The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila , and Humans
Open accessAbstract
Letting Pyruvate In: Transport of pyruvate is an important event in metabolism whereby the pyruvate formed in glycolysis is transported into mitochondria to feed into the tricarboxylic acid cycle (see the Perspective by Murphy and Divakaruni ). Two groups have now identified proteins that are components of the mitochondrial pyruvate transporter. Bricker et al. (p. 96 , published online 24 May) found that the proteins mitochondrial pyruvate carrier 1 and 2 (MPC1 and MPC2) are required for full pyruvate transport in yeast and Drosophila cells and that humans with mutations in MPC1 have metabolic defects consistent with loss of the transporter. Herzig et al. (p. 93 , published online 24 May) identified the same proteins as components of the carrier in yeast. Furthermore, expression of the mouse proteins in bacteria conferred increased transport of pyruvate into bacterial cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Pyruvate, the end product of glycolysis, is imported into mitochondria through the mitochondrial pyruvate carrier (MPC) (Bricker et al., 2012; Herzig et al., 2012).”
From Inhibition of the mitochondrial pyruvate carrier in astrocytes reduces amyloid and tau accumulation in the 3xTgAD mouse model of Alzheimer's disease (2024) · cites this paper as Bricker et al., 2012
In the citing paper
“In normoxia, pyruvate is generated via glycolysis and transported across the IMM through the Mitochondrial Pyruvate Carrier (MPC).15,16 Pyruvate is further catabolized inside mitochondria through the TCA cycle.”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [16]
In the citing paper
“Pharmacological inhibition of MPC represses mitochondrial pyruvate uptake, shifting reliance to glycolysis for ATP production.”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [16]
In the citing paper
“Two recent studies revealed strong evidence that the genes, renamed MPC1 and MPC2, encode the multimeric mitochondrial pyruvate carrier (MPC) complex embedded in the mitochondrial inner mitochondrial membrane (Bricker et al., 2012; Herzig et al., 2012).”
From Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (2014) · cites this paper as Bricker et al., 2012
In the citing paper
“These results are consistent with the severe growth defect previously observed in yeast with deletions in both mpc1 and mitochondrial malic enzyme growing on glucose (Bricker et al., 2012), highlighting the remarkably conserved nature of metabolism across species.”
From Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (2014) · cites this paper as Bricker et al., 2012
In the citing paper
“Our analyses also more explicitly delineate the roles of MPC1 and MPC2 as components of the mitochondrial pyruvate transporter.”
From Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (2014) · cites this paper as Bricker et al., 2012
In the citing paper
“Consistent with this change, Bricker et al. (Bricker et al., 2012) and Herzig et al. (Herzig et al., 2012) both observed growth defects in medium lacking leucine or valine in their characterizations of yeast with Mpc deletions.”
From Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (2014) · cites this paper as Bricker et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Mechanisms linking obesity to insulin resistance and type 2 diabetes
Kahn, S. E., Hull, R. L., & Utzschneider, K. M. (2006) · Nature · doi:10.1038/nature05482 · Cited by 5,448
A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology
Pagliarini, D. J., Calvo, S. E., Chang, B., Sheth, S. A., Vafai, S. B., Ong, S.-E., Walford, G. A., Sugiana, C., Boneh, A., Chen, W. K., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.016 · Cited by 1,994
The proteome of Saccharomyces cerevisiae mitochondria
Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R. P., Meyer, H. E., Schönfisch, B., Perschil, I., Chacińska, A., Guiard, B., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135385100 · Cited by 895
Identification and Functional Expression of the Mitochondrial Pyruvate Carrier
Herzig, S., Raemy, E., Montessuit, S., Veuthey, J.-L., Zamboni, N., Westermann, B., Kunji, E. R. S., & Martinou, J.-C. (2012) · Science · doi:10.1126/science.1218530 · Cited by 747
The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors
Halestrap, A. P. (1975) · Biochemical Journal · doi:10.1042/bj1480085 · Cited by 543
Halestrap, A. P., & Denton, R. M. (1974) · Biochemical Journal · doi:10.1042/bj1380313 · Cited by 383
Regulation of the activity of the pyruvate dehydrogenase complex
Harris, R. A., Bowker-Kinley, M. M., Huang, B., & Wu, P. (2002) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(01)00061-9 · Cited by 313
Identification of the Mitochondrial NAD+ Transporter in Saccharomyces cerevisiae
Todisco, S., Agrimi, G., Castegna, A., & Palmieri, F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510425200 · Cited by 228
Halestrap, A. P. (1978) · Biochemical Journal · doi:10.1042/bj1720377 · Cited by 179
Flagged first, then by citations
Cited by
Sorted by citations
Items 701–800 of 844
Rajaram, K., Rangel, G. W., Munro, J. T., Nair, S. C., Elahi, R., Llinás, M., & Prigge, S. T. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110248 · Cited by 2
Divakaruni, A. S., Wiley, S. E., Andreyev, A. Y., Rogers, G. W., McDonald, W. G., Colca, J. R., & Murphy, A. N. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.06.101 · Cited by 2
Kitagaki, H., Tan, H., & Jayakody, L. N. (2013) · Agri-bioscience monographs · doi:10.5047/agbm.2013.00301.0001 · Cited by 2
Mitochondria and Energy Metabolism: Networks, Mechanisms, and Control
Hassinen, I. E. (2014) · Series in cellular and clinical imaging · doi:10.1201/b17427-3 · Cited by 2
Gökcan, H., Bedoyan, J. K., & Isayev, O. (2022) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.2c00630 · Cited by 2
Experimental Investigations on the Structure of Yeast Mitochondrial Pyruvate Carriers
Li, L., Wen, M., Run, C., Wu, B., & OuYang, B. (2022) · Membranes · doi:10.3390/membranes12100916 · Cited by 2
Lactic acid as a systemic product and biomarker of physical load
Boretsky, Y. R., Hlozhyk, I. Z., Hashchyshyn, V., Tymochko-Voloshyn, R. I., Параняк, Н., Shavel, K. E., Stefanyshyn, M., Verbin, I. V., Ivashchenko, V., Gayda, G. Z., et al. (2023) · Studia Biologica · doi:10.30970/sbi.1701.703 · Cited by 2
Herzig, S., Li, L., Jiménez‐Sánchez, C., Martinou, J., & Maechler, P. (2023) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2023.130492 · Cited by 2
Contributions of Mitochondrial Dysfunction to β Cell Failure in Diabetes Mellitus
Parnis, J., & Rutter, G. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811752-1.00009-2 · Cited by 2
Metabolic downregulation during diapause in embryos of Artemia franciscana
Patil, Y. N. (2012) · doi:10.31390/gradschool_dissertations.323 · Cited by 2
Subcellular thermal profiling enables the deep functional exploration of the mitochondrial proteomePreprint
Rivera-Mejías, P., Sueur, C. L., Kurzawa, N., Becher, I., & Savitski, M. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.27.582308 · Cited by 2
Lineage specifying transcription factors determine cell function by direct control of metabolismPreprint
Bott, A. J., Youngs, J. C., Cunningham, C. N., Vranken, J. G. V., Wei, P., Cluntun, A. A., Gygi, S. P., Ayer, D. E., & Rutter, J. P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.02.735862 · Cited by 2
Self-citationRecent Advances in Mitochondrial Pyruvate Carrier Inhibitors
Huang, Y., Zhang, H., Peng, X., & Zhang, Q. (2024) · Pharmaceutical Fronts · doi:10.1055/s-0044-1788072 · Cited by 1
Kong, W., Li, T., Li, Y., Zhang, L., Xie, J., & Liu, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010264 · Cited by 1
At last: the mitochondrial pyruvate carrier structure revealed!
Finck, B. N., Hadfield, C. M., & McCommis, K. S. (2025) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2025.05.010 · Cited by 1
Wang, J., Wang, M., Li, J., Li, D., & Fu, D. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01240-9 · Cited by 1
Illuminating mitochondrial metabolism with genetically encoded fluorescent indicators
Aburto, C., Pinilla, A., Carrera-Arenas, F., & Martín, A. S. (2025) · Biosensors and Bioelectronics X · doi:10.1016/j.biosx.2025.100705 · Cited by 1
T-Cell Activation and Differentiation: Role of Signaling and Metabolic Cross-Talk
Bhowmick, R., Ganguli, P., & Sarkar, R. R. (2020) · Springer eBooks · doi:10.1007/978-981-15-3350-1_6 · Cited by 1
NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes
Wang, Z., Ding, W. J., Ruan, M., Liu, Y., Yang, J., Zhang, H., Shen, B. Q., Wang, J., & Li, Y. (2023) · Biomolecules · doi:10.3390/biom13050719 · Cited by 1
Jian, D., Hu, N., He, R., He, L., He, X., Peng, X., Peng, Y., Yang, Y., Dai, X., Wang, D., et al. (2025) · Discover Oncology · doi:10.1007/s12672-025-03053-6 · Cited by 1
Muscle Fuel Utilization with Glycolysis Viewed Right Side Up
Brooks, G. A. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_1 · Cited by 2
Metabolic regulation of development—Lessons from Drosophila melanogaster
Fleck, S. A., Tennessen, J. M., & Reis, T. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95424-2.00056-x · Cited by 1
Liu, C., Seban, N., & Srinivasan, S. (2026) · eLife · doi:10.7554/elife.109237.3 · Cited by 1
Mitochondrial Pyruvate Metabolism Controls Alveolar Stem Cell Fate and Inflammatory Balance
He, Z., (285380), X. L., Miao, X., Xu, G., Wang, S., Li, L., Wu, Q., & Chen, H. (2026) · Inflammation · doi:10.1007/s10753-026-02470-1 · Cited by 1
Paul, D., Bansal, N., Patel, A., & Ghosh, D. (2026) · Bioresource Technology Reports · doi:10.1016/j.biteb.2026.102824 · Cited by 1
Making sense of subcellular H2O2 in mammals
Waldeck‐Weiermair, M., Covington, T. A., Pandey, A. K., & Michel, T. M. (2026) · Redox Biochemistry and Chemistry · doi:10.1016/j.rbc.2026.100080 · Cited by 1
Gut stem cells: Interplay with immune system, microbiota, and aging
Marotta, F., Balakrishnan, B., Yazdani, A., Ayala, A., He, F., & Catanzaro, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820071-1.00017-7 · Cited by 1
Local recruitment and fueling of the cellular powerplant to support cell invasion
Shannon, N., & Cunniff, B. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.03.002 · Cited by 1
Mitochondria and cell metabolism
Ayturk, M. M., Sahin, H. Y., & Şımşek, G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18858-9.00002-0 · Cited by 1
Metabolic Cycles: A Unifying Concept for Energy Transfer in the Heart
Beito, M., & Taegtmeyer, H. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.08.002 · Cited by 1
Adaptive immunity and metabolism
Verbist, K., Sharma, P., Beere, H. M., & Green, D. R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-15447-8.00008-8 · Cited by 1
Carbohydrate and protein metabolism
Nishimura, T., & Yoshinari, Y. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95424-2.00011-x · Cited by 1
Shetye, S., Patil, A., Suryakanth, V. B., Ramesh Bhat, Y., & Kamath, S. U. (2025) · Discover Applied Sciences · doi:10.1007/s42452-025-07173-0 · Cited by 1
Mitochondrial Dysfunction in Metabolic Disease
Meiliana, A., & Wijaya, A. (2012) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v4i3.172 · Cited by 1
Vašková, J., Firment, J., & Vaško, L. (2018) · InTech eBooks · doi:10.5772/intechopen.72937 · Cited by 1
Impaired mitochondrial bioenergetics in psychiatric disorders
Petschner, P., Gál, Z., & Gonda, X. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819621-2.00008-5 · Cited by 1
Vest, K. E., & Cobine, P. A. (2004) · Encyclopedia of Inorganic and Bioinorganic Chemistry · doi:10.1002/9781119951438.eibc2155 · Cited by 1
Developmental Regulation of Mitochondrial Function in Ovine Fetal Skeletal Muscle
Davies, K. (2018) · Apollo (University of Cambridge) · doi:10.17863/cam.22845 · Cited by 1
Investigation of transformation process of 1,3-diphenylguanidine in disinfection water treatment
Ying, L. (2023) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/173728 · Cited by 1
The fate of pyruvate dictates cell growth by modulating cellular redox potentialPreprint
Toshniwal, A. G., Lam, G., Bott, A. J., Cluntun, A. A., Skabelund, R. A., Nam, H.-J., Wisidagama, D. R., Thummel, C. S., & Rutter, J. P. (2024) · eLife · doi:10.7554/elife.103705.1 · Cited by 1
Self-citationHexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics
Laboy, R., Ndoci, M., Syed, S. T., Vonolfen, M., Ballhysa, E., Droth, T., Schilling, K., Löhrke, A., Atanassov, I., & Antebi, A. (2023) · eLife · doi:10.7554/elife.89225.4 · Cited by 1
MPC is a facultative pyruvate / lactate exchangerPreprint
Cárcamo‐Lemus, N., Rauseo, D., Martín, A. S., Lagos, C. F., Barros, L. F., & Sandoval, P. Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.29.691055 · Cited by 1
Molecular basis of mitochondrial leucine transport by human Sideroflexin 1Preprint
Fitzpatrick, F., Jones, D. T. D., Aguirre, H., Fry, B. N., Kaemmerer, E. T., Tan, S., Veelken, L. E., Tong, W. H., Block, S., Aghvami, S. A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.18.732944 · Cited by 1
Fernández-Caggiano, M. (2013) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Microscopes in Biomedical Research
Johnson, M. (2015)
An electron dense substrate to study mitochondrial import sites in situ
Gold, V. A. M., Ieva, R., van der Laan, M., Pfanner, N., & Kühlbrandt, W. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.06.102
Postmortem metabolism in porcine skeletal muscle
England, E. M. (2015) · VTechWorks (Virginia Tech)
Identification of the sodium-dependent pyruvate transporter located in plastid envelops
Furumoto, T. (2012) · Journal of Pesticide Science · doi:10.1584/jpestics.w12-29
Vest, K. E., & Cobine, P. A. (2014) · Royal Society of Chemistry eBooks · doi:10.1039/9781849739979-00500
Mitochondria and Energy Metabolism: Networks, Mechanisms, and Control
Hassinen, I. E. (2014) · CRC Press eBooks · doi:10.1201/b17427-8
Assessment of low-force exercise in human paralyzed muscle
Petrie, M. A., Shields, R. K., Casey, D. P., Cook, T. M., DeJong, S. L., & Dove, E. L. (2016) · doi:10.17077/etd.03yfha7y
Mathematical models for angiogenic, metabolic and apoptotic processes in tumours
Phipps, C. J. (2014) · UWSpace (University of Waterloo)
Measuring Mitochondrial Pyruvate Oxidation
Gray, L. R., Rouault, A. A. J., Oonthonpan, L., Rauckhorst, A. J., Sebag, J. A., & Taylor, E. B. (2017) · Neuromethods · doi:10.1007/978-1-4939-6890-9_16
Self-citationKitagaki, H. (2014) · JOURNAL OF THE BREWING SOCIETY OF JAPAN · doi:10.6013/jbrewsocjapan.109.335
Zhao, F. L. (2014) · UA Campus Repository (The University of Arizona)
A Study on Molecular Mechanism of Novel Mitophagy Regulators
박성우 (2015) · Seoul National University Open Repository (Seoul National University)
Role of Lysine Acetylation in the Control of Cardiac Energy Metabolism
Alrub, A. (2014) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3g15tk4x
Naude, M. (2018) · UpSpace Institutional Repository (University of Pretoria)
Integrated Regulation of Cardiac Fatty Acid and Glucose Oxidation
Altamimi, T. (2018) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3028pv9d
Regulation of MPCs and KAT8 During Adipogenesis and Nutritional Regulation
Burrell, J. A. (2020) · Louisiana State University · doi:10.31390/gradschool_dissertations.5401
De Novo Acetate Production is Coupled to Central Carbon Metabolism in MammalsPreprint
Liu, X., Cooper, D. E., Cluntun, A. A., Warmoes, M. O., Zhao, S., Reid, M. A., Liu, J., Wellen, K. E., Kirsch, D. G., & Locasale, J. W. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3155509
Wei, P., Bott, A. J., Cluntun, A. A., Morgan, J., Cunningham, C. N., Schell, J. C., Ouyang, Y., Ficarro, S. B., Marto, J. A., Danial, N. N., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3979182
Self-citationla Rossa, A. D., Laporte, M. H., Astori, S., Marissal, T., Montessuit, S., Sheshadri, P., Ramos‐Fernández, E., Méndez, P., Khani, A., Quairiaux, C., et al. (2022) · eLife · doi:10.7554/elife.72595.sa2
Self-citationMSDC-0160 and MSDC-0602 Binding with Human Mitochondrial Pyruvate Carrier (MPC) 1 and 2 Heterodimer
Phelix, C. F., Bourdon, A. K., Dugan, J. L., Villareal, G., & Perry, G. L. (2020) · IGI Global eBooks · doi:10.4018/978-1-7998-3441-0.ch022
(2013) · Elsevier eBooks · doi:10.1016/b978-0-12-388425-1.00023-3
A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex
Yamashita, Y., Vinogradova, E. V., Zhang, X., Suciu, R. M., & Cravatt, B. F. (2019) · Angewandte Chemie · doi:10.1002/ange.201914391
Moriyama, T., Mori, N., & Sato, N. (2017) · Springer eBooks · doi:10.1007/978-981-10-6101-1_19
del Arco, A., & Satrústegui, J. (2013) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0024196
Exon definitive regions for MPC1 microexon splicing and its usage for splicing modulation
Koh, E., Shin, D., & Kim, K. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.01.010
Biosensor-Assisted Laboratory Evolution of Malonyl-CoA production in Saccharomyces cerevisiaePreprint
Ferreira, R., Hedin, K. A., Nielsen, J., & David, F. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.16.549225
Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamicsPreprint
Laboy, R., Ndoci, M., Vonolfen, M., Ballhysa, E., Atanassov, I., & Antebi, A. (2023) · eLife · doi:10.7554/elife.89225.1
Citations as First-Class Data Entities: Open Citation Identifiers
Shotton, D. M. (2018) · doi:10.59350/8pkca-5dx66
Jiang, H., Xu, C., Li, W., Zhou, L. Y., & Fang, F. (2023) · Stem Cell Research · doi:10.1016/j.scr.2023.103206
Visualizing the Role of ER Stress in Diabetic Cardiomyopathy: A Bibliometric AnalysisPreprint
Ji, Y., Jin, Z., xu, Z., Zhou, L., Wen, X., Gao, L., Su, W., Xia, Z., Xia, Z., & Lei, S. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4641193
Dong, H., Yang, J., He, K., Zheng, W.-B., Lai, D., Liu, J., Ding, H.-Y., Wu, R.-B., Brown, K. M., Hide, G., et al. (2024) · eLife · doi:10.7554/elife.88866.3.sa3
Bi, G., Bian, Y., Liang, J., Yin, J., Li, R., Zhao, M., Huang, Y., Lu, T., Zhan, C., Fan, H. X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14670329
Bu, X., Zhao, W.-S., Li, W., Zou, H., Wu, S., Li, M., & Wang, G. (2023) · Figshare · doi:10.6084/m9.figshare.22624943
Bi, G., Bian, Y., Liang, J., Yin, J., Li, R., Zhao, M., Huang, Y., Lu, T., Zhan, C., Fan, H. X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14670332
Bi, G., Bian, Y., Liang, J., Yin, J., Li, R., Zhao, M., Huang, Y., Lu, T., Zhan, C., Fan, H. X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14670323
Bi, G., Bian, Y., Liang, J., Yin, J., Li, R., Zhao, M., Huang, Y., Lu, T., Zhan, C., Fan, H. X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14670362
Bi, G., Bian, Y., Liang, J., Yin, J., Li, R., Zhao, M., Huang, Y., Lu, T., Zhan, C., Fan, H. X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14670326
Bi, G., Bian, Y., Liang, J., Yin, J., Li, R., Zhao, M., Huang, Y., Lu, T., Zhan, C., Fan, H. X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14670335
Role of lactic acid and lactylation in nonalcoholic fatty liver disease
Chen, Z., Zhang, L., & Fei, S. (2024) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v32.i4.243
Hadfield, C. M., Walker, J. K., Arnatt, C. K., & McCommis, K. S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.16.594520
Pyrihová, E., King, M. S., King, A. C., Toleco, M. R., van der Giezen, M., & Kunji, E. R. S. (2024) · eLife · doi:10.7554/elife.94187.3.sa4
Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamicsPreprint
Laboy, R., Ndoci, M., Vonolfen, M., Ballhysa, E., Syed, S. T., Droth, T., Schilling, K., Löhrke, A., Atanassov, I., & Antebi, A. (2024) · eLife · doi:10.7554/elife.89225.2
Pandey, N., Roy, C. S., Bellur, A., & Balaram, H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.06.631440
Huang, H., Zhi, W., Li, H., Wang, C., Chen, C., Liu, Y., Qin, J., Cao, S., & Yang, X. (2025) · Urolithiasis · doi:10.1007/s00240-025-01738-9
Bunnell, D., Buhl, M., McGee, J., Milas, G., & Chtarbanova, S. (2025) · Research Square · doi:10.21203/rs.3.rs-6816306/v1
The Function of Succinate Dehydrogenase in Maintaining Normal Health
Lari, M. Q., Kumar, D., Kumar, D., & Kumar, A. (2025) · Springer eBooks · doi:10.1007/978-981-96-6831-1_2
Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamicsPreprint
Laboy, R., Ndoci, M., Tabrez, S. S., Vonolfen, M., Ballhysa, E., Droth, T., Schilling, K., Löhrke, A., Atanassov, I., & Antebi, A. (2025) · eLife · doi:10.7554/elife.89225.3
Impact of the mitochondrial pyruvate carrier on astrocytic metabolism and mouse physiology
Rodríguez-Muñoz, D. (2025) · Gredos (University of Salamanca) · doi:10.14201/gredos.167136
The fate of pyruvate dictates cell growth by modulating cellular redox potentialPreprint
Toshniwal, A. G., Lam, G., Bott, A. J., Cluntun, A. A., Skabelund, R. A., Nam, H.-J., Wisidagama, D. R., Thummel, C. S., & Rutter, J. P. (2025) · eLife · doi:10.7554/elife.103705.2
Self-citationLee, C., Ruan, T., Debnath, S., Wacker, A. S., Figlioli, G., Babich, J. W., Nehmeh, S. A., Keshari, K. R., & Kelly, J. M. (2026) · npj Imaging · doi:10.1038/s44303-026-00165-8
Bacha, O., Galaï, S., Zioudi, A., Kraoua, I., Youssef-Turki, I. B., & Omar, S. (2025) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2025.100096
Citations as First-Class Data Entities: Open Citation Identifiers
Shotton, D. M. (2018) · doi:10.59350/7ry8b-njq77
Metadata
- Authors
- Bricker, D. K., Taylor, E. B., Schell, J. C., Orsak, T., Boutron, A., Chen, Y.-C., Cox, J. E., Cardon, C. M., Van Vranken, J. G., Dephoure, N., Redin, C., Boudina, S., Gygi, S. P., Brivet, M., Thummel, C. S., & Rutter, J.
- Affiliations
- University of Utah (US)
- Assistance Publique – Hôpitaux de Paris (FR)
- Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
- Harvard University (US)
- Institut de génétique et de biologie moléculaire et cellulaire (FR)
- Corresponding author
- Bricker, Daniel K.
- Taylor, Eric B.
- Schell, John C.
- Orsak, Thomas
- Rutter, Jared
- ORCID
- Venue
- Science
- Published
- 2012-07-06
- Volume
- 337
- Issue
- 6090
- Pages
- 96-100
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3690818
- OpenAlex
- W2019750161
- Cited by
- 843
- References
- 19
- Citations by year
- 2026: 36 · 2025: 60 · 2024: 68 · 2023: 77 · 2022: 70 · 2021: 81 · 2020: 76 · 2019: 58 · 2018: 57 · 2017: 48 · 2016: 52 · 2015: 46 · 2014: 57 · 2013: 38 · 2012: 17
- FWCI
- 20.33
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Institutes of Health (2r01dk071962-05a1)
- National Heart, Lung, and Blood Institute (P30HL101310)
- National Institute of General Medical Sciences (R01GM083746, R01GM087346, T32GM007464, R01GM094232)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK072437, RC1DK086426, R01 DK-071962, R24DK092784)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (K99AR059190)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- mitochondrial pyruvate carrier, MPC1, MPC2, pyruvate uptake, pyruvate oxidation, TCA cycle, inner mitochondrial membrane, lactic acidosis, carbon metabolism, yeast, Drosophila, human
- MeSH terms
- Amino Acid Sequence, Amino Acids, Animals, Biological Transport, Citric Acid Cycle, Drosophila melanogaster, Humans, Mitochondria, Molecular Sequence Data, Oxidation-Reduction, Saccharomyces cerevisiae, Point Mutation, Pyruvic Acid, Mitochondrial Proteins, Anion Transport Proteins, Monocarboxylic Acid Transporters, Saccharomyces cerevisiae Proteins, Drosophila Proteins, Mitochondrial Membrane Transport Proteins, Carbohydrate Metabolism, Mitochondrial Membranes, Metabolomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
