive Dysfunction, and Alzheimer’s Disease ProgressionKwangsik T. Nho, Alexandra Kueider‐Paisley, Matthias Arnold, Siamak MahmoudianDehkordi, Shannon L. Risacher, Gregory Louie, Colette Blach, Rebecca Baillie, Xianlin Han, Gabi Kastenmueller et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD MiceC.Y. Daniel Lee, Amberlene J. De La Rocha, Kellie Inouye, Peter Langfelder, Anthony Daggett, Xiaofeng Gu, Lu-Lin Jiang, Zoe Pamonag, Raymond Vaca, Jeffrey Richman et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- KOLF2.1J iTF-Microglia: A standardized platform to study microglial transcriptional regulatory networks in CNS diseaseIván Rodríguez-Nunez, Samuel C. Bartley, Jared W. Taylor, S. Quinn Johnston, Brianne B. Rogers, Sarah Kristen Meadows, Kimberly M. Newberry, J. Nicholas Cochran, R Myers · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Selected Age-Related DisordersChristian Behl, Christine Ziegler · 2013 · SpringerBriefs in molecular medicine
- Microglial involvement in brain physiopathology: in vitro studies using rat primary culturesIlaria Mengoni · 2014 · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna)
- Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E MetabolismJacob M. Basak · 2014 · Open Scholarship Institutional Repository (Washington University in St. Louis)
- AZ goes APOELev Z. Osherovich · 2012 · Science-Business eXchange
- Amyloid‐Plaques – wie sie entstehen und wie man sie wieder los wirdMichael Groß · 2012 · Chemie in unserer Zeit
- Probable Bexarotene Hepatotoxicity Associated With Transient Serum Antimitochondrial AntibodiesHoward J. Worman · 2012 · Journal of Medical Cases
- Toll-erating ADLev Z. Osherovich · 2013 · Science-Business eXchange
- 1 THE IMPACT OF RETINOIDS ON THE THYROID AXIS Running Head: RETINOIDS AND THYROID AXISJulia Graeppi-Dulac · 2016
- Other Genes Implicated in Alzheimer’s DiseaseMinerva M. Carrasquillo, Mariet Allen, Nilüfer Ertekin‐Taner · 2013 · Springer eBooks
- Human APOE4 affects microglial reactivity and spatial cognition in a mouse model of alzheimer's disease riskGustavo A. Rodriguez · 2014 · DigitalGeorgetown (Georgetown University Library)
- Apolipoprotein E and Mitochondria-associated Endoplasmic Reticulum DysfunctionMarc D. Tambini · 2016
- Cancer Drug Clears Amyloid Beta, Improves Behavior in Alzheimer Disease MiceRichard Robinson · 2012 · Neurology Today
- Review Article Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disordersVijay K. Ramanan, Andrew J. Saykin · 2013
- Immune activation in Aβ-related angiitis (ABRA) and a cell model of E280A presenilin-mutated Familial Alzheimer's DiseaseMarkus Glatzel · 2014
- Alzheimer’s Disease Therapeutics Targeting Apolipoprotein EFan Liao, David M. Holtzman · 2016 · Elsevier eBooks
- Anti-platelet aggregation activity of melaleuca bracteata var.revolution gold derived betulinic acid and its derivativesFoluso Oluwagbemiga Osunsanmi · 2015
- Frontiers in Clinical Drug Research - Alzheimer DisordersMarei, Hany E., Althani, Asmaa, Suhonen, Jaana, El Zowalaty, Mohamed E., Albanna, Mohammad A., Cenciarelli, Carlo, Wang, Tengfei, Caceci, Thomas · 2016 · BENTHAM SCIENCE PUBLISHERS eBooks
- Deciphering the role of 27-hydroxycholesterol in neurodegenerationMuhammad Al Mustafa Ismail · 2016 · Figshare
- Drug Directed at ApoE Production is Successful in Mouse Models of Alzheimer DiseaseAnthony L. Komaroff · 2012 · Journal watch
- Proxy-PET Building Blocks as a Design Element for Library SynthesisLainey Jo Mallin · 2015 · Journal of Bioresource Management
- Effect of liver x receptor target genes Apolipoprotein E and ATP-binding cassette transporter A1 on beta-amyloid dependent pathology in Alzheimer's disease model miceAlexis B. Carter · 2017 · D-Scholarship@Pitt (University of Pittsburgh)
- Amyloid-beta42 toxicity reduction in human neuroblastoma cells using cholera toxin b subunit-myelin basic protein expressed in chloroplastsAlexandra Ayache · 2012 · Journal of International Crisis and Risk Communication Research
- Association Between Blood Serum Antioxidant Status and Cognitive FunctionKaren Niemchick · 2017 · ScholarWorks (Walden University)
- Nitrate Chimeras: A New Class of Disease Modifying Agents for the Treatment of Alzheimer's DiseaseLawren A. VandeVrede · 2014 · Figshare
- Cerebral Innate ImmunityDavid Gate, Terrence Town · 2016 · Elsevier eBooks
- Metabolic study of Alzheimer’s disease using mutant C. elegansWaqar Ahmad · 2017 · The University of Queensland
- DEPLETION OF TDP-43 ACCELERATES NEURODEGENERATION IN AN ALZHEIMER’S MOUSE MODEL, INDEPENDENT OF BETA-AMYLOID PLAQUE BURDENKatherine D. LaClair · 2016
- Conformational Fluctuations of Biomolecules Studied Using Molecular Dynamics and Enhanced SamplingGeoffrey Gray · 2018 · Digital Commons - University of South Florida (University of South Florida)
- Exposition aux organochlorés et démence dans la population âgée du CanadaThierry Comlan Marc Medehouenou · 2013
- The role of apolipoprotein E in traumatic brain injury as determined by isoform and Abca1 haplodeficiencyEmilie L. Castranio · 2018 · D-Scholarship@Pitt (University of Pittsburgh)
- METAPLASTICITY IN A MOUSE MODEL OF ALZHEIMER’S DISEASE AND POSSIBLE THERAPEUTIC INTERVENTIONSAndrea Megill · 2014
- Oxidative modification of vesicular transporters in an animal model of Alzheimer’s diseaseYing Wang · 2015 · Mspace (University of Manitoba)
- Evidence that an HDAC2-targeted ASO persistently upregulates cortical acetylcholine and dopamine signaling via a CREB | Gs positive feedback loopTeresa Hinkle Sanders · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Genetic and functional studies of genes involved in the pathogenesis of Alzheimer's diseaseTeemu Natunen · 2014 · UEF eRepo (University of Eastern Finland)
- Engineering Human Induced Pluripotent Stem Cells (HIPSCS) to Investigate the Contribution of the APOE Risk Allele to the Onset and Progression of Alzheimer’s DiseaseNick Brookhouser · 2020 · UA Campus Repository (The University of Arizona)
- Human Ependymin Neurotrophic Factor Mimetic Increases Alzheimer’s Mice Cognitive Performance in a Morris Water-Maze TestTayeisha A. Jackson, Mortada Salman Najem · 2012 · Digital WPI
- Computational approaches to study drug resistance mechanismsZoya Khalid · 2017 · Sabanci University
- Evaluación del potencial terapéutico de un extracto de raíz de Zanthoxylum caribaeum en un modelo triple transgénico de Enfermedad de AlzheimerRuiz González, Juan Carlos · 2021
- REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR DETERMINATION OF BEXAROTENE IN CAPSULE DOSAGE FORMN Dhanvijay, Vijay Kumar Munipalli, M. Patel, S. Ghani, R. M Singh, Smita Nayak, Vaidhun H Bhaskar · 2018 · INDIAN DRUGS
- Krebsmittel gegen Alzheimer-Demenz?Kristina Endres · 2012 · InFo Neurologie + Psychiatrie
- Literaturverzeichnis zu Voderholzer, Hohagen (Hrsg.): Therapie psychischer Erkankungen, 9. Auflage2013 · Elsevier eBooks
- Apolipoprotein EMinerva M. Carrasquillo, Guojun Bu, Henrietta M. Nielsen · 2013 · Springer eBooks
- Literaturverzeichnis zu Voderholzer, Hohagen (Hrsg.): Therapie psychischer Erkrankungen, 10. Auflage2014 · Elsevier eBooks
- Targeting apolipoprotein E improves AD phenotype in mice2012 · Nature Reviews Neurology
- Additional file 2 of Bexarotene normalizes chemotherapy-induced myelin decompaction and reverses cognitive and sensorimotor deficits in miceAngie C.A. Chiang, Alexandre V. Seua, Pooja Singhmar, Luis D. Arroyo, Rajasekaran Mahalingam, JIAN LI HU, Annemieke Kavelaars, Cobi J. Heijnen · 2020 · Figshare
- Cancer signaling pathways: targets and treatmentBeere Vishnusai, Ravikant Sharma, Vipan Kumar Parihar, Nitesh Kumar · 2024 · Elsevier eBooks