The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics
Open accessAbstract
A Specific Oxidative Catastrophe: Three different classes of antibiotics induce bacterial cell death by the production of hydroxyl radicals. Hydroxyl radicals are powerful oxidizing agents in living cells and will oxidize the nucleic acid base, guanine, to form 8-oxoguanine, which is potentially mutagenic because it can pair with both cytosine and adenine and form lethal double-strand DNA breaks. Foti et al. (p. 315 ) discovered that overproduction of the nucleotide sanitizer MutT, which hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, gives striking protection against cell death.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858
Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro
Imlay, J. A., Chin, S. M., & Linn, S. (1988) · Science · doi:10.1126/science.2834821 · Cited by 1,555
Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products
Neeley, W. L., & Essigmann, J. M. (2006) · Chemical Research in Toxicology · doi:10.1021/tx0600043 · Cited by 510
Cited by
Beyond oxidative stress: an immunologist's guide to reactive oxygen species
Nathan, C., & Cunningham-Bussel, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3423 · Cited by 1,619
Antibiotic efficacy is linked to bacterial cellular respiration
Lobritz, M. A., Belenky, P., Porter, C. B. M., Gutierrez, A., Yang, J. H., Schwarz, E. G., Dwyer, D. J., Khalil, A. S., & Collins, J. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509743112 · Cited by 773
Self-citationReactive Oxygen Species-Related Nanoparticle Toxicity in the Biomedical Field
Yu, Z., Li, Q., Wang, J., Yu, Y., Wang, Y., Zhou, Q., & Li, P. (2020) · Nanoscale Research Letters · doi:10.1186/s11671-020-03344-7 · Cited by 709
Cell Death from Antibiotics Without the Involvement of Reactive Oxygen Species
Liu, Y., & Imlay, J. A. (2013) · Science · doi:10.1126/science.1232751 · Cited by 593
Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome
Modi, S. R., Lee, H. H., Spina, C. S., & Collins, J. J. (2013) · Nature · doi:10.1038/nature12212 · Cited by 542
Self-citation
Metadata
- Authors
- Foti, J. J., Devadoss, B., Winkler, J. A., Collins, J. J., & Walker, G. C.
- Venue
- Science
- Published
- 2012-04-20
- Volume
- 336
- Issue
- 6079
- Pages
- 315-319
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1544022371
- Cited by
- 497
- References
- 3
- FWCI
- 16.38
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics. https://app.cochat.ai/papers/10.1126/science.1219192
- The paper
- Foti, J. J., Devadoss, B., Winkler, J. A., Collins, J. J., & Walker, G. C. (2012). Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics. Science. https://doi.org/10.1126/science.1219192
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
