ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Cramer, Paige E., Cirrito, John R., Wesson, Daniel W., Lee, C. Y. Daniel, Karlo, J. Colleen, Zinn, Adriana E., Casali, Brad T., Restivo, Jessica L. +5 more·2012·Science

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  81. Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer’s disease through inhibition of inflammation
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  87. Plasma apolipoprotein E levels and risk of dementia: A Mendelian randomization study of 106,562 individuals
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  91. Apolipoprotein E Genotype Affects Size of ApoE Complexes in Cerebrospinal Fluid
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  92. Towards drug repositioning: a unified computational framework for integrating multiple aspects of drug similarity and disease similarity.
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  95. Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer’s disease (AD)
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  96. Response to Comments on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models”
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