The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides
Abstract
Made and Modified: The polytheonamides are 48-residue toxins derived from marine sponges that include 18 D -amino acids, as well as many other unusual amino acid modifications. Given the complexity, one might guess that these peptides are the product of nonribosomal, peptide synthetase (NRPS). However, Freeman et al. (p. 387 , published online 13 September now show that polytheonamides are produced by a bacterial symbiont using a ribosomal pathway. Six candidate enzymes for the 48 posttranslational modifications were identified and three were functionally validated. Such ribosomal systems could be useful in bioengineering.
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Piel, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222481399 · Cited by 609
Self-citationSchmidt, E. W., Nelson, J. T., Rasko, D. A., Sudek, S., Eisen, J. A., Haygood, M. G., & Ravel, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501424102 · Cited by 567
Frey, P. A., Hegeman, A. D., & Ruzicka, F. J. (2008) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701829169 · Cited by 551
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Self-citationBacterial Protection of Beetle-Fungus Mutualism
Scott, J. J., Oh, D.-C., Yuceer, M. C., Klepzig, K. D., Clardy, J., & Currie, C. R. (2008) · Science · doi:10.1126/science.1160423 · Cited by 478
Nonribosomal peptide synthetases: structures and dynamics
Strieker, M., Tanović, A., & Marahiel, M. A. (2010) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2010.01.009 · Cited by 441
Follow the leader: the use of leader peptides to guide natural product biosynthesis
Oman, T. J., & van der Donk, W. A. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.286 · Cited by 408
Nguyen, T., Ishida, K., Jenke-Kodama, H., Dittmann, E., Gurgui, C., Hochmuth, T., Taudien, S., Platzer, M., Hertweck, C., & Piel, J. (2008) · Nature Biotechnology · doi:10.1038/nbt1379 · Cited by 390
Self-citationRibosomal peptide natural products: bridging the ribosomal and nonribosomal worlds
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Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., Camarero, J. A., Campopiano, D. J., Challis, G. L., Clardy, J., et al. (2013) · Nat. Prod. Rep. · doi:10.1039/c2np20085f · Cited by 2,076
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Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters
Cimermancic, P., Medema, M. H., Claesen, J., Kurita, K., Wieland Brown, L. C., Mavrommatis, K., Pati, A., Godfrey, P. A., Koehrsen, M., Clardy, J., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.034 · Cited by 981
New developments in RiPP discovery, enzymology and engineering
Montalbán-López, M., Scott, T. A., Ramesh, S., Rahman, I. R., van Heel, A. J., Viel, J. H., Bandarian, V., Dittmann, E., Genilloud, O., Goto, Y., et al. (2021) · Natural Product Reports · doi:10.1039/d0np00027b · Cited by 787
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Metadata
- Authors
- Freeman, M. F., Gurgui, C., Helf, M. J., Morinaka, B. I., Uria, A. R., Oldham, N. J., Sahl, H.-G., Matsunaga, S., & Piel, J.
- Venue
- Science
- Published
- 2012-10-19
- Volume
- 338
- Issue
- 6105
- Pages
- 387-390
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2045636632
- Cited by
- 347
- References
- 28
- FWCI
- 15.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Freeman, M. F., Gurgui, C., Helf, M. J., Morinaka, B. I., Uria, A. R., Oldham, N. J., Sahl, H.-G., Matsunaga, S., & Piel, J. (2012). Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides. Science. https://doi.org/10.1126/science.1226121
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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