The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila , and Humans
Open accessAbstract
Letting Pyruvate In: Transport of pyruvate is an important event in metabolism whereby the pyruvate formed in glycolysis is transported into mitochondria to feed into the tricarboxylic acid cycle (see the Perspective by Murphy and Divakaruni ). Two groups have now identified proteins that are components of the mitochondrial pyruvate transporter. Bricker et al. (p. 96 , published online 24 May) found that the proteins mitochondrial pyruvate carrier 1 and 2 (MPC1 and MPC2) are required for full pyruvate transport in yeast and Drosophila cells and that humans with mutations in MPC1 have metabolic defects consistent with loss of the transporter. Herzig et al. (p. 93 , published online 24 May) identified the same proteins as components of the carrier in yeast. Furthermore, expression of the mouse proteins in bacteria conferred increased transport of pyruvate into bacterial cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Pyruvate, the end product of glycolysis, is imported into mitochondria through the mitochondrial pyruvate carrier (MPC) (Bricker et al., 2012; Herzig et al., 2012).”
From Inhibition of the mitochondrial pyruvate carrier in astrocytes reduces amyloid and tau accumulation in the 3xTgAD mouse model of Alzheimer's disease (2024) · cites this paper as Bricker et al., 2012
In the citing paper
“In normoxia, pyruvate is generated via glycolysis and transported across the IMM through the Mitochondrial Pyruvate Carrier (MPC).15,16 Pyruvate is further catabolized inside mitochondria through the TCA cycle.”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [16]
In the citing paper
“Pharmacological inhibition of MPC represses mitochondrial pyruvate uptake, shifting reliance to glycolysis for ATP production.”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [16]
In the citing paper
“Two recent studies revealed strong evidence that the genes, renamed MPC1 and MPC2, encode the multimeric mitochondrial pyruvate carrier (MPC) complex embedded in the mitochondrial inner mitochondrial membrane (Bricker et al., 2012; Herzig et al., 2012).”
From Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (2014) · cites this paper as Bricker et al., 2012
In the citing paper
“These results are consistent with the severe growth defect previously observed in yeast with deletions in both mpc1 and mitochondrial malic enzyme growing on glucose (Bricker et al., 2012), highlighting the remarkably conserved nature of metabolism across species.”
From Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (2014) · cites this paper as Bricker et al., 2012
In the citing paper
“Our analyses also more explicitly delineate the roles of MPC1 and MPC2 as components of the mitochondrial pyruvate transporter.”
From Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (2014) · cites this paper as Bricker et al., 2012
In the citing paper
“Consistent with this change, Bricker et al. (Bricker et al., 2012) and Herzig et al. (Herzig et al., 2012) both observed growth defects in medium lacking leucine or valine in their characterizations of yeast with Mpc deletions.”
From Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (2014) · cites this paper as Bricker et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Mechanisms linking obesity to insulin resistance and type 2 diabetes
Kahn, S. E., Hull, R. L., & Utzschneider, K. M. (2006) · Nature · doi:10.1038/nature05482 · Cited by 5,448
A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology
Pagliarini, D. J., Calvo, S. E., Chang, B., Sheth, S. A., Vafai, S. B., Ong, S.-E., Walford, G. A., Sugiana, C., Boneh, A., Chen, W. K., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.016 · Cited by 1,994
The proteome of Saccharomyces cerevisiae mitochondria
Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R. P., Meyer, H. E., Schönfisch, B., Perschil, I., Chacińska, A., Guiard, B., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135385100 · Cited by 895
Identification and Functional Expression of the Mitochondrial Pyruvate Carrier
Herzig, S., Raemy, E., Montessuit, S., Veuthey, J.-L., Zamboni, N., Westermann, B., Kunji, E. R. S., & Martinou, J.-C. (2012) · Science · doi:10.1126/science.1218530 · Cited by 747
The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors
Halestrap, A. P. (1975) · Biochemical Journal · doi:10.1042/bj1480085 · Cited by 543
Halestrap, A. P., & Denton, R. M. (1974) · Biochemical Journal · doi:10.1042/bj1380313 · Cited by 383
Regulation of the activity of the pyruvate dehydrogenase complex
Harris, R. A., Bowker-Kinley, M. M., Huang, B., & Wu, P. (2002) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(01)00061-9 · Cited by 313
Identification of the Mitochondrial NAD+ Transporter in Saccharomyces cerevisiae
Todisco, S., Agrimi, G., Castegna, A., & Palmieri, F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510425200 · Cited by 228
Halestrap, A. P. (1978) · Biochemical Journal · doi:10.1042/bj1720377 · Cited by 179
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 844
Nancolas, B., Guo, L., Zhou, R., Nath, K., NELSON, D. S., Leeper, D. B., Blair, I. A., Glickson, J. D., & Halestrap, A. P. (2016) · Biochemical Journal · doi:10.1042/bj20151120 · Cited by 131
Metabolic Reprogramming in Brain Tumors
Venneti, S., & Thompson, C. B. (2017) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012615-044329 · Cited by 139
The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease
Romero, F. A., Jones, C. T., Xu, Y., Fenaux, M., & Halcomb, R. L. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01701 · Cited by 126
Protein Acetylation and Acetyl Coenzyme A Metabolism in Budding Yeast
Galdieri, L. C., Zhang, T., Rogerson, D., Lleshi, R., & Vančura, A. (2014) · Eukaryotic Cell · doi:10.1128/ec.00189-14 · Cited by 135
Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis
Finck, B. N. (2018) · Diabetes · doi:10.2337/dbi18-0024 · Cited by 125
ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly
Vranken, J. G. V., Nowinski, S. M., Clowers, K. J., Jeong, M.-Y., Ouyang, Y., Berg, J. A., Gygi, J. P., Gygi, S. P., Winge, D. R., & Rutter, J. P. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.06.039 · Cited by 122
Self-citationKamel, K. S., Oh, M. S., & Halperin, M. L. (2019) · Kidney International · doi:10.1016/j.kint.2019.08.023 · Cited by 128
Traller, J. C., Cokus, S. J., López, D. A., Gaidarenko, O., Smith, S. R., McCrow, J. P., Gallaher, S. D., Podell, S. B., Thompson, M. J., Cook, O., et al. (2016) · Biotechnology for Biofuels · doi:10.1186/s13068-016-0670-3 · Cited by 120
Yun, Z., Guo, Z., Li, X., Shen, Y., Nan, M., Dong, Q., & Hou, L. (2023) · Cancer Medicine · doi:10.1002/cam4.6022 · Cited by 122
The mitochondrial pyruvate carrier in health and disease: To carry or not to carry?
Bender, T., & Martinou, J. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.01.017 · Cited by 122
Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review
Prata, D. P., Costa-Neves, B., Cosme, G., & Vassos, E. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.04.007 · Cited by 123
Jain, A., & Zoncu, R. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101481 · Cited by 122
Stairs, C. W., Eme, L., Brown, M. W., Mutsaers, C., Susko, E., Dellaire, G., Soanes, D. M., van der Giezen, M., & Roger, A. J. (2014) · Current Biology · doi:10.1016/j.cub.2014.04.033 · Cited by 111
Tracing the lactate shuttle to the mitochondrial reticulum
Brooks, G. A., Curl, C. C., Leija, R. G., Osmond, A. D., Duong, J. J., & Arevalo, J. A. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00802-3 · Cited by 119
Temporal Coordination of Carbohydrate Metabolism during Mosquito Reproduction
Hou, Y., Wang, X., Saha, T. T., Roy, S., Zhao, B., Raikhel, A. S., & Zou, Z. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005309 · Cited by 109
SDHAF4 Promotes Mitochondrial Succinate Dehydrogenase Activity and Prevents Neurodegeneration
Vranken, J. G. V., Bricker, D. K., Dephoure, N., Gygi, S. P., Cox, J. E., Thummel, C. S., & Rutter, J. P. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.012 · Cited by 108
Self-citationRossi, A., Rigotto, G., Valente, G., Giorgio, V., Basso, E., Filadi, R., & Pizzo, P. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.060 · Cited by 109
Bräutigam, A., Schliesky, S., Külahoglu, C., Osborne, C. P., & Weber, A. P. M. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru100 · Cited by 107
Brooks, G. A., & Martin, N. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00408 · Cited by 107
Mitochondrial fusion is required for spermatogonial differentiation and meiosis
Varuzhanyan, G., Rojansky, R. B., Sweredoski, M. J., Graham, R. L., Hess, S. Y., Ladinsky, M. S., & Chan, D. C. (2019) · eLife · doi:10.7554/elife.51601 · Cited by 109
Pereira, R. O., Wende, A. R., Olsen, C. D., Soto, J. E., Rawlings, T. A., Zhu, Y., Anderson, S. M., & Abel, E. D. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000301 · Cited by 105
Glutathione Metabolism and the Novel Role of Mitochondrial GSH in Retinal Degeneration
Sreekumar, P. G., Ferrington, D. A., & Kannan, R. (2021) · Antioxidants · doi:10.3390/antiox10050661 · Cited by 107
Vigueira, P. A., McCommis, K. S., Schweitzer, G. G., Remedi, M. S., Chambers, K. T., Fu, X., McDonald, W. G., Cole, S. L., Colca, J. R., Kletzien, R. F., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.017 · Cited by 103
Loss of MPC1 reprograms retinal metabolism to impair visual function
Grenell, A., Wang, Y., Yam, M., Swarup, A., Dilan, T. L., Hauer, A., Linton, J. D., Philp, N. J., Gregor, E., Zhu, S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812941116 · Cited by 101
Arce‐Molina, R., Cortés‐Molina, F., Sandoval, P. Y., Galaz, A., Alegría, K., Schirmeier, S., Barros, L. F., & Martín, A. S. (2020) · eLife · doi:10.7554/elife.53917 · Cited by 102
Carley, A. N., Taegtmeyer, H., & Lewandowski, E. D. (2014) · Circulation Research · doi:10.1161/circresaha.114.301863 · Cited by 101
Tymoshenko, S., Oppenheim, R. D., Ågren, R., Nielsen, J., Soldati‐Favre, D., & Vassily Hatzimanikatis, A. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004261 · Cited by 99
Patterson, J. N., Cousteils, K., Lou, J. W., Manning Fox, J. E., MacDonald, P. E., & Joseph, J. W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.521666 · Cited by 98
Enzymes involved in l-lactate metabolism in humans
Adeva‐Andany, M. M., González-Lucán, M., Seco-Cervera, M., & Donapetry, C. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.08.011 · Cited by 98
The tortuous path of lactate shuttle discovery: From cinders and boards to the lab and ICU
Brooks, G. A. (2020) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2020.02.006 · Cited by 106
Seipin regulates lipid homeostasis by ensuring calcium‐dependent mitochondrial metabolism
Ding, L., Yang, X. N., Tian, H., Liang, J., Zhang, F., Wang, G., Wang, Y., Ding, M., Shui, G., & Huang, X. (2018) · The EMBO Journal · doi:10.15252/embj.201797572 · Cited by 98
NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis
Gansemer, E. R., McCommis, K. S., Martino, M. R., King-McAlpin, A. Q., Potthoff, M. J., Finck, B. N., Taylor, E. B., & Rutkowski, D. T. (2020) · iScience · doi:10.1016/j.isci.2020.101116 · Cited by 102
Self-citationBharath, L. P., Cho, J. M., Park, S.-K., Ruan, T., Li, Y., Mueller, R., Bean, T., Reese, V. R., Richardson, R. S., Cai, J., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309510 · Cited by 98
Self-citationThe Pancreatic β-Cell: A Bioenergetic Perspective
Nicholls, D. G. (2016) · Physiological Reviews · doi:10.1152/physrev.00009.2016 · Cited by 100
Díaz‐García, C. M., Meyer, D. J., Nathwani, N., Rahman, M., Martínez‐François, J. R., & Yellen, G. (2021) · eLife · doi:10.7554/elife.64821 · Cited by 98
Metabolism and epigenetics at the heart of T cell function
Soriano‐Baguet, L., & Brenner, D. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.01.002 · Cited by 97
Mechanical Unloading Promotes Myocardial Energy Recovery in Human Heart Failure
Gupte, A. A., Hamilton, D. J., Cordero‐Reyes, A. M., Youker, K. A., Yin, Z., Estep, J. D., Stevens, R. D., Wenner, B. R., Ilkayeva, O., Loebe, M. M., et al. (2014) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.113.000404 · Cited by 94
Cárdenas, J., & Silva, N. A. D. (2016) · Metabolic Engineering · doi:10.1016/j.ymben.2016.02.009 · Cited by 93
Compan, V., Pierredon, S., Vanderperre, B., Krznar, P., Marchiq, I., Zamboni, N., Pouysségur, J., & Martinou, J. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.035 · Cited by 92
Functional Properties of the Mitochondrial Carrier System
Taylor, E. B. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.04.004 · Cited by 94
Self-citationMalleable Mitochondrion of Trypanosoma brucei
Verner, Z., Basu, S., Benz, C., Dixit, S., Dobáková, E., Faktorová, D., Hashimi, H., Horáková, E., Huang, Z., Paris, Z., et al. (2015) · International review of cytology · doi:10.1016/bs.ircmb.2014.11.001 · Cited by 91
Cerebral gluconeogenesis and diseases
Yip, J., Geng, X., Shen, J., & Ding, Y. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00521 · Cited by 89
Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation
Lin, H., Chen, Y.-J., Wei, Y., Lin, H., Chen, C., Liu, T., Hsieh, Y.-L., Huang, K., Lin, K., Wang, H.-H., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.630380 · Cited by 91
Self-citationVariability of the transporter gene complement in ammonia-oxidizing archaea
Offre, P., Kerou, M., Spang, A., & Schleper, C. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.07.007 · Cited by 88
Renal Cortical Pyruvate Depletion during AKI
Zager, R. A., Johnson, A. C. M., & Becker, K. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013070791 · Cited by 87
Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference
Gherardi, G., Nogara, L., Ciciliot, S., Fadini, G. P., Blaauw, B., Braghetta, P., Bonaldo, P., Stefani, D. D., Rizzuto, R., & Mammucari, C. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0191-7 · Cited by 84
Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells
Petrelli, F., Scandella, V., Montessuit, S., Zamboni, N., Martinou, J., & Knobloch, M. (2023) · Science Advances · doi:10.1126/sciadv.add5220 · Cited by 89
Du, J., Cleghorn, W. M., Contreras, L., Lindsay, K. J., Rountree, A. M., Chertov, A. O., Turner, S. J., Sahaboglu, A., Linton, J., Sadı́lek, M., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.507285 · Cited by 86
Clinical Proof-of-Concept Study With MSDC-0160, a Prototype mTOT-Modulating Insulin Sensitizer
Colca, J. R., VanderLugt, J. T., Adams, W. J., Shashlo, A., McDonald, W. G., Liang, J., Zhou, R., & Orloff, D. G. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2013.10 · Cited by 85
NH4+ triggers the release of astrocytic lactate via mitochondrial pyruvate shunting
Lerchundi, R., Fernández‐Moncada, I., Contreras‐Baeza, Y., Sotelo-Hitschfeld, T., Mächler, P., Wyss, M. T., Stobart, J. L., Baeza‐Lehnert, F., Alegría, K., Weber, B., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508259112 · Cited by 89
Chicken or the egg: Warburg effect and mitochondrial dysfunction
Senyilmaz, D., & Teleman, A. A. (2015) · F1000Prime Reports · doi:10.12703/p7-41 · Cited by 89
The long and winding road to the mitochondrial pyruvate carrier
Schell, J. C., & Rutter, J. P. (2013) · Cancer & Metabolism · doi:10.1186/2049-3002-1-6 · Cited by 90
Self-citationNew drugs for NAFLD: lessons from basic models to the clinic
Reimer, K. C., Wree, A., Roderburg, C., & Tacke, F. (2019) · Hepatology International · doi:10.1007/s12072-019-10001-4 · Cited by 84
Energy metabolism in brown adipose tissue
Wang, Z., Wang, Q. A., Liu, Y., & Jiang, L. (2021) · FEBS Journal · doi:10.1111/febs.16015 · Cited by 87
Le, X. H., Lee, C. P., & Millar, A. H. (2021) · The Plant Cell · doi:10.1093/plcell/koab148 · Cited by 83
New insights into TCR β-selection
Dutta, A., Zhao, B., & Love, P. E. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.06.005 · Cited by 83
Metabolic regulation of tissue stem cells
Shapira, S. N., & Christofk, H. R. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.04.004 · Cited by 82
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited
Li, Z., Ji, B. W., Dixit, P. D., Tchourine, K., Lien, E. C., Hosios, A. M., Abbott, K. L., Rutter, J. C., Westermark, A. M., Gorodetsky, E. F., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00588-8 · Cited by 81
Self-citationStructural Mechanism of Transport of Mitochondrial Carriers
Ruprecht, J. J., & Kunji, E. R. S. (2021) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-072820-020508 · Cited by 81
Li, C., Wang, M., Ma, X., & Zhang, W. (2014) · Molecular Plant · doi:10.1093/mp/ssu061 · Cited by 81
Zhong, Y., Li, X., Yu, D., Li, X., Li, Y., Long, Y., Yuan, Y., Ji, Z., Zhang, M., Wen, J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5386 · Cited by 85
Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
Babu, M. S., Mahanta, S. K., Lakhter, A. J., Hato, T., Paul, S., & Naidu, S. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191419 · Cited by 80
Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase
Golias, T., Kery, M., Radenkovic, S., & Papandreou, I. (2018) · International Journal of Cancer · doi:10.1002/ijc.31812 · Cited by 82
Brown Adipose Tissue Heterogeneity, Energy Metabolism, and Beyond
Shinde, A. B., Song, A., & Wang, Q. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.651763 · Cited by 82
Amino Acid Homeostasis in Mammalian Cells with a Focus on Amino Acid Transport
Bröer, S., & Gauthier-Coles, G. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab342 · Cited by 86
Zhang, T., Bu, P., Zeng, J., & Vančura, A. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.790923 · Cited by 80
Impairments in oxidative glucose metabolism in epilepsy and metabolic treatments thereof
McDonald, T., Puchowicz, M., & Borges, K. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00274 · Cited by 77
Tompkins, S. C., Sheldon, R. D., Rauckhorst, A. J., Noterman, M. F., Solst, S. R., Buchanan, J. L., Mapuskar, K. A., Pewa, A. D., Gray, L. R., Oonthonpan, L., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.098 · Cited by 79
Self-citationHe, L., Jing, Y., Shen, J., Li, X., Liu, H., Geng, Z., Wang, M., Li, Y., Chen, D., Gao, J., et al. (2019) · PLANT PHYSIOLOGY · doi:10.1104/pp.18.01610 · Cited by 79
Mitochondrial pyruvate import and its effects on homeostasis
Vanderperre, B., Bender, T., Kunji, E. R. S., & Martinou, J. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.10.008 · Cited by 83
Cai, M., Wang, H., Song, H., Yang, R., Wang, L., Xue, X., Sun, W., & Hu, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.800901 · Cited by 87
Zhu, Y., Pereira, R. O., O'Neill, B. T., Riehle, C., Ilkun, O. L., Wende, A. R., Rawlings, T. A., Zhang, Y. C., Zhang, Q., Klip, A., et al. (2012) · Molecular Endocrinology · doi:10.1210/me.2012-1210 · Cited by 80
Expression and putative role of mitochondrial transport proteins in cancer
Lytovchenko, O., & Kunji, E. R. S. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.03.006 · Cited by 80
Xiberras, J., Klein, M., & Nevoigt, E. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.03.017 · Cited by 80
The Importance of Mitochondrial Pyruvate Carrier in Cancer Cell Metabolism and Tumorigenesis
Ruiz-Iglesias, A., & Mañes, S. (2021) · Cancers · doi:10.3390/cancers13071488 · Cited by 83
Cell cycle progression is regulated by intertwined redox oscillators
Moreira, J. D. V., Pérès, S., Steyaert, J., Bigan, E., Paulevé, L., Lévy, M., & Schwartz, L. H. (2015) · Theoretical Biology and Medical Modelling · doi:10.1186/s12976-015-0005-2 · Cited by 80
Quansah, E., Peelaerts, W., Langston, J. W., Simon, D. K., Colca, J. R., & Brundin, P. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0260-x · Cited by 76
The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state
Tavoulari, S., Thangaratnarajah, C., Mavridou, V., Harbour, M. E., Martinou, J., & Kunji, E. R. (2019) · The EMBO Journal · doi:10.15252/embj.2018100785 · Cited by 73
Rauckhorst, A. J., Gray, L. R., Sheldon, R. D., Fu, X., Pewa, A. D., Feddersen, C. R., Dupuy, A. J., Gibson-Corley, K. N., Cox, J. E., Burgess, S. C., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.09.002 · Cited by 74
Self-citationConvergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss
Lewis, W. H., Lind, A. E., Sendra, K. M., Onsbring, H., Williams, T. A., Esteban, G. F., Hirt, R. P., Ettema, T. J. G., & Embley, T. M. (2019) · Molecular Biology and Evolution · doi:10.1093/molbev/msz239 · Cited by 74
Epigenetic regulation of tumor immunity
Pang, L., Zhou, F., Liu, Y., Ali, H. A., Khan, F., Heimberger, A. B., & Chen, P. (2024) · Journal of Clinical Investigation · doi:10.1172/jci178540 · Cited by 75
Azevedo‐Silva, J., Queirós, O., Baltazar, F., Ułaszewski, S., Goffeau, A., Ko, Y. H., Pedersen, P. L., Preto, A., & Casal, M. (2016) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-016-9670-z · Cited by 74
Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila
Rabah, Y., Francés, R., Minatchy, J., Guédon, L., Desnous, C., Plaçais, P.-Y., & Préat, T. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00910-y · Cited by 76
Liu, L., Markham, K. A., Blazeck, J., Zhou, N., Leon, D., Otoupal, P. B., & Alper, H. S. (2015) · Metabolic Engineering · doi:10.1016/j.ymben.2015.07.004 · Cited by 73
Li, X., Han, G., Li, X., Kan, Q., Fan, Z., Li, Y., Ji, Y., Zhao, J., Zhang, M., Grigalavicius, M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18199 · Cited by 78
Metabolic reprogramming and disease progression in cancer patients
Torresano, L., Nuevo‐Tapioles, C., Santacatterina, F., & Cuezva, J. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165721 · Cited by 73
Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity
Nemani, N., Dong, Z., Daw, C. C., Madaris, T. R., Karthik, R., Enslow, B. T., Rubannelsonkumar, C. S., Shanmughapriya, S., Mallireddigari, V., Maity, S., et al. (2020) · Science Signaling · doi:10.1126/scisignal.aaz6206 · Cited by 71
Harnessing sub-organelle metabolism for biosynthesis of isoprenoids in yeast
Cao, X. D., Yang, S. L., Cao, C., & Zhou, Y. J. (2020) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2020.06.005 · Cited by 71
Heart failure—emerging roles for the mitochondrial pyruvate carrier
Fernández-Caggiano, M., & Eaton, P. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-020-00729-0 · Cited by 70
Differential sensitivities to lactate transport inhibitors of breast cancer cell lines
Morais-Santos, F., Miranda‐Gonçalves, V., Pinheiro, S., Vieira, A. F., Paredes, J., Schmitt, F. C., Baltazar, F., & Pinheiro, C. M. (2013) · Endocrine Related Cancer · doi:10.1530/erc-13-0132 · Cited by 70
Okegawa, T., Morimoto, M., Nishizawa, S., Kitazawa, S., Honda, K., Araki, H., Tamura, T., Ando, A., Satomi, Y., Nutahara, K., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.009 · Cited by 71
Tsai, J.-H., Chi, M. M.-Y., Schulte, M. B., & Moley, K. H. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.113.113217 · Cited by 68
Neitzel, C., Demuth, P., Wittmann, S., & Fahrer, J. (2020) · Cancers · doi:10.3390/cancers12071731 · Cited by 70
Regulation of pyruvate metabolism in metabolic-related diseases
Jeoung, N. H., Harris, C. R., & Harris, R. A. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9284-2 · Cited by 68
Sharma, A., Oonthonpan, L., Sheldon, R. D., Rauckhorst, A. J., Zhu, Z., Tompkins, S. C., Cho, K., Grzesik, W. J., Gray, L. R., Scerbo, D. A., et al. (2019) · eLife · doi:10.7554/elife.45873 · Cited by 68
Self-citationThe Earliest Stages of Mitochondrial Adaptation to Low Oxygen Revealed in a Novel Rhizarian
Gawryluk, R. M. R., Kamikawa, R., Stairs, C. W., Silberman, J. D., Brown, M. W., & Roger, A. J. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.025 · Cited by 66
Mitochondrial proteome research: the road ahead
Baker, Z. N., Forny, P., & Pagliarini, D. J. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00650-7 · Cited by 67
Mitochondrial Bioenergetics and Dysfunction in Failing Heart
Sheeran, F. L., & Pepe, S. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_4 · Cited by 66
Metabolomic Studies in Drosophila
Cox, J. E., Thummel, C. S., & Tennessen, J. M. (2017) · Genetics · doi:10.1534/genetics.117.200014 · Cited by 65
Self-citationExcitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown
Plotegher, N., Filadi, R., Pizzo, P., & Duchen, M. R. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.01.001 · Cited by 65
Metadata
- Authors
- Bricker, D. K., Taylor, E. B., Schell, J. C., Orsak, T., Boutron, A., Chen, Y.-C., Cox, J. E., Cardon, C. M., Van Vranken, J. G., Dephoure, N., Redin, C., Boudina, S., Gygi, S. P., Brivet, M., Thummel, C. S., & Rutter, J.
- Affiliations
- University of Utah (US)
- Assistance Publique – Hôpitaux de Paris (FR)
- Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
- Harvard University (US)
- Institut de génétique et de biologie moléculaire et cellulaire (FR)
- Corresponding author
- Bricker, Daniel K.
- Taylor, Eric B.
- Schell, John C.
- Orsak, Thomas
- Rutter, Jared
- ORCID
- Venue
- Science
- Published
- 2012-07-06
- Volume
- 337
- Issue
- 6090
- Pages
- 96-100
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3690818
- OpenAlex
- W2019750161
- Cited by
- 843
- References
- 19
- Citations by year
- 2026: 36 · 2025: 60 · 2024: 68 · 2023: 77 · 2022: 70 · 2021: 81 · 2020: 76 · 2019: 58 · 2018: 57 · 2017: 48 · 2016: 52 · 2015: 46 · 2014: 57 · 2013: 38 · 2012: 17
- FWCI
- 20.33
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Institutes of Health (2r01dk071962-05a1)
- National Heart, Lung, and Blood Institute (P30HL101310)
- National Institute of General Medical Sciences (R01GM083746, R01GM087346, T32GM007464, R01GM094232)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK072437, RC1DK086426, R01 DK-071962, R24DK092784)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (K99AR059190)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- mitochondrial pyruvate carrier, MPC1, MPC2, pyruvate uptake, pyruvate oxidation, TCA cycle, inner mitochondrial membrane, lactic acidosis, carbon metabolism, yeast, Drosophila, human
- MeSH terms
- Amino Acid Sequence, Amino Acids, Animals, Biological Transport, Citric Acid Cycle, Drosophila melanogaster, Humans, Mitochondria, Molecular Sequence Data, Oxidation-Reduction, Saccharomyces cerevisiae, Point Mutation, Pyruvic Acid, Mitochondrial Proteins, Anion Transport Proteins, Monocarboxylic Acid Transporters, Saccharomyces cerevisiae Proteins, Drosophila Proteins, Mitochondrial Membrane Transport Proteins, Carbohydrate Metabolism, Mitochondrial Membranes, Metabolomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
