ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Cited by (1,000)

Items 301–400 of 1,000

  1. Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan
    Fu, Yuan, Zhao, Jing, Atagi, Yuka, Nielsen, Henrietta M., Liu, Chia-Chen, Zheng, Honghua, Shinohara, Mitsuru, Kanekiyo, Takahisa, Bu, Guojun · 2016 · Molecular Neurodegeneration
  2. A randomized controlled study to evaluate the effect of bexarotene on amyloid‐β and apolipoprotein E metabolism in healthy subjects
    Ghosal, Kaushik, Haag, Michael, Verghese, Philip B., West, Tim, Veenstra, Tim, Braunstein, Joel B., Bateman, Randall J., Holtzman, David M., Landreth, Gary E. · 2016 · Alzheimer's & Dementia: Translational Research & Clinical Interventions
  3. Biological Hallmarks of Cancer in Alzheimer’s Disease
    Kelly Nicole Holohan Nudelman, Brenna C. McDonald, Debomoy K. Lahiri, Andrew J. Saykin · 2019 · Molecular Neurobiology
  4. Biological applications of near infrared fluorescence dye probes in monitoring Alzheimer’s disease
    Yusif Issahak Gyasi, Yipeng Pang, Xinrui Li, Jing-xue Gu, Xiaojing Cheng, Jiao Liu, Ting Xu, Yi Liu · 2019 · European Journal of Medicinal Chemistry
  5. A multitude of signaling pathways associated with Alzheimer's disease and their roles in AD pathogenesis and therapy
    Kundlik Gadhave, Deepak Kumar, Vladimir Nikolaevich Uversky, Rajanish Giri · 2020 · Medicinal Research Reviews
  6. Neuroanatomical phenotypes in a mouse model of the 22q11.2 microdeletion
    Jacob Ellegood, Sander Markx, Jason P. Lerch, Patrick E. Steadman, C Genç, Frank A. Provenzano, Steven A. Kushner, R. Mark Henkelman, Maria Karayiorgou, Joseph A. Gogos · 2013 · Molecular Psychiatry
  7. CSF Apo-E levels associate with cognitive decline and MRI changes
    For the Alzheimer’s Disease Neuroimaging Initiative, Toledo, Jon B., Da, Xiao, Weiner, Michael W., Wolk, David A., Xie, Sharon X., Arnold, Steven E., Davatzikos, Christos, Shaw, Leslie M., Trojanowski, John Q. · 2014 · Acta Neuropathologica
  8. EGFR is a potential dual molecular target for cancer and Alzheimer’s disease
    Hee-Jeong Choi, Yoo Joo Jeong, Jieun Kim, Hyang‐Sook Hoe · 2023 · Frontiers in Pharmacology
  9. The emerging role of bexarotene in the treatment of Alzheimer’s disease: current evidence
    Tousi, Babak · 2015 · Neuropsychiatric Disease and Treatment
  10. The Role of Cholesterol Metabolism in Alzheimer’s Disease
    Sun, Jia-Hao, Yu, Jin-Tai, Tan, Lan · 2015 · Molecular Neurobiology
  11. Alzheimer's disease pathology in APOE transgenic mouse models: The Who, What, When, Where, Why, and How
    Lewandowski, Cutler T., Maldonado Weng, Juan, LaDu, Mary Jo · 2020 · Neurobiology of Disease
  12. Bexarotene Blocks Calcium-Permeable Ion Channels Formed by Neurotoxic Alzheimer’s β-Amyloid Peptides
    Jacques Fantini, Coralie Di Scala, Nouara Yahi, Jean‐Denis Troadec, Kevin Sadelli, Henri Chahinian, Nicolas Garmy · 2014 · ACS Chemical Neuroscience
  13. Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease
    Wenjin Xu, Shane M. Fitzgerald, Ralph A. Nixon, Efrat Levy, Donald A. Wilson · 2014 · Experimental Neurology
  14. ApoE2 Exaggerates PTSD-Related Behavioral, Cognitive, and Neuroendocrine Alterations
    Johnson, Lance A, Zuloaga, Damian G, Bidiman, Erin, Marzulla, Tessa, Weber, Sydney, Wahbeh, Helane, Raber, Jacob · 2015 · Neuropsychopharmacology
  15. PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis
    Audrey S. Dickey, Dafne N. Sanchez, Martin Arreola, Kunal R. Sampat, Weiwei Fan, Nicolas Arbez, Sergey Akimov, Michael J. Van Kanegan, Kohta Ohnishi, Stephen K. Gilmore-Hall et al. · 2017 · Science Translational Medicine
  16. Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery
    Michele Perni, Pavan K. Challa, Julius B. Kirkegaard, Ryan Limbocker, Mandy Koopman, Maarten C. Hardenberg, Pietro Sormanni, Thomas H. Müller, Kadi Liis Saar, Lianne W. Y. Roode et al. · 2018 · Journal of Neuroscience Methods
  17. Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice
    Fitz, Nicholas F., Wolfe, Cody M., Playso, Brittany E., Biedrzycki, Richard J., Lu, Yi, Nam, Kyong Nyon, Lefterov, Iliya, Koldamova, Radosveta · 2020 · Molecular Neurodegeneration
  18. One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina
    Vivek Gupta, Veer B. Gupta, Nitin Chitranshi, Sumudu V. S. Gangoda, Roshana Vander Wall, Mojdeh Abbasi, Mojtaba Golzan, Yogita Dheer, Tejal M. Shah, Alberto P. Avolio et al. · 2016 · Cellular and Molecular Life Sciences
  19. Amyloid β-interacting partners in Alzheimer's disease: From accomplices to possible therapeutic targets
    Han, Sun-Ho, Park, Jong-Chan, Mook-Jung, Inhee · 2016 · Progress in Neurobiology
  20. Transcriptional regulation and its misregulation in Alzheimer’s disease
    Xiao‐Fen Chen, Yun‐wu Zhang, Huaxi Xu, Guojun Bu · 2013 · Molecular Brain
  21. C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer’s disease
    Yiyuan Xia, Zhi-Hao Wang, Jichun Zhang, Xia Liu, Shan Ping Yu, Karen X. Ye, Jian–Zhi Wang, Keqiang Ye, Xiaochuan Wang · 2020 · Molecular Psychiatry
  22. Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation
    Sabine Willems, Daniel Zaienne, Daniel Merk · 2021 · Journal of Medicinal Chemistry
  23. On the central role of brain connectivity in neurodegenerative disease progression
    Yasser Iturria‐Medina, Alan Charles Evans · 2015 · Frontiers in Aging Neuroscience
  24. The NR4A orphan nuclear receptors mediate transcription-dependent hippocampal synaptic plasticity
    Bridi, Morgan S., Abel, Ted · 2013 · Neurobiology of Learning and Memory
  25. Activation of RXR/PPARγ underlies neuroprotection by bexarotene in ischemic stroke
    Michelangelo Certo, Yasuyuki Endo, Kiminori Ohta, Shinobu Sakurada, Giacinto Bagetta, Diana Amantea · 2015 · Pharmacological Research
  26. ABCA1 is Necessary for Bexarotene-Mediated Clearance of Soluble Amyloid Beta from the Hippocampus of APP/PS1 Mice
    Angela W. Corona, Nathan Kodoma, Brad T. Casali, Gary E. Landreth · 2015 · Journal of Neuroimmune Pharmacology
  27. Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Dopamine Neurons and Can Alleviate α-Synuclein Disrupted Gene Expression
    Nikolaos Volakakis, Katarína Tiklová, Mickaël Decressac, Maria Papathanou, Bengt Mattsson, Linda Gillberg, André Nobre, Anders Björklund, Thomas Perlmann · 2015 · Journal of Neuroscience
  28. Blood metabolite markers of cognitive performance and brain function in aging
    Brittany N. Simpson, Min Gyu Kim, Yi‐Fang Chuang, Lori L. Beason‐Held, Melissa H. Kitner‐Triolo, Michael A. Kraut, Seth T. Lirette, B. Gwen Windham, Michael E Griswold, Cristina Legido‐Quigley et al. · 2015 · Journal of Cerebral Blood Flow & Metabolism
  29. Bexarotene protects against traumatic brain injury in mice partially through apolipoprotein E
    Jianjun Zhong, Chongjie Cheng, Han Liu, Zhijian Huang, Yue Wu, Zhipeng Teng, Junchi He, Hongrong Zhang, Jinchuan Wu, Fang Cao et al. · 2016 · Neuroscience
  30. Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity
    Mounier, A., Georgiev, D., Nam, K. N., Fitz, N. F., Castranio, E. L., Wolfe, C. M., Cronican, A. A., Schug, J., Lefterov, I., Koldamova, R. · 2015 · Journal of Neuroscience
  31. APOE and dementia – resequencing and genotyping in 105,597 individuals
    Rasmussen, Katrine L., Tybjærg‐Hansen, Anne, Nordestgaard, Børge G., Frikke‐Schmidt, Ruth · 2020 · Alzheimer's & Dementia
  32. An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice
    Jeffrey L. Frost, Bin Liu, Jens‐Ulrich Rahfeld, Martin Kleinschmidt, Brian O’Nuallain, Kevin X. Le, Inge Lues, Barbara J. Caldarone, Stephan Schilling, Hans‐Ulrich Demuth et al. · 2015 · Neurobiology of Aging
  33. Wogonin increases β-amyloid clearance and inhibits tau phosphorylation via inhibition of mammalian target of rapamycin: potential drug to treat Alzheimer’s disease
    Yuyou Zhu, Juan Wang · 2015 · Neurological Sciences
  34. Anti-inflammatory Signaling in Microglia Exacerbates Alzheimer’s Disease-Related Pathology
    Jean-Philippe Michaud, Serge Rivest · 2015 · Neuron
  35. Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways
    Christopher Böhm, F. Chen, Jean Sévalle, Seema Qamar, Roger B. Dodd, Y. Li, Gerold Schmitt‐Ulms, Paul E. Fraser, Peter St George‐Hyslop · 2015 · Molecular and Cellular Neuroscience
  36. New insights in lipid metabolism: potential therapeutic targets for the treatment of Alzheimer’s disease
    Cao, Yuan, Zhao, Lin-Wei, Chen, Zi-Xin, Li, Shao-Hua · 2024 · Frontiers in Neuroscience
  37. Bexarotene reduces network excitability in models of Alzheimer's disease and epilepsy
    Valerie C. Bomben, Jerrah K. Holth, John G. Reed, Paige E. Cramer, Gary E. Landreth, Jeffrey L. Noebels · 2014 · Neurobiology of Aging
  38. Evidence of oxidative stress and mitochondrial dysfunction in spinocerebellar ataxia type 2 (SCA2) patient fibroblasts: Effect of coenzyme Q10 supplementation on these parameters
    Nanna Cornelius, Jonathan Henry Wardman, Iain Parry Hargreaves, Viruna Neergheen, Anne Sigaard Bie, Zeynep Tümer, Jørgen Erik Nielsen, Troels T. Nielsen · 2017 · Mitochondrion
  39. Peripheral versus central nervous system APOE in Alzheimer’s disease: Interplay across the blood-brain barrier
    Dustin Chernick, Stephanie Ortiz‐Valle, Angela Jeong, Wenhui Qu, Ling Li · 2019 · Neuroscience Letters
  40. Microglial Function and Regulation during Development, Homeostasis and Alzheimer’s Disease
    Brad T. Casali, Erin G. Reed-Geaghan · 2021 · Cells
  41. The small HDL particle hypothesis of Alzheimer's disease
    Ashley E. Martinez, Gali H. Weissberger, Zsuzsanna Kuklenyik, Xulei He, Cristiana Joy Meuret, Trusha Parekh, Jon C. Rees, Bryan A. Parks, Michael S. Gardner, Sarah M. King et al. · 2022 · Alzheimer s & Dementia
  42. Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease
    Brad T. Casali, Angela W. Corona, Monica M. Mariani, J. Colleen Karlo, K. Ghosal, Gary E. Landreth · 2015 · Journal of Neuroscience
  43. Link between Cancer and Alzheimer Disease via Oxidative Stress Induced by Nitric Oxide-Dependent Mitochondrial DNA Overproliferation and Deletion
    Gjumrakch Aliev, Mark E. Obrenovich, Shams S. M. Tabrez, Nasimudeen R. Jabir, V. Prakash Reddy, Yi Li, Geoffrey Burnstock, Ramón Cacabelos, Mohammad Amjad Kamal · 2013 · Oxidative Medicine and Cellular Longevity
  44. Age- and time-dependent model of the prevalence of non-communicable diseases and application to dementia in Germany
    Ralph Brinks, Sandra Landwehr · 2013 · Theoretical Population Biology
  45. Metabolic Syndrome and the Cellular Phase of Alzheimer's Disease
    Subbiah Pugazhenthi · 2017 · Progress in molecular biology and translational science
  46. Liver X receptors: Emerging therapeutic targets for Alzheimer's disease
    Sodhi, Rupinder K., Singh, Nirmal · 2013 · Pharmacological Research
  47. Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome
    Line De Kimpe, Elise S. van Haastert, Archontia Kaminari, Rob Zwart, Helma Rutjes, Jeroen J.M. Hoozemans, Wiep Scheper · 2012 · AGE
  48. Cancer Chemotherapy Related Cognitive Impairment and the Impact of the Alzheimer’s Disease Risk Factor APOE
    Harvey R. Fernandez, Ashima Varma, Sarah A. Flowers, George William Rebeck · 2020 · Cancers
  49. Hereditary features, treatment, and prognosis of the lipoprotein glomerulopathy in patients with the APOE Kyoto mutation
    Hu, Zhangxue, Huang, Songmin, Wu, Yu, Liu, Yunqiang, Liu, Xiaoxia, Su, Dan, Tao, Ye, Fu, Ping, Zhang, Xiuhui, Peng, Ziying et al. · 2014 · Kidney International
  50. Dual-function triazole–pyridine derivatives as inhibitors of metal-induced amyloid-β aggregation
    Michael R. Jones, E.L. Service, J. R. Thompson, Michael C. P. Wang, Isaac J. Kimsey, Alaina S. DeToma, Ayyalusamy Ramamoorthy, Mi Hee Lim, Tim Storr · 2012 · Metallomics
  51. Age-Dependent Regulation of the Blood-Brain Barrier Influx/Efflux Equilibrium of Amyloid-β Peptide in a Mouse Model of Alzheimer’s Disease (3xTg-AD)
    Tuan Nguyen Minh, Agnès Dodacki, Waël Alata, Frédéric Calon, Sophie Nicolic, Jean‐Michel Scherrmann, Robert Farinotti, Fanchon Bourasset · 2015 · Journal of Alzheimer s Disease
  52. Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease
    Xiaodong Shi, Kai Sun, Rui Hu, Xiao-Ya Liu, Qiu‐Mei Hu, Xiaoyu Sun, Bin Yao, Nan Sun, Jing‐Ru Hao, Pan Wei et al. · 2016 · Journal of Neuroscience
  53. Be positive about negatives–recommendations for the publication of negative (or null) results
    Bespalov, Anton, Steckler, Thomas, Skolnick, Phil · 2019 · European Neuropsychopharmacology
  54. Beta-Amyloid and Tau-Protein: Structure, Interaction, and Prion-Like Properties
    Olga G. Tatarnikova, М. А. Орлов, Natalia V. Bobkova · 2015 · Biochemistry (Moscow)
  55. Spectroscopic Signature for Stable β-Amyloid Fibrils versus β-Sheet-Rich Oligomers
    Justin P. Lomont, Kacie L. Rich, Michał Maj, Jia-Jung Ho, Joshua S. Ostrander, Martin T. Zanni · 2017 · The Journal of Physical Chemistry B
  56. Effects of Baicalein on Cortical Proinflammatory Cytokines and the Intestinal Microbiome in Senescence Accelerated Mouse Prone 8
    Li Gao, Jiaqi Li, Yuzhi Zhou, Xudong Huang, Xuemei Qin, Guanhua Du · 2018 · ACS Chemical Neuroscience
  57. Glutamatergic Transmission Aberration: A Major Cause of Behavioral Deficits in a Murine Model of Down's Syndrome
    Kaur, Gurjinder, Sharma, Ajay, Xu, Wenjin, Gerum, Scott, Alldred, Melissa J., Subbanna, Shivakumar, Basavarajappa, Balapal S., Pawlik, Monika, Ohno, Masuo, Ginsberg, Stephen D. et al. · 2014 · The Journal of Neuroscience
  58. Proteolytic Cleavage of Apolipoprotein E4 as the Keystone for the Heightened Risk Associated with Alzheimer’s Disease
    Troy T. Rohn · 2013 · International Journal of Molecular Sciences
  59. Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation
    Julius Carl Pollinger, Leonie Gellrich, Simone Schierle, Whitney Kilu, Jurema Schmidt, Lena Kalinowsky, Julia Ohrndorf, Astrid Kaiser, Jan Heering, Ewgenij Proschak et al. · 2019 · Journal of Medicinal Chemistry
  60. Molecular Signaling Mechanisms of Natural and Synthetic Retinoids for Inhibition of Pathogenesis in Alzheimer’s Disease
    Chakrabarti, Mrinmay, McDonald, Alexander J., Will Reed, J., Moss, Melissa A., Das, Bhaskar C., Ray, Swapan K. · 2016 · Journal of Alzheimer's Disease
  61. Connecting the Dots Between Hypercholesterolemia and Alzheimer’s Disease: A Potential Mechanism Based on 27-Hydroxycholesterol
    Mingan Wu, Yingying Zhai, Xiaoyi Liang, Wei‐Chun Chen, Ruiyi Lin, Linlin Ma, Yi Huang, Di Zhao, Yong Liang, Wei Zhao et al. · 2022 · Frontiers in Neuroscience
  62. Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1
    Masaya Tachibana, Mitsuru Shinohara, Yu Yamazaki, Chia‐Chen Liu, Justin T. Rogers, Guojun Bu, Takahisa Kanekiyo · 2015 · Experimental Neurology
  63. Cholesterol in the Pathogenesis of Alzheimer’s, Parkinson’s Diseases and Autism: Link to Synaptic Dysfunction
    Alexey M. Petrov, Marat R. Kasimov, Andrey Lvovich Zefirov · 2017 · Acta Naturae
  64. Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury
    Emilie L. Castranio, Anaïs Mounier, Cody M. Wolfe, Kyong Nyon Nam, Nicholas Francis Fitz, Florent Letronne, Jonathan Schug, Radosveta P. Koldamova, Iliya M. Lefterov · 2017 · Neurobiology of Disease
  65. Neuroprotective Effect of Bexarotene in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
    Javier Riancho, María Ruiz‐Soto, Maria Teresa Berciano, José Berciano, Miguel Lafarga · 2015 · Frontiers in Cellular Neuroscience
  66. Epigenetic Treatment of Neurodegenerative Disorders: Alzheimer and Parkinson Diseases
    Michael H. Irwin, Walter H. Moos, Douglas V. Faller, Kosta Steliou, Carl A. Pinkert · 2016 · Drug Development Research
  67. Bexarotene Promotes Cholesterol Efflux and Restricts Apical-to-Basolateral Transport of Amyloid-β Peptides in an In Vitro Model of the Human Blood-Brain Barrier
    Kuntz, Mélanie, Candela, Pietra, Saint-Pol, Julien, Lamartinière, Yordenca, Boucau, Marie-Christine, Sevin, Emmanuel, Fenart, Laurence, Gosselet, Fabien · 2015 · Journal of Alzheimer's Disease
  68. Role of Liver X Receptor in AD Pathophysiology
    Adrián Gabriel Sandoval-Hernández, Luna Buitrago, Herman Moreno, Gloria Patricia Cardona‐Gómez, Gonzálo Arboleda · 2015 · PLoS ONE
  69. Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology
    Jianping Guo, Ji Cheng, Brian J. North, Wenyi Wei · 2017 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  70. Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation
    Miguel Moutinho, Juan Francisco Codocedo, Shweta S. Puntambekar, Gary E. Landreth · 2018 · The Annual Review of Pharmacology and Toxicology
  71. Emerging role of HDL in brain cholesterol metabolism and neurodegenerative disorders
    Turri, Marta, Marchi, Cinzia, Adorni, Maria Pia, Calabresi, Laura, Zimetti, Francesca · 2022 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  72. Amyloid Beta Inhibits Olfactory Bulb Activity and the Ability to Smell
    Reynaldo Alvarado-Martínez, Karla Salgado-Puga, Fernando Peña‐Ortega · 2013 · PLoS ONE
  73. 1,25-Dihydroxyvitamin D and Klotho
    Mark R. Haussler, G. Kerr Whitfield, Carol A. Haussler, Marya S. Sabir, Zainab Khan, Ruby Sandoval, Peter W. Jurutka · 2016 · Vitamins and hormones
  74. Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress
    Dongsheng Shang, Yin Hong, Wangwang Xie, Zhigang Tu, Jun Liang Xu · 2020 · Frontiers in Neurology
  75. L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer’s disease via activating dopamine D1 receptor/PKA signaling pathway
    Hao, J-R, Sun, N, Lei, L, Li, X-Y, Yao, B, Sun, K, Hu, R, Zhang, X, Shi, X-D, Gao, C · 2015 · Cell Death & Disease
  76. Traumatic Brain Injury, Microglia, and Beta Amyloid
    Rebekah Mannix, Michael J. Whalen · 2012 · International Journal of Alzheimer s Disease
  77. Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke
    Eunhee Kim, Moon-Sook Woo, Luye Qin, Thong Chi Ma, Cesar Beltran, Yi Bao, Jason A. Bailey, Dale Corbett, Rajiv R. Ratan, Debomoy K. Lahiri et al. · 2015 · Journal of Neuroscience
  78. Alzheimer's disease: Only prevention makes sense
    José Viña, Jorge Sanz‐Ros · 2018 · European Journal of Clinical Investigation
  79. High‐density lipoprotein mimetic peptide 4F mitigates amyloid‐β‐induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia
    Chernick, Dustin, Ortiz‐Valle, Stephanie, Jeong, Angela, Swaminathan, Suresh K., Kandimalla, Karunya K., Rebeck, G. William, Li, Ling · 2018 · Journal of Neurochemistry
  80. The role of Locus Coeruleus in neuroinflammation occurring in Alzheimer’s disease
    Filippo Sean Giorgi, Luigi Francesco Saccaro, Alessandro Galgani, Carla Letizia Busceti, Francesca Biagioni, Alessandro Frati, Francesco Fornai · 2019 · Brain Research Bulletin
  81. Molecular Insight into the Therapeutic Promise of TargetingAPOE4for Alzheimer’s Disease
    Abdullah Al Mamun, Md. Sahab Uddin, Md. Fahim Bin Bashar, Sonia Zaman, Yesmin Begum, Israt Jahan Bulbul, Md. Siddiqul Islam, Md Shahid Sarwar, Bijo Mathew, Md. Shah Amran et al. · 2020 · Oxidative Medicine and Cellular Longevity
  82. The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer’s Disease-related Pathogenesis
    Seong Gak Jeon, Anji Yoo, Dong Wook Chun, Sang Bum Hong, Hyunju Chung, Jin-Il Kim, Minho Moon · 2020 · Aging and Disease
  83. Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine
    Crystal D. Hayes, Debleena Dey, Juan Pablo Palavicini, Hongjie Wang, Kshitij A. Patkar, Dmitriy Minond, Adel Nefzi, Madepalli Krishnappa Lakshmana · 2013 · BMC Medicine
  84. Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats
    Gaoshang Chai, Dong-Xiao Duan, Rong-Hong Ma, Jianying Shen, Honglian Li, Zhiwei Ma, Yu Luo, Lu Wang, Xin-Hua Qi, Jian‐Zhi Wang et al. · 2014 · Neuroscience Bulletin
  85. Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration
    Goldis Malek, Eleonora Maries Lad · 2014 · Cellular and Molecular Life Sciences
  86. Alzheimer’s disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs
    Juan Manuel Zolezzi, Sussy Bastias Candia, Manuel J. Santos, Nibaldo C. Inestrosa · 2014 · Frontiers in Aging Neuroscience
  87. Lipid transporter Spns2 promotes microglia pro‐inflammatory activation in response to amyloid‐beta peptide
    Liansheng Zhong, Xue Jiang, Zhihui Zhu, Haiyan Qin, Michael B. Dinkins, Ji‐Na Kong, Silvia Leanhart, Rebecca Wang, Ahmed M. Elsherbini, Erhard Bieberich et al. · 2018 · Glia
  88. Cooperative Therapeutic Action of Retinoic Acid Receptor and Retinoid X Receptor Agonists in a Mouse Model of Alzheimer's Disease
    Kawahara, Kohichi, Suenobu, Michita, Ohtsuka, Hideyuki, Kuniyasu, Akihiko, Sugimoto, Yukihiko, Nakagomi, Madoka, Fukasawa, Hiroshi, Shudo, Koichi, Nakayama, Hitoshi · 2014 · Journal of Alzheimer's Disease
  89. Modulation of the Aβ peptide aggregation pathway by KP1019 limits Aβ-associated neurotoxicity
    Jones, Michael R., Mu, Changhua, Wang, Michael C. P., Webb, Michael I., Walsby, Charles J., Storr, Tim · 2015 · Metallomics
  90. Small-molecule drugs development for Alzheimer's disease
    Weiwei Yao, Huihui Yang, Jinfei Yang · 2022 · Frontiers in Aging Neuroscience
  91. Drug Repositioning: An Opportunity to Develop Novel Treatments for Alzheimer’s Disease
    Anne Corbett, Gareth Haydn Williams, Clive G. Ballard · 2013 · Pharmaceuticals
  92. Age-Dependent, Non-Cell-Autonomous Deposition of Amyloid from Synthesis of β-Amyloid by Cells Other Than Excitatory Neurons
    Karthikeyan Veeraraghavalu, Can Martin Zhang, Xiaoqiong Zhang, Rudolph E. Tanzi, Sangram S. Sisodia · 2014 · Journal of Neuroscience
  93. A Unified Hypothesis of Early- and Late-Onset Alzheimer’s Disease Pathogenesis
    Craig Atwood, Richard L. Bowen · 2015 · Journal of Alzheimer s Disease
  94. Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype
    Pascal Heitel, Leonie Gellrich, Lena Kalinowsky, Jan Heering, Astrid Kaiser, Julia Ohrndorf, Ewgenij Proschak, Daniel Merk · 2019 · ACS Medicinal Chemistry Letters
  95. Allosteric small molecule modulators of nuclear receptors
    Femke A. Meijer, Iris A. Leijten-van de Gevel, Rens M. J. M. de Vries, Luc Brunsveld · 2019 · Molecular and Cellular Endocrinology
  96. Astaxanthin exerts protective effects similar to bexarotene in Alzheimer's disease by modulating amyloid-beta and cholesterol homeostasis in blood-brain barrier endothelial cells
    Elham Fanaee‐Danesh, Chaitanya Chakravarthi Gali, Jelena Tadić, Martina Zandl‐Lang, Alexandra Carmen Kober, Vicente Roca Agujetas, Cristina de Dios, Carmen Tam‐Amersdorfer, Anika Stracke, Nicole Maria Albrecher et al. · 2019 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  97. Significant Upregulation of Alzheimer's β‐Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides
    Chao Ma, Juanjuan Su, Yao Sun, Yang Feng, Nolan Shen, Bo Li, Yingxia Liang, Xintong Yang, Hui Wu, Hongjie Zhang et al. · 2019 · Angewandte Chemie International Edition
  98. In Vivo and In Vitro Effects of an Apolipoprotein E Mimetic Peptide on Amyloid-β Pathology
    Shaila P. Handattu, Candyce E. Monroe, Gaurav Nayyar, Mayakonda N. Palgunachari, Inga Kadish, Thomas van Groen, G.M. Anantharamaiah, David W. Garber · 2013 · Journal of Alzheimer s Disease
  99. Meta-Analysis of Peripheral Blood Apolipoprotein E Levels in Alzheimer’s Disease
    Chong Wang, Jin‐Tai Yu, Hui-Fu Wang, Teng Jiang, Chen‐Chen Tan, Xiangfei Meng, Holly D Soares, Lan Tan · 2014 · PLoS ONE
  100. Apolipoprotein E, amyloid-ß clearance and therapeutic opportunities in Alzheimer's disease
    Adam D. Kline · 2012 · Alzheimer s Research & Therapy