The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Cell Death from Antibiotics Without the Involvement of Reactive Oxygen Species
Open accessAbstract
Antibiotic Mechanisms Revisited: Several recent studies have suggested that bactericidal antibiotics kill cells by a common mechanism involving reactive oxygen species (ROS). Two groups tested this hypothesis using diverse experiments, with both finding that quinolone, lactam, and aminoglycoside antibiotics had similar efficacy for killing in the presence or absence of oxygen (or nitrate). Liu et al. (p. 1210 ) saw no increase in hydrogen peroxide production in antibiotic-exposed cells and found no association between antibiotic exposure and the expected symptoms of oxidative damage, such as the breakdown of iron-sulfur clusters in enzymes or of hydroxyl radical injuries to DNA. Similarly, Keren et al. (p. 1213 ) found no correlation between the production of ROS, inferred from hydroxyphenyl fluorescein dye measurements, and bacterial survival, nor was there any significant protective effect engendered by thiourea. The results do not support a common mode of action for bactericidal antibiotics mediated by ROS.
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Self-citationThe oxidative environment and protein damage
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The role of iron and reactive oxygen species in cell death
Dixon, S. J., & Stockwell, B. R. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1416 · Cited by 2,381
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Reactive Oxygen Species-Related Nanoparticle Toxicity in the Biomedical Field
Yu, Z., Li, Q., Wang, J., Yu, Y., Wang, Y., Zhou, Q., & Li, P. (2020) · Nanoscale Research Letters · doi:10.1186/s11671-020-03344-7 · Cited by 709
ROS and diseases: role in metabolism and energy supply
Yang, S., & Lian, G. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03667-9 · Cited by 658
Post-stress bacterial cell death mediated by reactive oxygen species
Hong, Y., Zeng, J., Wang, X., Drlica, K., & Zhao, X. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901730116 · Cited by 513
Metadata
- Authors
- Liu, Y., & Imlay, J. A.
- Venue
- Science
- Published
- 2013-03-08
- Volume
- 339
- Issue
- 6124
- Pages
- 1210-1213
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982029231
- Cited by
- 593
- References
- 35
- FWCI
- 45.12
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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