The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response
Open accessAbstract
Influenza's Cryptic Constraint: Because of the well-known pandemic potential of influenza viruses, it is important to understand the range of molecular interactions between the virus and its host. Despite years of intensive research on the virus, Jagger et al. (p. 199 , published online 28 June; see the Perspective by Yewdell and Ince ) have found that the influenza A virus has been hiding a gene in its small negative-sense RNA genome. An overlapping open reading frame was found contained in the PA viral RNA polymerase gene, which is accessed by ribosomal frameshifting to produce a fusion protein containing the N-terminal messenger RNA (mRNA) endonuclease domain of PA and an alternative C-terminal X domain. The resulting polypeptide, PA-X, selectively degrades host mRNAs and, in a mouse model of infection, modulated cellular immune responses, thus limiting viral pathogenesis.
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Self-citationA novel influenza A virus mitochondrial protein that induces cell death
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Self-citationThe cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
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Innate Immune Evasion by Human Respiratory RNA Viruses
Kikkert, M. (2020) · Journal of Innate Immunity · doi:10.1159/000503030 · Cited by 406
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Mapping the Phosphoproteome of Influenza A and B Viruses by Mass Spectrometry
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Kash, J. C., Xiao, Y., Davis, A. S., Walters, K.-A., Chertow, D. S., Easterbrook, J. D., Dunfee, R. L., Sandouk, A., Jagger, B. W., Schwartzman, L. M., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.10.014 · Cited by 43
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Metadata
- Authors
- Jagger, B. W., Wise, H. M., Kash, J. C., Walters, K.-A., Wills, N. M., Xiao, Y.-L., Dunfee, R. L., Schwartzman, L. M., Ozinsky, A., Bell, G. L., Dalton, R. M., Lo, A., Efstathiou, S., Atkins, J. F., Firth, A. E., Taubenberger, J. K., & Digard, P.
- Venue
- Science
- Published
- 2012-07-13
- Volume
- 337
- Issue
- 6091
- Pages
- 199-204
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2001788095
- Cited by
- 640
- References
- 31
- FWCI
- 51.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Jagger, B. W., Wise, H. M., Kash, J. C., Walters, K.-A., Wills, N. M., Xiao, Y.-L., Dunfee, R. L., Schwartzman, L. M., Ozinsky, A., Bell, G. L., Dalton, R. M., Lo, A., Efstathiou, S., Atkins, J. F., Firth, A. E., Taubenberger, J. K., & Digard, P. (2012). An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response. Science. https://doi.org/10.1126/science.1222213
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