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The Crystal Structure of Human Argonaute2
Open accessAbstract
Human Argonaute Revealed: RNA interference (RNAi) is mediated by Argonaute (Ago) proteins, which bind small regulatory RNAs that have sequence complementarity to target RNAs destined to be silenced. The structure of bacterial homologs of the Ago proteins, and fragments of eukaryotic Ago proteins, have provided initial insights into Ago function. Now, Schirle and MacRae (p. 1037 , published online 26 April; see the Perspective by Kaya and Doudna ) have determined the structure of the full-length human Ago protein bound to a single-stranded (ss) guide RNA. Within the bilobed structure, eight nucleotides of the ssRNA are visibly positioned in the RNA-guide, strand-binding site. The “seed” region of the ssRNA has its Watson-and-Crick base edges exposed to solvent, likely aiding target recognition. The location of two free tryptophans in the Piwi domain suggests a possible recruitment site for Ago-interacting proteins.
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PHENIX : a comprehensive Python-based system for macromolecular structure solution
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MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
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Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462
Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751
Regulation of microRNA function in animals
Gebert, L. F. R., & MacRae, I. J. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0045-7 · Cited by 2,284
Self-citationTowards a molecular understanding of microRNA-mediated gene silencing
Jonas, S., & Izaurralde, E. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3965 · Cited by 1,872
Metadata
- Authors
- Schirle, N. T., & MacRae, I. J.
- Venue
- Science
- Published
- 2012-05-25
- Volume
- 336
- Issue
- 6084
- Pages
- 1037-1040
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2132691262
- Cited by
- 696
- References
- 5
- FWCI
- 23.47
- Type
- journal article
- Language
- en
- Open access
- green
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