ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Cramer, Paige E., Cirrito, John R., Wesson, Daniel W., Lee, C. Y. Daniel, Karlo, J. Colleen, Zinn, Adriana E., Casali, Brad T., Restivo, Jessica L., Goebel, Whitney D., James, Michael J., Brunden, Kurt R., Wilson, Donald A., Landreth, Gary E.·2012·Science
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- Apolipoprotein E, amyloid-ß clearance and therapeutic opportunities in Alzheimer's diseaseAdam D. Kline · 2012 · Alzheimer s Research & Therapy